Long-term visuospatial retention unaffected by fornix transection.

abstract：:The hippocampus receives two streams of information, spatial and nonspatial, via major afferent inputs from the medial (MEC) and lateral entorhinal cortexes (LEC). The MEC and LEC projections in the temporoammonic pathway are topographically organized along the transverse-axis of area CA1. The potential for functional...

journal_title：Hippocampus

authors： Ito HT,Schuman EM

更新日期：2012-02-01 00:00:00

abstract：:The hippocampus is critical for memory tasks which require an active maintenance of memory for a short period of time; however, the underlying neural mechanisms remain unknown. Most theoretical and computational models, which date back to the classic proposals by Donald Hebb in , have been self-constrained by anatomy,...

journal_title：Hippocampus

authors： Knauer B,Jochems A,Valero-Aracama MJ,Yoshida M

更新日期：2013-09-01 00:00:00

abstract：:Previous research has revealed that the functional components of spatial cognition are lateralized in the forebrain of birds, including the hippocampal formation (HF). To investigate how HF cells in the left and right avian brain may differentially participate in representations of space, we recorded single-units from...

journal_title：Hippocampus

authors： Siegel JJ,Nitz D,Bingman VP

更新日期：2006-01-01 00:00:00

abstract：:We have previously shown that, in HEK 293 cells, overexpression of acidic calponin, an actin-binding protein, induces remodeling of actin filaments, leading to a change in cell morphology. In addition, this protein is found in dendritic spines of adult hippocampal neurons. We hypothesized that this protein plays a rol...

journal_title：Hippocampus

authors： Ferhat L,Esclapez M,Represa A,Fattoum A,Shirao T,Ben-Ari Y

更新日期：2003-01-01 00:00:00

abstract：:Persistent neural activity lasting for seconds after transient stimulation has been observed in several brain areas. This activity has been taken to be indicative of the integration of inputs on long time scales. Passive membrane properties render neural time constants to be on the order of milliseconds. Intense synap...

journal_title：Hippocampus

authors： Huhn Z,Orbán G,Erdi P,Lengyel M

更新日期：2005-01-01 00:00:00

abstract：:Information storage in the brain is a temporally graded process involving different memory types or phases. It has been assumed for over a century that one or more short-term memory (STM) processes are involved in processing new information while long-term memory (LTM) is being formed. Because brain-derived neutrophic...

journal_title：Hippocampus

authors： Alonso M,Vianna MR,Depino AM,Mello e Souza T,Pereira P,Szapiro G,Viola H,Pitossi F,Izquierdo I,Medina JH

更新日期：2002-01-01 00:00:00

abstract：:The past decade has witnessed burgeoning evidence that antidepressant medications and physical exercise increase the expression of hippocampal brain-derived neurotrophic factor (BDNF). This phenomenon has gained widespread appeal, because BDNF is one of the first macromolecules observed to play a central role not only...

journal_title：Hippocampus

authors： Chen MJ,Russo-Neustadt AA

更新日期：2009-10-01 00:00:00

abstract：:Human navigation studies show that landmarks are used for orientation, whereas objects contribute to the contextual representation of an environment. What constitutes a landmark? Classic rodent studies show that hippocampal place fields are controlled by distal, polarizing cues. Place fields, however, are also influen...

journal_title：Hippocampus

authors： Scaplen KM,Gulati AA,Heimer-McGinn VL,Burwell RD

更新日期：2014-11-01 00:00:00

abstract：:Key pathological features of Parkinson's Disease (PD) include the progressive degeneration of midbrain dopaminergic (DA) neurons and hindbrain noradrenergic (NA) neurons. The loss of DA neurons has been extensively studied and is the main cause of motor dysfunction. Importantly, however, there are a range of 'non-move...

journal_title：Hippocampus

authors： Ermine CM,Wright JL,Frausin S,Kauhausen JA,Parish CL,Stanic D,Thompson LH

更新日期：2018-05-01 00:00:00

abstract：:Reorganization of excitatory and inhibitory circuits in the hippocampal formation following seizure-induced neuronal loss has been proposed to underlie the development of chronic seizures in temporal lobe epilepsy (TLE). Here, we investigated whether specific morphological alterations of the GABAergic system can be re...

