Abstract:
:We aimed at identifying the cerebral structures whose synaptic function subserves the recollection of lifetime's episodic autobiographical memory (AM) via autonoetic consciousness. Twelve healthy middle-aged subjects (mean age: 59 years +/- 2.5) underwent a specially designed cognitive test to assess the ability to relive richly detailed episodic autobiographical memories from five time periods using the Remember/Know procedure. We computed an index of episodicity (number of Remember responses justified by the recall of specific events and details) and an index of retrieval spontaneity, and additionally an index of semanticized memories (number of Know responses). The regional cerebral blood flow (rCBF) was measured in the resting state, with H(2)O(15) as part of an activation PET study. The indexes were correlated with blood flow using volumes of interest in frontotemporal regions, including hippocampus and voxel-wise analyses in SPM. With both analyses, significant correlations were mainly found between the index of episodicity and rCBF in the medial temporal lobe, including hippocampus, across the five time periods (unlike the index of semanticized memories) and between the spontaneity index and rCBF in the prefrontal areas. These results highlight, in healthy subjects, the distinct role of these two structures in AM retrieval and support the view that the hippocampus is needed for reexperiencing detailed episodic memories no matter how old they are.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Piolino P,Desgranges B,Hubert V,Bernard FA,Matuszewski V,Chételat G,Baron JC,Eustache Fdoi
10.1002/hipo.20406subject
Has Abstractpub_date
2008-01-01 00:00:00pages
445-59issue
5eissn
1050-9631issn
1098-1063journal_volume
18pub_type
杂志文章相关文献
HIPPOCAMPUS文献大全abstract::There is limited knowledge regarding how the brain controls the timing of meals. Similarly, there is a large gap in our understanding of how top-down cognitive processes, such as memory influence energy intake. We hypothesize that dorsal hippocampal (dHC) neurons, which are critical for episodic memory, form a memory ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22532
更新日期:2016-03-01 00:00:00
abstract::The precise timing of pre-postsynaptic activity is vital for the induction of long-term potentiation (LTP) or depression (LTD) at many central synapses. We show in synapses of rat CA1 pyramidal neurons in vitro that spike timing dependent plasticity (STDP) protocols that induce LTP at glutamatergic synapses can evoke ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22196
更新日期:2013-12-01 00:00:00
abstract::Processing of multimodal sensory information by the morphological subdivisions of the hippocampus and its input and output structures was investigated in unanesthetized rabbits by extracellular recording of neuronal activity. Analysis shows principal differences between CA3 neurons with uniform multimodal, mainly inhi...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.1073
更新日期:2001-01-01 00:00:00
abstract::The conditioned cue preference (CCP) task was used to study the ability of rats to discriminate between spatial locations. Food-deprived rats explored an eight-arm radial maze with no food present (pre-exposure). On subsequent days, they were alternately confined in one arm of the maze with food and in another arm wit...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20127
更新日期:2005-01-01 00:00:00
abstract::Functional differences in the anterior and posterior hippocampus during episodic memory processing have not been examined in human electrophysiological data. This is in spite of strong evidence for such differences in rodent data, including greater place cell specificity in the dorsal hippocampus, greater sensitivity ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22751
更新日期:2017-10-01 00:00:00
abstract::It is well documented that place cells and grid cells in echolocating bats show properties similar to those described in rodents, and yet, continuous theta-frequency oscillations, proposed to play a central role in grid/place cell formation, are not present in bat recordings. These comparative neurophysiological data ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22469
更新日期:2015-12-01 00:00:00
abstract::GABAergic inhibitory interneurons control fundamental aspects of neuronal network function. Their functional roles are assumed to be defined by the identity of their input synapses, the architecture of their dendritic tree, the passive and active membrane properties and finally the nature of their postsynaptic targets...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22214
更新日期:2014-02-01 00:00:00
