Theta band power increases in the posterior hippocampus predict successful episodic memory encoding in humans.

Abstract:

:Functional differences in the anterior and posterior hippocampus during episodic memory processing have not been examined in human electrophysiological data. This is in spite of strong evidence for such differences in rodent data, including greater place cell specificity in the dorsal hippocampus, greater sensitivity to the aversive or motivational content of memories in ventral regions, connectivity analyses identifying preferential ventral hippocampal connections with the amygdala, and gene expression analyses identifying a dorsal-ventral gradient. We asked if memory-related oscillatory patterns observed in human hippocampal recordings, including the gamma band and slow-theta (2.5-5 Hz) subsequent memory effects, would exhibit differences along the longitudinal axis and between hemispheres. We took advantage of a new dataset of stereo electroencephalography patients with simultaneous, robotically targeted anterior, and posterior hippocampal electrodes to directly compare oscillatory subsequent memory effects during item encoding. This same data set allowed us to examine left-right connectivity and hemispheric differences in hippocampal oscillatory patterns. Our data suggest that a power increase during successful item encoding in the 2.5-5 Hz slow-theta frequency range preferentially occurs in the posterior hippocampus during the first 1,000 ms after item presentation, while a gamma band power increase is stronger in the dominant hemisphere. This dominant-nondominant pattern in the gamma range appears to reverse during item retrieval, however. Intrahippocampal phase coherence was found to be stronger during successful item encoding. Our phase coherence data are also consistent with existing reports of a traveling wave for theta oscillations propagating along the septotemporal (longitudinal) axis of the human hippocampus. We examine how our findings fit with theories of functional specialization along the hippocampal axis.

journal_name

Hippocampus

journal_title

Hippocampus

authors

Lin JJ,Rugg MD,Das S,Stein J,Rizzuto DS,Kahana MJ,Lega BC

doi

10.1002/hipo.22751

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

1040-1053

issue

10

eissn

1050-9631

issn

1098-1063

journal_volume

27

pub_type

杂志文章
  • Hippocampal neurons inhibit meal onset.

    abstract::There is extensive research regarding the neural mechanisms involved in satiety and meal termination; in contrast, there is very limited understanding of how meal onset is regulated. On the basis of several converging lines of evidence, we hypothesized that hippocampal neurons form a memory of a meal and inhibit meal ...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22062

    authors: Henderson YO,Smith GP,Parent MB

    更新日期:2013-01-01 00:00:00

  • Visual recognition memory: a double anatomo-functional dissociation.

    abstract::There is an ongoing debate regarding the respective role of anterior subhippocampal structures and the hippocampus in recognition memory. Here, we report a double anatomo-functional dissociation observed in two brain-damaged patients, FRG and JMG. They both suffered from complete destruction of left MTL structures. In...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20848

    authors: Barbeau EJ,Pariente J,Felician O,Puel M

    更新日期:2011-09-01 00:00:00

  • Selective effects of aniracetam across receptor types and forms of synaptic facilitation in hippocampus.

    abstract::Aniracetam reversibly increased synaptic responses mediated by the AMPA but not the NMDA subclass of glutamate receptors in hippocampus and was considerably more potent than structurally similar nootropics. The drug had greater effects on field excitatory postsynaptic potentials (EPSPs) in the dentate gyrus and CA1 re...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.450010405

    authors: Xiao P,Staubli U,Kessler M,Lynch G

    更新日期:1991-10-01 00:00:00

  • A computational model of systems memory consolidation and reconsolidation.

    abstract::In the mammalian brain, newly acquired memories depend on the hippocampus (HPC) for maintenance and recall, but over time, the neocortex takes over these functions, rendering memories HPC-independent. The process responsible for this transformation is called systems memory consolidation. Reactivation of a well-consoli...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.23187

    authors: Helfer P,Shultz TR

    更新日期:2020-07-01 00:00:00

  • Lesion-induced gelsolin upregulation in the hippocampus following entorhinal deafferentation.

    abstract::Gelsolin is an actin-binding protein that regulates actin filament-severing and capping activity in the various processes of cell motilities. Here, we report the expression of gelsolin mRNA and protein in the hippocampus following transections of the entorhinal afferents. Northern blot analysis showed that transcript ...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20134

    authors: Dong JH,Ying GX,Liu X,Wang WY,Wang Y,Ni ZM,Zhou CF

    更新日期:2006-01-01 00:00:00

  • Otoconia-deficient mice show selective spatial deficits.

