Abstract:
:In rodents, pyramidal cell firing patterns from waking may be replayed in nonrapid eye movement sleep (NREM) sleep during hippocampal sharp wave ripples (HC-SWR). In humans, HC-SWR have only been recorded with electrodes implanted to localize epileptogenicity. Here, we characterize human HC-SWR with rigorous rejection of epileptiform activity, requiring multiple oscillations and coordinated sharp waves. We demonstrated typical SWR in those rare HC recordings which lack interictal epileptiform spikes (IIS) and with no or minimal seizure involvement. These HC-SWR have a similar rate (~12 min-1 on average, variable across NREM stages and anterior/posterior HC) and apparent intra-HC topography (ripple maximum in putative stratum pyramidale, slow wave in radiatum) as rodents, though with lower frequency (~85 Hz compared to ~140 Hz in rodents). Similar SWR are found in HC with IIS, but no significant seizure involvement. These SWR were modulated by behavior, being largely absent (<2 min-1 ) except during NREM sleep in both Stage 2 (~9 min-1 ) and Stage 3 (~15 min-1 ), distinguishing them from IIS. This study quantifies the basic characteristics of a strictly selected sample of SWR recorded in relatively healthy human hippocampi.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Jiang X,Gonzalez-Martinez J,Cash SS,Chauvel P,Gale J,Halgren Edoi
10.1002/hipo.23183subject
Has Abstractpub_date
2020-06-01 00:00:00pages
610-622issue
6eissn
1050-9631issn
1098-1063journal_volume
30pub_type
杂志文章相关文献
HIPPOCAMPUS文献大全abstract::We have studied 5-hydroxytryptamine (5-HT) release in the hippocampal formation following electrical stimulation of the dorsal and median raphé nuclei in the behaving rat. The primary finding in this study is a decrease in neuronal release of serotonin in the dorsal hippocampal formation following electrical stimulati...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1998)8:3<262::AID-HIPO8>3.
更新日期:1998-01-01 00:00:00
abstract::The importance of the hippocampal theta oscillation (4-8 Hz) to memory formation has been well-established through studies in animals, prompting researchers to propose comprehensive theories of memory and learning that rely on theta oscillations for integrating information in the hippocampus and neocortex. Yet, empiri...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20937
更新日期:2012-04-01 00:00:00
abstract::Wnt proteins have emerged as transmembrane signaling molecules that regulate learning and memory as well as synaptic plasticity at central synapses (Inestrosa and Arenas (2010) Nat Rev Neurosci 11:77-86; Maguschak and Ressler (2011) J Neurosci 31:13057-13067; Tabatadze et al. (2012) Hippocampus 22: 1228-1241; Fortress...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22239
更新日期:2014-04-01 00:00:00
abstract::Human navigation studies show that landmarks are used for orientation, whereas objects contribute to the contextual representation of an environment. What constitutes a landmark? Classic rodent studies show that hippocampal place fields are controlled by distal, polarizing cues. Place fields, however, are also influen...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22331
更新日期:2014-11-01 00:00:00
abstract::Neurons in the supramammillary nucleus (SUM) of urethane-anesthetized rats fire rhythmically in synchrony with hippocampal theta rhythm. As these neurons project to the septum and hippocampus, it is generally assumed that their role is to mediate ascending activation, leading to the hippocampal theta rhythm. However, ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20180
更新日期:2006-01-01 00:00:00
abstract::The hippocampus and the medial temporal lobe cortex [medial temporal lobe cortices (MTLC)] both contribute to long-term memory. Although their contributions are thought to be dissociable, the nature of the representations that each region supports remains unclear. The Complementary Learning Systems (CLS) modeling appr...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20967
更新日期:2012-05-01 00:00:00
abstract::Cocaine induces an increase in hippocampal and nucleus accumbens (Nac) serotonin (5-HT) concentration parallel to locomotor activation. Both effects can be modulated by systemic 5-HT(1A)-receptor agonism/antagonism. Given the contribution of the hippocampus to spontaneous behavioral activity, these observations sugges...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10209
更新日期:2004-01-01 00:00:00
abstract::Watermaze tests of place learning and memory in rodents and corresponding reverse-translated human paradigms in real or virtual environments are key tools to study hippocampal function. In common variants, the animal or human participant has to find a hidden goal that remains in the same place over many trials, allowi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22992
