Dorsal hippocampus infusions of CNQX into the dentate gyrus disrupt expression of trace fear conditioning.

Abstract:

:The hippocampus is essential for the consolidation of some explicit long-term memories, including trace conditioning. Lesions and pharmacological manipulations of the dorsal hippocampus (DH) have provided strong evidence for its involvement in the acquisition and expression of trace fear memories. However, no studies have specifically targeted DH subregions [CA1 and dentate gyrus (DG)] to determine their involvement in trace fear conditioning. In the present study, rats received bilateral cannulation targeting either the DG or CA1 of the DH. Following surgery, animals were trace fear conditioned. Forty-eight hours following training, rats received bilateral infusions of the AMPA/kainate glutamate receptor antagonist, CNQX, or vehicle. Following the infusion, rats were placed in a novel context for the tone test. Rats that received CNQX into the DG froze significantly less during the tone and trace interval as compared to controls. Rats that received CNQX into the DH CA1 showed no difference in freezing during the tone or trace interval as compared to controls. These data support a role for the DG in the expression of trace tone fear conditioning.

journal_name

Hippocampus

journal_title

Hippocampus

authors

Pierson JL,Pullins SE,Quinn JJ

doi

10.1002/hipo.22413

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

779-85

issue

7

eissn

1050-9631

issn

1098-1063

journal_volume

25

pub_type

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