Lesion-induced gelsolin upregulation in the hippocampus following entorhinal deafferentation.

abstract：:The survival of adult-born dentate gyrus granule cells critically depends on their synaptic integration into the existing neuronal network. Excitatory inputs are thought to increase the survival rate of adult born neurons. Therefore, whether enhancing the stability of newly formed excitatory synapses by overexpressing...

journal_title：Hippocampus

authors： Doengi M,Krupp AJ,Körber N,Stein V

更新日期：2016-03-01 00:00:00

abstract：:The importance of the hippocampal theta oscillation (4-8 Hz) to memory formation has been well-established through studies in animals, prompting researchers to propose comprehensive theories of memory and learning that rely on theta oscillations for integrating information in the hippocampus and neocortex. Yet, empiri...

journal_title：Hippocampus

authors： Lega BC,Jacobs J,Kahana M

更新日期：2012-04-01 00:00:00

abstract：:Both natural and synthetic cannabinoid receptor (e.g., CB1) agonists such as Δ(9)-THC, WIN 55,212-2 (WIN-2), and HU-210 disrupt spatial cognition presumably through the inhibition of synchrony of hippocampal ensemble firing to task-related events. Although the CB1 receptor agonist CP 55,940 also disrupts the synchrono...

journal_title：Hippocampus

authors： Goonawardena AV,Riedel G,Hampson RE

更新日期：2011-05-01 00:00:00

abstract：:In the human neocortex, progressive synaptogenesis in early postnatal life is followed by a decline in synaptic density, then stability from adolescence until middle age. No comparable data are available in the hippocampus. In this study, the integral synaptic vesicle protein synaptophysin, measured immunoautoradiogra...

journal_title：Hippocampus

authors： Eastwood SL,Weickert CS,Webster MJ,Herman MM,Kleinman JE,Harrison PJ

更新日期：2006-01-01 00:00:00

abstract：:There is extensive research regarding the neural mechanisms involved in satiety and meal termination; in contrast, there is very limited understanding of how meal onset is regulated. On the basis of several converging lines of evidence, we hypothesized that hippocampal neurons form a memory of a meal and inhibit meal ...

journal_title：Hippocampus

authors： Henderson YO,Smith GP,Parent MB

更新日期：2013-01-01 00:00:00

abstract：:The hippocampal formation plays a role in mnemonic tasks and epileptic discharges in vivo. In vitro, these functions and malfunctions may relate to persistent firing (PF) and depolarization block (DB), respectively. Pyramidal neurons of the CA1 field have previously been reported to engage in either PF or DB during ch...

journal_title：Hippocampus

authors： Knauer B,Yoshida M

更新日期：2019-09-01 00:00:00

abstract：:Two recent meta-analyses, drawing on data from many of the same studies with monkeys, reached different conclusions about the relationship between hippocampal damage and recognition memory performance. Both studies found evidence of recognition memory impairment following hippocampal damage. However, Zola et al. (J Ne...

journal_title：Hippocampus

authors： Zola SM,Squire LR

更新日期：2001-01-01 00:00:00

abstract：:Entorhinal cortex lesion (ECL) leads to anterograde degeneration of perforant path axons and is known to induce a rapid and intense reaction of astrocytes and microglial cells in the deafferented dentate gyrus. Phagocytosis of degenerating axons involves the establishment and maintenance of cell-matrix and cell-cell i...

journal_title：Hippocampus

authors： Hailer NP,Bechmann I,Heizmann S,Nitsch R

更新日期：1997-01-01 00:00:00

abstract：:The goal of the present research was to assess the degree to which a pattern completion process operates in cue-induced relapse to cocaine-seeking behavior. Using a novel cue-preference version of the place preference task, rats were administered cocaine or saline, which resulted in a preference for the cocaine-paired...

journal_title：Hippocampus

authors： Kesner RP,Kirk RA,Clark JK,Moore A,Keefe K

更新日期：2016-07-01 00:00:00

abstract：:The hippocampus receives two streams of information, spatial and nonspatial, via major afferent inputs from the medial (MEC) and lateral entorhinal cortexes (LEC). The MEC and LEC projections in the temporoammonic pathway are topographically organized along the transverse-axis of area CA1. The potential for functional...

