Abstract:
:The hippocampus is essential for the consolidation of some explicit long-term memories, including trace conditioning. Lesions and pharmacological manipulations of the dorsal hippocampus (DH) have provided strong evidence for its involvement in the acquisition and expression of trace fear memories. However, no studies have specifically targeted DH subregions [CA1 and dentate gyrus (DG)] to determine their involvement in trace fear conditioning. In the present study, rats received bilateral cannulation targeting either the DG or CA1 of the DH. Following surgery, animals were trace fear conditioned. Forty-eight hours following training, rats received bilateral infusions of the AMPA/kainate glutamate receptor antagonist, CNQX, or vehicle. Following the infusion, rats were placed in a novel context for the tone test. Rats that received CNQX into the DG froze significantly less during the tone and trace interval as compared to controls. Rats that received CNQX into the DH CA1 showed no difference in freezing during the tone or trace interval as compared to controls. These data support a role for the DG in the expression of trace tone fear conditioning.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Pierson JL,Pullins SE,Quinn JJdoi
10.1002/hipo.22413subject
Has Abstractpub_date
2015-07-01 00:00:00pages
779-85issue
7eissn
1050-9631issn
1098-1063journal_volume
25pub_type
杂志文章相关文献
HIPPOCAMPUS文献大全abstract::The present study investigated the delayed and persistent effects of 4 beta-phorbol 12,13-dibutyrate (PDBu) on the K(+)-evoked release of endogenous glutamate and dynorphin B-like immunoreactivity from a subcellular fraction (P3) that is enriched in hippocampal mossy fiber synaptosomes. It is demonstrated that the alp...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450030212
更新日期:1993-04-01 00:00:00
abstract::For memory retrieval, pattern completion is a crucial process that restores memories from partial or degraded cues. Neurocognitive aging models suggest that the aged memory system is biased toward pattern completion, resulting in a behavioral preference for retrieval over encoding of memories. Here, we built on our pr...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23030
更新日期:2019-04-01 00:00:00
abstract::Hippocampal adult neurogenesis contributes to key functions of the dentate gyrus (DG), including contextual discrimination. This is due, at least in part, to the unique form of plasticity that new neurons display at a specific stage of their development when compared with the surrounding principal neurons. In addition...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22313
更新日期:2014-11-01 00:00:00
abstract::Hippocampal adult neurogenesis results in the persisting formation of new neurons that contribute to hippocampal-dependent learning and memory. This has led to the hypothesis that memory impairments associated with neurodegenerative diseases such as Alzheimer's disease may involve abnormal neurogenesis. Supporting thi...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.23052
更新日期:2019-07-01 00:00:00
abstract::Granule cells of the mouse fascia dentata are widely used in studies on neuronal development and plasticity. In contrast to the rat, however, high-resolution morphometric data on these cells are scarce. Thus, we have analyzed granule cells in the fascia dentata of the adult Thy1-GFP mouse (C57BL/6 background). In this...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20398
更新日期:2008-01-01 00:00:00
abstract::Subjective and objective memory deficits represent a frequent and ill-understood aspect of multiple sclerosis (MS), and a significant cause of disability and quality of life reduction. The aim of the study is to verify the role of hippocampal and temporal associative fibers' damage in MS-related memory complaints. To ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22237
更新日期:2014-04-01 00:00:00
abstract::Aging is associated with an impaired ability to maintain long-term potentiation (LTP), but the underlying cause of the impairment remains unclear. To gain a better understanding of the cellular and molecular mechanisms responsible for this impairment, the synaptic transmission and plasticity were studied in the CA1 re...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10032
更新日期:2002-01-01 00:00:00
abstract::Recent evidence suggests that activity-regulated cytoskeleton associated protein (Arc) and brain-derived neurotrophic factor (BDNF) are key players in the cellular mechanisms that trigger synaptic changes and memory consolidation. Cholinergic deafferentiation of hippocampus has been largely shown to induce memory impa...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20812
更新日期:2011-09-01 00:00:00
abstract::Neuregulins (NRGs) are ligands of ErbB receptor tyrosine kinases. The NRG1-ErbB4 pathway has been shown to modulate hippocampal synaptic plasticity and network oscillations in the adult rodent brain. To identify cells that mediate these effects, here we determine the expression pattern of ErbB4 in four functionally di...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20675
更新日期:2010-06-01 00:00:00
abstract::The effects of selective ibotenate lesions of the complete hippocampus (CHip), the hippocampal ventral pole (VP), or the medial prefrontal cortex (mPFC) in male rats were assessed on several measures related to energy regulation (i.e., body weight gain, food intake, body adiposity, metabolic activity, general behavior...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20499
更新日期:2009-03-01 00:00:00
abstract::Aging has been associated with a decline in relational memory, which is critically supported by the hippocampus. By adapting the transitivity paradigm (Bunsey and Eichenbaum (1996) Nature 379:255-257), which traditionally has been used in nonhuman animal research, this work examined the extent to which aging is accomp...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22501
更新日期:2016-02-01 00:00:00
abstract::The mammalian hippocampus plays a key role in spatial learning and memory, but the exact nature of the hippocampal representation of space is still being explored. Recently, there has been a fair amount of success in modeling hippocampal spatial maps in rats, assuming a topological perspective on spatial information p...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22610
更新日期:2016-10-01 00:00:00
abstract::Animal studies on the effects of chronic variable stress during the peripubertal-juvenile period on hippocampal structure and function are lacking. Twenty-eight-day-old Sprague-Dawley rats were subjected to random, variable physical or social stress regimens for 4 weeks. Hippocampal volume was found to continue to gro...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10207
更新日期:2004-01-01 00:00:00
