Human temporal lobe epilepsy analyses by tissue proteomics.

abstract：:Hippocampal mossy fibers have long been proposed to impose new patterns to learn onto CA3 neurons during new memory formation. However, inconsistent with this theory, we found in our previous study that mossy fiber stimulation induces only transient changes in CA3 spatial firing in a familiar environment. Here, we tes...

journal_title：Hippocampus

authors： Lee J,Bae C,Lee D,Jung MW

更新日期：2020-07-01 00:00:00

abstract：:This study investigated the effects of progesterone (P4) on the production and survival of neurons in the hippocampal dentate gyrus of adult male mice. The administration of P4 (4 mg/kg) for 3 consecutive days beginning on the 0-2nd day after the first BrdU-injection (BrdU-D(0-2)) produced an approximately twofold inc...

journal_title：Hippocampus

authors： Zhang Z,Yang R,Zhou R,Li L,Sokabe M,Chen L

更新日期：2010-03-01 00:00:00

abstract：:The conditioned cue preference (CCP) task was used to study the ability of rats to discriminate between spatial locations. Food-deprived rats explored an eight-arm radial maze with no food present (pre-exposure). On subsequent days, they were alternately confined in one arm of the maze with food and in another arm wit...

journal_title：Hippocampus

authors： Gaskin S,Chai SC,White NM

更新日期：2005-01-01 00:00:00

abstract：:Aniracetam reversibly increased synaptic responses mediated by the AMPA but not the NMDA subclass of glutamate receptors in hippocampus and was considerably more potent than structurally similar nootropics. The drug had greater effects on field excitatory postsynaptic potentials (EPSPs) in the dentate gyrus and CA1 re...

journal_title：Hippocampus

authors： Xiao P,Staubli U,Kessler M,Lynch G

更新日期：1991-10-01 00:00:00

abstract：:Despite evidence that the extracellular matrix glycoprotein tenascin-C (TNC) is implicated in brain development and plasticity, its roles in the intact adult brain are unknown. Here we report that spontaneous local field potential (LFP) activity in freely moving adult TNC-deficient mice is abnormal. The power of corti...

journal_title：Hippocampus

authors： Gurevicius K,Kuang F,Stoenica L,Irintchev A,Gureviciene I,Dityatev A,Schachner M,Tanila H

更新日期：2009-12-01 00:00:00

abstract：:Ontogenesis of GABAergic signaling may play an important role in developmental changes in seizure susceptibility in the high-potassium model of ictogenesis in vitro. The age-dependent effects of [K(+)](o) on the reversal potential of the GABA(A)-mediated responses and membrane potential in hippocampal slices in vitro ...

journal_title：Hippocampus

authors： Isaev D,Isaeva E,Khazipov R,Holmes GL

更新日期：2007-01-01 00:00:00

abstract：:For memory retrieval, pattern completion is a crucial process that restores memories from partial or degraded cues. Neurocognitive aging models suggest that the aged memory system is biased toward pattern completion, resulting in a behavioral preference for retrieval over encoding of memories. Here, we built on our pr...

journal_title：Hippocampus

authors： Vieweg P,Riemer M,Berron D,Wolbers T

更新日期：2019-04-01 00:00:00

abstract：:The role of subicular neurons is explored with respect to their participation in short-term memory during performance of a spatial Delayed-Nonmatch-to-Sample (DNMS) task by well-trained rats. Subicular and CA1 neuron firing was examined in the same animals in relation to the encoding of task-relevant events during the...

journal_title：Hippocampus

authors： Hampson RE,Deadwyler SA

更新日期：2003-01-01 00:00:00

abstract：:Functional neuroimaging is uniquely placed to examine the dynamic nature of normal human memory, the distributed brain networks that support it, and how they are modulated. Memory has traditionally been classified into context-specific memories personally experienced ("episodic memory") and impersonal non-context-spec...

journal_title：Hippocampus

authors： Maguire EA,Mummery CJ

更新日期：1999-01-01 00:00:00

abstract：:The advent of high-resolution magnetic resonance imaging (MRI) has enabled in vivo research in a variety of populations and diseases on the structure and function of hippocampal subfields and subdivisions of the parahippocampal gyrus. Because of the many extant and highly discrepant segmentation protocols, comparing r...

