Abstract:
:In this article, we present a framework to perform statistical shape analysis for segmented hippocampi, including an efficient permutation test for detecting subtle class differences, and a regularized discriminative direction method for visualizing the shape discrepancy. Fisher permutation and bootstrap tests are preferred to traditional hypothesis tests which impose assumptions on the distribution of the samples. In this article, an efficient algorithm is adopted to rapidly perform the exact tests. We extend this algorithm to multivariate data by projecting the shape descriptors onto an informative direction that preserves the original discriminative information as much as possible to generate a scalar test statistic. This informative direction is further used to seek a discriminative direction to isolate the discriminative shape difference between classes from the individual variability. Compared with existing methods, the discriminative direction used in this article is regularized by requiring that the shapes deformed along it respect the underlying shape distribution as well as reflecting the essential shape differences between two populations. Hence, a more accurate localization of difference is produced. We apply our methods to analyze the hippocampal shapes for controls and subjects with Alzheimer's disease from the publicly available OASIS MRI database. We show how to localize the shape differences between the two classes.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Zhou L,Lieby P,Barnes N,Réglade-Meslin C,Walker J,Cherbuin N,Hartley Rdoi
10.1002/hipo.20639subject
Has Abstractpub_date
2009-06-01 00:00:00pages
533-40issue
6eissn
1050-9631issn
1098-1063journal_volume
19pub_type
杂志文章相关文献
HIPPOCAMPUS文献大全abstract::It has been demonstrated that the dorsal CA1 subregion of the hippocampus mediates temporal processing of information, that dorsal CA3 participates in the spatiotemporal processing of memory, and the dorsal dentate gyrus (DG) mediates spatial pattern separation. A temporal ordering of spatial locations task was develo...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20455
更新日期:2008-01-01 00:00:00
abstract::It has been well-established that cell proliferation and neurogenesis in the adult mouse dentate gyrus (DG) can be regulated by voluntary exercise. Recent evidence has suggested that the effects of voluntary exercise can in turn be influenced by environmental factors that regulate the amount of stress an animal is exp...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20514
更新日期:2009-10-01 00:00:00
abstract::The conditioned cue preference (CCP) task was used to study the ability of rats to discriminate between spatial locations. Food-deprived rats explored an eight-arm radial maze with no food present (pre-exposure). On subsequent days, they were alternately confined in one arm of the maze with food and in another arm wit...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20127
更新日期:2005-01-01 00:00:00
abstract::One of the most striking features of the hippocampal network is its ability to self-generate neuronal sequences representing temporally compressed, spatially coherent paths. These brief events, often termed "replay" in the scientific literature, are largely confined to non-exploratory states such as sleep or quiet res...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22824
更新日期:2020-01-01 00:00:00
abstract::Structural integrity of the human hippocampus is widely acknowledged to be necessary for the successful encoding and retrieval of autobiographical memories. However, evidence for an association between hippocampal volume and the ability to recall such memories in healthy individuals is mixed. Here we examined this iss...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23293
更新日期:2020-12-15 00:00:00
abstract::Functional differences in the anterior and posterior hippocampus during episodic memory processing have not been examined in human electrophysiological data. This is in spite of strong evidence for such differences in rodent data, including greater place cell specificity in the dorsal hippocampus, greater sensitivity ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22751
更新日期:2017-10-01 00:00:00
abstract::Hippocampal synaptic plasticity comprises a key cellular mechanism for information storage. In the hippocampus, both long-term potentiation (LTP) and long-term depression (LTD) are triggered by synaptic Ca2+ -elevations that are typically mediated by the opening of voltage-gated cation channels, such as N-methyl-d-asp...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22742
更新日期:2017-08-01 00:00:00
abstract::Septal nuclei are suggested to work as an interface between the hippocampal formation, involved in higher cognitive functions, and the hypothalamus, involved in motivational behaviors such as feeding, drinking, and intracranial self-stimulation. In the present study, to elucidate a role of the septal nuclei in motivat...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1997)7:5<536::AID-HIPO9>3.
