Neonatal exposure to novelty enhances long-term potentiation in CA1 of the rat hippocampus.

abstract：:For well over a century, ethanol was believed to exert its effects on cognition and behavior by producing a ubiquitous depression of central nervous system activity. A general disruption in brain function was consistent with the belief that ethanol's effects on cognition and behavior were also quite general. Substanti...

journal_title：Hippocampus

authors： White AM,Matthews DB,Best PJ

更新日期：2000-01-01 00:00:00

abstract：:Once thought to produce global, nonspecific brain injury, drugs of abuse are now known to produce selective neuro-adaptations in particular brain regions. These neuro-adaptations are being closely examined for clues to the development, maintenance, and treatment of addiction. The hippocampus is an area of particular i...

journal_title：Hippocampus

authors： Eisch AJ,Harburg GC

更新日期：2006-01-01 00:00:00

abstract：:This study investigated the effects of progesterone (P4) on the production and survival of neurons in the hippocampal dentate gyrus of adult male mice. The administration of P4 (4 mg/kg) for 3 consecutive days beginning on the 0-2nd day after the first BrdU-injection (BrdU-D(0-2)) produced an approximately twofold inc...

journal_title：Hippocampus

authors： Zhang Z,Yang R,Zhou R,Li L,Sokabe M,Chen L

更新日期：2010-03-01 00:00:00

abstract：:A large body of evidence exists to demonstrate that excitatory amino acids (EAA) and their receptors are involved in the pathophysiological mechanisms linking several acute brain insults, such as cerebral ischemia, to neuronal degeneration and death. Accordingly, the use of EAA receptor antagonists can be beneficial i...

journal_title：Hippocampus

authors： Virgili M,Contestabile A,Barnabei O

更新日期：1995-01-01 00:00:00

abstract：:Ontogenesis of GABAergic signaling may play an important role in developmental changes in seizure susceptibility in the high-potassium model of ictogenesis in vitro. The age-dependent effects of [K(+)](o) on the reversal potential of the GABA(A)-mediated responses and membrane potential in hippocampal slices in vitro ...

journal_title：Hippocampus

authors： Isaev D,Isaeva E,Khazipov R,Holmes GL

更新日期：2007-01-01 00:00:00

abstract：:Subjective and objective memory deficits represent a frequent and ill-understood aspect of multiple sclerosis (MS), and a significant cause of disability and quality of life reduction. The aim of the study is to verify the role of hippocampal and temporal associative fibers' damage in MS-related memory complaints. To ...

journal_title：Hippocampus

authors： Pardini M,Bergamino M,Bommarito G,Bonzano L,Luigi Mancardi G,Roccatagliata L

更新日期：2014-04-01 00:00:00

abstract：:The vestibular system contributes to the performance of various spatial memory tasks, but few studies have attempted to disambiguate the roles of the semicircular canals and otolith organs in this performance. This study tested the otolithic contribution to spatial working and reference memory by evaluating the perfor...

journal_title：Hippocampus

authors： Yoder RM,Kirby SL

更新日期：2014-10-01 00:00:00

abstract：:The hippocampus receives two streams of information, spatial and nonspatial, via major afferent inputs from the medial (MEC) and lateral entorhinal cortexes (LEC). The MEC and LEC projections in the temporoammonic pathway are topographically organized along the transverse-axis of area CA1. The potential for functional...

journal_title：Hippocampus

authors： Ito HT,Schuman EM

更新日期：2012-02-01 00:00:00

abstract：:The human medial temporal lobe (MTL) is known to be involved in declarative memory, yet the exact contributions of the various MTL structures are not well understood. In particular, the data as to whether the hippocampal region is preferentially involved in the encoding and/or retrieval of associative memory have not ...

journal_title：Hippocampus

authors： Kirwan CB,Stark CE

更新日期：2004-01-01 00:00:00

abstract：:Structural integrity of the human hippocampus is widely acknowledged to be necessary for the successful encoding and retrieval of autobiographical memories. However, evidence for an association between hippocampal volume and the ability to recall such memories in healthy individuals is mixed. Here we examined this iss...

journal_title：Hippocampus

authors： Barry DN,Clark IA,Maguire EA

更新日期：2020-12-15 00:00:00

abstract：:We aimed at identifying the cerebral structures whose synaptic function subserves the recollection of lifetime's episodic autobiographical memory (AM) via autonoetic consciousness. Twelve healthy middle-aged subjects (mean age: 59 years +/- 2.5) underwent a specially designed cognitive test to assess the ability to re...

