Quantitative and morphological analysis of dentate granule cells with recurrent basal dendrites from normal and epileptic rats.


:Granule cells with recurrent basal dendrites (RBDs) were previously reported in both control and epileptic rats. RBDs are dendrites that arise from the basal half of granule cell bodies and curve toward and extend into the molecular layer. They are increased in frequency in the pilocarpine model of epilepsy. The present study was undertaken to analyze the distribution and morphology of granule cells with RBDs and the synaptic connections of RBDs. Granule cells were labeled by retrograde transport of biocytin. Those with an RBD were found throughout the granule cell layer, but were most numerous at the hilar border. The morphology of these cells varied in the different depths of the granule cell layer; the angle of their cell body's long axis was mainly vertical at the hilar margin, and changed to virtually horizontal close to the molecular layer border. Quantitative data on the distribution of granule cells with RBDs and the angle of the cell body's long axis confirmed these descriptions. At the electron microscopic level, RBDs showed the typical features of dendrites and formed numerous axodendritic and axospinous synapses with labeled and unlabeled axon terminals. These results showed that RBDs of granule cells from epileptic rats are postsynaptic to axon terminals, including mossy fibers, and thus are involved in a similar synaptic circuitry as apical dendrites of granule cells from these animals.






Dashtipour K,Yan XX,Dinh TT,Okazaki MM,Nadler JV,Ribak CE





Has Abstract


2002-01-01 00:00:00












  • Cell discharge correlates of posterior hypothalamic theta rhythm recorded in anesthetized rats and brain slices.

    abstract::Kowalczyk et al. (Hippocampus 2014; 24:7-20) were probably the first to conduct a systemic study of posterior hypothalamic area (PHa) theta rhythm in anesthetized rats. They demonstrated that local PHa theta field potentials were tail-pinch resistant and could be generated in urethane-anesthetized rats independently o...


    pub_type: 杂志文章


    authors: Bocian R,Kłos-Wojtczak P,Caban B,Kowalczyk T,Kaźmierska P,Konopacki J

    更新日期:2016-10-01 00:00:00

  • Dissociation of spatial memory systems in Williams syndrome.

    abstract::Williams syndrome (WS), a genetic deletion syndrome, is characterized by severe visuospatial deficits affecting performance on both tabletop spatial tasks and on tasks which assess orientation and navigation. Nevertheless, previous studies of WS spatial capacities have ignored the fact that two different spatial memor...


    pub_type: 杂志文章


    authors: Bostelmann M,Fragnière E,Costanzo F,Di Vara S,Menghini D,Vicari S,Lavenex P,Lavenex PB

    更新日期:2017-11-01 00:00:00

  • Representation of three-dimensional objects by the rat perirhinal cortex.

    abstract::The perirhinal cortex (PRC) is known to play an important role in object recognition. Little is known, however, regarding the activity of PRC neurons during the presentation of stimuli that are commonly used for recognition memory tasks in rodents, that is, three-dimensional objects. Rats in the present study were exp...


    pub_type: 杂志文章


    authors: Burke SN,Maurer AP,Hartzell AL,Nematollahi S,Uprety A,Wallace JL,Barnes CA

    更新日期:2012-10-01 00:00:00

  • Effects of age and alcohol exposure during early life on pyramidal cell numbers in the CA1-CA3 region of the rat hippocampus.

    abstract::We have previously shown that exposing rats to a relatively high dose of ethanol during early postnatal life can result in an alteration in spatial learning ability. The hippocampal formation is known to be involved in the control of this ability. The purpose of the present study was to determine whether exposure of r...


    pub_type: 杂志文章


    authors: Miki T,Harris SJ,Wilce PA,Takeuchi Y,Bedi KS

    更新日期:2004-01-01 00:00:00

  • Selective populations of hippocampal interneurons express ErbB4 and their number and distribution is altered in ErbB4 knockout mice.

    abstract::Neuregulins (NRGs) are ligands of ErbB receptor tyrosine kinases. The NRG1-ErbB4 pathway has been shown to modulate hippocampal synaptic plasticity and network oscillations in the adult rodent brain. To identify cells that mediate these effects, here we determine the expression pattern of ErbB4 in four functionally di...


    pub_type: 杂志文章


    authors: Neddens J,Buonanno A

    更新日期:2010-06-01 00:00:00

  • Disruption of amygdala-entorhinal-hippocampal network in late-life depression.

