Abstract:
:Synaptic responses mediated by the N-methyl-D-aspartate receptor (NMDAr) and non-NMDAr activation were compared in CA1 hippocampal region of young (3-4 months old) and aged (25-33 months old) Sprague-Dawley rats with the use of ex vivo extracellular recordings techniques. In aged rats, the amplitude of the NMDAr-mediated field excitatory postsynaptic potentials (fEPSPs) was not altered, whereas their duration was significantly increased. In contrast, the magnitude of non-NMDAr-mediated fEPSPs was significantly smaller. The presynaptic fiber volley was not affected by age. Considering that the depression of non-NMDAr-mediated responses was previously attributed to fewer synaptic contacts between glutamatergic afferent fibers and pyramidal cells in aged animals (see Barnes et al., Hippocampus 1992;2:457-468), the absence of age-related changes in the amplitude of NMDAr-mediated fEPSPs suggests that compensatory mechanisms may occur. The contribution of gamma-aminobutyric acid (GABA) and acetylcholine to these mechanisms was addressed. The NMDAr-mediated fEPSPs were then recorded (1) in young and aged rats before and after blockade of the GABA(B) receptor-mediated inhibition by the specific antagonist CGP 55845 and (2) in young rats after a selective cholinergic denervation of the hippocampus by the immunotoxin 192 IgG-saporin. The results did not indicate statistically relevant age-related effects of CGP 55845. In contrast, the loss of the cholinergic innervation by the immunotoxin induced a significant increase in both the amplitude and duration of the NMDAr-mediated fEPSPs. Our results indicate that the functional properties of the ionotropic glutamate receptor subtypes located on CA1 pyramidal cells are differentially affected by aging and suggest that the cholinergic deficit that occurs during aging may be involved in the maintenance of robust NMDAr-mediated synaptic responses.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Jouvenceau A,Dutar P,Billard JMdoi
10.1002/(SICI)1098-1063(1998)8:6<627::AID-HIPO5>3.subject
Has Abstractpub_date
1998-01-01 00:00:00pages
627-37issue
6eissn
1050-9631issn
1098-1063journal_volume
8pub_type
杂志文章相关文献
HIPPOCAMPUS文献大全abstract::Rats use time-of-day cues to modulate learned taste aversion memories. If adult rats are accustomed to drinking saline in the evening and they receive a lithium chloride injection after drinking saline in the morning, they form a stronger aversion to saline than rats that were conditioned after drinking saline at the ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20481
更新日期:2009-01-01 00:00:00
abstract::Nuclear factor-kappa B (NFκB) signal is essential for neuronal survival and its activation may protect neuron against various stimuli. Since purinergic signals activate NFκB through the P2X7 receptor, we investigated the distinct pattern of NF-κB phosphorylation in neurons by P2X7 receptor activation following status ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22109
更新日期:2013-06-01 00:00:00
abstract::In this article, we present a framework to perform statistical shape analysis for segmented hippocampi, including an efficient permutation test for detecting subtle class differences, and a regularized discriminative direction method for visualizing the shape discrepancy. Fisher permutation and bootstrap tests are pre...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20639
更新日期:2009-06-01 00:00:00
abstract::Norepinephrine, is involved in the enhancement of learning and memory formation by regulating synaptic mechanisms through its ability to activate pre- and post-synaptic adrenergic receptors. Here we show that β-agonists of norepinephrine facilitate the induction of both associational LTP and sharp wave ripples (SPW-Rs...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22665
更新日期:2016-12-01 00:00:00
abstract::Although the parahippocampal cortex (PHc) is known to be critical for memory formation, little is known about what is encoded by this area. Using multi-voxel pattern analysis of high-resolution functional magnetic resonance imaging (MRI) data, we examined responses to blocks of categorically coherent stimuli and found...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20433
更新日期:2008-01-01 00:00:00
abstract::Dorsoventral lesion studies of the hippocampus have indicated that the dorsal axis of the hippocampus is important for spatial processing and the ventral axis of the hippocampus is important for olfactory learning and memory and anxiety. There is some evidence to suggest that the ventral CA3 and ventral CA1 conduct pa...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22248
更新日期:2014-05-01 00:00:00
abstract::We have shown previously that chronic nicotine treatment reverses adult-onset hypothyroidism-induced impairment of late-phase long-term potentiation (L-LTP) in area CA1 of the hippocampus. In the present study, basal and stimulated levels of signaling molecules essential for the expression of L-LTP were determined in ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20306
更新日期:2007-01-01 00:00:00
abstract::Nearby grid cells have been observed to express a remarkable degree of long-range order, which is often idealized as extending potentially to infinity. Yet their strict periodic firing and ensemble coherence are theoretically possible only in flat environments, much unlike the burrows which rodents usually live in. Ar...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23144
