Abstract:
:Wnt proteins have emerged as transmembrane signaling molecules that regulate learning and memory as well as synaptic plasticity at central synapses (Inestrosa and Arenas (2010) Nat Rev Neurosci 11:77-86; Maguschak and Ressler (2011) J Neurosci 31:13057-13067; Tabatadze et al. (2012) Hippocampus 22: 1228-1241; Fortress et al. (2013) J Neurosci 33:12619-12626). For example, there is both a training-selective and Wnt isoform-specific increase in Wnt 7 levels in hippocampus seven days after spatial learning in rats (Tabatadze et al. (2012) Hippocampus 22: 1228-1241). Despite growing interest in Wnt signaling pathways in the adult brain, intracellular distribution and release of Wnt molecules from synaptic compartments as well as their influence on synaptic strength and connectivity remain less well understood. As a first step in such an analysis, we show here that Wnt 7 levels in primary hippocampal cells are elevated by potassium or glutamate activation in a time-dependent manner. Subsequent Wnt 7 elevation in dendrites suggests selective somato-dendritic trafficking followed by transport from dendrites to their spines. Wnt 7 elevation is also TTX-reversible, establishing that its elevation is indeed an activity-dependent process. A second stimulation given 6 h after the first significantly reduces Wnt 7 levels in dendrites 3 h later as compared to non-stimulated controls suggesting activity-dependent Wnt 7 release from dendrites and spines. In a related experiment designed to mimic the release of Wnt 7, exogenous recombinant Wnt 7 increased the number of active zones in presynaptic terminals as indexed by bassoon. This suggests the formation of new presynaptic release sites and/or presynaptic terminals. Wnt signaling inhibitor sFRP-1 completely blocked this Wnt 7-induced elevation of bassoon cluster number and cluster area. We suggest that Wnt 7 is a plasticity-related protein involved in the regulation of presynaptic plasticity via a retrograde signaling mechanism as previously proposed (Routtenberg (1999) Trends in Neuroscience 22:255-256). These findings provide support for this proposal, which offers a new perspective on the synaptic tagging mechanism (Redondo and Morris (2011) Nat Rev Neurosci 12:17-30).
journal_name
Hippocampusjournal_title
Hippocampusauthors
Tabatadze N,McGonigal R,Neve RL,Routtenberg Adoi
10.1002/hipo.22239subject
Has Abstractpub_date
2014-04-01 00:00:00pages
455-65issue
4eissn
1050-9631issn
1098-1063journal_volume
24pub_type
杂志文章相关文献
HIPPOCAMPUS文献大全abstract::The hippocampus is essential for learning and memory but also regulates emotional behavior. We previously identified the hippocampus as a major brain region that differs in rats bred for emotionality differences. Rats bred for low novelty response (LRs) exhibit high levels of anxiety- and depression-like behavior comp...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23092
更新日期:2019-10-01 00:00:00
abstract::Adaptive memory requires the organism to form associations that bridge between events separated in time. Many studies show interactions between hippocampus (HPC) and prefrontal cortex (PFC) during formation of such associations. We analyze neural recording from monkey HPC and PFC during a memory task that requires the...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23282
更新日期:2020-12-01 00:00:00
abstract::There is an ongoing debate regarding the respective role of anterior subhippocampal structures and the hippocampus in recognition memory. Here, we report a double anatomo-functional dissociation observed in two brain-damaged patients, FRG and JMG. They both suffered from complete destruction of left MTL structures. In...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20848
更新日期:2011-09-01 00:00:00
abstract::In a comparative approach, the anatomical organization of the hippocampus was investigated in two species of megachiropteran bats, the grey-headed flying fox, Pteropus poliocephalus, and the little red flying fox, Pteropus scapulatus. In general, the cytoarchitectonic appearance of the flying fox hippocampus correspon...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450010203
更新日期:1991-04-01 00:00:00
abstract::To minimize the variability in the extent of lesions made by injections of the excitotoxin ibotenic acid in rhesus monkeys, we developed and validated an MRI-based method to determine the efficacy of the injections soon after surgery. T2-weighted MR images were obtained 6-11 days after surgery from 17 brain hemisphere...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.1050
更新日期:2001-01-01 00:00:00
abstract::Subjective and objective memory deficits represent a frequent and ill-understood aspect of multiple sclerosis (MS), and a significant cause of disability and quality of life reduction. The aim of the study is to verify the role of hippocampal and temporal associative fibers' damage in MS-related memory complaints. To ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22237
更新日期:2014-04-01 00:00:00