abstract::Thrombin and other clotting factors regulate long-term potentiation (LTP) in the hippocampus through the activation of the protease activated receptor 1 (PAR1) and consequent potentiation of N-methyl-d-aspartate receptor (NMDAR) functions. We have recently shown that the activation of PAR1 either by thrombin or the an...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22288
更新日期:2014-08-01 00:00:00
abstract::L-aspartate is the amino-acid residue most susceptible to spontaneous isomerization. This denaturation causes an alteration in the biological activity of the protein and is regarded as an aging process of the protein. Protein L-isoaspartyl methyltransferase (PIMT) repairs this post-translational modification and thus ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.1043
更新日期:2001-01-01 00:00:00
abstract::Effective navigation depends upon reliable estimates of head direction (HD). Visual, vestibular, and outflow motor signals combine for this purpose in a brain system that includes dorsal tegmental nucleus, lateral mammillary nuclei, anterior dorsal thalamic nucleus, and the postsubiculum. Learning is needed to combine...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22040
更新日期:2012-12-01 00:00:00
abstract::Information storage in the brain is a temporally graded process involving different memory types or phases. It has been assumed for over a century that one or more short-term memory (STM) processes are involved in processing new information while long-term memory (LTM) is being formed. Because brain-derived neutrophic...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10035
更新日期:2002-01-01 00:00:00
abstract::High-frequency stimulation of excitatory synapses in many regions of the brain triggers a lasting increase in the efficacy of synaptic transmission referred to as long-term potentiation (LTP) and believed to contribute to learning and memory. One hypothesis proposed to account for the stability and properties of this ...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/1098-1063(2000)10:5<596::AID-HIPO10>3.0.CO
更新日期:2000-01-01 00:00:00
abstract::For well over a century, ethanol was believed to exert its effects on cognition and behavior by producing a ubiquitous depression of central nervous system activity. A general disruption in brain function was consistent with the belief that ethanol's effects on cognition and behavior were also quite general. Substanti...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1098-1063(2000)10:1<88::AID-HIPO10>3
更新日期:2000-01-01 00:00:00
abstract::Nuclear factor-kappa B (NFκB) signal is essential for neuronal survival and its activation may protect neuron against various stimuli. Since purinergic signals activate NFκB through the P2X7 receptor, we investigated the distinct pattern of NF-κB phosphorylation in neurons by P2X7 receptor activation following status ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22109
更新日期:2013-06-01 00:00:00
abstract::Septal nuclei are suggested to work as an interface between the hippocampal formation, involved in higher cognitive functions, and the hypothalamus, involved in motivational behaviors such as feeding, drinking, and intracranial self-stimulation. In the present study, to elucidate a role of the septal nuclei in motivat...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1997)7:5<536::AID-HIPO9>3.
更新日期:1997-01-01 00:00:00
abstract::Watermaze tests of place learning and memory in rodents and corresponding reverse-translated human paradigms in real or virtual environments are key tools to study hippocampal function. In common variants, the animal or human participant has to find a hidden goal that remains in the same place over many trials, allowi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22992
更新日期:2018-11-01 00:00:00
abstract::LTD of synaptic transmission is a form of long-term synaptic plasticity with the potential to be as significant as LTP to both the activity-dependent development of neural circuitry and adult memory storage. In addition, interactions between LTP and LTD and the dynamic regulation of the gain of synaptic plasticity mec...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1098-1063(1996)6:1<35::AID-HIPO7>3.0
更新日期:1996-01-01 00:00:00
abstract::Aging is associated with an impaired ability to maintain long-term potentiation (LTP), but the underlying cause of the impairment remains unclear. To gain a better understanding of the cellular and molecular mechanisms responsible for this impairment, the synaptic transmission and plasticity were studied in the CA1 re...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10032
更新日期:2002-01-01 00:00:00
abstract::Lynn Nadel has been a trailblazer in memory research for decades. In just one example, Nadel and Zola-Morgan [Infantile amnesia, In Infant memory, Springer, Boston, MA, 1984, pp. 145-172] were the first to present the provocative notion that the extended development of the hippocampus may underlie the period of infant...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23149
