Paired-pulse depression of excitatory postsynaptic current sinks in hippocampal CA1 in vivo.

abstract：:Fear can be extinguished by repeated exposure to a cue that signals threat. However, extinction does not erase fear, as an extinguished cue presented in a context distinct from that of extinction results in renewed fear of that cue. The hippocampus, which is involved in the formation of contextual representations, is ...

journal_title：Hippocampus

authors： Zelikowsky M,Pham DL,Fanselow MS

更新日期：2012-05-01 00:00:00

abstract：:Rats use time-of-day cues to modulate learned taste aversion memories. If adult rats are accustomed to drinking saline in the evening and they receive a lithium chloride injection after drinking saline in the morning, they form a stronger aversion to saline than rats that were conditioned after drinking saline at the ...

journal_title：Hippocampus

authors： Manrique T,Morón I,Ballesteros MA,Guerrero RM,Fenton AA,Gallo M

更新日期：2009-01-01 00:00:00

abstract：:In the mammalian brain, newly acquired memories depend on the hippocampus (HPC) for maintenance and recall, but over time, the neocortex takes over these functions, rendering memories HPC-independent. The process responsible for this transformation is called systems memory consolidation. Reactivation of a well-consoli...

journal_title：Hippocampus

authors： Helfer P,Shultz TR

更新日期：2020-07-01 00:00:00

abstract：:Stratum lacunosum-moleculare interneurons (L-Mi) in hippocampal area CA3 target the apical dendrite of pyramidal cells providing feedforward inhibition. Here we report that selective activation of group III metabotropic glutamate receptors (mGluRs) 4/8 with L(+)-2-amino-4-phosphnobytyric acid (L-AP4; 10 μM) decreased ...

journal_title：Hippocampus

authors： Cosgrove KE,Meriney SD,Barrionuevo G

更新日期：2011-12-01 00:00:00

abstract：:CA3 lesions impair encoding, whereas CA1 lesions impair retrieval during learning of a Hebb-Williams maze. CA3 efferents in the fimbria were transected, taking care to spare cholinergic and GABAergic afferents. CA1 efferents in the dorsal fornix were similarly transected. Fimbria transections, but not dorsal fornix tr...

journal_title：Hippocampus

authors： Hunsaker MR,Tran GT,Kesner RP

更新日期：2008-01-01 00:00:00

abstract：:Place and grid cells in the hippocampal formation are commonly thought to support a unified and coherent cognitive map of space. This mapping mechanism faces a challenge when a navigator is placed in a familiar environment that has been deformed from its original shape. Under such circumstances, many transformations c...

journal_title：Hippocampus

authors： Keinath AT,Rechnitz O,Balasubramanian V,Epstein RA

更新日期：2021-01-01 00:00:00

abstract：:The hippocampal formation plays a role in mnemonic tasks and epileptic discharges in vivo. In vitro, these functions and malfunctions may relate to persistent firing (PF) and depolarization block (DB), respectively. Pyramidal neurons of the CA1 field have previously been reported to engage in either PF or DB during ch...

journal_title：Hippocampus

authors： Knauer B,Yoshida M

更新日期：2019-09-01 00:00:00

abstract：:Neuregulins (NRGs) are ligands of ErbB receptor tyrosine kinases. The NRG1-ErbB4 pathway has been shown to modulate hippocampal synaptic plasticity and network oscillations in the adult rodent brain. To identify cells that mediate these effects, here we determine the expression pattern of ErbB4 in four functionally di...

journal_title：Hippocampus

authors： Neddens J,Buonanno A

更新日期：2010-06-01 00:00:00

abstract：:A couple of papers indicate that patients with depression show a decrease in serum neuropeptide Y (NPY). To study the role of NPY in depression, we examined the effects of infusion of NPY into the hippocampus of learned helplessness (LH) rats (an animal model of depression). Infusion of NPY into the cerebral ventricle...

journal_title：Hippocampus

authors： Ishida H,Shirayama Y,Iwata M,Katayama S,Yamamoto A,Kawahara R,Nakagome K

更新日期：2007-01-01 00:00:00

abstract：:The survival of adult-born dentate gyrus granule cells critically depends on their synaptic integration into the existing neuronal network. Excitatory inputs are thought to increase the survival rate of adult born neurons. Therefore, whether enhancing the stability of newly formed excitatory synapses by overexpressing...

