Intact verbal and nonverbal short-term memory following damage to the human hippocampus.

abstract：:Ontogenesis of GABAergic signaling may play an important role in developmental changes in seizure susceptibility in the high-potassium model of ictogenesis in vitro. The age-dependent effects of [K(+)](o) on the reversal potential of the GABA(A)-mediated responses and membrane potential in hippocampal slices in vitro ...

journal_title：Hippocampus

authors： Isaev D,Isaeva E,Khazipov R,Holmes GL

更新日期：2007-01-01 00:00:00

abstract：:At the neuromuscular junction, spontaneous miniature excitatory synaptic currents mediated by acetylcholine are considered elementary, "quantal" transmissions. These miniature conductances can be quantitatively dichotomized into a large-mode class whose mode is the mean of a normal, bell-shaped distribution and a smal...

journal_title：Hippocampus

authors： Vautrin J,Schaffner AE,Barker JL

更新日期：1993-01-01 00:00:00

abstract：:We have studied 5-hydroxytryptamine (5-HT) release in the hippocampal formation following electrical stimulation of the dorsal and median raphé nuclei in the behaving rat. The primary finding in this study is a decrease in neuronal release of serotonin in the dorsal hippocampal formation following electrical stimulati...

journal_title：Hippocampus

authors： Mokler DJ,Lariviere D,Johnson DW,Theriault NL,Bronzino JD,Dixon M,Morgane PJ

更新日期：1998-01-01 00:00:00

abstract：:The hippocampus is essential for learning and memory but also regulates emotional behavior. We previously identified the hippocampus as a major brain region that differs in rats bred for emotionality differences. Rats bred for low novelty response (LRs) exhibit high levels of anxiety- and depression-like behavior comp...

journal_title：Hippocampus

authors： Widman AJ,Cohen JL,McCoy CR,Unroe KA,Glover ME,Khan AU,Bredemann T,McMahon LL,Clinton SM

更新日期：2019-10-01 00:00:00

abstract：:Aging is associated with an impaired ability to maintain long-term potentiation (LTP), but the underlying cause of the impairment remains unclear. To gain a better understanding of the cellular and molecular mechanisms responsible for this impairment, the synaptic transmission and plasticity were studied in the CA1 re...

journal_title：Hippocampus

authors： Hsu KS,Huang CC,Liang YC,Wu HM,Chen YL,Lo SW,Ho WC

更新日期：2002-01-01 00:00:00

abstract：:Nuclear factor-kappa B (NFκB) signal is essential for neuronal survival and its activation may protect neuron against various stimuli. Since purinergic signals activate NFκB through the P2X7 receptor, we investigated the distinct pattern of NF-κB phosphorylation in neurons by P2X7 receptor activation following status ...

journal_title：Hippocampus

authors： Kim JE,Kim DS,Jin Ryu H,Il Kim W,Kim MJ,Won Kim D,Young Choi S,Kang TC

更新日期：2013-06-01 00:00:00

abstract：:Hippocampal synaptic plasticity comprises a key cellular mechanism for information storage. In the hippocampus, both long-term potentiation (LTP) and long-term depression (LTD) are triggered by synaptic Ca2+ -elevations that are typically mediated by the opening of voltage-gated cation channels, such as N-methyl-d-asp...

journal_title：Hippocampus

authors： Jansen S,Gottschling C,Faissner A,Manahan-Vaughan D

更新日期：2017-08-01 00:00:00

abstract：:The growth arrest specific 5 (gas5) is a noncoding protein gene that hosts small nucleolar RNAs. Based on the observation that gas5 RNA level in the brain is highest in the hippocampus and remarkably enhanced in aged mice, we tested the hypothesis that gas5 is involved in functions controlled by the hippocampus and kn...

journal_title：Hippocampus

authors： Meier I,Fellini L,Jakovcevski M,Schachner M,Morellini F

更新日期：2010-09-01 00:00:00

abstract：:The ERK/MAPK signaling pathway has been extensively studied in the context of learning and memory. Defects in this pathway underlie genetic diseases associated with intellectual disability, including impaired learning and memory. Numerous studies have investigated the impact of acute ERK/MAPK inhibition on long-term p...

journal_title：Hippocampus

authors： Vithayathil J,Pucilowska J,Friel D,Landreth GE

更新日期：2017-12-01 00:00:00

abstract：:Spike-timing-dependent long-term potentiation (LTP) and long-term depression (LTD) were investigated in the CA1 area of hippocampal slices using optical imaging. A pair of electrical pulses were used to stimulate the Schaffer-commissural collateral and the stratum oriens with various sets of relative timing (tau) betw...