    abstract::The vestibular system contributes to the performance of various spatial memory tasks, but few studies have attempted to disambiguate the roles of the semicircular canals and otolith organs in this performance. This study tested the otolithic contribution to spatial working and reference memory by evaluating the perfor...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22300

    authors: Yoder RM,Kirby SL

    更新日期:2014-10-01 00:00:00

  • Lesions of the ventral hippocampus attenuate the acquisition but not expression of sign-tracking behavior in rats.

    abstract::Individual variation in the attribution of motivational salience to reward-related cues is believed to underlie addiction vulnerability. Pavlovian conditioned approach measures individual variation in motivational salience by identifying rats that are attracted to and motivated by reward cues (sign-trackers) or motiva...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22619

    authors: Fitzpatrick CJ,Creeden JF,Perrine SA,Morrow JD

    更新日期:2016-11-01 00:00:00

  • The relationship between hippocampal subfield volumes and autobiographical memory persistence.

    abstract::Structural integrity of the human hippocampus is widely acknowledged to be necessary for the successful encoding and retrieval of autobiographical memories. However, evidence for an association between hippocampal volume and the ability to recall such memories in healthy individuals is mixed. Here we examined this iss...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.23293

    authors: Barry DN,Clark IA,Maguire EA

    更新日期:2020-12-15 00:00:00

  • Retrieval flexibility and reinstatement in the developing hippocampus.

    abstract::Episodic memory improves during childhood and this improvement has been associated with age differences in hippocampal function, but previous research has not manipulated the possible underlying mechanisms. We tested the hypothesis that age-related differences in hippocampal activation may reflect changes in retrieval...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22538

    authors: DeMaster D,Coughlin C,Ghetti S

    更新日期:2016-04-01 00:00:00

  • Activity-dependent Wnt 7 dendritic targeting in hippocampal neurons: plasticity- and tagging-related retrograde signaling mechanism?

    abstract::Wnt proteins have emerged as transmembrane signaling molecules that regulate learning and memory as well as synaptic plasticity at central synapses (Inestrosa and Arenas (2010) Nat Rev Neurosci 11:77-86; Maguschak and Ressler (2011) J Neurosci 31:13057-13067; Tabatadze et al. (2012) Hippocampus 22: 1228-1241; Fortress...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22239

    authors: Tabatadze N,McGonigal R,Neve RL,Routtenberg A

    更新日期:2014-04-01 00:00:00

  • Interfering with Fos expression in rat perirhinal cortex impairs recognition memory.

    abstract::Previous work has shown that immunohistochemical imaging of Fos protein is a reliable marker for changes in activity related to recognition memory in the perirhinal (PRH) cortex of the medial temporal lobe; however, whether PRH Fos expression is necessary for recognition memory had not been established. To investigate...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22028

    authors: Seoane A,Tinsley CJ,Brown MW

    更新日期:2012-11-01 00:00:00

  • Partial coherence and frustration in self-organizing spherical grids.

    abstract::Nearby grid cells have been observed to express a remarkable degree of long-range order, which is often idealized as extending potentially to infinity. Yet their strict periodic firing and ensemble coherence are theoretically possible only in flat environments, much unlike the burrows which rodents usually live in. Ar...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.23144

    authors: Stella F,Urdapilleta E,Luo Y,Treves A

    更新日期:2020-04-01 00:00:00

  • Differential modulation of a common memory retrieval network revealed by positron emission tomography.

    abstract::Functional neuroimaging is uniquely placed to examine the dynamic nature of normal human memory, the distributed brain networks that support it, and how they are modulated. Memory has traditionally been classified into context-specific memories personally experienced ("episodic memory") and impersonal non-context-spec...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/(SICI)1098-1063(1999)9:1<54::AID-HIPO6>3.0

    authors: Maguire EA,Mummery CJ

    更新日期:1999-01-01 00:00:00

  • Episodic memory--from brain to mind.

    abstract::Neuronal mechanisms of episodic memory, the conscious recollection of autobiographical events, are largely unknown because electrophysiological studies in humans are conducted only in exceptional circumstances. Unit recording studies in animals are thus crucial for understanding the neurophysiological substrate that e...