journal_title：Hippocampus

authors： André V,Marescaux C,Nehlig A,Fritschy JM

更新日期：2001-01-01 00:00:00

abstract：:Metabolic integrity of glial cells in field CA1 of the guinea pig hippocampus is critical to maintenance of synaptic transmission (Keyser and Pellmar [1994] Glia 10:237-243). To determine if this tight glial-neuronal coupling is equally important in other brain regions, we compared the effect of fluoroacetate (FAC), a...

journal_title：Hippocampus

authors： Keyser DO,Pellmar TC

更新日期：1997-01-01 00:00:00

abstract：:In rodents, pyramidal cell firing patterns from waking may be replayed in nonrapid eye movement sleep (NREM) sleep during hippocampal sharp wave ripples (HC-SWR). In humans, HC-SWR have only been recorded with electrodes implanted to localize epileptogenicity. Here, we characterize human HC-SWR with rigorous rejection...

journal_title：Hippocampus

authors： Jiang X,Gonzalez-Martinez J,Cash SS,Chauvel P,Gale J,Halgren E

更新日期：2020-06-01 00:00:00

abstract：:Effective navigation depends upon reliable estimates of head direction (HD). Visual, vestibular, and outflow motor signals combine for this purpose in a brain system that includes dorsal tegmental nucleus, lateral mammillary nuclei, anterior dorsal thalamic nucleus, and the postsubiculum. Learning is needed to combine...

journal_title：Hippocampus

authors： Fortenberry B,Gorchetchnikov A,Grossberg S

更新日期：2012-12-01 00:00:00

abstract：:It is argued that while the hippocampus is not vital for all classes of configural learning, it is vital for a specific subclass of configural tasks called "structural learning." The defining feature of structural learning is that in addition to binding stimulus elements to make unique arrays (as in all configural lea...

journal_title：Hippocampus

authors： Aggleton JP,Sanderson DJ,Pearce JM

更新日期：2007-01-01 00:00:00

abstract：:We have previously shown that exposing rats to a relatively high dose of ethanol during early postnatal life can result in an alteration in spatial learning ability. The hippocampal formation is known to be involved in the control of this ability. The purpose of the present study was to determine whether exposure of r...

journal_title：Hippocampus

authors： Miki T,Harris SJ,Wilce PA,Takeuchi Y,Bedi KS

更新日期：2004-01-01 00:00:00

abstract：:Recent evidence suggests that activity-regulated cytoskeleton associated protein (Arc) and brain-derived neurotrophic factor (BDNF) are key players in the cellular mechanisms that trigger synaptic changes and memory consolidation. Cholinergic deafferentiation of hippocampus has been largely shown to induce memory impa...

journal_title：Hippocampus

authors： Gil-Bea FJ,Solas M,Mateos L,Winblad B,Ramírez MJ,Cedazo-Mínguez A

更新日期：2011-09-01 00:00:00

abstract：:The locomotor effects of intra-NAcc injection of dopamine receptor agonists following discrete lesion or inhibition of the DH or the VH have been poorly investigated using only the indirect dopamine receptor agonist amphetamine. In the present study, we investigated how lidocaine in the DH or the VH modulated hyperloc...

journal_title：Hippocampus

authors： Rouillon C,Abraini JH,David HN

更新日期：2007-01-01 00:00:00

abstract：:The conditioned cue preference (CCP) task was used to study the ability of rats to discriminate between spatial locations. Food-deprived rats explored an eight-arm radial maze with no food present (pre-exposure). On subsequent days, they were alternately confined in one arm of the maze with food and in another arm wit...

journal_title：Hippocampus

authors： Gaskin S,Chai SC,White NM

更新日期：2005-01-01 00:00:00

abstract：:The importance of the hippocampal theta oscillation (4-8 Hz) to memory formation has been well-established through studies in animals, prompting researchers to propose comprehensive theories of memory and learning that rely on theta oscillations for integrating information in the hippocampus and neocortex. Yet, empiri...

journal_title：Hippocampus

authors： Lega BC,Jacobs J,Kahana M

更新日期：2012-04-01 00:00:00

abstract：:Spike-timing-dependent long-term potentiation (LTP) and long-term depression (LTD) were investigated in the CA1 area of hippocampal slices using optical imaging. A pair of electrical pulses were used to stimulate the Schaffer-commissural collateral and the stratum oriens with various sets of relative timing (tau) betw...