journal_title：Hippocampus

authors： Wisse LEM,Daugherty AM,Olsen RK,Berron D,Carr VA,Stark CEL,Amaral RSC,Amunts K,Augustinack JC,Bender AR,Bernstein JD,Boccardi M,Bocchetta M,Burggren A,Chakravarty MM,Chupin M,Ekstrom A,de Flores R,Insausti R,Kanel P

更新日期：2017-01-01 00:00:00

abstract：:Rats were trained on an operant conditional discrimination in which an ambiguous stimulus (X) indicated both the occasions on which responding in the presence of a second cue (A) would be reinforced and the occasions on which responding in the presence of a third cue (B) would not be reinforced (X --> A+, A-, X --> B-...

journal_title：Hippocampus

authors： Han JS,Gallagher M,Holland P

更新日期：1998-01-01 00:00:00

abstract：:Two recent meta-analyses, drawing on data from many of the same studies with monkeys, reached different conclusions about the relationship between hippocampal damage and recognition memory performance. Both studies found evidence of recognition memory impairment following hippocampal damage. However, Zola et al. (J Ne...

journal_title：Hippocampus

authors： Zola SM,Squire LR

更新日期：2001-01-01 00:00:00

abstract：:The multifactorial causes impacting the risk of developing sporadic forms of Alzheimer's disease (AD) remain to date poorly understood. Epidemiologic studies in humans and research in rodents have suggested that hypothyroidism could participate in the etiology of AD. Recently, we reported that adult-onset hypothyroidi...

journal_title：Hippocampus

authors： Chaalal A,Poirier R,Blum D,Gillet B,Le Blanc P,Basquin M,Buée L,Laroche S,Enderlin V

更新日期：2014-11-01 00:00:00

abstract：:Alzheimer's disease (AD) and ageing are associated with impaired learning and memory, and recent findings point toward modulating chromatin remodeling through histone acetylation as a promising therapeutic strategy. Here we report that systemic administration of the HDAC inhibitor 4-phenylbutyrate (PBA) reinstated fea...

journal_title：Hippocampus

authors： Ricobaraza A,Cuadrado-Tejedor M,Marco S,Pérez-Otaño I,García-Osta A

更新日期：2012-05-01 00:00:00

abstract：:Previous investigation of CA1-evoked subicular responses has used either single low-frequency pulses (LF), paired-pulses (PP), or high-frequency bursts. Here we test for the first time how subiculum responds to naturalistic stimulation trains (NSTs). We recorded CA1-evoked field potentials from dorsal rat subiculum in...

journal_title：Hippocampus

authors： Tunstall B,Agnew ZK,Panzeri S,Gigg J

更新日期：2010-02-01 00:00:00

abstract：:The hippocampus creates distinct episodes from highly similar events through a process called pattern separation and can retrieve memories from partial or degraded cues through a process called pattern completion. These processes have been studied in humans using tasks where participants must distinguish studied items...

journal_title：Hippocampus

authors： Molitor RJ,Ko PC,Hussey EP,Ally BA

更新日期：2014-06-01 00:00:00

abstract：:The role of the hippocampus in retrograde amnesia remains controversial and poorly understood. Two cases are reported of discrete bilateral hippocampal damage, one of which was a rare case of limbic encephalitis secondary to the human herpes virus 6. Detailed memory testing showed marked anterograde memory impairment,...

journal_title：Hippocampus

authors： Kapur N,Brooks DJ

更新日期：1999-01-01 00:00:00

abstract：:GABAergic inhibitory interneurons control fundamental aspects of neuronal network function. Their functional roles are assumed to be defined by the identity of their input synapses, the architecture of their dendritic tree, the passive and active membrane properties and finally the nature of their postsynaptic targets...

journal_title：Hippocampus

authors： Hosp JA,Strüber M,Yanagawa Y,Obata K,Vida I,Jonas P,Bartos M

更新日期：2014-02-01 00:00:00

abstract：:Several recent studies have compared episodic and spatial memory in neuroimaging paradigms in order to understand better the contribution of the hippocampus to each of these tasks. In the present study, we build on previous findings showing common neural activation in default network areas during episodic and spatial ...

journal_title：Hippocampus

authors： Robin J,Hirshhorn M,Rosenbaum RS,Winocur G,Moscovitch M,Grady CL

更新日期：2015-01-01 00:00:00

abstract：:Both natural and synthetic cannabinoid receptor (e.g., CB1) agonists such as Δ(9)-THC, WIN 55,212-2 (WIN-2), and HU-210 disrupt spatial cognition presumably through the inhibition of synchrony of hippocampal ensemble firing to task-related events. Although the CB1 receptor agonist CP 55,940 also disrupts the synchrono...

