Spatiotemporal analysis of NO production upon NMDA and tetanic stimulation of the hippocampus.

abstract：:It has been well-established that cell proliferation and neurogenesis in the adult mouse dentate gyrus (DG) can be regulated by voluntary exercise. Recent evidence has suggested that the effects of voluntary exercise can in turn be influenced by environmental factors that regulate the amount of stress an animal is exp...

journal_title：Hippocampus

authors： Kannangara TS,Webber A,Gil-Mohapel J,Christie BR

更新日期：2009-10-01 00:00:00

abstract：:It is argued that while the hippocampus is not vital for all classes of configural learning, it is vital for a specific subclass of configural tasks called "structural learning." The defining feature of structural learning is that in addition to binding stimulus elements to make unique arrays (as in all configural lea...

journal_title：Hippocampus

authors： Aggleton JP,Sanderson DJ,Pearce JM

更新日期：2007-01-01 00:00:00

abstract：:The mechanism supporting the role of the hippocampal formation in novelty detection remains controversial. A comparator function has been variously ascribed to CA1 or subiculum, whereas the theta rhythm has been suggested to separate neural firing into encoding and retrieval phases. We investigated theta phase of firi...

journal_title：Hippocampus

authors： Lever C,Burton S,Jeewajee A,Wills TJ,Cacucci F,Burgess N,O'Keefe J

更新日期：2010-02-01 00:00:00

abstract：:With the aim of establishing a quantitative structural basis for comparative and experimental studies, the volumes of the hippocampal subdivisions and the total number of neurons in each subdivision were estimated in domestic pig brains using modern stereological techniques. In addition to a detailed description of th...

journal_title：Hippocampus

authors： Holm IE,West MJ

更新日期：1994-02-01 00:00:00

abstract：:The locomotor effects of intra-NAcc injection of dopamine receptor agonists following discrete lesion or inhibition of the DH or the VH have been poorly investigated using only the indirect dopamine receptor agonist amphetamine. In the present study, we investigated how lidocaine in the DH or the VH modulated hyperloc...

journal_title：Hippocampus

authors： Rouillon C,Abraini JH,David HN

更新日期：2007-01-01 00:00:00

abstract：:Increased consumption of high-fat diet (HFD) leads to obesity and adverse neurocognitive outcomes. Childhood and adolescence are important periods of brain maturation shaping cognitive function. These periods could consequently be particularly sensitive to the detrimental effects of HFD intake. In mice, juvenile and a...

journal_title：Hippocampus

authors： Boitard C,Etchamendy N,Sauvant J,Aubert A,Tronel S,Marighetto A,Layé S,Ferreira G

更新日期：2012-11-01 00:00:00

abstract：:Neuronal mechanisms of episodic memory, the conscious recollection of autobiographical events, are largely unknown because electrophysiological studies in humans are conducted only in exceptional circumstances. Unit recording studies in animals are thus crucial for understanding the neurophysiological substrate that e...

journal_title：Hippocampus

authors： Ferbinteanu J,Kennedy PJ,Shapiro ML

更新日期：2006-01-01 00:00:00

abstract：:Various paradigms have been used to assess the capacity of the adult brain to undergo activity-dependent morphological plasticity. In this report we have employed recurrent limbic seizures as a means of studying the effects of this form of enhanced neuronal activity on cellular morphology and, in particular, on the in...

journal_title：Hippocampus

authors： Bundman MC,Pico RM,Gall CM

更新日期：1994-10-01 00:00:00

abstract：:Two patients, with magnetic resonance imaging (MRI)-confirmed relatively selective hippocampal damage, showed distinct patterns of performance on tests of recall, item recognition, and associative recognition. Patient AC showed a mean bilateral volume reduction of the hippocampus of 28%, but displayed no memory defici...

journal_title：Hippocampus

authors： Holdstock JS,Parslow DM,Morris RG,Fleminger S,Abrahams S,Denby C,Montaldi D,Mayes AR

更新日期：2008-01-01 00:00:00

abstract：:This study investigates relationship between regional cerebral volumes and performances over time of a categorical fluency task, in a sample of older adults (n = 316). Using voxel-wise technique, the relationship between local grey matter volume and Isaacs Set Test (IST) scores at its early (first 15 sec) and late (la...

journal_title：Hippocampus

authors： Catheline G,Amieva H,Dilharreguy B,Bernard C,Duperron MG,Helmer C,Dartigues JF,Allard M