更新日期:2018-11-01 00:00:00
abstract::High-frequency stimulation of excitatory synapses in many regions of the brain triggers a lasting increase in the efficacy of synaptic transmission referred to as long-term potentiation (LTP) and believed to contribute to learning and memory. One hypothesis proposed to account for the stability and properties of this ...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/1098-1063(2000)10:5<596::AID-HIPO10>3.0.CO
更新日期:2000-01-01 00:00:00
abstract::Changes in synaptic efficacy and morphology have been proposed as mechanisms underlying learning and memory processes. In our previous studies, high frequency stimulation (HFS) sufficient to induce LTP at the hippocampal mossy fiber (MF) pathway, leads to MF synaptogenesis, in a prominent contralateral form, at the st...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20866
更新日期:2012-01-01 00:00:00
abstract::The authors propose a computational theory of the hippocampal region's function in mediating stimulus representations. The theory assumes that the hippocampal region develops new stimulus representations that enhance the discriminability of differentially predictive cues while compressing the representation of redunda...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450030410
更新日期:1993-10-01 00:00:00
abstract::In this study the subcortical afferents for the rat PER areas 35 and 36, POR, and the lateral and medial entorhinal areas (LEA and MEA) were characterized. We analyzed 33 retrograde tract-tracing experiments distributed across the five regions. For each experiment, we estimated the total numbers, percentages, and dens...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22603
更新日期:2016-09-01 00:00:00
abstract::People retain more new verbal episodic information for at least 7 days if they rest for a few minutes after learning than if they attend to new information. It is hypothesized that rest allows for superior consolidation of new memories. In rodents, rest periods promote hippocampal replay of a recently travelled route,...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22424
更新日期:2015-09-01 00:00:00
abstract::We have shown previously that chronic nicotine treatment reverses adult-onset hypothyroidism-induced impairment of late-phase long-term potentiation (L-LTP) in area CA1 of the hippocampus. In the present study, basal and stimulated levels of signaling molecules essential for the expression of L-LTP were determined in ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20306
更新日期:2007-01-01 00:00:00
abstract::Changes in the spatial arrangement or identity of objects inside a familiar environment induce reexploration. The present study looks at modifications of place cell activity during such renewed exploration. Hungry rats foraged for food in a cylinder with a salient cue card attached to the wall and with two distinct ob...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20060
更新日期:2005-01-01 00:00:00
abstract::Aging has been associated with a decline in relational memory, which is critically supported by the hippocampus. By adapting the transitivity paradigm (Bunsey and Eichenbaum (1996) Nature 379:255-257), which traditionally has been used in nonhuman animal research, this work examined the extent to which aging is accomp...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22501
更新日期:2016-02-01 00:00:00
abstract::Animal studies on the effects of chronic variable stress during the peripubertal-juvenile period on hippocampal structure and function are lacking. Twenty-eight-day-old Sprague-Dawley rats were subjected to random, variable physical or social stress regimens for 4 weeks. Hippocampal volume was found to continue to gro...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10207
更新日期:2004-01-01 00:00:00
abstract::Rett syndrome (RTT) is a neurodevelopment disorder associated with intellectual disabilities and caused by loss-of-function mutations in the gene encoding the transcriptional regulator Methyl-CpG-binding Protein-2 (MeCP2). Neuronal dysfunction and changes in cortical excitability occur in RTT individuals and Mecp2-def...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22360
更新日期:2015-02-01 00:00:00
abstract::Our model of the spatial and temporal aspects of place cell firing and their role in rat navigation is reviewed. The model provides a candidate mechanism, at the level of individual cells, by which place cell information concerning self-localization could be used to guide navigation to previously visited reward sites....