abstract::Kindling is characterized by a progressive intensification of seizure activity culminating in generalized seizures following repeated administration of an initially subconvulsive electrical or chemical stimulus. Since it is known that epilepsy induces morphological alterations in the limbic system, we examined the neu...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10179
更新日期:2004-01-01 00:00:00
abstract::The precise timing of pre-postsynaptic activity is vital for the induction of long-term potentiation (LTP) or depression (LTD) at many central synapses. We show in synapses of rat CA1 pyramidal neurons in vitro that spike timing dependent plasticity (STDP) protocols that induce LTP at glutamatergic synapses can evoke ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22196
更新日期:2013-12-01 00:00:00
abstract::Previous work has shown that the dorsal hippocampus has greater activity than ventral regions during place navigation. Exposure to a novel context has also been found to increase hippocampal activation, possibly due to increased spatial demands. However, activation patterns in dorsal and ventral regions have not been ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23157
更新日期:2019-11-01 00:00:00
abstract::Both the hippocampus and ventromedial prefrontal cortex (vmPFC) appear to be critical for episodic future simulation. Damage to either structure affects one's ability to remember the past and imagine the future, and both structures are commonly activated as part of a wider core network during future simulation. Howeve...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22812
更新日期:2018-02-01 00:00:00
abstract::Learning and memory can be controlled by distinct memory systems. How these systems are coordinated to optimize learning and behavior has long been unclear. Accumulating evidence indicates that stress may modulate the engagement of multiple memory systems. In particular, rodent and human studies demonstrate that stres...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.22175
更新日期:2013-11-01 00:00:00
abstract::Various forms of synaptic plasticity in the brain have been proposed to result from modifications in the properties of glutamate receptors by calcium-dependent mechanisms. In the present study, changes in glutamate receptors elicited by calcium treatment of previously frozen mouse brain sections were evaluated by qual...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/1098-1063(2000)10:6<645::AID-HIPO1002>3.0.
更新日期:2000-01-01 00:00:00
abstract::We investigated the effects of a surgical lesion of one vestibular inner ear (unilateral vestibular damage [UVD]) on the field potential responses of CA1 neurons in vitro. Hippocampal slices were removed from rats at 4-6 weeks or 5-6 months post-UVD, and the field responses of CA1 neurons to electrical stimulation of ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10174
更新日期:2003-01-01 00:00:00
abstract::In a comparative approach, the anatomical organization of the hippocampus was investigated in two species of megachiropteran bats, the grey-headed flying fox, Pteropus poliocephalus, and the little red flying fox, Pteropus scapulatus. In general, the cytoarchitectonic appearance of the flying fox hippocampus correspon...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450010203
更新日期:1991-04-01 00:00:00
abstract::In the human neocortex, progressive synaptogenesis in early postnatal life is followed by a decline in synaptic density, then stability from adolescence until middle age. No comparable data are available in the hippocampus. In this study, the integral synaptic vesicle protein synaptophysin, measured immunoautoradiogra...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20194
更新日期:2006-01-01 00:00:00
abstract::Septal nuclei are suggested to work as an interface between the hippocampal formation, involved in higher cognitive functions, and the hypothalamus, involved in motivational behaviors such as feeding, drinking, and intracranial self-stimulation. In the present study, to elucidate a role of the septal nuclei in motivat...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1997)7:5<536::AID-HIPO9>3.
更新日期:1997-01-01 00:00:00
abstract::Rats were trained on an operant conditional discrimination in which an ambiguous stimulus (X) indicated both the occasions on which responding in the presence of a second cue (A) would be reinforced and the occasions on which responding in the presence of a third cue (B) would not be reinforced (X --> A+, A-, X --> B-...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1998)8:2<138::AID-HIPO6>3.
更新日期:1998-01-01 00:00:00
abstract::Temporal difference learning (TD) is a popular algorithm in machine learning. Two learning signals that are derived from this algorithm, the predictive value and the prediction error, have been shown to explain changes in neural activity and behavior during learning across species. Here, the predictive value signal is...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20535
更新日期:2009-05-01 00:00:00
abstract::Individuals with schizophrenia display a number of structural and cytoarchitectural alterations in the hippocampus, suggesting that other functions such as synaptic plasticity may also be modified. Altered hippocampal plasticity is likely to affect memory processing, and therefore any such pathology may contribute to ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22193
更新日期:2013-12-01 00:00:00
abstract::The functional organization of the perforant path input to the dentate gyrus of the exposed hippocampus was studied in adult rabbits anesthetized with urethane and chloralose. Electrical stimulation of perforant path fibers caused excitation of granule cells along narrow, nearly transverse strips (lamellae) of tissue....
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20538
更新日期:2009-07-01 00:00:00
abstract::Kowalczyk et al. (Hippocampus 2014; 24:7-20) were probably the first to conduct a systemic study of posterior hypothalamic area (PHa) theta rhythm in anesthetized rats. They demonstrated that local PHa theta field potentials were tail-pinch resistant and could be generated in urethane-anesthetized rats independently o...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22612
更新日期:2016-10-01 00:00:00
abstract::Granule cells born in the adult dentate gyrus undergo a 4-week developmental period characterized by high susceptibility to cell death. Two forms of hippocampus-dependent learning have been shown to rescue many of the new neurons during this critical period. Here, we show that a natural form of associative learning, s...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20097
更新日期:2005-01-01 00:00:00
abstract::Paired-pulse depression (PPD), a short-term neural plasticity, was studied in hippocampal CA1 of urethane-anesthetized rats in vivo, using field potential recordings and current source density analysis. PPD was robust when an ipsilateral CA3 (iCA3) conditioning pulse of moderate stimulus intensity was followed 30-200 ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20458
更新日期:2008-01-01 00:00:00