更新日期：2015-09-01 00:00:00

abstract：:CA3 lesions impair encoding, whereas CA1 lesions impair retrieval during learning of a Hebb-Williams maze. CA3 efferents in the fimbria were transected, taking care to spare cholinergic and GABAergic afferents. CA1 efferents in the dorsal fornix were similarly transected. Fimbria transections, but not dorsal fornix tr...

journal_title：Hippocampus

authors： Hunsaker MR,Tran GT,Kesner RP

更新日期：2008-01-01 00:00:00

abstract：:Previous work has shown that immunohistochemical imaging of Fos protein is a reliable marker for changes in activity related to recognition memory in the perirhinal (PRH) cortex of the medial temporal lobe; however, whether PRH Fos expression is necessary for recognition memory had not been established. To investigate...

journal_title：Hippocampus

authors： Seoane A,Tinsley CJ,Brown MW

更新日期：2012-11-01 00:00:00

abstract：:This study investigated the effects of progesterone (P4) on the production and survival of neurons in the hippocampal dentate gyrus of adult male mice. The administration of P4 (4 mg/kg) for 3 consecutive days beginning on the 0-2nd day after the first BrdU-injection (BrdU-D(0-2)) produced an approximately twofold inc...

journal_title：Hippocampus

authors： Zhang Z,Yang R,Zhou R,Li L,Sokabe M,Chen L

更新日期：2010-03-01 00:00:00

abstract：:Recent studies have demonstrated that remembering past experiences and imagining future scenarios recruits a core network including the hippocampus. Even so, constructing future events engages the hippocampus more than remembering past events. This fMRI study examined whether increased hippocampal activity for future ...

journal_title：Hippocampus

authors： Addis DR,Cheng T,Roberts RP,Schacter DL

更新日期：2011-10-01 00:00:00

abstract：:The hippocampus and related structures are thought to be capable of 1) representing cortical activity in a way that minimizes overlap of the representations assigned to different cortical patterns (pattern separation); and 2) modifying synaptic connections so that these representations can later be reinstated from par...

journal_title：Hippocampus

authors： O'Reilly RC,McClelland JL

更新日期：1994-12-01 00:00:00

abstract：:Although there are many types of epilepsy, temporal lobe epilepsy (TLE) is probably in humans the most common and most often studied. TLE represents 40% of the total epilepsy form of the disease and is difficult to treat. Despite a wealth of descriptive data obtained from the disease history of patients, the EEG recor...

journal_title：Hippocampus

authors： Mériaux C,Franck J,Park DB,Quanico J,Kim YH,Chung CK,Park YM,Steinbusch H,Salzet M,Fournier I

更新日期：2014-06-01 00:00:00

abstract：:Seizures induced by fever (febrile seizures) are the most frequent seizures affecting infants and children; however, their impact on the developing hippocampal formation is not completely understood. Such understanding is highly important because of the potential relationship of prolonged febrile seizures to temporal ...

journal_title：Hippocampus

authors： Bender RA,Dubé C,Gonzalez-Vega R,Mina EW,Baram TZ

更新日期：2003-01-01 00:00:00

abstract：:The functional organization of the perforant path input to the dentate gyrus of the exposed hippocampus was studied in adult rabbits anesthetized with urethane and chloralose. Electrical stimulation of perforant path fibers caused excitation of granule cells along narrow, nearly transverse strips (lamellae) of tissue....

journal_title：Hippocampus

authors： Lømo T

更新日期：2009-07-01 00:00:00

abstract：:The hippocampus plays an important role in spatial learning and memory. However, the biochemical alterations that subserve this function remain to be fully elucidated. In this study, rats were subjected to a single-trial contextual fear conditioning (CFC) paradigm; the activation of different protein kinase C (PKC) su...

journal_title：Hippocampus

authors： Young E,Cesena T,Meiri KF,Perrone-Bizzozero NI

更新日期：2002-01-01 00:00:00

abstract：:Watermaze tests of place learning and memory in rodents and corresponding reverse-translated human paradigms in real or virtual environments are key tools to study hippocampal function. In common variants, the animal or human participant has to find a hidden goal that remains in the same place over many trials, allowi...

journal_title：Hippocampus

authors： Buckley MG,Bast T

更新日期：2018-11-01 00:00:00

abstract：:Information storage in the brain is a temporally graded process involving different memory types or phases. It has been assumed for over a century that one or more short-term memory (STM) processes are involved in processing new information while long-term memory (LTM) is being formed. Because brain-derived neutrophic...