journal_title：Hippocampus

authors： Piolino P,Desgranges B,Hubert V,Bernard FA,Matuszewski V,Chételat G,Baron JC,Eustache F

更新日期：2008-01-01 00:00:00

abstract：:Recent observations have caused a drastic shift in the conception of the hippocampus as a homogeneous structure that subserves cognitive functions, either spatial maps or short term episodic memory, to a structure that is associated with both cognitive and emotional functions. In fact, the assignment of cognitive func...

journal_title：Hippocampus

authors： Segal M,Richter-Levin G,Maggio N

更新日期：2010-12-01 00:00:00

abstract：:Nitric oxide (NO) is a gaseous neuromessenger. Although increasing evidence reveals significant physiological effects of NO in the hippocampal synaptic plasticity, the spatial distribution of NO production has remained largely uncharacterized due to the poor development of techniques for real-time NO imaging. In this ...

journal_title：Hippocampus

authors： Takata N,Harada T,Rose JA,Kawato S

更新日期：2005-01-01 00:00:00

abstract：:Neurogenesis persists in the adult rat rostral forebrain subventricular zone (SVZ) and is stimulated by status epilepticus (SE). More caudal SVZ (cSVZ) neural progenitors migrate to the hippocampus after ischemic injury and contribute to CA1 pyramidal cell regeneration. Because SE also damages the hippocampus, we exam...

journal_title：Hippocampus

authors： Parent JM,von dem Bussche N,Lowenstein DH

更新日期：2006-01-01 00:00:00

abstract：:This study examines whether 4-8-Hz theta oscillations can be seen in the human hippocampus, and whether these oscillations increase during virtual movement and searching, as they do in rodents. Recordings from both hippocampal and neocortical depth electrodes were analyzed while six epileptic patients played a virtual...

journal_title：Hippocampus

authors： Ekstrom AD,Caplan JB,Ho E,Shattuck K,Fried I,Kahana MJ

更新日期：2005-01-01 00:00:00

abstract：:Metabolic integrity of glial cells in field CA1 of the guinea pig hippocampus is critical to maintenance of synaptic transmission (Keyser and Pellmar [1994] Glia 10:237-243). To determine if this tight glial-neuronal coupling is equally important in other brain regions, we compared the effect of fluoroacetate (FAC), a...

journal_title：Hippocampus

authors： Keyser DO,Pellmar TC

更新日期：1997-01-01 00:00:00

abstract：:Williams syndrome (WS), a genetic deletion syndrome, is characterized by severe visuospatial deficits affecting performance on both tabletop spatial tasks and on tasks which assess orientation and navigation. Nevertheless, previous studies of WS spatial capacities have ignored the fact that two different spatial memor...

journal_title：Hippocampus

authors： Bostelmann M,Fragnière E,Costanzo F,Di Vara S,Menghini D,Vicari S,Lavenex P,Lavenex PB

更新日期：2017-11-01 00:00:00

abstract：:In contextual fear conditioning (CFC), the use of pharmacological and lesion approaches has helped to understand that there are differential roles for the dorsal hippocampus (DH) and the ventral hippocampus (VH) in the acquisition, consolidation and retrieval phases. Concomitant analysis of the DH and the VH in indivi...

journal_title：Hippocampus

authors： Sase S,Sase A,Sialana FJ Jr,Gröger M,Bennett KL,Stork O,Lubec G,Li L

更新日期：2015-12-01 00:00:00

abstract：:At the neuromuscular junction, spontaneous miniature excitatory synaptic currents mediated by acetylcholine are considered elementary, "quantal" transmissions. These miniature conductances can be quantitatively dichotomized into a large-mode class whose mode is the mean of a normal, bell-shaped distribution and a smal...

journal_title：Hippocampus

authors： Vautrin J,Schaffner AE,Barker JL

更新日期：1993-01-01 00:00:00

abstract：:The growth arrest specific 5 (gas5) is a noncoding protein gene that hosts small nucleolar RNAs. Based on the observation that gas5 RNA level in the brain is highest in the hippocampus and remarkably enhanced in aged mice, we tested the hypothesis that gas5 is involved in functions controlled by the hippocampus and kn...