    abstract::Episodic memory deficits are evident in late-life depression (LLD) and are associated with subtle synaptic and neurochemical changes in the medial temporal lobes (MTL). However, the particular mechanisms by which memory impairment occurs in LLD are currently unknown. We tested older adults with (DS+) and without (DS-)...


    pub_type: 杂志文章


    authors: Leal SL,Noche JA,Murray EA,Yassa MA

    更新日期:2017-04-01 00:00:00

  • Dorsal hippocampus infusions of CNQX into the dentate gyrus disrupt expression of trace fear conditioning.

    abstract::The hippocampus is essential for the consolidation of some explicit long-term memories, including trace conditioning. Lesions and pharmacological manipulations of the dorsal hippocampus (DH) have provided strong evidence for its involvement in the acquisition and expression of trace fear memories. However, no studies ...


    pub_type: 杂志文章


    authors: Pierson JL,Pullins SE,Quinn JJ

    更新日期:2015-07-01 00:00:00

  • Opiates, psychostimulants, and adult hippocampal neurogenesis: Insights for addiction and stem cell biology.

    abstract::Once thought to produce global, nonspecific brain injury, drugs of abuse are now known to produce selective neuro-adaptations in particular brain regions. These neuro-adaptations are being closely examined for clues to the development, maintenance, and treatment of addiction. The hippocampus is an area of particular i...


    pub_type: 杂志文章,评审


    authors: Eisch AJ,Harburg GC

    更新日期:2006-01-01 00:00:00

  • The impact of experienced stress on aged spatial discrimination: Cortical overreliance as a result of hippocampal impairment.

    abstract::A large body of neuroscientific work indicates that exposure to experienced stress causes damage to both cortical and hippocampal cells and results in impairments to cognitive abilities associated with these structures. Similarly, work within the domain of cognitive aging demonstrates that elderly participants who rep...


    pub_type: 杂志文章


    authors: Marshall AC,Cooper NR,Geeraert N

    更新日期:2016-03-01 00:00:00

  • Objects and landmarks: hippocampal place cells respond differently to manipulations of visual cues depending on size, perspective, and experience.

    abstract::Human navigation studies show that landmarks are used for orientation, whereas objects contribute to the contextual representation of an environment. What constitutes a landmark? Classic rodent studies show that hippocampal place fields are controlled by distal, polarizing cues. Place fields, however, are also influen...


    pub_type: 杂志文章


    authors: Scaplen KM,Gulati AA,Heimer-McGinn VL,Burwell RD

    更新日期:2014-11-01 00:00:00

  • Double dissociation of learned approach-avoidance conflict processing and spatial pattern separation along the dorsoventral axis of the dentate gyrus.

    abstract::The ventral portion of the rodent hippocampus (HPC; anterior in primates) has been implicated in the detection and resolution of approach-avoidance conflict, which arises when an organism encounters a stimulus that predicts both positive and negative outcomes. Previous work has found differential regulation of approac...


    pub_type: 杂志文章


    authors: Yeates DCM,Ussling A,Lee ACH,Ito R

    更新日期:2020-06-01 00:00:00

  • Ras-GRF2 mediates long-term potentiation, survival, and response to an enriched environment of newborn neurons in the hippocampus.

    abstract::Hippocampal adult neurogenesis contributes to key functions of the dentate gyrus (DG), including contextual discrimination. This is due, at least in part, to the unique form of plasticity that new neurons display at a specific stage of their development when compared with the surrounding principal neurons. In addition...


    pub_type: 杂志文章


    authors: Darcy MJ,Trouche S,Jin SX,Feig LA

    更新日期:2014-11-01 00:00:00

  • Relationship between magnitude of damage to the hippocampus and impaired recognition memory in monkeys.

    abstract::Two recent meta-analyses, drawing on data from many of the same studies with monkeys, reached different conclusions about the relationship between hippocampal damage and recognition memory performance. Both studies found evidence of recognition memory impairment following hippocampal damage. However, Zola et al. (J Ne...


    pub_type: 杂志文章,评审


    authors: Zola SM,Squire LR

    更新日期:2001-01-01 00:00:00

  • Place cell assemblies remain intact, despite reduced phase precession, after cholinergic disruption.

    abstract::The hippocampal theta rhythm is frequently viewed as a clocking mechanism that coordinates the spiking activity of neurons across the hippocampus to form coherent neural assemblies. Phase precession is a form of temporal coding evidencing this mechanism and is degraded following systemic pharmacological disruption of ...