journal_title：Hippocampus

authors： Tsukada M,Aihara T,Kobayashi Y,Shimazaki H

更新日期：2005-01-01 00:00:00

abstract：:Previous studies have shown that estrogens, originating from ovaries, have a wide variety of estrogen receptor (ER)-mediated effects in the hippocampus. In the present study, we have investigated whether estrogens, which are synthesized in the hippocampus, could induce these effects as well. As a parameter, we used ER...

journal_title：Hippocampus

authors： Prange-Kiel J,Wehrenberg U,Jarry H,Rune GM

更新日期：2003-01-01 00:00:00

abstract：:White matter hyperintensities (WMH) constitute the visible spectrum of cerebral small vessel disease (SVD) markers and are associated with cognitive decline, although they do not fully account for memory decline observed in individuals with SVD. We hypothesize that WMH might exert their effect on memory decline indire...

journal_title：Hippocampus

authors： van Leijsen EMC,Tay J,van Uden IWM,Kooijmans ECM,Bergkamp MI,van der Holst HM,Ghafoorian M,Platel B,Norris DG,Kessels RPC,Markus HS,Tuladhar AM,de Leeuw FE

更新日期：2019-06-01 00:00:00

abstract：:Our lives are a continuous stream of experience. Our episodic memories on the other hand have a definitive beginning, middle, and end. Theories of event segmentation suggest that salient changes in our environment produce event boundaries which partition the past from the present and, as a result, produce discretized ...

journal_title：Hippocampus

authors： Griffiths BJ,Fuentemilla L

更新日期：2020-02-01 00:00:00

abstract：:A large body of evidence exists to demonstrate that excitatory amino acids (EAA) and their receptors are involved in the pathophysiological mechanisms linking several acute brain insults, such as cerebral ischemia, to neuronal degeneration and death. Accordingly, the use of EAA receptor antagonists can be beneficial i...

journal_title：Hippocampus

authors： Virgili M,Contestabile A,Barnabei O

更新日期：1995-01-01 00:00:00

abstract：:Hippocampal mossy fibers have long been proposed to impose new patterns to learn onto CA3 neurons during new memory formation. However, inconsistent with this theory, we found in our previous study that mossy fiber stimulation induces only transient changes in CA3 spatial firing in a familiar environment. Here, we tes...

journal_title：Hippocampus

authors： Lee J,Bae C,Lee D,Jung MW

更新日期：2020-07-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP), a neurotrophic and neuromodulatory peptide, was recently shown to enhance NMDA receptor-mediated currents in the hippocampus (Macdonald, et al. 2005. J Neurosci 25:11374-11384). To check if PACAP might also modulate AMPA receptor function, we tested its effec...

journal_title：Hippocampus

authors： Costa L,Santangelo F,Li Volsi G,Ciranna L

更新日期：2009-01-01 00:00:00

abstract：:Episodic memory deficits are evident in late-life depression (LLD) and are associated with subtle synaptic and neurochemical changes in the medial temporal lobes (MTL). However, the particular mechanisms by which memory impairment occurs in LLD are currently unknown. We tested older adults with (DS+) and without (DS-)...

journal_title：Hippocampus

authors： Leal SL,Noche JA,Murray EA,Yassa MA

更新日期：2017-04-01 00:00:00

abstract：:The rodent hippocampus expresses a variety of neuronal network oscillations depending on the behavioral state of the animal. Locomotion and active exploration are accompanied by theta-nested gamma oscillations while resting states and slow-wave sleep are dominated by intermittent sharp wave-ripple complexes. It is bel...

journal_title：Hippocampus

authors： Geschwill P,Kaiser ME,Grube P,Lehmann N,Thome C,Draguhn A,Hollnagel JO,Both M

更新日期：2020-10-01 00:00:00

abstract：:Short periods of forced exercise have been reported to selectively induce enhancements in hippocampal-dependent cognitive function, possibly via brain-derived neurotrophic factor (BDNF)-mediated mechanisms. In this study, we report that 1 week of treadmill running significantly enhanced both object displacement (spati...

journal_title：Hippocampus

authors： Griffin EW,Bechara RG,Birch AM,Kelly AM

更新日期：2009-10-01 00:00:00

abstract：:In the mammalian brain, newly acquired memories depend on the hippocampus (HPC) for maintenance and recall, but over time, the neocortex takes over these functions, rendering memories HPC-independent. The process responsible for this transformation is called systems memory consolidation. Reactivation of a well-consoli...