journal_title：Hippocampus

authors： Ito HT,Schuman EM

更新日期：2012-02-01 00:00:00

abstract：:Various paradigms have been used to assess the capacity of the adult brain to undergo activity-dependent morphological plasticity. In this report we have employed recurrent limbic seizures as a means of studying the effects of this form of enhanced neuronal activity on cellular morphology and, in particular, on the in...

journal_title：Hippocampus

authors： Bundman MC,Pico RM,Gall CM

更新日期：1994-10-01 00:00:00

abstract：:Although the entorhinal cortex is a key structure connecting the hippocampal formation with the rest of the cerebral cortex, little is known about its early chemoanatomical development in primates. In the present study, a cytoarchitectonic analysis and immunocytochemical detection of somatostatin, neurotensin, parvalb...

journal_title：Hippocampus

authors： Berger B,Alvarez C,Goldman-Rakic PS

更新日期：1993-07-01 00:00:00

abstract：:In this article, we present a framework to perform statistical shape analysis for segmented hippocampi, including an efficient permutation test for detecting subtle class differences, and a regularized discriminative direction method for visualizing the shape discrepancy. Fisher permutation and bootstrap tests are pre...

journal_title：Hippocampus

authors： Zhou L,Lieby P,Barnes N,Réglade-Meslin C,Walker J,Cherbuin N,Hartley R

更新日期：2009-06-01 00:00:00

abstract：:We have previously shown that exposing rats to a relatively high dose of ethanol during early postnatal life can result in an alteration in spatial learning ability. The hippocampal formation is known to be involved in the control of this ability. The purpose of the present study was to determine whether exposure of r...

journal_title：Hippocampus

authors： Miki T,Harris SJ,Wilce PA,Takeuchi Y,Bedi KS

更新日期：2004-01-01 00:00:00

abstract：:The effects of intradentate colchicine injections on the performance of tasks requiring spatial working and reference memory are controversial. Multiple-site colchicine injections (7 microg/microl; via a drawn micropipette) throughout the dentate gyrus (DG) of rats (nine sites in each hemisphere, 0.06 microl at each s...

journal_title：Hippocampus

authors： Xavier GF,Oliveira-Filho FJ,Santos AM

更新日期：1999-01-01 00:00:00

abstract：:The hippocampus is critical for memory tasks which require an active maintenance of memory for a short period of time; however, the underlying neural mechanisms remain unknown. Most theoretical and computational models, which date back to the classic proposals by Donald Hebb in , have been self-constrained by anatomy,...

journal_title：Hippocampus

authors： Knauer B,Jochems A,Valero-Aracama MJ,Yoshida M

更新日期：2013-09-01 00:00:00

abstract：:As part of an earlier experiment (Kwok and Buckley, 2009), six macaque monkeys (three with fornix transection and three unoperated controls) were trained postoperatively to discriminate a total of 104 new concurrent visuospatial conditional problems to criterion. Our experiment measured and compared long-term retentio...

journal_title：Hippocampus

authors： Kwok SC,Buckley MJ

更新日期：2010-08-01 00:00:00

abstract：:There is an ongoing debate regarding the respective role of anterior subhippocampal structures and the hippocampus in recognition memory. Here, we report a double anatomo-functional dissociation observed in two brain-damaged patients, FRG and JMG. They both suffered from complete destruction of left MTL structures. In...

journal_title：Hippocampus

authors： Barbeau EJ,Pariente J,Felician O,Puel M

更新日期：2011-09-01 00:00:00

abstract：:The ventral portion of the rodent hippocampus (HPC; anterior in primates) has been implicated in the detection and resolution of approach-avoidance conflict, which arises when an organism encounters a stimulus that predicts both positive and negative outcomes. Previous work has found differential regulation of approac...

journal_title：Hippocampus

authors： Yeates DCM,Ussling A,Lee ACH,Ito R

更新日期：2020-06-01 00:00:00

abstract：:It has been well-established that cell proliferation and neurogenesis in the adult mouse dentate gyrus (DG) can be regulated by voluntary exercise. Recent evidence has suggested that the effects of voluntary exercise can in turn be influenced by environmental factors that regulate the amount of stress an animal is exp...

journal_title：Hippocampus

authors： Kannangara TS,Webber A,Gil-Mohapel J,Christie BR

更新日期：2009-10-01 00:00:00

abstract：:A large body of neuroscientific work indicates that exposure to experienced stress causes damage to both cortical and hippocampal cells and results in impairments to cognitive abilities associated with these structures. Similarly, work within the domain of cognitive aging demonstrates that elderly participants who rep...