journal_title：Hippocampus

authors： Meier I,Fellini L,Jakovcevski M,Schachner M,Morellini F

更新日期：2010-09-01 00:00:00

abstract：:This study examined the ability of cognitively normal young adults (n = 30) and older adults (n = 30) to perform a delayed match-to-sample task involving varying degrees of spatial interference to assess spatial pattern separation. Each trial consisted of a sample phase followed by a choice phase. During the sample ph...

journal_title：Hippocampus

authors： Holden HM,Hoebel C,Loftis K,Gilbert PE

更新日期：2012-09-01 00:00:00

abstract：:Trace eyeblink classical conditioning is a non-spatial learning paradigm that requires an intact hippocampus. This task is hippocampus-dependent because the auditory tone conditioned stimulus (CS) is temporally separated from the corneal airpuff unconditioned stimulus (US) by a 500-ms trace interval. Our laboratory ha...

journal_title：Hippocampus

authors： McEchron MD,Disterhoft JF

更新日期：1999-01-01 00:00:00

abstract：:During certain movements (termed "type I," "instrumental," or "voluntary"), the rodent hippocampal EEG is dominated by regular 7-10 Hz waves. This "theta rhythm" is accompanied by increased firing of hippocampal interneurons and dentate gyrus granule cells. No obvious theta rhythm is present in comparable situations i...

journal_title：Hippocampus

authors： Halgren E

更新日期：1991-04-01 00:00:00

abstract：:The hippocampus is critical for memory tasks which require an active maintenance of memory for a short period of time; however, the underlying neural mechanisms remain unknown. Most theoretical and computational models, which date back to the classic proposals by Donald Hebb in , have been self-constrained by anatomy,...

journal_title：Hippocampus

authors： Knauer B,Jochems A,Valero-Aracama MJ,Yoshida M

更新日期：2013-09-01 00:00:00

abstract：:Changes in synaptic efficacy and morphology have been proposed as mechanisms underlying learning and memory processes. In our previous studies, high frequency stimulation (HFS) sufficient to induce LTP at the hippocampal mossy fiber (MF) pathway, leads to MF synaptogenesis, in a prominent contralateral form, at the st...

journal_title：Hippocampus

authors： Schjetnan AG,Escobar ML

更新日期：2012-01-01 00:00:00

abstract：:Social isolation negatively affects the behavior and health of laboratory rats. Recently, it has been found that social isolation retards exercise-induced neurogenesis in the hippocampal dentate gyrus (DG) of male rats (Stranahan et al. (2006) Nat Neurosci 9:526-533). Since male and female rats react differently to ho...

journal_title：Hippocampus

authors： Leasure JL,Decker L

更新日期：2009-10-01 00:00:00

abstract：:Despite evidence that the extracellular matrix glycoprotein tenascin-C (TNC) is implicated in brain development and plasticity, its roles in the intact adult brain are unknown. Here we report that spontaneous local field potential (LFP) activity in freely moving adult TNC-deficient mice is abnormal. The power of corti...

journal_title：Hippocampus

authors： Gurevicius K,Kuang F,Stoenica L,Irintchev A,Gureviciene I,Dityatev A,Schachner M,Tanila H

更新日期：2009-12-01 00:00:00

abstract：:We have studied 5-hydroxytryptamine (5-HT) release in the hippocampal formation following electrical stimulation of the dorsal and median raphé nuclei in the behaving rat. The primary finding in this study is a decrease in neuronal release of serotonin in the dorsal hippocampal formation following electrical stimulati...

journal_title：Hippocampus

authors： Mokler DJ,Lariviere D,Johnson DW,Theriault NL,Bronzino JD,Dixon M,Morgane PJ

更新日期：1998-01-01 00:00:00

abstract：:Individuals with schizophrenia display a number of structural and cytoarchitectural alterations in the hippocampus, suggesting that other functions such as synaptic plasticity may also be modified. Altered hippocampal plasticity is likely to affect memory processing, and therefore any such pathology may contribute to ...

journal_title：Hippocampus

authors： Savanthrapadian S,Wolff AR,Logan BJ,Eckert MJ,Bilkey DK,Abraham WC

更新日期：2013-12-01 00:00:00

abstract：:For memory retrieval, pattern completion is a crucial process that restores memories from partial or degraded cues. Neurocognitive aging models suggest that the aged memory system is biased toward pattern completion, resulting in a behavioral preference for retrieval over encoding of memories. Here, we built on our pr...

journal_title：Hippocampus

authors： Vieweg P,Riemer M,Berron D,Wolbers T

更新日期：2019-04-01 00:00:00