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1996)6:6<749::AID-HIPO16>3
更新日期:1996-01-01 00:00:00
abstract::The modulatory actions of GABA(A) receptor subunits are crucial for morphological and transcriptional neuronal activities. In this study, growth of hamster hippocampal neurons on biohybrid membrane substrates allowed us to show for the first time that the two major GABA(A) alpha receptor subunits (alpha(2,5)) are capa...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20584
更新日期:2009-11-01 00:00:00
abstract::Effective navigation depends upon reliable estimates of head direction (HD). Visual, vestibular, and outflow motor signals combine for this purpose in a brain system that includes dorsal tegmental nucleus, lateral mammillary nuclei, anterior dorsal thalamic nucleus, and the postsubiculum. Learning is needed to combine...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22040
更新日期:2012-12-01 00:00:00
abstract::Both natural and synthetic cannabinoid receptor (e.g., CB1) agonists such as Δ(9)-THC, WIN 55,212-2 (WIN-2), and HU-210 disrupt spatial cognition presumably through the inhibition of synchrony of hippocampal ensemble firing to task-related events. Although the CB1 receptor agonist CP 55,940 also disrupts the synchrono...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20769
更新日期:2011-05-01 00:00:00
abstract::Previous studies with excitotoxically lesioned organotypic hippocampal slice cultures (OHSC) have revealed that the immunosuppressant mycophenolate mofetil (MMF) inhibits microglial activation and suppresses neuronal injury in the dentate gyrus. We here investigate whether MMF also has beneficial effects on axon survi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20182
更新日期:2006-01-01 00:00:00
abstract::Longitudinal studies on patients for schizophrenia suggest that functional brain perturbations precede the onset of symptoms. Rats with a neonatal ventral hippocampal lesion (NVHL) are considered as a heuristic neurodevelopmental model of schizophrenia. We characterized basal metabolic changes observed in NVHL rats be...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20686
更新日期:2010-07-01 00:00:00
abstract::There is limited knowledge regarding how the brain controls the timing of meals. Similarly, there is a large gap in our understanding of how top-down cognitive processes, such as memory influence energy intake. We hypothesize that dorsal hippocampal (dHC) neurons, which are critical for episodic memory, form a memory ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22532
更新日期:2016-03-01 00:00:00
abstract::We aimed at identifying the cerebral structures whose synaptic function subserves the recollection of lifetime's episodic autobiographical memory (AM) via autonoetic consciousness. Twelve healthy middle-aged subjects (mean age: 59 years +/- 2.5) underwent a specially designed cognitive test to assess the ability to re...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20406
更新日期:2008-01-01 00:00:00
abstract::Trans-synaptic cell-adhesion molecules have been implicated in regulating CNS synaptogenesis. Among these, the Neuroligin (NL) family (NLs 1-4) of postsynaptic adhesion proteins has been shown to promote the development and specification of excitatory versus inhibitory synapses. NLs form a heterophilic complex with th...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20630
更新日期:2010-02-01 00:00:00
abstract::Norepinephrine, is involved in the enhancement of learning and memory formation by regulating synaptic mechanisms through its ability to activate pre- and post-synaptic adrenergic receptors. Here we show that β-agonists of norepinephrine facilitate the induction of both associational LTP and sharp wave ripples (SPW-Rs...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22665
更新日期:2016-12-01 00:00:00
abstract::Trace eyeblink classical conditioning is a non-spatial learning paradigm that requires an intact hippocampus. This task is hippocampus-dependent because the auditory tone conditioned stimulus (CS) is temporally separated from the corneal airpuff unconditioned stimulus (US) by a 500-ms trace interval. Our laboratory ha...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1098-1063(1999)9:4<385::AID-HIPO5>3.
更新日期:1999-01-01 00:00:00
abstract::The hippocampus receives two streams of information, spatial and nonspatial, via major afferent inputs from the medial (MEC) and lateral entorhinal cortexes (LEC). The MEC and LEC projections in the temporoammonic pathway are topographically organized along the transverse-axis of area CA1. The potential for functional...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20909
更新日期:2012-02-01 00:00:00