journal_title：Hippocampus

authors： Goonawardena AV,Riedel G,Hampson RE

更新日期：2011-05-01 00:00:00

abstract：:Neurons in the supramammillary nucleus (SUM) of urethane-anesthetized rats fire rhythmically in synchrony with hippocampal theta rhythm. As these neurons project to the septum and hippocampus, it is generally assumed that their role is to mediate ascending activation, leading to the hippocampal theta rhythm. However, ...

journal_title：Hippocampus

authors： Kocsis B,Kaminski M

更新日期：2006-01-01 00:00:00

abstract：:Intracellular recording and computational modelling suggest that interactions of subthreshold membrane potential oscillation frequency in different dendritic branches of entorhinal cortex stellate cells could underlie the functional coding of continuous dimensions of space and time. Among other things, these interacti...

journal_title：Hippocampus

authors： Hasselmo ME,Giocomo LM,Zilli EA

更新日期：2007-01-01 00:00:00

abstract：:It has been well-established that cell proliferation and neurogenesis in the adult mouse dentate gyrus (DG) can be regulated by voluntary exercise. Recent evidence has suggested that the effects of voluntary exercise can in turn be influenced by environmental factors that regulate the amount of stress an animal is exp...

journal_title：Hippocampus

authors： Kannangara TS,Webber A,Gil-Mohapel J,Christie BR

更新日期：2009-10-01 00:00:00

abstract：:Individuals with schizophrenia display a number of structural and cytoarchitectural alterations in the hippocampus, suggesting that other functions such as synaptic plasticity may also be modified. Altered hippocampal plasticity is likely to affect memory processing, and therefore any such pathology may contribute to ...

journal_title：Hippocampus

authors： Savanthrapadian S,Wolff AR,Logan BJ,Eckert MJ,Bilkey DK,Abraham WC

更新日期：2013-12-01 00:00:00

abstract：:Persistent neural activity lasting for seconds after transient stimulation has been observed in several brain areas. This activity has been taken to be indicative of the integration of inputs on long time scales. Passive membrane properties render neural time constants to be on the order of milliseconds. Intense synap...

journal_title：Hippocampus

authors： Huhn Z,Orbán G,Erdi P,Lengyel M

更新日期：2005-01-01 00:00:00

abstract：:Structural integrity of the human hippocampus is widely acknowledged to be necessary for the successful encoding and retrieval of autobiographical memories. However, evidence for an association between hippocampal volume and the ability to recall such memories in healthy individuals is mixed. Here we examined this iss...

journal_title：Hippocampus

authors： Barry DN,Clark IA,Maguire EA

更新日期：2020-12-15 00:00:00

abstract：:In this article, we present a framework to perform statistical shape analysis for segmented hippocampi, including an efficient permutation test for detecting subtle class differences, and a regularized discriminative direction method for visualizing the shape discrepancy. Fisher permutation and bootstrap tests are pre...

journal_title：Hippocampus

authors： Zhou L,Lieby P,Barnes N,Réglade-Meslin C,Walker J,Cherbuin N,Hartley R

更新日期：2009-06-01 00:00:00

abstract：:Kindling is characterized by a progressive intensification of seizure activity culminating in generalized seizures following repeated administration of an initially subconvulsive electrical or chemical stimulus. Since it is known that epilepsy induces morphological alterations in the limbic system, we examined the neu...

journal_title：Hippocampus

authors： von Bohlen und Halbach O,Schulze K,Albrecht D

更新日期：2004-01-01 00:00:00

abstract：:Although a large body of evidence indicates that sleep plays an important role in learning and memory processes, the actual existence of a sleep-dependent spatial memory consolidation has been not firmly established. Here, by using a computerized 3D virtual navigation tool, we were able to show that topographical orie...

journal_title：Hippocampus

authors： Ferrara M,Iaria G,Tempesta D,Curcio G,Moroni F,Marzano C,De Gennaro L,Pacitti C

更新日期：2008-01-01 00:00:00

abstract：:Our model of the spatial and temporal aspects of place cell firing and their role in rat navigation is reviewed. The model provides a candidate mechanism, at the level of individual cells, by which place cell information concerning self-localization could be used to guide navigation to previously visited reward sites....

journal_title：Hippocampus

authors： Burgess N,O'Keefe J

更新日期：1996-01-01 00:00:00