Neuronal computations underlying the firing of place cells and their role in navigation.

abstract：:Studies of the neuropharmacological substrates of spatial memory formation have focused on the contribution of septohippocampal pathways. Although these pathways include, among others, cholinergic and GABAergic fibers innervating the hippocampus, research has essentially been oriented towards the role of their choline...

journal_title：Hippocampus

authors： Lecourtier L,de Vasconcelos AP,Leroux E,Cosquer B,Geiger K,Lithfous S,Cassel JC

更新日期：2011-12-01 00:00:00

abstract：:The role of subicular neurons is explored with respect to their participation in short-term memory during performance of a spatial Delayed-Nonmatch-to-Sample (DNMS) task by well-trained rats. Subicular and CA1 neuron firing was examined in the same animals in relation to the encoding of task-relevant events during the...

journal_title：Hippocampus

authors： Hampson RE,Deadwyler SA

更新日期：2003-01-01 00:00:00

abstract：:The molecular mechanisms of regionalization of the medial pallium (MP), the anlage of the hippocampus, and transitional (cingulate and retrosplenial) cortices are largely unknown. Previous analyses have outlined an important role of the transcription factor (TF) Zbtb20 for hippocampal CA1 field specification (Nielsen ...

journal_title：Hippocampus

authors： Rosenthal EH,Tonchev AB,Stoykova A,Chowdhury K

更新日期：2012-11-01 00:00:00

abstract：:Although the entorhinal cortex is a key structure connecting the hippocampal formation with the rest of the cerebral cortex, little is known about its early chemoanatomical development in primates. In the present study, a cytoarchitectonic analysis and immunocytochemical detection of somatostatin, neurotensin, parvalb...

journal_title：Hippocampus

authors： Berger B,Alvarez C,Goldman-Rakic PS

更新日期：1993-07-01 00:00:00

abstract：:Both the hippocampus and ventromedial prefrontal cortex (vmPFC) appear to be critical for episodic future simulation. Damage to either structure affects one's ability to remember the past and imagine the future, and both structures are commonly activated as part of a wider core network during future simulation. Howeve...

journal_title：Hippocampus

authors： Campbell KL,Madore KP,Benoit RG,Thakral PP,Schacter DL

更新日期：2018-02-01 00:00:00

abstract：:Dorsoventral lesion studies of the hippocampus have indicated that the dorsal axis of the hippocampus is important for spatial processing and the ventral axis of the hippocampus is important for olfactory learning and memory and anxiety. There is some evidence to suggest that the ventral CA3 and ventral CA1 conduct pa...

journal_title：Hippocampus

authors： Weeden CS,Hu NJ,Ho LU,Kesner RP

更新日期：2014-05-01 00:00:00

abstract：:Ontogenesis of GABAergic signaling may play an important role in developmental changes in seizure susceptibility in the high-potassium model of ictogenesis in vitro. The age-dependent effects of [K(+)](o) on the reversal potential of the GABA(A)-mediated responses and membrane potential in hippocampal slices in vitro ...

journal_title：Hippocampus

authors： Isaev D,Isaeva E,Khazipov R,Holmes GL

更新日期：2007-01-01 00:00:00

abstract：:The hippocampus is essential for learning and memory but also regulates emotional behavior. We previously identified the hippocampus as a major brain region that differs in rats bred for emotionality differences. Rats bred for low novelty response (LRs) exhibit high levels of anxiety- and depression-like behavior comp...

journal_title：Hippocampus

authors： Widman AJ,Cohen JL,McCoy CR,Unroe KA,Glover ME,Khan AU,Bredemann T,McMahon LL,Clinton SM

更新日期：2019-10-01 00:00:00

abstract：:A little over 20 years ago, (Teyler and DiScenna,1986; Behav Neurosci 100:147-152) proposed the hippocampal memory index theory. It offered an account of episodic memory based on the intrinsic organization of the hippocampus, its synaptic physiology and its anatomical relationship to other regions of the brain. The es...

journal_title：Hippocampus

authors： Teyler TJ,Rudy JW

更新日期：2007-01-01 00:00:00

abstract：:There is limited knowledge regarding how the brain controls the timing of meals. Similarly, there is a large gap in our understanding of how top-down cognitive processes, such as memory influence energy intake. We hypothesize that dorsal hippocampal (dHC) neurons, which are critical for episodic memory, form a memory ...

journal_title：Hippocampus

authors： Henderson YO,Nalloor R,Vazdarjanova A,Parent MB

更新日期：2016-03-01 00:00:00

abstract：:Previous attempts to elucidate whether a loss of hippocampal synapses occurs during aging provided conflicting results, possibly due to the unavailability, at the time, of unbiased methods for synapse quantitation. This study was designed to reexamine the issue by means of modern technical procedures that provide unbi...

