Modelling the dopamine and noradrenergic cell loss that occurs in Parkinson's disease and the impact on hippocampal neurogenesis.

abstract：:One functional aspect of theta oscillations that recent studies have begun to explore in humans is their role for the recollection of personal events. A specific role of theta for recollection but not for stimulus-familiarity would support links between cortical theta oscillations and hippocampal functioning, given th...

journal_title：Hippocampus

authors： Guderian S,Düzel E

更新日期：2005-01-01 00:00:00

abstract：:Various forms of synaptic plasticity in the brain have been proposed to result from modifications in the properties of glutamate receptors by calcium-dependent mechanisms. In the present study, changes in glutamate receptors elicited by calcium treatment of previously frozen mouse brain sections were evaluated by qual...

journal_title：Hippocampus

authors： Lapierre L,Valastro B,Miceli D,Massicotte G

更新日期：2000-01-01 00:00:00

abstract：:We present a neural network that characterizes a remarkably large number of classical conditioning paradigms and describes the effects of many neurophysiological manipulations. First, the network 1) describes behavior in real time 2) comprises simple and configural stimulus representations, and 3) includes attentional...

journal_title：Hippocampus

authors： Buhusi CV,Schmajuk NA

更新日期：1996-01-01 00:00:00

abstract：:Effective navigation depends upon reliable estimates of head direction (HD). Visual, vestibular, and outflow motor signals combine for this purpose in a brain system that includes dorsal tegmental nucleus, lateral mammillary nuclei, anterior dorsal thalamic nucleus, and the postsubiculum. Learning is needed to combine...

journal_title：Hippocampus

authors： Fortenberry B,Gorchetchnikov A,Grossberg S

更新日期：2012-12-01 00:00:00

abstract：:We have previously shown that, in HEK 293 cells, overexpression of acidic calponin, an actin-binding protein, induces remodeling of actin filaments, leading to a change in cell morphology. In addition, this protein is found in dendritic spines of adult hippocampal neurons. We hypothesized that this protein plays a rol...

journal_title：Hippocampus

authors： Ferhat L,Esclapez M,Represa A,Fattoum A,Shirao T,Ben-Ari Y

更新日期：2003-01-01 00:00:00

abstract：:Previous research has revealed that the functional components of spatial cognition are lateralized in the forebrain of birds, including the hippocampal formation (HF). To investigate how HF cells in the left and right avian brain may differentially participate in representations of space, we recorded single-units from...

journal_title：Hippocampus

authors： Siegel JJ,Nitz D,Bingman VP

更新日期：2006-01-01 00:00:00

abstract：:Changes in the spatial arrangement or identity of objects inside a familiar environment induce reexploration. The present study looks at modifications of place cell activity during such renewed exploration. Hungry rats foraged for food in a cylinder with a salient cue card attached to the wall and with two distinct ob...

journal_title：Hippocampus

authors： Lenck-Santini PP,Rivard B,Muller RU,Poucet B

更新日期：2005-01-01 00:00:00

abstract：:In urethane-anesthetized rats, cortical regions which provide distal dendritic excitation of the dentate gyrus and CA1 of the dorsal hippocampus were studied using current source density analysis. Electrical stimulation of the lateral perforant path (LPP) in the lateral angular bundle, lateral entorhinal cortex (LEC),...

journal_title：Hippocampus

authors： Canning KJ,Leung LS

更新日期：1997-01-01 00:00:00

abstract：:For well over a century, ethanol was believed to exert its effects on cognition and behavior by producing a ubiquitous depression of central nervous system activity. A general disruption in brain function was consistent with the belief that ethanol's effects on cognition and behavior were also quite general. Substanti...

journal_title：Hippocampus

authors： White AM,Matthews DB,Best PJ

更新日期：2000-01-01 00:00:00

abstract：:Cocaine induces an increase in hippocampal and nucleus accumbens (Nac) serotonin (5-HT) concentration parallel to locomotor activation. Both effects can be modulated by systemic 5-HT(1A)-receptor agonism/antagonism. Given the contribution of the hippocampus to spontaneous behavioral activity, these observations sugges...

journal_title：Hippocampus

authors： Müller CP,Thönnessen H,Barros M,Tomaz C,Carey RJ,Huston JP

更新日期：2004-01-01 00:00:00

abstract：:Granule cells of the mouse fascia dentata are widely used in studies on neuronal development and plasticity. In contrast to the rat, however, high-resolution morphometric data on these cells are scarce. Thus, we have analyzed granule cells in the fascia dentata of the adult Thy1-GFP mouse (C57BL/6 background). In this...