abstract::The hippocampus, the prefrontal cortex, and interconnected neural circuits are implicated in several aspects of cognitive and memory processes. The present review is dedicated to the description of the anatomo-functional characteristics of the hippocampo-prefrontal pathway and related neuronal circuits in the rat. Thi...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/1098-1063(2000)10:4<411::AID-HIPO7>3.0.CO;
更新日期:2000-01-01 00:00:00
abstract::Exposing rats to an enriched environment over an extended period of time has been shown to enhance hippocampal long-term potentiation (LTP). Whether such prolonged exposure to environmental manipulation is necessary for LTP enhancement and whether the environmentally induced enhancement can persist long after the cess...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10017
更新日期:2002-01-01 00:00:00
abstract::Learning and memory can be controlled by distinct memory systems. How these systems are coordinated to optimize learning and behavior has long been unclear. Accumulating evidence indicates that stress may modulate the engagement of multiple memory systems. In particular, rodent and human studies demonstrate that stres...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.22175
更新日期:2013-11-01 00:00:00
abstract::Rett syndrome (RTT) is a neurodevelopment disorder associated with intellectual disabilities and caused by loss-of-function mutations in the gene encoding the transcriptional regulator Methyl-CpG-binding Protein-2 (MeCP2). Neuronal dysfunction and changes in cortical excitability occur in RTT individuals and Mecp2-def...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22360
更新日期:2015-02-01 00:00:00
abstract::The selective lesion of basal forebrain cholinergic neurons (BFCNs) is an unestimable tool to study the implication of these neurons in cognition, an interest widely motivated by their degeneration in Alzheimer's disease. Here we evaluated the histochemical and behavioral effects of a selective lesion of BFCNs in C57B...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20422
更新日期:2008-01-01 00:00:00
abstract::This study investigated the effects of progesterone (P4) on the production and survival of neurons in the hippocampal dentate gyrus of adult male mice. The administration of P4 (4 mg/kg) for 3 consecutive days beginning on the 0-2nd day after the first BrdU-injection (BrdU-D(0-2)) produced an approximately twofold inc...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20642
更新日期:2010-03-01 00:00:00
abstract::The hippocampus and the medial temporal lobe cortex [medial temporal lobe cortices (MTLC)] both contribute to long-term memory. Although their contributions are thought to be dissociable, the nature of the representations that each region supports remains unclear. The Complementary Learning Systems (CLS) modeling appr...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20967
更新日期:2012-05-01 00:00:00
abstract::This study examines the extent to which simultaneous olfactory discrimination learning increases spine density on hippocampal CA1 pyramidal neurons in C57BL/6J (C57) and DBA/2J (DBA) inbred mice, characterized by spontaneous differences in hippocampal plasticity and hippocampus-related learning. The behavioral data fi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20174
更新日期:2006-01-01 00:00:00
abstract::Gelsolin is an actin-binding protein that regulates actin filament-severing and capping activity in the various processes of cell motilities. Here, we report the expression of gelsolin mRNA and protein in the hippocampus following transections of the entorhinal afferents. Northern blot analysis showed that transcript ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20134
更新日期:2006-01-01 00:00:00
abstract::One functional aspect of theta oscillations that recent studies have begun to explore in humans is their role for the recollection of personal events. A specific role of theta for recollection but not for stimulus-familiarity would support links between cortical theta oscillations and hippocampal functioning, given th...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20125
更新日期:2005-01-01 00:00:00
abstract::The ventral portion of the rodent hippocampus (HPC; anterior in primates) has been implicated in the detection and resolution of approach-avoidance conflict, which arises when an organism encounters a stimulus that predicts both positive and negative outcomes. Previous work has found differential regulation of approac...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23182
更新日期:2020-06-01 00:00:00
abstract::Lynn Nadel has been a trailblazer in memory research for decades. In just one example, Nadel and Zola-Morgan [Infantile amnesia, In Infant memory, Springer, Boston, MA, 1984, pp. 145-172] were the first to present the provocative notion that the extended development of the hippocampus may underlie the period of infant...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23149
更新日期:2020-08-01 00:00:00
abstract::Trace eyeblink classical conditioning is a non-spatial learning paradigm that requires an intact hippocampus. This task is hippocampus-dependent because the auditory tone conditioned stimulus (CS) is temporally separated from the corneal airpuff unconditioned stimulus (US) by a 500-ms trace interval. Our laboratory ha...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1098-1063(1999)9:4<385::AID-HIPO5>3.