journal_title：Hippocampus

authors： Alonso M,Vianna MR,Depino AM,Mello e Souza T,Pereira P,Szapiro G,Viola H,Pitossi F,Izquierdo I,Medina JH

更新日期：2002-01-01 00:00:00

abstract：:In contextual fear conditioning (CFC), hippocampus is thought to process environmental stimuli into a configural representation of the context and send it to amygdala nuclei, which current evidences point to be the site of CS-US association and fear memory storage. If it is true, hippocampus should influence learning-...

journal_title：Hippocampus

authors： de Oliveira Coelho CA,Ferreira TL,Soares JC,Oliveira MG

更新日期：2013-07-01 00:00:00

abstract：:The ERK/MAPK signaling pathway has been extensively studied in the context of learning and memory. Defects in this pathway underlie genetic diseases associated with intellectual disability, including impaired learning and memory. Numerous studies have investigated the impact of acute ERK/MAPK inhibition on long-term p...

journal_title：Hippocampus

authors： Vithayathil J,Pucilowska J,Friel D,Landreth GE

更新日期：2017-12-01 00:00:00

abstract：:Replicas of an aspect of an experienced event can serve as effective reminders, yet little is known about the neural basis of such reminding effects. Here we examined the neural activity underlying the memory-enhancing effect of reminders 1 week after encoding of naturalistic film clip events. We used fMRI to determin...

journal_title：Hippocampus

authors： Sekeres MJ,Moscovitch M,Winocur G,Pishdadian S,Nichol D,Grady CL

更新日期：2021-01-01 00:00:00

abstract：:L-aspartate is the amino-acid residue most susceptible to spontaneous isomerization. This denaturation causes an alteration in the biological activity of the protein and is regarded as an aging process of the protein. Protein L-isoaspartyl methyltransferase (PIMT) repairs this post-translational modification and thus ...

journal_title：Hippocampus

authors： Ikegaya Y,Yamada M,Fukuda T,Kuroyanagi H,Shirasawa T,Nishiyama N

更新日期：2001-01-01 00:00:00

abstract：:The conditioned cue preference (CCP) task was used to study the ability of rats to discriminate between spatial locations. Food-deprived rats explored an eight-arm radial maze with no food present (pre-exposure). On subsequent days, they were alternately confined in one arm of the maze with food and in another arm wit...

journal_title：Hippocampus

authors： Gaskin S,Chai SC,White NM

更新日期：2005-01-01 00:00:00

abstract：:Synaptic responses mediated by the N-methyl-D-aspartate receptor (NMDAr) and non-NMDAr activation were compared in CA1 hippocampal region of young (3-4 months old) and aged (25-33 months old) Sprague-Dawley rats with the use of ex vivo extracellular recordings techniques. In aged rats, the amplitude of the NMDAr-media...

journal_title：Hippocampus

authors： Jouvenceau A,Dutar P,Billard JM

更新日期：1998-01-01 00:00:00

abstract：:Multiple factors are involved in the glutamate-induced excitotoxicity phenomenon, such as overload of ionotropic and metabotropic receptors, excess Ca(2+) influx, nitric oxide synthase activation, oxidative damage due to increase in free radicals, and release of endogenous polyamine, among others. In order to attempt ...

journal_title：Hippocampus

authors： Ortuño-Sahagún D,Rivera-Cervantes MC,Gudiño-Cabrera G,Junyent F,Verdaguer E,Auladell C,Pallàs M,Camins A,Beas-Zárate C

更新日期：2012-02-01 00:00:00

abstract：:Lynn Nadel has been a trailblazer in memory research for decades. In just one example, Nadel and Zola-Morgan [Infantile amnesia, In Infant memory, Springer, Boston, MA, 1984, pp. 145-172] were the first to present the provocative notion that the extended development of the hippocampus may underlie the period of infant...

journal_title：Hippocampus

authors： Edgin JO,Liu Y,Hughes K,Spanò G,Clark CAC

更新日期：2020-08-01 00:00:00

abstract：:Subjective and objective memory deficits represent a frequent and ill-understood aspect of multiple sclerosis (MS), and a significant cause of disability and quality of life reduction. The aim of the study is to verify the role of hippocampal and temporal associative fibers' damage in MS-related memory complaints. To ...

journal_title：Hippocampus

authors： Pardini M,Bergamino M,Bommarito G,Bonzano L,Luigi Mancardi G,Roccatagliata L

更新日期：2014-04-01 00:00:00