journal_title：Hippocampus

authors： Doengi M,Krupp AJ,Körber N,Stein V

更新日期：2016-03-01 00:00:00

abstract：:This study examines whether 4-8-Hz theta oscillations can be seen in the human hippocampus, and whether these oscillations increase during virtual movement and searching, as they do in rodents. Recordings from both hippocampal and neocortical depth electrodes were analyzed while six epileptic patients played a virtual...

journal_title：Hippocampus

authors： Ekstrom AD,Caplan JB,Ho E,Shattuck K,Fried I,Kahana MJ

更新日期：2005-01-01 00:00:00

abstract：:Although it is well established that the integrity of the medial temporal lobe (MTL) is critical for declarative memory, the functional organization of the MTL remains a matter of intense debate. One issue that has received little consideration so far is whether the hippocampus can function normally in the presence of...

journal_title：Hippocampus

authors： Bowles B,O'Neil EB,Mirsattari SM,Poppenk J,Köhler S

更新日期：2011-08-01 00:00:00

abstract：:The hippocampus is essential for the consolidation of some explicit long-term memories, including trace conditioning. Lesions and pharmacological manipulations of the dorsal hippocampus (DH) have provided strong evidence for its involvement in the acquisition and expression of trace fear memories. However, no studies ...

journal_title：Hippocampus

authors： Pierson JL,Pullins SE,Quinn JJ

更新日期：2015-07-01 00:00:00

abstract：:Synaptic responses mediated by the N-methyl-D-aspartate receptor (NMDAr) and non-NMDAr activation were compared in CA1 hippocampal region of young (3-4 months old) and aged (25-33 months old) Sprague-Dawley rats with the use of ex vivo extracellular recordings techniques. In aged rats, the amplitude of the NMDAr-media...

journal_title：Hippocampus

authors： Jouvenceau A,Dutar P,Billard JM

更新日期：1998-01-01 00:00:00

abstract：:Aniracetam reversibly increased synaptic responses mediated by the AMPA but not the NMDA subclass of glutamate receptors in hippocampus and was considerably more potent than structurally similar nootropics. The drug had greater effects on field excitatory postsynaptic potentials (EPSPs) in the dentate gyrus and CA1 re...

journal_title：Hippocampus

authors： Xiao P,Staubli U,Kessler M,Lynch G

更新日期：1991-10-01 00:00:00

abstract：:The hippocampus is critical for memory tasks which require an active maintenance of memory for a short period of time; however, the underlying neural mechanisms remain unknown. Most theoretical and computational models, which date back to the classic proposals by Donald Hebb in , have been self-constrained by anatomy,...

journal_title：Hippocampus

authors： Knauer B,Jochems A,Valero-Aracama MJ,Yoshida M

更新日期：2013-09-01 00:00:00

abstract：:Spatial navigation relies on multiple mnemonic mechanisms and previous work in younger adults has described two separate types of spatial memory. One type uses directional as well as boundary-related information for spatial memory and mainly implicates the hippocampal formation. The other type has been linked to direc...

journal_title：Hippocampus

authors： Schuck NW,Doeller CF,Schjeide BM,Schröder J,Frensch PA,Bertram L,Li SC

更新日期：2013-10-01 00:00:00

abstract：:The functional organization of the perforant path input to the dentate gyrus of the exposed hippocampus was studied in adult rabbits anesthetized with urethane and chloralose. Electrical stimulation of perforant path fibers caused excitation of granule cells along narrow, nearly transverse strips (lamellae) of tissue....

journal_title：Hippocampus

authors： Lømo T

更新日期：2009-07-01 00:00:00

abstract：:Light and electron microscopic immunocytochemical techniques were used to study the interneuron population staining for somatostatin (SRIF) in cultured slices of rat hippocampus. The SRIF immunoreactive somata were most dense in stratum oriens of areas CA1 and CA3, and in the dentate hilus. Somatostatin immunoreactive...

journal_title：Hippocampus

authors： Kunkel DD,Nguyen LB,Harrigan MR,Schwartzkroin PA,Malouf AT

更新日期：1994-04-01 00:00:00

abstract：:A large body of evidence exists to demonstrate that excitatory amino acids (EAA) and their receptors are involved in the pathophysiological mechanisms linking several acute brain insults, such as cerebral ischemia, to neuronal degeneration and death. Accordingly, the use of EAA receptor antagonists can be beneficial i...

