Abstract:
:The rodent hippocampus expresses a variety of neuronal network oscillations depending on the behavioral state of the animal. Locomotion and active exploration are accompanied by theta-nested gamma oscillations while resting states and slow-wave sleep are dominated by intermittent sharp wave-ripple complexes. It is believed that gamma rhythms create a framework for efficient acquisition of information whereas sharp wave-ripples are thought to be involved in consolidation and retrieval of memory. While not strictly mutually exclusive, one of the two patterns usually dominates in a given behavioral state. Here we explore how different input patterns induce either of the two network states, using an optogenetic stimulation approach in hippocampal brain slices of mice. We report that the pattern of the evoked oscillation depends strongly on the initial synchrony of activation of excitatory cells within CA3. Short, synchronous activation favors the emergence of sharp wave-ripple complexes while persistent but less synchronous activity-as typical for sensory input during exploratory behavior-supports the generation of gamma oscillations. This dichotomy is reflected by different degrees of synchrony of excitatory and inhibitory synaptic currents within these two states. Importantly, the induction of these two fundamental network patterns does not depend on the presence of any neuromodulatory transmitter like acetylcholine, but is merely based on a different synchrony in the initial activation pattern.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Geschwill P,Kaiser ME,Grube P,Lehmann N,Thome C,Draguhn A,Hollnagel JO,Both Mdoi
10.1002/hipo.23214subject
Has Abstractpub_date
2020-10-01 00:00:00pages
1044-1057issue
10eissn
1050-9631issn
1098-1063journal_volume
30pub_type
杂志文章相关文献
HIPPOCAMPUS文献大全abstract::Previous investigation of CA1-evoked subicular responses has used either single low-frequency pulses (LF), paired-pulses (PP), or high-frequency bursts. Here we test for the first time how subiculum responds to naturalistic stimulation trains (NSTs). We recorded CA1-evoked field potentials from dorsal rat subiculum in...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20629
更新日期:2010-02-01 00:00:00
abstract::In this review, we aim to reappraise the organization of intrinsic and extrinsic networks of the entorhinal cortex with a focus on the concept of parallel cortical connectivity streams. The concept of two entorhinal areas, the lateral and medial entorhinal cortex, belonging to two parallel input-output streams mediati...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.23145
更新日期:2019-12-01 00:00:00
abstract::Hippocampal neurogenesis declines substantially in chronic temporal lobe epilepsy (TLE). However, it is unclear whether this decline is linked to altered production of new cells and/or diminished survival and neuronal fate-choice decision of newly born cells. We quantified different components of hippocampal neurogene...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20594
更新日期:2010-01-01 00:00:00
abstract::Hippocampal adult neurogenesis results in the persisting formation of new neurons that contribute to hippocampal-dependent learning and memory. This has led to the hypothesis that memory impairments associated with neurodegenerative diseases such as Alzheimer's disease may involve abnormal neurogenesis. Supporting thi...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.23052
更新日期:2019-07-01 00:00:00
abstract::Hippocampal neurons are selectively active when a rat occupies restricted locations in an environment. These place cells derive their specificity from a multitude of sources, including idiothetic cues and sensory input derived from both distal and local landmarks. Most experiments have attempted to dissociate the rela...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10092
更新日期:2003-01-01 00:00:00
abstract::Granule cells of the mouse fascia dentata are widely used in studies on neuronal development and plasticity. In contrast to the rat, however, high-resolution morphometric data on these cells are scarce. Thus, we have analyzed granule cells in the fascia dentata of the adult Thy1-GFP mouse (C57BL/6 background). In this...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20398
更新日期:2008-01-01 00:00:00
abstract::To clarify the specific contribution of the medial temporal lobe structures in spatial memory, we tested monkeys (Macaca mulatta) with sham operations and with lesions of either the hippocampal formation, areas TH/TF or perirhinal cortex on two versions of the visual-paired comparison task, measuring Spatial Location,...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20369
更新日期:2008-01-01 00:00:00