更新日期:2020-08-01 00:00:00
abstract::Key pathological features of Parkinson's Disease (PD) include the progressive degeneration of midbrain dopaminergic (DA) neurons and hindbrain noradrenergic (NA) neurons. The loss of DA neurons has been extensively studied and is the main cause of motor dysfunction. Importantly, however, there are a range of 'non-move...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22835
更新日期:2018-05-01 00:00:00
abstract::This study investigated the effects of progesterone (P4) on the production and survival of neurons in the hippocampal dentate gyrus of adult male mice. The administration of P4 (4 mg/kg) for 3 consecutive days beginning on the 0-2nd day after the first BrdU-injection (BrdU-D(0-2)) produced an approximately twofold inc...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20642
更新日期:2010-03-01 00:00:00
abstract::The modulatory actions of GABA(A) receptor subunits are crucial for morphological and transcriptional neuronal activities. In this study, growth of hamster hippocampal neurons on biohybrid membrane substrates allowed us to show for the first time that the two major GABA(A) alpha receptor subunits (alpha(2,5)) are capa...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20584
更新日期:2009-11-01 00:00:00
abstract::Exposing rats to an enriched environment over an extended period of time has been shown to enhance hippocampal long-term potentiation (LTP). Whether such prolonged exposure to environmental manipulation is necessary for LTP enhancement and whether the environmentally induced enhancement can persist long after the cess...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10017
更新日期:2002-01-01 00:00:00
abstract::We have previously shown that exposing rats to a relatively high dose of ethanol during early postnatal life can result in an alteration in spatial learning ability. The hippocampal formation is known to be involved in the control of this ability. The purpose of the present study was to determine whether exposure of r...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10155
更新日期:2004-01-01 00:00:00
abstract::It has been well-established that cell proliferation and neurogenesis in the adult mouse dentate gyrus (DG) can be regulated by voluntary exercise. Recent evidence has suggested that the effects of voluntary exercise can in turn be influenced by environmental factors that regulate the amount of stress an animal is exp...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20514
更新日期:2009-10-01 00:00:00
abstract::To examine the effects of long-term potentiation (LTP) on individual neurons in the intact brain, anesthetized rats were implanted with a recording stereotrode in the right CA1 layer of the hippocampus and a stimulating electrode in the right and left CA3 layers. The evoked and spontaneous firing of single CA1 neurons...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/1098-1063(2000)10:3<207::AID-HIPO1>3.0.CO;
更新日期:2000-01-01 00:00:00
abstract::Stratum lacunosum-moleculare interneurons (L-Mi) in hippocampal area CA3 target the apical dendrite of pyramidal cells providing feedforward inhibition. Here we report that selective activation of group III metabotropic glutamate receptors (mGluRs) 4/8 with L(+)-2-amino-4-phosphnobytyric acid (L-AP4; 10 μM) decreased ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20842
更新日期:2011-12-01 00:00:00
abstract::We analyzed intracranial electroencephalographic (EEG) recordings from the medial temporal lobes of 12 epilepsy patients during a continuous word recognition paradigm, contrasting trials of correctly recognized repeated words (hits) and correctly identified new words (correct rejections). Using a wavelet-based analysi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20117
更新日期:2005-01-01 00:00:00
abstract::The selective lesion of basal forebrain cholinergic neurons (BFCNs) is an unestimable tool to study the implication of these neurons in cognition, an interest widely motivated by their degeneration in Alzheimer's disease. Here we evaluated the histochemical and behavioral effects of a selective lesion of BFCNs in C57B...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20422
更新日期:2008-01-01 00:00:00
abstract::Pituitary adenylate cyclase-activating polypeptide (PACAP), a neurotrophic and neuromodulatory peptide, was recently shown to enhance NMDA receptor-mediated currents in the hippocampus (Macdonald, et al. 2005. J Neurosci 25:11374-11384). To check if PACAP might also modulate AMPA receptor function, we tested its effec...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20488
更新日期:2009-01-01 00:00:00