journal_title：Hippocampus

authors： Helfer P,Shultz TR

更新日期：2020-07-01 00:00:00

abstract：:We analyzed intracranial electroencephalographic (EEG) recordings from the medial temporal lobes of 12 epilepsy patients during a continuous word recognition paradigm, contrasting trials of correctly recognized repeated words (hits) and correctly identified new words (correct rejections). Using a wavelet-based analysi...

journal_title：Hippocampus

authors： Mormann F,Fell J,Axmacher N,Weber B,Lehnertz K,Elger CE,Fernández G

更新日期：2005-01-01 00:00:00

abstract：:This study examines the extent to which simultaneous olfactory discrimination learning increases spine density on hippocampal CA1 pyramidal neurons in C57BL/6J (C57) and DBA/2J (DBA) inbred mice, characterized by spontaneous differences in hippocampal plasticity and hippocampus-related learning. The behavioral data fi...

journal_title：Hippocampus

authors： Restivo L,Roman FS,Ammassari-Teule M,Marchetti E

更新日期：2006-01-01 00:00:00

abstract：:In a comparative approach, the anatomical organization of the hippocampus was investigated in two species of megachiropteran bats, the grey-headed flying fox, Pteropus poliocephalus, and the little red flying fox, Pteropus scapulatus. In general, the cytoarchitectonic appearance of the flying fox hippocampus correspon...

journal_title：Hippocampus

authors： Buhl EH,Dann JF

更新日期：1991-04-01 00:00:00

abstract：:The functional organization of the perforant path input to the dentate gyrus of the exposed hippocampus was studied in adult rabbits anesthetized with urethane and chloralose. Electrical stimulation of perforant path fibers caused excitation of granule cells along narrow, nearly transverse strips (lamellae) of tissue....

journal_title：Hippocampus

authors： Lømo T

更新日期：2009-07-01 00:00:00

abstract：:Structural integrity of the human hippocampus is widely acknowledged to be necessary for the successful encoding and retrieval of autobiographical memories. However, evidence for an association between hippocampal volume and the ability to recall such memories in healthy individuals is mixed. Here we examined this iss...

journal_title：Hippocampus

authors： Barry DN,Clark IA,Maguire EA

更新日期：2020-12-15 00:00:00

abstract：:By acting on serotonin 5-HT2A receptors (5-HT2A Rs), serotonergic psychedelic drugs induce perceptual and visual hallucinations by increasing neuronal excitability and altering visual-evoked neuronal responses. The present study was designed to examine whether the perceptual alterations induced by a serotonergic psych...

journal_title：Hippocampus

authors： Zhang G,Cinalli D,Stackman RW Jr

更新日期：2017-05-01 00:00:00

abstract：:There is an ongoing debate regarding the respective role of anterior subhippocampal structures and the hippocampus in recognition memory. Here, we report a double anatomo-functional dissociation observed in two brain-damaged patients, FRG and JMG. They both suffered from complete destruction of left MTL structures. In...

journal_title：Hippocampus

authors： Barbeau EJ,Pariente J,Felician O,Puel M

更新日期：2011-09-01 00:00:00

abstract：:The hippocampus plays an important role in spatial learning and memory. However, the biochemical alterations that subserve this function remain to be fully elucidated. In this study, rats were subjected to a single-trial contextual fear conditioning (CFC) paradigm; the activation of different protein kinase C (PKC) su...

journal_title：Hippocampus

authors： Young E,Cesena T,Meiri KF,Perrone-Bizzozero NI

更新日期：2002-01-01 00:00:00

abstract：:Once thought to produce global, nonspecific brain injury, drugs of abuse are now known to produce selective neuro-adaptations in particular brain regions. These neuro-adaptations are being closely examined for clues to the development, maintenance, and treatment of addiction. The hippocampus is an area of particular i...

journal_title：Hippocampus

authors： Eisch AJ,Harburg GC

更新日期：2006-01-01 00:00:00

abstract：:In this study the subcortical afferents for the rat PER areas 35 and 36, POR, and the lateral and medial entorhinal areas (LEA and MEA) were characterized. We analyzed 33 retrograde tract-tracing experiments distributed across the five regions. For each experiment, we estimated the total numbers, percentages, and dens...

journal_title：Hippocampus

authors： Tomás Pereira I,Agster KL,Burwell RD

更新日期：2016-09-01 00:00:00