journal_title：Hippocampus

authors： Geinisman Y,deToledo-Morrell L,Morrell F,Persina IS,Rossi M

更新日期：1992-10-01 00:00:00

abstract：:The hippocampus, the prefrontal cortex, and interconnected neural circuits are implicated in several aspects of cognitive and memory processes. The present review is dedicated to the description of the anatomo-functional characteristics of the hippocampo-prefrontal pathway and related neuronal circuits in the rat. Thi...

journal_title：Hippocampus

authors： Thierry AM,Gioanni Y,Dégénétais E,Glowinski J

更新日期：2000-01-01 00:00:00

abstract：:The selective lesion of basal forebrain cholinergic neurons (BFCNs) is an unestimable tool to study the implication of these neurons in cognition, an interest widely motivated by their degeneration in Alzheimer's disease. Here we evaluated the histochemical and behavioral effects of a selective lesion of BFCNs in C57B...

journal_title：Hippocampus

authors： Moreau PH,Cosquer B,Jeltsch H,Cassel JC,Mathis C

更新日期：2008-01-01 00:00:00

abstract：:Two experiments assessed the effects of 1) combined subicular complex and posterior cingulate cortical lesions on training-induced neuronal activity (TIA) in the anterior ventral (AV) and medial dorsal (MD) thalamic nuclei; 2) hippocampal (Ammon's horn and dentate gyrus) lesions on TIA in cingulate cortex and in the A...

journal_title：Hippocampus

authors： Kang E,Gabriel M

更新日期：1998-01-01 00:00:00

abstract：:Individuals with schizophrenia display a number of structural and cytoarchitectural alterations in the hippocampus, suggesting that other functions such as synaptic plasticity may also be modified. Altered hippocampal plasticity is likely to affect memory processing, and therefore any such pathology may contribute to ...

journal_title：Hippocampus

authors： Savanthrapadian S,Wolff AR,Logan BJ,Eckert MJ,Bilkey DK,Abraham WC

更新日期：2013-12-01 00:00:00

abstract：:We analyzed intracranial electroencephalographic (EEG) recordings from the medial temporal lobes of 12 epilepsy patients during a continuous word recognition paradigm, contrasting trials of correctly recognized repeated words (hits) and correctly identified new words (correct rejections). Using a wavelet-based analysi...

journal_title：Hippocampus

authors： Mormann F,Fell J,Axmacher N,Weber B,Lehnertz K,Elger CE,Fernández G

更新日期：2005-01-01 00:00:00

abstract：:A large body of evidence exists to demonstrate that excitatory amino acids (EAA) and their receptors are involved in the pathophysiological mechanisms linking several acute brain insults, such as cerebral ischemia, to neuronal degeneration and death. Accordingly, the use of EAA receptor antagonists can be beneficial i...

journal_title：Hippocampus

authors： Virgili M,Contestabile A,Barnabei O

更新日期：1995-01-01 00:00:00

abstract：:Vasopressin receptors are present in both the developing and mature dentate gyrus of the rat brain and are of the V1 vasopressor type. Because vasopressin has been shown to influence memory function when injected into the dentate gyrus, the influence of this peptide on an electrophysiological model of learning and mem...

journal_title：Hippocampus

authors： Chen C,Díaz Brinton RD,Shors TJ,Thompson RF

更新日期：1993-04-01 00:00:00

abstract：:This study investigated the effects of progesterone (P4) on the production and survival of neurons in the hippocampal dentate gyrus of adult male mice. The administration of P4 (4 mg/kg) for 3 consecutive days beginning on the 0-2nd day after the first BrdU-injection (BrdU-D(0-2)) produced an approximately twofold inc...

journal_title：Hippocampus

authors： Zhang Z,Yang R,Zhou R,Li L,Sokabe M,Chen L

更新日期：2010-03-01 00:00:00

abstract：:This study investigates relationship between regional cerebral volumes and performances over time of a categorical fluency task, in a sample of older adults (n = 316). Using voxel-wise technique, the relationship between local grey matter volume and Isaacs Set Test (IST) scores at its early (first 15 sec) and late (la...

journal_title：Hippocampus

authors： Catheline G,Amieva H,Dilharreguy B,Bernard C,Duperron MG,Helmer C,Dartigues JF,Allard M