    journal_title:Hippocampus

    pub_type: 杂志文章,评审

    doi:10.1002/hipo.20204

    authors: Ferbinteanu J,Kennedy PJ,Shapiro ML

    更新日期:2006-01-01 00:00:00

  • Modulation of AMPA receptor-mediated ion current by pituitary adenylate cyclase-activating polypeptide (PACAP) in CA1 pyramidal neurons from rat hippocampus.

    abstract::Pituitary adenylate cyclase-activating polypeptide (PACAP), a neurotrophic and neuromodulatory peptide, was recently shown to enhance NMDA receptor-mediated currents in the hippocampus (Macdonald, et al. 2005. J Neurosci 25:11374-11384). To check if PACAP might also modulate AMPA receptor function, we tested its effec...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20488

    authors: Costa L,Santangelo F,Li Volsi G,Ciranna L

    更新日期:2009-01-01 00:00:00

  • Hippocampal mediation of stimulus representation: a computational theory.

    abstract::The authors propose a computational theory of the hippocampal region's function in mediating stimulus representations. The theory assumes that the hippocampal region develops new stimulus representations that enhance the discriminability of differentially predictive cues while compressing the representation of redunda...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.450030410

    authors: Gluck MA,Myers CE

    更新日期:1993-10-01 00:00:00

  • Intrahippocampal administration of BDNF in adult rats affects short-term behavioral plasticity in the Morris water maze and performance in the elevated plus-maze.

    abstract::The present study evaluated the effects of a single intrahippocampal administration of brain-derived neurotrophic factor (BDNF) on memory retention in a water maze. Adult rats were trained in a water maze (acquisition phase, day 1). Immediately after the last training trial subjects were injected in the right hippocam...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.10220

    authors: Cirulli F,Berry A,Chiarotti F,Alleva E

    更新日期:2004-01-01 00:00:00

  • The human perirhinal cortex and recognition memory.

    abstract::The importance of the perirhinal cortex for visual recognition memory performance is undisputed. However, it has not been clear whether its contribution to performance is mainly perceptual, or mainly mnemonic, or whether the perirhinal cortex contributes to both perception and memory. We determined the effects of medi...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/(SICI)1098-1063(1998)8:4<330::AID-HIPO3>3.

    authors: Buffalo EA,Reber PJ,Squire LR

    更新日期:1998-01-01 00:00:00

  • Genetic ablation of tenascin-C expression leads to abnormal hippocampal CA1 structure and electrical activity in vivo.

    abstract::Despite evidence that the extracellular matrix glycoprotein tenascin-C (TNC) is implicated in brain development and plasticity, its roles in the intact adult brain are unknown. Here we report that spontaneous local field potential (LFP) activity in freely moving adult TNC-deficient mice is abnormal. The power of corti...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20585

    authors: Gurevicius K,Kuang F,Stoenica L,Irintchev A,Gureviciene I,Dityatev A,Schachner M,Tanila H

    更新日期:2009-12-01 00:00:00

  • A single-trace dual-process model of episodic memory: a novel computational account of familiarity and recollection.

    abstract::Dual-process theories of episodic memory state that retrieval is contingent on two independent processes: familiarity (providing a sense of oldness) and recollection (recovering events and their context). A variety of studies have reported distinct neural signatures for familiarity and recollection, supporting dual-pr...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20606

    authors: Greve A,Donaldson DI,van Rossum MC

    更新日期:2010-02-01 00:00:00

  • Intact verbal and nonverbal short-term memory following damage to the human hippocampus.

    abstract::Short-term memory was assessed in two groups of amnesic patients. Six patients had confirmed or suspected damage to the hippocampal formation, and six patients had diencephalic damage as a result of alcoholic Korsakoff's syndrome. Verbal short-term memory was evaluated with seven separate administrations of the standa...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.450020207

    authors: Cave CB,Squire LR

    更新日期:1992-04-01 00:00:00

  • Hippocampus as comparator: role of the two input and two output systems of the hippocampus in selection and registration of information.

    abstract::Processing of multimodal sensory information by the morphological subdivisions of the hippocampus and its input and output structures was investigated in unanesthetized rabbits by extracellular recording of neuronal activity. Analysis shows principal differences between CA3 neurons with uniform multimodal, mainly inhi...

    journal_title:Hippocampus

    pub_type: 杂志文章,评审

    doi:10.1002/hipo.1073

    authors: Vinogradova OS

    更新日期:2001-01-01 00:00:00

  • Inactivation of the dorsal hippocampus does not affect learning during exploration of a novel environment.