journal_title：Hippocampus

authors： Virgili M,Contestabile A,Barnabei O

更新日期：1995-01-01 00:00:00

abstract：:Functional differences in the anterior and posterior hippocampus during episodic memory processing have not been examined in human electrophysiological data. This is in spite of strong evidence for such differences in rodent data, including greater place cell specificity in the dorsal hippocampus, greater sensitivity ...

journal_title：Hippocampus

authors： Lin JJ,Rugg MD,Das S,Stein J,Rizzuto DS,Kahana MJ,Lega BC

更新日期：2017-10-01 00:00:00

abstract：:We have shown previously that chronic nicotine treatment reverses adult-onset hypothyroidism-induced impairment of late-phase long-term potentiation (L-LTP) in area CA1 of the hippocampus. In the present study, basal and stimulated levels of signaling molecules essential for the expression of L-LTP were determined in ...

journal_title：Hippocampus

authors： Alzoubi KH,Aleisa AM,Alkadhi KA

更新日期：2007-01-01 00:00:00

abstract：:Previous studies with excitotoxically lesioned organotypic hippocampal slice cultures (OHSC) have revealed that the immunosuppressant mycophenolate mofetil (MMF) inhibits microglial activation and suppresses neuronal injury in the dentate gyrus. We here investigate whether MMF also has beneficial effects on axon survi...

journal_title：Hippocampus

authors： Oest TM,Dehghani F,Korf HW,Hailer NP

更新日期：2006-01-01 00:00:00

abstract：:The ERK/MAPK signaling pathway has been extensively studied in the context of learning and memory. Defects in this pathway underlie genetic diseases associated with intellectual disability, including impaired learning and memory. Numerous studies have investigated the impact of acute ERK/MAPK inhibition on long-term p...

journal_title：Hippocampus

authors： Vithayathil J,Pucilowska J,Friel D,Landreth GE

更新日期：2017-12-01 00:00:00

abstract：:The hippocampus plays an important role in spatial learning and memory. However, the biochemical alterations that subserve this function remain to be fully elucidated. In this study, rats were subjected to a single-trial contextual fear conditioning (CFC) paradigm; the activation of different protein kinase C (PKC) su...

journal_title：Hippocampus

authors： Young E,Cesena T,Meiri KF,Perrone-Bizzozero NI

更新日期：2002-01-01 00:00:00

abstract：:Although the entorhinal cortex is a key structure connecting the hippocampal formation with the rest of the cerebral cortex, little is known about its early chemoanatomical development in primates. In the present study, a cytoarchitectonic analysis and immunocytochemical detection of somatostatin, neurotensin, parvalb...

journal_title：Hippocampus

authors： Berger B,Alvarez C,Goldman-Rakic PS

更新日期：1993-07-01 00:00:00

abstract：:C57 and DBA mice were trained in a crossed maze to assess possible strain differences in place or response learning as a function of training duration (8 or 17 days) and extramaze cueing conditions. The first condition consisted of a diffuse visually cued environment (rich cueing). The second was the same plus an expl...

journal_title：Hippocampus

authors： Passino E,Middei S,Restivo L,Bertaina-Anglade V,Ammassari-Teule M

更新日期：2002-01-01 00:00:00

abstract：:The importance of the hippocampal theta oscillation (4-8 Hz) to memory formation has been well-established through studies in animals, prompting researchers to propose comprehensive theories of memory and learning that rely on theta oscillations for integrating information in the hippocampus and neocortex. Yet, empiri...

journal_title：Hippocampus

authors： Lega BC,Jacobs J,Kahana M

更新日期：2012-04-01 00:00:00

abstract：:We aimed at identifying the cerebral structures whose synaptic function subserves the recollection of lifetime's episodic autobiographical memory (AM) via autonoetic consciousness. Twelve healthy middle-aged subjects (mean age: 59 years +/- 2.5) underwent a specially designed cognitive test to assess the ability to re...

journal_title：Hippocampus

authors： Piolino P,Desgranges B,Hubert V,Bernard FA,Matuszewski V,Chételat G,Baron JC,Eustache F

更新日期：2008-01-01 00:00:00

abstract：:By acting on serotonin 5-HT2A receptors (5-HT2A Rs), serotonergic psychedelic drugs induce perceptual and visual hallucinations by increasing neuronal excitability and altering visual-evoked neuronal responses. The present study was designed to examine whether the perceptual alterations induced by a serotonergic psych...

journal_title：Hippocampus

authors： Zhang G,Cinalli D,Stackman RW Jr

更新日期：2017-05-01 00:00:00