abstract::Nuclear factor-kappa B (NFκB) signal is essential for neuronal survival and its activation may protect neuron against various stimuli. Since purinergic signals activate NFκB through the P2X7 receptor, we investigated the distinct pattern of NF-κB phosphorylation in neurons by P2X7 receptor activation following status ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22109
更新日期:2013-06-01 00:00:00
abstract::The importance of the hippocampal theta oscillation (4-8 Hz) to memory formation has been well-established through studies in animals, prompting researchers to propose comprehensive theories of memory and learning that rely on theta oscillations for integrating information in the hippocampus and neocortex. Yet, empiri...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20937
更新日期:2012-04-01 00:00:00
abstract::Information storage in the brain is a temporally graded process involving different memory types or phases. It has been assumed for over a century that one or more short-term memory (STM) processes are involved in processing new information while long-term memory (LTM) is being formed. Because brain-derived neutrophic...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10035
更新日期:2002-01-01 00:00:00
abstract::We have previously shown that exposing rats to a relatively high dose of ethanol during early postnatal life can result in an alteration in spatial learning ability. The hippocampal formation is known to be involved in the control of this ability. The purpose of the present study was to determine whether exposure of r...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10155
更新日期:2004-01-01 00:00:00
abstract::Nearby grid cells have been observed to express a remarkable degree of long-range order, which is often idealized as extending potentially to infinity. Yet their strict periodic firing and ensemble coherence are theoretically possible only in flat environments, much unlike the burrows which rodents usually live in. Ar...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23144
更新日期:2020-04-01 00:00:00
abstract::This study examines the extent to which simultaneous olfactory discrimination learning increases spine density on hippocampal CA1 pyramidal neurons in C57BL/6J (C57) and DBA/2J (DBA) inbred mice, characterized by spontaneous differences in hippocampal plasticity and hippocampus-related learning. The behavioral data fi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20174
更新日期:2006-01-01 00:00:00
abstract::The hippocampus creates distinct episodes from highly similar events through a process called pattern separation and can retrieve memories from partial or degraded cues through a process called pattern completion. These processes have been studied in humans using tasks where participants must distinguish studied items...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22256
更新日期:2014-06-01 00:00:00
abstract::Pituitary adenylate cyclase-activating polypeptide (PACAP), a neurotrophic and neuromodulatory peptide, was recently shown to enhance NMDA receptor-mediated currents in the hippocampus (Macdonald, et al. 2005. J Neurosci 25:11374-11384). To check if PACAP might also modulate AMPA receptor function, we tested its effec...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20488
更新日期:2009-01-01 00:00:00
abstract::The electrically induced increase in hippocampal synaptic strength known as long-term potentiation (LTP) is thought to involve some of the same mechanisms as those mediating information storage during spatial learning. Physiological saturation of synaptic weights might therefore be expected to occlude spatial learning...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450030205
更新日期:1993-04-01 00:00:00
abstract::We recorded neuromagnetic fields evoked by a somatosensory oddball task requiring subjects to discriminate target stimuli from nontarget stimuli, which are different in stimulation intensity, with a mental count of the target stimuli. A whole head type 80-channel magnetoencephalography (MEG) system with a 50-mm baseli...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10196
更新日期:2004-01-01 00:00:00
abstract::Temporal difference learning (TD) is a popular algorithm in machine learning. Two learning signals that are derived from this algorithm, the predictive value and the prediction error, have been shown to explain changes in neural activity and behavior during learning across species. Here, the predictive value signal is...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20535
更新日期:2009-05-01 00:00:00
abstract::A striking similarity has been suggested between past and future thinking in Alzheimer's Disease (AD), a similarity attributable to abnormalities in common modular cognitive functions and neuroanatomical substrates. This study extends this literature by identifying specific executive function deficits underlying past ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22465