更新日期:1999-01-01 00:00:00
abstract::Adult neurogenesis in the dentate gyrus (DG) plays a crucial role for pattern separation, and there are sex differences in the regulation of neurogenesis. Although sex differences, favoring males, in spatial navigation have been reported, it is not known whether there are sex differences in pattern separation. The cur...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22493
更新日期:2016-01-01 00:00:00
abstract::It is argued that while the hippocampus is not vital for all classes of configural learning, it is vital for a specific subclass of configural tasks called "structural learning." The defining feature of structural learning is that in addition to binding stimulus elements to make unique arrays (as in all configural lea...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.20323
更新日期:2007-01-01 00:00:00
abstract::The hippocampus creates distinct episodes from highly similar events through a process called pattern separation and can retrieve memories from partial or degraded cues through a process called pattern completion. These processes have been studied in humans using tasks where participants must distinguish studied items...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22256
更新日期:2014-06-01 00:00:00
abstract::White matter hyperintensities (WMH) constitute the visible spectrum of cerebral small vessel disease (SVD) markers and are associated with cognitive decline, although they do not fully account for memory decline observed in individuals with SVD. We hypothesize that WMH might exert their effect on memory decline indire...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23039
更新日期:2019-06-01 00:00:00
abstract::There is limited knowledge regarding how the brain controls the timing of meals. Similarly, there is a large gap in our understanding of how top-down cognitive processes, such as memory influence energy intake. We hypothesize that dorsal hippocampal (dHC) neurons, which are critical for episodic memory, form a memory ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22532
更新日期:2016-03-01 00:00:00
abstract::Our model of the spatial and temporal aspects of place cell firing and their role in rat navigation is reviewed. The model provides a candidate mechanism, at the level of individual cells, by which place cell information concerning self-localization could be used to guide navigation to previously visited reward sites....
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1996)6:6<749::AID-HIPO16>3
更新日期:1996-01-01 00:00:00
abstract::Neuronal oscillations and cross-frequency interactions in the rat hippocampus relate in important ways to memory processes and serve as a model for studying oscillatory activity in cognition more broadly. We report here that hippocampal synchrony (CA3-CA1 coherence) increased markedly in the low gamma range as rats we...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22228
更新日期:2014-03-01 00:00:00
abstract::Fear can be extinguished by repeated exposure to a cue that signals threat. However, extinction does not erase fear, as an extinguished cue presented in a context distinct from that of extinction results in renewed fear of that cue. The hippocampus, which is involved in the formation of contextual representations, is ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20954
更新日期:2012-05-01 00:00:00
abstract::A couple of papers indicate that patients with depression show a decrease in serum neuropeptide Y (NPY). To study the role of NPY in depression, we examined the effects of infusion of NPY into the hippocampus of learned helplessness (LH) rats (an animal model of depression). Infusion of NPY into the cerebral ventricle...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20264
更新日期:2007-01-01 00:00:00
abstract::Neural correlates of spatial representation can be found in the activity of the hippocampal place cells. These neurons are characterized by firing whenever the animal is located in a particular area of the space, the place field. Place fields are modulated by sensory cues, such as visual, auditory, or olfactory cues, ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22198
更新日期:2013-12-01 00:00:00
abstract::Granule cells born in the adult dentate gyrus undergo a 4-week developmental period characterized by high susceptibility to cell death. Two forms of hippocampus-dependent learning have been shown to rescue many of the new neurons during this critical period. Here, we show that a natural form of associative learning, s...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20097
更新日期:2005-01-01 00:00:00