    abstract::The conditioned cue preference (CCP) task was used to study the ability of rats to discriminate between spatial locations. Food-deprived rats explored an eight-arm radial maze with no food present (pre-exposure). On subsequent days, they were alternately confined in one arm of the maze with food and in another arm wit...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20127

    authors: Gaskin S,Chai SC,White NM

    更新日期:2005-01-01 00:00:00

  • Teasing apart tangrams: testing hippocampal pattern separation with a collaborative referencing paradigm.

    abstract::The hippocampus and the medial temporal lobe cortex [medial temporal lobe cortices (MTLC)] both contribute to long-term memory. Although their contributions are thought to be dissociable, the nature of the representations that each region supports remains unclear. The Complementary Learning Systems (CLS) modeling appr...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20967

    authors: Duff MC,Warren DE,Gupta R,Vidal JP,Tranel D,Cohen NJ

    更新日期:2012-05-01 00:00:00

  • Relationship between magnitude of damage to the hippocampus and impaired recognition memory in monkeys.

    abstract::Two recent meta-analyses, drawing on data from many of the same studies with monkeys, reached different conclusions about the relationship between hippocampal damage and recognition memory performance. Both studies found evidence of recognition memory impairment following hippocampal damage. However, Zola et al. (J Ne...

    journal_title:Hippocampus

    pub_type: 杂志文章,评审

    doi:10.1002/hipo.1027

    authors: Zola SM,Squire LR

    更新日期:2001-01-01 00:00:00

  • Hippocampal involvement in retrieval of odor vs. object memories.

    abstract::The aim of this study was to investigate the role of the human hippocampus in episodic retrieval of odors, in comparison with episodic retrieval of visual objects. Subjects encoded a set of unique odors and objects, and retrieval was tested the next day during functional magnetic resonance imaging (fMRI). Subjects wer...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22073

    authors: Lehn H,Kjønigsen LJ,Kjelvik G,Håberg AK

    更新日期:2013-02-01 00:00:00

  • Dentate gyrus-selective colchicine lesion and disruption of performance in spatial tasks: difficulties in "place strategy" because of a lack of flexibility in the use of environmental cues?

    abstract::The effects of intradentate colchicine injections on the performance of tasks requiring spatial working and reference memory are controversial. Multiple-site colchicine injections (7 microg/microl; via a drawn micropipette) throughout the dentate gyrus (DG) of rats (nine sites in each hemisphere, 0.06 microl at each s...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/(SICI)1098-1063(1999)9:6<668::AID-HIPO8>3.

    authors: Xavier GF,Oliveira-Filho FJ,Santos AM

    更新日期:1999-01-01 00:00:00

  • Medial temporal lobe activation during encoding and retrieval of novel face-name pairs.

    abstract::The human medial temporal lobe (MTL) is known to be involved in declarative memory, yet the exact contributions of the various MTL structures are not well understood. In particular, the data as to whether the hippocampal region is preferentially involved in the encoding and/or retrieval of associative memory have not ...

    journal_title:Hippocampus

    pub_type: 临床试验,杂志文章

    doi:10.1002/hipo.20014

    authors: Kirwan CB,Stark CE

    更新日期:2004-01-01 00:00:00

  • Progesterone promotes the survival of newborn neurons in the dentate gyrus of adult male mice.

    abstract::This study investigated the effects of progesterone (P4) on the production and survival of neurons in the hippocampal dentate gyrus of adult male mice. The administration of P4 (4 mg/kg) for 3 consecutive days beginning on the 0-2nd day after the first BrdU-injection (BrdU-D(0-2)) produced an approximately twofold inc...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20642

    authors: Zhang Z,Yang R,Zhou R,Li L,Sokabe M,Chen L

    更新日期:2010-03-01 00:00:00

  • Task difficulty in the Morris water task influences the survival of new neurons in the dentate gyrus.

    abstract::Adult neurogenesis continues throughout life in the mammalian hippocampus. The precise function of the adult generated neurons remains uncertain although there is growing evidence that they are involved in hippocampus-dependent learning and memory. Training rats on a hidden platform version of the Morris water task ha...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20692

    authors: Epp JR,Haack AK,Galea LA

    更新日期:2010-07-01 00:00:00