journal_title：Hippocampus

authors： Vuksic M,Del Turco D,Bas Orth C,Burbach GJ,Feng G,Müller CM,Schwarzacher SW,Deller T

更新日期：2008-01-01 00:00:00

abstract：:Hippocampal adult neurogenesis contributes to key functions of the dentate gyrus (DG), including contextual discrimination. This is due, at least in part, to the unique form of plasticity that new neurons display at a specific stage of their development when compared with the surrounding principal neurons. In addition...

journal_title：Hippocampus

authors： Darcy MJ,Trouche S,Jin SX,Feig LA

更新日期：2014-11-01 00:00:00

abstract：:Ontogenesis of GABAergic signaling may play an important role in developmental changes in seizure susceptibility in the high-potassium model of ictogenesis in vitro. The age-dependent effects of [K(+)](o) on the reversal potential of the GABA(A)-mediated responses and membrane potential in hippocampal slices in vitro ...

journal_title：Hippocampus

authors： Isaev D,Isaeva E,Khazipov R,Holmes GL

更新日期：2007-01-01 00:00:00

abstract：:The hippocampus and related structures are thought to be capable of 1) representing cortical activity in a way that minimizes overlap of the representations assigned to different cortical patterns (pattern separation); and 2) modifying synaptic connections so that these representations can later be reinstated from par...

journal_title：Hippocampus

authors： O'Reilly RC,McClelland JL

更新日期：1994-12-01 00:00:00

abstract：:The electrophysiological properties of neurons in the rat perirhinal cortex were analyzed with intracellular recordings in an in vitro slice preparation. Cells included in this study (n = 59) had resting membrane potential (RMP) = -73.9 +/- 8.5 mV (mean +/- SD), action potential amplitude = 95.5 +/- 10.4 mV, input res...

journal_title：Hippocampus

authors： D'Antuono M,Biagini G,Tancredi V,Avoli M

更新日期：2001-01-01 00:00:00

abstract：:It has been demonstrated that the dorsal CA1 subregion of the hippocampus mediates temporal processing of information, that dorsal CA3 participates in the spatiotemporal processing of memory, and the dorsal dentate gyrus (DG) mediates spatial pattern separation. A temporal ordering of spatial locations task was develo...

journal_title：Hippocampus

authors： Hunsaker MR,Kesner RP

更新日期：2008-01-01 00:00:00

abstract：:At the neuromuscular junction, spontaneous miniature excitatory synaptic currents mediated by acetylcholine are considered elementary, "quantal" transmissions. These miniature conductances can be quantitatively dichotomized into a large-mode class whose mode is the mean of a normal, bell-shaped distribution and a smal...

journal_title：Hippocampus

authors： Vautrin J,Schaffner AE,Barker JL

更新日期：1993-01-01 00:00:00

abstract：:Processing of multimodal sensory information by the morphological subdivisions of the hippocampus and its input and output structures was investigated in unanesthetized rabbits by extracellular recording of neuronal activity. Analysis shows principal differences between CA3 neurons with uniform multimodal, mainly inhi...

journal_title：Hippocampus

authors： Vinogradova OS

更新日期：2001-01-01 00:00:00

abstract：:The past decade has witnessed burgeoning evidence that antidepressant medications and physical exercise increase the expression of hippocampal brain-derived neurotrophic factor (BDNF). This phenomenon has gained widespread appeal, because BDNF is one of the first macromolecules observed to play a central role not only...

journal_title：Hippocampus

authors： Chen MJ,Russo-Neustadt AA

更新日期：2009-10-01 00:00:00

abstract：:Accurate and reproducible in vivo measurement of hippocampal volumes using magnetic resonance (MR) imaging is complicated by the morphological complexity of the structure. Additionally, separation of certain parts of the hippocampus from the adjacent brain structures on MR images is sometimes very difficult. These dif...

journal_title：Hippocampus

authors： Pantel J,O'Leary DS,Cretsinger K,Bockholt HJ,Keefe H,Magnotta VA,Andreasen NC