    pub_type: 杂志文章


    authors: Venditto SJC,Le B,Newman EL

    更新日期:2019-11-01 00:00:00

  • Improved identification and differentiation from epileptiform activity of human hippocampal sharp wave ripples during NREM sleep.

    abstract::In rodents, pyramidal cell firing patterns from waking may be replayed in nonrapid eye movement sleep (NREM) sleep during hippocampal sharp wave ripples (HC-SWR). In humans, HC-SWR have only been recorded with electrodes implanted to localize epileptogenicity. Here, we characterize human HC-SWR with rigorous rejection...


    pub_type: 杂志文章


    authors: Jiang X,Gonzalez-Martinez J,Cash SS,Chauvel P,Gale J,Halgren E

    更新日期:2020-06-01 00:00:00

  • Two case studies illustrating how relatively selective hippocampal lesions in humans can have quite different effects on memory.

    abstract::Two patients, with magnetic resonance imaging (MRI)-confirmed relatively selective hippocampal damage, showed distinct patterns of performance on tests of recall, item recognition, and associative recognition. Patient AC showed a mean bilateral volume reduction of the hippocampus of 28%, but displayed no memory defici...


    pub_type: 杂志文章


    authors: Holdstock JS,Parslow DM,Morris RG,Fleminger S,Abrahams S,Denby C,Montaldi D,Mayes AR

    更新日期:2008-01-01 00:00:00

  • Updating the hippocampal representation of space: place cell firing fields are controlled by a novel spatial stimulus.

    abstract::To ask if the properties of spatial learning supported by the hippocampus are distinct from the properties of conditioning, we conducted a blocking-like experiment in which the measured variable was not a conditioned response but rather the ability of a novel visual stimulus to control the location of place cell firin...


    pub_type: 杂志文章


    authors: Barry J,Muller R

    更新日期:2011-05-01 00:00:00

  • Selective effects of aniracetam across receptor types and forms of synaptic facilitation in hippocampus.

    abstract::Aniracetam reversibly increased synaptic responses mediated by the AMPA but not the NMDA subclass of glutamate receptors in hippocampus and was considerably more potent than structurally similar nootropics. The drug had greater effects on field excitatory postsynaptic potentials (EPSPs) in the dentate gyrus and CA1 re...


    pub_type: 杂志文章


    authors: Xiao P,Staubli U,Kessler M,Lynch G

    更新日期:1991-10-01 00:00:00

  • Stress differentially regulates the effects of voluntary exercise on cell proliferation in the dentate gyrus of mice.

    abstract::It has been well-established that cell proliferation and neurogenesis in the adult mouse dentate gyrus (DG) can be regulated by voluntary exercise. Recent evidence has suggested that the effects of voluntary exercise can in turn be influenced by environmental factors that regulate the amount of stress an animal is exp...


    pub_type: 杂志文章


    authors: Kannangara TS,Webber A,Gil-Mohapel J,Christie BR

    更新日期:2009-10-01 00:00:00

  • Nicotine prevents disruption of the late phase LTP-related molecular cascade in adult-onset hypothyroidism.

    abstract::We have shown previously that chronic nicotine treatment reverses adult-onset hypothyroidism-induced impairment of late-phase long-term potentiation (L-LTP) in area CA1 of the hippocampus. In the present study, basal and stimulated levels of signaling molecules essential for the expression of L-LTP were determined in ...


    pub_type: 杂志文章


    authors: Alzoubi KH,Aleisa AM,Alkadhi KA

    更新日期:2007-01-01 00:00:00

  • Temporal factors control hippocampal contributions to fear renewal after extinction.

    abstract::Fear can be extinguished by repeated exposure to a cue that signals threat. However, extinction does not erase fear, as an extinguished cue presented in a context distinct from that of extinction results in renewed fear of that cue. The hippocampus, which is involved in the formation of contextual representations, is ...


    pub_type: 杂志文章


    authors: Zelikowsky M,Pham DL,Fanselow MS

    更新日期:2012-05-01 00:00:00

  • A natural form of learning can increase and decrease the survival of new neurons in the dentate gyrus.

    abstract::Granule cells born in the adult dentate gyrus undergo a 4-week developmental period characterized by high susceptibility to cell death. Two forms of hippocampus-dependent learning have been shown to rescue many of the new neurons during this critical period. Here, we show that a natural form of associative learning, s...


    pub_type: 杂志文章


    authors: Olariu A,Cleaver KM,Shore LE,Brewer MD,Cameron HA

    更新日期:2005-01-01 00:00:00

  • Reliving lifelong episodic autobiographical memories via the hippocampus: a correlative resting PET study in healthy middle-aged subjects.

