Abstract:
:We present a neural network that characterizes a remarkably large number of classical conditioning paradigms and describes the effects of many neurophysiological manipulations. First, the network 1) describes behavior in real time 2) comprises simple and configural stimulus representations, and 3) includes attentional control of storage and retrieval. Second, mapping of the network onto the brain can be summarized by several information processing loops: 1) a hippocampal-cortical configural loop, 2) a hippocampal-cerebellar conditioned-response loop, 3) a hippocampal-accumbens-thalamic attentional loop, and 4) a hippocampal-medial raphe-medial septum error loop. Third, within this global view of brain function, it is assumed that the hippocampal formation computes 1) the aggregate prediction of environmental events and 2) the error signals for cortical learning. These assumptions are supported by rigorous computer simulations consistent with a large body of data on hippocampal and septal neural activity, induction and blockade of hippocampal long-term potentiation, administration of cholinergic agonists and antagonists, administration of haloperidol, and selective and nonselective hippocampal and cortical lesions.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Buhusi CV,Schmajuk NAdoi
10.1002/(SICI)1098-1063(1996)6:6<621::AID-HIPO6>3.subject
Has Abstractpub_date
1996-01-01 00:00:00pages
621-42issue
6eissn
1050-9631issn
1098-1063journal_volume
6pub_type
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