journal_title：Hippocampus

authors： Tsukada M,Aihara T,Kobayashi Y,Shimazaki H

更新日期：2005-01-01 00:00:00

abstract：:Increased consumption of high-fat diet (HFD) leads to obesity and adverse neurocognitive outcomes. Childhood and adolescence are important periods of brain maturation shaping cognitive function. These periods could consequently be particularly sensitive to the detrimental effects of HFD intake. In mice, juvenile and a...

journal_title：Hippocampus

authors： Boitard C,Etchamendy N,Sauvant J,Aubert A,Tronel S,Marighetto A,Layé S,Ferreira G

更新日期：2012-11-01 00:00:00

abstract：:Vasopressin receptors are present in both the developing and mature dentate gyrus of the rat brain and are of the V1 vasopressor type. Because vasopressin has been shown to influence memory function when injected into the dentate gyrus, the influence of this peptide on an electrophysiological model of learning and mem...

journal_title：Hippocampus

authors： Chen C,Díaz Brinton RD,Shors TJ,Thompson RF

更新日期：1993-04-01 00:00:00

abstract：:Despite evidence that the extracellular matrix glycoprotein tenascin-C (TNC) is implicated in brain development and plasticity, its roles in the intact adult brain are unknown. Here we report that spontaneous local field potential (LFP) activity in freely moving adult TNC-deficient mice is abnormal. The power of corti...

journal_title：Hippocampus

authors： Gurevicius K,Kuang F,Stoenica L,Irintchev A,Gureviciene I,Dityatev A,Schachner M,Tanila H

更新日期：2009-12-01 00:00:00

abstract：:The role of perforant pathway-dentate granule cell synapses in cognitive behavior was examined focusing on synaptic Zn(2+) signaling in the dentate gyrus. Object recognition memory was transiently impaired when extracellular Zn(2+) levels were decreased by injection of clioquinol and N,N,N',N'-tetrakis-(2-pyridylmethy...

journal_title：Hippocampus

authors： Takeda A,Tamano H,Ogawa T,Takada S,Nakamura M,Fujii H,Ando M

更新日期：2014-11-01 00:00:00

abstract：:People retain more new verbal episodic information for at least 7 days if they rest for a few minutes after learning than if they attend to new information. It is hypothesized that rest allows for superior consolidation of new memories. In rodents, rest periods promote hippocampal replay of a recently travelled route,...

journal_title：Hippocampus

authors： Craig M,Dewar M,Della Sala S,Wolbers T

更新日期：2015-09-01 00:00:00

abstract：:Synaptic responses mediated by the N-methyl-D-aspartate receptor (NMDAr) and non-NMDAr activation were compared in CA1 hippocampal region of young (3-4 months old) and aged (25-33 months old) Sprague-Dawley rats with the use of ex vivo extracellular recordings techniques. In aged rats, the amplitude of the NMDAr-media...

journal_title：Hippocampus

authors： Jouvenceau A,Dutar P,Billard JM

更新日期：1998-01-01 00:00:00

abstract：:Recent studies have established that environmental factors can modify hippocampal structure and enhance function in adult rodents, but the extent to which genes and the environment exert differential contributions to hippocampal structural integrity in humans is unknown. Here, we applied the twin model in a large samp...

journal_title：Hippocampus

authors： Sullivan EV,Pfefferbaum A,Swan GE,Carmelli D

更新日期：2001-01-01 00:00:00

abstract：:To study the possible involvement of the hippocampus in learned conditional responding, rats with aspiration lesions of the hippocampus and others that had the hippocampus removed with ibotenic acid were trained on concurrent Pavlovian conditional and nonconditional discriminations. In agreement with the results repor...

journal_title：Hippocampus

authors： Jarrard LE,Davidson TL

更新日期：1991-01-01 00:00:00

abstract：:The vestibular system contributes to the performance of various spatial memory tasks, but few studies have attempted to disambiguate the roles of the semicircular canals and otolith organs in this performance. This study tested the otolithic contribution to spatial working and reference memory by evaluating the perfor...

journal_title：Hippocampus

authors： Yoder RM,Kirby SL

更新日期：2014-10-01 00:00:00

abstract：:The hippocampus and related structures are thought to be capable of 1) representing cortical activity in a way that minimizes overlap of the representations assigned to different cortical patterns (pattern separation); and 2) modifying synaptic connections so that these representations can later be reinstated from par...

journal_title：Hippocampus

authors： O'Reilly RC,McClelland JL

更新日期：1994-12-01 00:00:00