更新日期：2000-01-01 00:00:00

abstract：:Septal nuclei are suggested to work as an interface between the hippocampal formation, involved in higher cognitive functions, and the hypothalamus, involved in motivational behaviors such as feeding, drinking, and intracranial self-stimulation. In the present study, to elucidate a role of the septal nuclei in motivat...

journal_title：Hippocampus

authors： Nishijo H,Kita T,Tamura R,Eifuku S,Terasawa K,Ono T

更新日期：1997-01-01 00:00:00

abstract：:During certain movements (termed "type I," "instrumental," or "voluntary"), the rodent hippocampal EEG is dominated by regular 7-10 Hz waves. This "theta rhythm" is accompanied by increased firing of hippocampal interneurons and dentate gyrus granule cells. No obvious theta rhythm is present in comparable situations i...

journal_title：Hippocampus

authors： Halgren E

更新日期：1991-04-01 00:00:00

abstract：:The entorhinal cortex has long been recognized as an important interface between the hippocampal formation and the neocortex. The notion of bidirectional connections between the entorhinal cortex and the hippocampal formation have led to the suggestion that hippocampal output originating in CA1 and subiculum may reent...

journal_title：Hippocampus

authors： Kloosterman F,van Haeften T,Lopes da Silva FH

更新日期：2004-01-01 00:00:00

abstract：:Although it is well established that the integrity of the medial temporal lobe (MTL) is critical for declarative memory, the functional organization of the MTL remains a matter of intense debate. One issue that has received little consideration so far is whether the hippocampus can function normally in the presence of...

journal_title：Hippocampus

authors： Bowles B,O'Neil EB,Mirsattari SM,Poppenk J,Köhler S

更新日期：2011-08-01 00:00:00

abstract：:This study investigated the effects of neonatal hippocampal ablation on the development of spatial learning and memory abilities in rats. Newborn rats sustained bilateral electrolytic lesions of the hippocampus or were sham-operated on postnatal day 1 (PN1). At PN20-25, PN50-55, or PN90-95, separate groups of rats wer...

journal_title：Hippocampus

authors： Altemus KL,Almli CR

更新日期：1997-01-01 00:00:00

abstract：:By acting on serotonin 5-HT2A receptors (5-HT2A Rs), serotonergic psychedelic drugs induce perceptual and visual hallucinations by increasing neuronal excitability and altering visual-evoked neuronal responses. The present study was designed to examine whether the perceptual alterations induced by a serotonergic psych...

journal_title：Hippocampus

authors： Zhang G,Cinalli D,Stackman RW Jr

更新日期：2017-05-01 00:00:00

abstract：:In rodents, pyramidal cell firing patterns from waking may be replayed in nonrapid eye movement sleep (NREM) sleep during hippocampal sharp wave ripples (HC-SWR). In humans, HC-SWR have only been recorded with electrodes implanted to localize epileptogenicity. Here, we characterize human HC-SWR with rigorous rejection...

journal_title：Hippocampus

authors： Jiang X,Gonzalez-Martinez J,Cash SS,Chauvel P,Gale J,Halgren E

更新日期：2020-06-01 00:00:00

abstract：:Metabolic integrity of glial cells in field CA1 of the guinea pig hippocampus is critical to maintenance of synaptic transmission (Keyser and Pellmar [1994] Glia 10:237-243). To determine if this tight glial-neuronal coupling is equally important in other brain regions, we compared the effect of fluoroacetate (FAC), a...

journal_title：Hippocampus

authors： Keyser DO,Pellmar TC

更新日期：1997-01-01 00:00:00

abstract：:Recent evidence suggests that activity-regulated cytoskeleton associated protein (Arc) and brain-derived neurotrophic factor (BDNF) are key players in the cellular mechanisms that trigger synaptic changes and memory consolidation. Cholinergic deafferentiation of hippocampus has been largely shown to induce memory impa...

journal_title：Hippocampus

authors： Gil-Bea FJ,Solas M,Mateos L,Winblad B,Ramírez MJ,Cedazo-Mínguez A

更新日期：2011-09-01 00:00:00

abstract：:The influence of the learning process on the persistence of the newly acquired behavior is relevant both for our knowledge of the learning/memory mechanisms and for the educational policy. However, it is unclear whether during an operant conditioning process with a continuous reinforcement paradigm, individual differe...

journal_title：Hippocampus

authors： Gradari S,Pérez-Domper P,Butler RG,Martínez-Cué C,de Polavieja GG,Trejo JL

更新日期：2016-07-01 00:00:00