Morpho-physiological criteria divide dentate gyrus interneurons into classes.

Abstract:

:GABAergic inhibitory interneurons control fundamental aspects of neuronal network function. Their functional roles are assumed to be defined by the identity of their input synapses, the architecture of their dendritic tree, the passive and active membrane properties and finally the nature of their postsynaptic targets. Indeed, interneurons display a high degree of morphological and physiological heterogeneity. However, whether their morphological and physiological characteristics are correlated and whether interneuron diversity can be described by a continuum of GABAergic cell types or by distinct classes has remained unclear. Here we perform a detailed morphological and physiological characterization of GABAergic cells in the dentate gyrus, the input region of the hippocampus. To achieve an unbiased and efficient sampling and classification we used knock-in mice expressing the enhanced green fluorescent protein (eGFP) in glutamate decarboxylase 67 (GAD67)-positive neurons and performed cluster analysis. We identified five interneuron classes, each of them characterized by a distinct set of anatomical and physiological parameters. Cross-correlation analysis further revealed a direct relation between morphological and physiological properties indicating that dentate gyrus interneurons fall into functionally distinct classes which may differentially control neuronal network activity.

journal_name

Hippocampus

journal_title

Hippocampus

authors

Hosp JA,Strüber M,Yanagawa Y,Obata K,Vida I,Jonas P,Bartos M

doi

10.1002/hipo.22214

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

189-203

issue

2

eissn

1050-9631

issn

1098-1063

journal_volume

24

pub_type

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