Abstract:
:We review evidence from experiments conducted in our laboratory on retrograde amnesia in rats with damage to the hippocampal formation. In a new experiment reported here, we show that N-methyl-D-aspartate (NMDA)-induced hippocampal damage produced retrograde amnesia for both hidden platform and two-choice visible platform discriminations in the Morris water task. For both problems there was a significant trend for longer training-surgery intervals to be associated with worse retention performance. Little support is offered by our work for the concept that there is a process involving hippocampal-dependent consolidation of memories in extrahippocampal permanent storage sites. Long-term memory consolidation may take place within the hippocampus. The hippocampus may be involved permanently in storage and/or retrieval of a variety of relational and nonrelational memories if it was intact at the time of learning, even involving information which is definitely not affected in anterograde amnesia after hippocampal damage.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Sutherland RJ,Weisend MP,Mumby D,Astur RS,Hanlon FM,Koerner A,Thomas MJ,Wu Y,Moses SN,Cole C,Hamilton DA,Hoesing JMdoi
10.1002/1098-1063(2001)11:1<27::AID-HIPO1017>3.0.Ckeywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
27-42issue
1eissn
1050-9631issn
1098-1063journal_volume
11pub_type
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