journal_title：Hippocampus

authors： Marshall AC,Cooper NR,Geeraert N

更新日期：2016-03-01 00:00:00

abstract：:Studies of differential eyeblink conditioning (CS+ and CS-) have demonstrated that successful conditioning requires awareness of the stimulus contingencies and that delay conditioning does not. Two experiments were carried out to determine whether awareness is also important for single-cue trace eyeblink conditioning....

journal_title：Hippocampus

authors： Manns JR,Clark RE,Squire LR

更新日期：2000-01-01 00:00:00

abstract：:Two patients, with magnetic resonance imaging (MRI)-confirmed relatively selective hippocampal damage, showed distinct patterns of performance on tests of recall, item recognition, and associative recognition. Patient AC showed a mean bilateral volume reduction of the hippocampus of 28%, but displayed no memory defici...

journal_title：Hippocampus

authors： Holdstock JS,Parslow DM,Morris RG,Fleminger S,Abrahams S,Denby C,Montaldi D,Mayes AR

更新日期：2008-01-01 00:00:00

abstract：:The hippocampus plays an important role in spatial learning and memory. However, the biochemical alterations that subserve this function remain to be fully elucidated. In this study, rats were subjected to a single-trial contextual fear conditioning (CFC) paradigm; the activation of different protein kinase C (PKC) su...

journal_title：Hippocampus

authors： Young E,Cesena T,Meiri KF,Perrone-Bizzozero NI

更新日期：2002-01-01 00:00:00

abstract：:Previous studies have shown that estrogens, originating from ovaries, have a wide variety of estrogen receptor (ER)-mediated effects in the hippocampus. In the present study, we have investigated whether estrogens, which are synthesized in the hippocampus, could induce these effects as well. As a parameter, we used ER...

journal_title：Hippocampus

authors： Prange-Kiel J,Wehrenberg U,Jarry H,Rune GM

更新日期：2003-01-01 00:00:00

abstract：:Converging behavioral, electrophysiological, and neurochemical data suggest that lesions to the peripheral vestibular system result in impairment of the hippocampus. Nonetheless, relatively few studies have examined the hippocampus or behavior related to it, over a long period of time following the lesion, to determin...

journal_title：Hippocampus

authors： Zheng Y,Goddard M,Darlington CL,Smith PF

更新日期：2007-01-01 00:00:00

abstract：:We have previously shown that, in HEK 293 cells, overexpression of acidic calponin, an actin-binding protein, induces remodeling of actin filaments, leading to a change in cell morphology. In addition, this protein is found in dendritic spines of adult hippocampal neurons. We hypothesized that this protein plays a rol...

journal_title：Hippocampus

authors： Ferhat L,Esclapez M,Represa A,Fattoum A,Shirao T,Ben-Ari Y

更新日期：2003-01-01 00:00:00

abstract：:Aniracetam reversibly increased synaptic responses mediated by the AMPA but not the NMDA subclass of glutamate receptors in hippocampus and was considerably more potent than structurally similar nootropics. The drug had greater effects on field excitatory postsynaptic potentials (EPSPs) in the dentate gyrus and CA1 re...

journal_title：Hippocampus

authors： Xiao P,Staubli U,Kessler M,Lynch G

更新日期：1991-10-01 00:00:00

abstract：:Key pathological features of Parkinson's Disease (PD) include the progressive degeneration of midbrain dopaminergic (DA) neurons and hindbrain noradrenergic (NA) neurons. The loss of DA neurons has been extensively studied and is the main cause of motor dysfunction. Importantly, however, there are a range of 'non-move...

journal_title：Hippocampus

authors： Ermine CM,Wright JL,Frausin S,Kauhausen JA,Parish CL,Stanic D,Thompson LH

更新日期：2018-05-01 00:00:00

abstract：:Recent studies have demonstrated that remembering past experiences and imagining future scenarios recruits a core network including the hippocampus. Even so, constructing future events engages the hippocampus more than remembering past events. This fMRI study examined whether increased hippocampal activity for future ...

journal_title：Hippocampus

authors： Addis DR,Cheng T,Roberts RP,Schacter DL

更新日期：2011-10-01 00:00:00