更新日期:1997-01-01 00:00:00
abstract::The hippocampus is essential for learning and memory but also regulates emotional behavior. We previously identified the hippocampus as a major brain region that differs in rats bred for emotionality differences. Rats bred for low novelty response (LRs) exhibit high levels of anxiety- and depression-like behavior comp...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23092
更新日期:2019-10-01 00:00:00
abstract::Neuregulins (NRGs) are ligands of ErbB receptor tyrosine kinases. The NRG1-ErbB4 pathway has been shown to modulate hippocampal synaptic plasticity and network oscillations in the adult rodent brain. To identify cells that mediate these effects, here we determine the expression pattern of ErbB4 in four functionally di...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20675
更新日期:2010-06-01 00:00:00
abstract::Nuclear factor-kappa B (NFκB) signal is essential for neuronal survival and its activation may protect neuron against various stimuli. Since purinergic signals activate NFκB through the P2X7 receptor, we investigated the distinct pattern of NF-κB phosphorylation in neurons by P2X7 receptor activation following status ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22109
更新日期:2013-06-01 00:00:00
abstract::We recorded neuromagnetic fields evoked by a somatosensory oddball task requiring subjects to discriminate target stimuli from nontarget stimuli, which are different in stimulation intensity, with a mental count of the target stimuli. A whole head type 80-channel magnetoencephalography (MEG) system with a 50-mm baseli...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10196
更新日期:2004-01-01 00:00:00
abstract::Autism spectrum disorder (ASD) is a class of neurodevelopmental disorders characterized by persistent deficits in social communication/interaction, together with restricted/repetitive patterns of behavior. ASD is among the most heritable neuropsychiatric conditions, and while available evidence points to a complex set...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22741
更新日期:2017-08-01 00:00:00
abstract::To study the possible involvement of the hippocampus in learned conditional responding, rats with aspiration lesions of the hippocampus and others that had the hippocampus removed with ibotenic acid were trained on concurrent Pavlovian conditional and nonconditional discriminations. In agreement with the results repor...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450010110
更新日期:1991-01-01 00:00:00
abstract::The present study investigated the delayed and persistent effects of 4 beta-phorbol 12,13-dibutyrate (PDBu) on the K(+)-evoked release of endogenous glutamate and dynorphin B-like immunoreactivity from a subcellular fraction (P3) that is enriched in hippocampal mossy fiber synaptosomes. It is demonstrated that the alp...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450030212
更新日期:1993-04-01 00:00:00
abstract::The hippocampus is essential for the consolidation of some explicit long-term memories, including trace conditioning. Lesions and pharmacological manipulations of the dorsal hippocampus (DH) have provided strong evidence for its involvement in the acquisition and expression of trace fear memories. However, no studies ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22413
更新日期:2015-07-01 00:00:00
abstract::The role of subicular neurons is explored with respect to their participation in short-term memory during performance of a spatial Delayed-Nonmatch-to-Sample (DNMS) task by well-trained rats. Subicular and CA1 neuron firing was examined in the same animals in relation to the encoding of task-relevant events during the...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10119
更新日期:2003-01-01 00:00:00
abstract::Williams syndrome (WS), a genetic deletion syndrome, is characterized by severe visuospatial deficits affecting performance on both tabletop spatial tasks and on tasks which assess orientation and navigation. Nevertheless, previous studies of WS spatial capacities have ignored the fact that two different spatial memor...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22764
更新日期:2017-11-01 00:00:00
abstract::The molecular mechanisms of regionalization of the medial pallium (MP), the anlage of the hippocampus, and transitional (cingulate and retrosplenial) cortices are largely unknown. Previous analyses have outlined an important role of the transcription factor (TF) Zbtb20 for hippocampal CA1 field specification (Nielsen ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22035
更新日期:2012-11-01 00:00:00
abstract::By acting on serotonin 5-HT2A receptors (5-HT2A Rs), serotonergic psychedelic drugs induce perceptual and visual hallucinations by increasing neuronal excitability and altering visual-evoked neuronal responses. The present study was designed to examine whether the perceptual alterations induced by a serotonergic psych...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22712
更新日期:2017-05-01 00:00:00
abstract::To examine the effects of long-term potentiation (LTP) on individual neurons in the intact brain, anesthetized rats were implanted with a recording stereotrode in the right CA1 layer of the hippocampus and a stimulating electrode in the right and left CA3 layers. The evoked and spontaneous firing of single CA1 neurons...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/1098-1063(2000)10:3<207::AID-HIPO1>3.0.CO;
更新日期:2000-01-01 00:00:00
abstract::Several recent studies have compared episodic and spatial memory in neuroimaging paradigms in order to understand better the contribution of the hippocampus to each of these tasks. In the present study, we build on previous findings showing common neural activation in default network areas during episodic and spatial ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22352
更新日期:2015-01-01 00:00:00
abstract::Nearby grid cells have been observed to express a remarkable degree of long-range order, which is often idealized as extending potentially to infinity. Yet their strict periodic firing and ensemble coherence are theoretically possible only in flat environments, much unlike the burrows which rodents usually live in. Ar...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23144
更新日期:2020-04-01 00:00:00
abstract::Hippocampal theta oscillations have been implicated in spatial memory function in both rodents and humans. What is less clear is how hippocampal theta interacts with higher frequency oscillations to support long-term memory. Here we asked 10 presurgical epilepsy patients undergoing intracranial EEG recording to perfor...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23284
更新日期:2021-02-01 00:00:00
abstract::Granule cells born in the adult dentate gyrus undergo a 4-week developmental period characterized by high susceptibility to cell death. Two forms of hippocampus-dependent learning have been shown to rescue many of the new neurons during this critical period. Here, we show that a natural form of associative learning, s...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20097
更新日期:2005-01-01 00:00:00
abstract::Seizures induced by fever (febrile seizures) are the most frequent seizures affecting infants and children; however, their impact on the developing hippocampal formation is not completely understood. Such understanding is highly important because of the potential relationship of prolonged febrile seizures to temporal ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10089
更新日期:2003-01-01 00:00:00
abstract::The entorhinal cortex has long been recognized as an important interface between the hippocampal formation and the neocortex. The notion of bidirectional connections between the entorhinal cortex and the hippocampal formation have led to the suggestion that hippocampal output originating in CA1 and subiculum may reent...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20022
更新日期:2004-01-01 00:00:00
abstract::A large body of neuroscientific work indicates that exposure to experienced stress causes damage to both cortical and hippocampal cells and results in impairments to cognitive abilities associated with these structures. Similarly, work within the domain of cognitive aging demonstrates that elderly participants who rep...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22525
更新日期:2016-03-01 00:00:00
abstract::We have previously shown that, in HEK 293 cells, overexpression of acidic calponin, an actin-binding protein, induces remodeling of actin filaments, leading to a change in cell morphology. In addition, this protein is found in dendritic spines of adult hippocampal neurons. We hypothesized that this protein plays a rol...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10136
更新日期:2003-01-01 00:00:00
abstract::Processing of multimodal sensory information by the morphological subdivisions of the hippocampus and its input and output structures was investigated in unanesthetized rabbits by extracellular recording of neuronal activity. Analysis shows principal differences between CA3 neurons with uniform multimodal, mainly inhi...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.1073
更新日期:2001-01-01 00:00:00