Abstract:
:Hippocampal theta oscillations have been implicated in spatial memory function in both rodents and humans. What is less clear is how hippocampal theta interacts with higher frequency oscillations to support long-term memory. Here we asked 10 presurgical epilepsy patients undergoing intracranial EEG recording to perform a long-term spatial memory task in desktop virtual reality and found that increased theta power in two discrete bands ("low" 2-5 Hz and "high" 6-11 Hz) during cued retrieval was associated with improved task performance. Similarly, increased coupling between "low" theta phase and gamma amplitude during the same period was associated with improved task performance. Finally, low and high gamma amplitude appeared to peak at different phases of the theta cycle; providing a novel connection between human hippocampal function and rodent data. These results help to elucidate the role of theta oscillations and theta-gamma phase-amplitude coupling in human long-term memory.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Vivekananda U,Bush D,Bisby JA,Baxendale S,Rodionov R,Diehl B,Chowdhury FA,McEvoy AW,Miserocchi A,Walker MC,Burgess Ndoi
10.1002/hipo.23284subject
Has Abstractpub_date
2021-02-01 00:00:00pages
213-220issue
2eissn
1050-9631issn
1098-1063journal_volume
31pub_type
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