    abstract::We aimed at identifying the cerebral structures whose synaptic function subserves the recollection of lifetime's episodic autobiographical memory (AM) via autonoetic consciousness. Twelve healthy middle-aged subjects (mean age: 59 years +/- 2.5) underwent a specially designed cognitive test to assess the ability to re...


    pub_type: 杂志文章


    authors: Piolino P,Desgranges B,Hubert V,Bernard FA,Matuszewski V,Chételat G,Baron JC,Eustache F

    更新日期:2008-01-01 00:00:00

  • PTU-induced hypothyroidism in rats leads to several early neuropathological signs of Alzheimer's disease in the hippocampus and spatial memory impairments.

    abstract::The multifactorial causes impacting the risk of developing sporadic forms of Alzheimer's disease (AD) remain to date poorly understood. Epidemiologic studies in humans and research in rodents have suggested that hypothyroidism could participate in the etiology of AD. Recently, we reported that adult-onset hypothyroidi...


    pub_type: 杂志文章


    authors: Chaalal A,Poirier R,Blum D,Gillet B,Le Blanc P,Basquin M,Buée L,Laroche S,Enderlin V

    更新日期:2014-11-01 00:00:00

  • Cumulative long-term potentiation in the rat dentate gyrus correlates with, but does not modify, performance in the water maze.

    abstract::The electrically induced increase in hippocampal synaptic strength known as long-term potentiation (LTP) is thought to involve some of the same mechanisms as those mediating information storage during spatial learning. Physiological saturation of synaptic weights might therefore be expected to occlude spatial learning...


    pub_type: 杂志文章


    authors: Jeffery KJ,Morris RG

    更新日期:1993-04-01 00:00:00

  • Targeting hippocampal adult neurogenesis using transcription factors to reduce Alzheimer's disease-associated memory impairments.

    abstract::Hippocampal adult neurogenesis results in the persisting formation of new neurons that contribute to hippocampal-dependent learning and memory. This has led to the hypothesis that memory impairments associated with neurodegenerative diseases such as Alzheimer's disease may involve abnormal neurogenesis. Supporting thi...


    pub_type: 杂志文章,评审


    authors: Dard RF,Dahan L,Rampon C

    更新日期:2019-07-01 00:00:00

  • Cholinergic, but not NMDA, receptors in the lateral entorhinal cortex mediate acquisition in trace eyeblink conditioning.

    abstract::Anatomical and electrophysiological studies collectively suggest that the entorhinal cortex consists of several subregions, each of which is involved in the processing of different types of information. Consistent with this idea, we previously reported that the dorsolateral portion of the entorhinal cortex (DLE), but ...


    pub_type: 杂志文章


    authors: Tanninen SE,Yu X,Giritharan T,Tran L,Bakir R,Volle J,Morrissey MD,Takehara-Nishiuchi K

    更新日期:2015-11-01 00:00:00

  • Chronic impairment of ERK signaling in glutamatergic neurons of the forebrain does not affect spatial memory retention and LTP in the same manner as acute blockade of the ERK pathway.

    abstract::The ERK/MAPK signaling pathway has been extensively studied in the context of learning and memory. Defects in this pathway underlie genetic diseases associated with intellectual disability, including impaired learning and memory. Numerous studies have investigated the impact of acute ERK/MAPK inhibition on long-term p...


    pub_type: 杂志文章


    authors: Vithayathil J,Pucilowska J,Friel D,Landreth GE

    更新日期:2017-12-01 00:00:00

  • Rest boosts the long-term retention of spatial associative and temporal order information.

    abstract::People retain more new verbal episodic information for at least 7 days if they rest for a few minutes after learning than if they attend to new information. It is hypothesized that rest allows for superior consolidation of new memories. In rodents, rest periods promote hippocampal replay of a recently travelled route,...


    pub_type: 杂志文章


    authors: Craig M,Dewar M,Della Sala S,Wolbers T

    更新日期:2015-09-01 00:00:00

  • Hippocampus of the domestic pig: a stereological study of subdivisional volumes and neuron numbers.

    abstract::With the aim of establishing a quantitative structural basis for comparative and experimental studies, the volumes of the hippocampal subdivisions and the total number of neurons in each subdivision were estimated in domestic pig brains using modern stereological techniques. In addition to a detailed description of th...


    pub_type: 杂志文章


    authors: Holm IE,West MJ

    更新日期:1994-02-01 00:00:00