更新日期:2015-11-01 00:00:00
abstract::For memory retrieval, pattern completion is a crucial process that restores memories from partial or degraded cues. Neurocognitive aging models suggest that the aged memory system is biased toward pattern completion, resulting in a behavioral preference for retrieval over encoding of memories. Here, we built on our pr...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23030
更新日期:2019-04-01 00:00:00
abstract::Paired-pulse depression (PPD), a short-term neural plasticity, was studied in hippocampal CA1 of urethane-anesthetized rats in vivo, using field potential recordings and current source density analysis. PPD was robust when an ipsilateral CA3 (iCA3) conditioning pulse of moderate stimulus intensity was followed 30-200 ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20458
更新日期:2008-01-01 00:00:00
abstract::A large body of evidence exists to demonstrate that excitatory amino acids (EAA) and their receptors are involved in the pathophysiological mechanisms linking several acute brain insults, such as cerebral ischemia, to neuronal degeneration and death. Accordingly, the use of EAA receptor antagonists can be beneficial i...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450050111
更新日期:1995-01-01 00:00:00
abstract::It has been demonstrated that the dorsal CA1 subregion of the hippocampus mediates temporal processing of information, that dorsal CA3 participates in the spatiotemporal processing of memory, and the dorsal dentate gyrus (DG) mediates spatial pattern separation. A temporal ordering of spatial locations task was develo...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20455
更新日期:2008-01-01 00:00:00
abstract::Space and time are both essential features of episodic memory, for which the hippocampus is critical (Howard & Eichenbaum, 2015). Spatial tasks have been used effectively to study the behavioral relevance of place cells. However, the behavioral paradigms utilized for the study of time cells have not used time duration...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23261
更新日期:2021-01-01 00:00:00
abstract::Sleep is important for memory consolidation, and an abundant literature suggests that reactivation in the hippocampus during sleep is instrumental to this process. Yet, the current interpretation of activity during sharp-waves ripples (SWRs), as replay of wake experiences, relies on hypotheses that, while widely accep...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23143
更新日期:2020-01-01 00:00:00
abstract::Unilateral injection of kainic acid (KA) into the dorsal hippocampus of adult mice induces spontaneous recurrent partial seizures and replicates histopathological changes observed in human mesial temporal lobe epilepsy (MTLE) (Bouilleret V et al., Neuroscience 1999; 89:717-729). Alterations in pre- and postsynaptic co...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/1098-1063(2000)10:3<305::AID-HIPO11>3.0.CO
更新日期:2000-01-01 00:00:00
abstract::Rats use time-of-day cues to modulate learned taste aversion memories. If adult rats are accustomed to drinking saline in the evening and they receive a lithium chloride injection after drinking saline in the morning, they form a stronger aversion to saline than rats that were conditioned after drinking saline at the ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20481
更新日期:2009-01-01 00:00:00
abstract::To minimize the variability in the extent of lesions made by injections of the excitotoxin ibotenic acid in rhesus monkeys, we developed and validated an MRI-based method to determine the efficacy of the injections soon after surgery. T2-weighted MR images were obtained 6-11 days after surgery from 17 brain hemisphere...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.1050
更新日期:2001-01-01 00:00:00
abstract::Two recent meta-analyses, drawing on data from many of the same studies with monkeys, reached different conclusions about the relationship between hippocampal damage and recognition memory performance. Both studies found evidence of recognition memory impairment following hippocampal damage. However, Zola et al. (J Ne...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.1027
更新日期:2001-01-01 00:00:00
abstract::We investigated the effects of a surgical lesion of one vestibular inner ear (unilateral vestibular damage [UVD]) on the field potential responses of CA1 neurons in vitro. Hippocampal slices were removed from rats at 4-6 weeks or 5-6 months post-UVD, and the field responses of CA1 neurons to electrical stimulation of ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10174
更新日期:2003-01-01 00:00:00