更新日期：2015-09-01 00:00:00

abstract：:Cocaine induces an increase in hippocampal and nucleus accumbens (Nac) serotonin (5-HT) concentration parallel to locomotor activation. Both effects can be modulated by systemic 5-HT(1A)-receptor agonism/antagonism. Given the contribution of the hippocampus to spontaneous behavioral activity, these observations sugges...

journal_title：Hippocampus

authors： Müller CP,Thönnessen H,Barros M,Tomaz C,Carey RJ,Huston JP

更新日期：2004-01-01 00:00:00

abstract：:The multifactorial causes impacting the risk of developing sporadic forms of Alzheimer's disease (AD) remain to date poorly understood. Epidemiologic studies in humans and research in rodents have suggested that hypothyroidism could participate in the etiology of AD. Recently, we reported that adult-onset hypothyroidi...

journal_title：Hippocampus

authors： Chaalal A,Poirier R,Blum D,Gillet B,Le Blanc P,Basquin M,Buée L,Laroche S,Enderlin V

更新日期：2014-11-01 00:00:00

abstract：:Dual-process theories of episodic memory state that retrieval is contingent on two independent processes: familiarity (providing a sense of oldness) and recollection (recovering events and their context). A variety of studies have reported distinct neural signatures for familiarity and recollection, supporting dual-pr...

journal_title：Hippocampus

authors： Greve A,Donaldson DI,van Rossum MC

更新日期：2010-02-01 00:00:00

abstract：:Gelsolin is an actin-binding protein that regulates actin filament-severing and capping activity in the various processes of cell motilities. Here, we report the expression of gelsolin mRNA and protein in the hippocampus following transections of the entorhinal afferents. Northern blot analysis showed that transcript ...

journal_title：Hippocampus

authors： Dong JH,Ying GX,Liu X,Wang WY,Wang Y,Ni ZM,Zhou CF

更新日期：2006-01-01 00:00:00

abstract：:White matter hyperintensities (WMH) constitute the visible spectrum of cerebral small vessel disease (SVD) markers and are associated with cognitive decline, although they do not fully account for memory decline observed in individuals with SVD. We hypothesize that WMH might exert their effect on memory decline indire...

journal_title：Hippocampus

authors： van Leijsen EMC,Tay J,van Uden IWM,Kooijmans ECM,Bergkamp MI,van der Holst HM,Ghafoorian M,Platel B,Norris DG,Kessels RPC,Markus HS,Tuladhar AM,de Leeuw FE

更新日期：2019-06-01 00:00:00

abstract：:The hippocampus receives robust serotonergic innervation that is thought to control the excitability of both pyramidal cells and GABAergic interneurons. Previous work has addressed serotonergic regulation of pyramidal cells but considerable gaps remain in our understanding of how serotonin regulates different interneu...

journal_title：Hippocampus

authors： Wyskiel DR,Andrade R

更新日期：2016-09-01 00:00:00

abstract：:Spike-timing-dependent long-term potentiation (LTP) and long-term depression (LTD) were investigated in the CA1 area of hippocampal slices using optical imaging. A pair of electrical pulses were used to stimulate the Schaffer-commissural collateral and the stratum oriens with various sets of relative timing (tau) betw...

journal_title：Hippocampus

authors： Tsukada M,Aihara T,Kobayashi Y,Shimazaki H

更新日期：2005-01-01 00:00:00

abstract：:Fear can be extinguished by repeated exposure to a cue that signals threat. However, extinction does not erase fear, as an extinguished cue presented in a context distinct from that of extinction results in renewed fear of that cue. The hippocampus, which is involved in the formation of contextual representations, is ...

journal_title：Hippocampus

authors： Zelikowsky M,Pham DL,Fanselow MS

更新日期：2012-05-01 00:00:00

abstract：:We have previously shown that, in HEK 293 cells, overexpression of acidic calponin, an actin-binding protein, induces remodeling of actin filaments, leading to a change in cell morphology. In addition, this protein is found in dendritic spines of adult hippocampal neurons. We hypothesized that this protein plays a rol...

journal_title：Hippocampus

authors： Ferhat L,Esclapez M,Represa A,Fattoum A,Shirao T,Ben-Ari Y

更新日期：2003-01-01 00:00:00

abstract：:In this review, we aim to reappraise the organization of intrinsic and extrinsic networks of the entorhinal cortex with a focus on the concept of parallel cortical connectivity streams. The concept of two entorhinal areas, the lateral and medial entorhinal cortex, belonging to two parallel input-output streams mediati...

journal_title：Hippocampus

authors： Nilssen ES,Doan TP,Nigro MJ,Ohara S,Witter MP

更新日期：2019-12-01 00:00:00