更新日期:2020-04-01 00:00:00
abstract::Fear can be extinguished by repeated exposure to a cue that signals threat. However, extinction does not erase fear, as an extinguished cue presented in a context distinct from that of extinction results in renewed fear of that cue. The hippocampus, which is involved in the formation of contextual representations, is ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20954
更新日期:2012-05-01 00:00:00
abstract::Williams syndrome (WS), a genetic deletion syndrome, is characterized by severe visuospatial deficits affecting performance on both tabletop spatial tasks and on tasks which assess orientation and navigation. Nevertheless, previous studies of WS spatial capacities have ignored the fact that two different spatial memor...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22764
更新日期:2017-11-01 00:00:00
abstract::Early life stress predisposes to the development of psychiatric disorders. In this context the hippocampal formation is of particular interest, because it is affected by stress on the structural and cognitive level. Since little is known how early life stress is translated on the molecular level, we mimicked early lif...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20907
更新日期:2012-03-01 00:00:00
abstract::Deficits in episodic memory are associated with deficits in the ability to imagine future experiences (i.e., mental time travel). We show that K.C., a person with episodic amnesia and an inability to imagine future experiences, nonetheless systematically discounts the value of future rewards, and his discounting is wi...
journal_title:Hippocampus
pub_type: 杂志文章,随机对照试验
doi:10.1002/hipo.20981
更新日期:2012-06-01 00:00:00
abstract::Two experiments assessed the effects of 1) combined subicular complex and posterior cingulate cortical lesions on training-induced neuronal activity (TIA) in the anterior ventral (AV) and medial dorsal (MD) thalamic nuclei; 2) hippocampal (Ammon's horn and dentate gyrus) lesions on TIA in cingulate cortex and in the A...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1998)8:5<491::AID-HIPO8>3.
更新日期:1998-01-01 00:00:00
abstract::Social isolation negatively affects the behavior and health of laboratory rats. Recently, it has been found that social isolation retards exercise-induced neurogenesis in the hippocampal dentate gyrus (DG) of male rats (Stranahan et al. (2006) Nat Neurosci 9:526-533). Since male and female rats react differently to ho...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20563
更新日期:2009-10-01 00:00:00
abstract::One of the most striking features of the hippocampal network is its ability to self-generate neuronal sequences representing temporally compressed, spatially coherent paths. These brief events, often termed "replay" in the scientific literature, are largely confined to non-exploratory states such as sleep or quiet res...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22824
更新日期:2020-01-01 00:00:00
abstract::The mechanism supporting the role of the hippocampal formation in novelty detection remains controversial. A comparator function has been variously ascribed to CA1 or subiculum, whereas the theta rhythm has been suggested to separate neural firing into encoding and retrieval phases. We investigated theta phase of firi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20671
更新日期:2010-02-01 00:00:00
abstract::Changes in the spatial arrangement or identity of objects inside a familiar environment induce reexploration. The present study looks at modifications of place cell activity during such renewed exploration. Hungry rats foraged for food in a cylinder with a salient cue card attached to the wall and with two distinct ob...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20060
更新日期:2005-01-01 00:00:00
abstract::The hippocampus is essential for the consolidation of some explicit long-term memories, including trace conditioning. Lesions and pharmacological manipulations of the dorsal hippocampus (DH) have provided strong evidence for its involvement in the acquisition and expression of trace fear memories. However, no studies ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22413
更新日期:2015-07-01 00:00:00
abstract::Paired-pulse depression (PPD), a short-term neural plasticity, was studied in hippocampal CA1 of urethane-anesthetized rats in vivo, using field potential recordings and current source density analysis. PPD was robust when an ipsilateral CA3 (iCA3) conditioning pulse of moderate stimulus intensity was followed 30-200 ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20458
更新日期:2008-01-01 00:00:00
abstract::Exposing rats to an enriched environment over an extended period of time has been shown to enhance hippocampal long-term potentiation (LTP). Whether such prolonged exposure to environmental manipulation is necessary for LTP enhancement and whether the environmentally induced enhancement can persist long after the cess...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10017
更新日期:2002-01-01 00:00:00
abstract::The retrosplenial cortex is situated at the crossroads between the hippocampal formation and many areas of the neocortex, but few studies have examined the connections between the hippocampal formation and the retrosplenial cortex in detail. Each subdivision of the retrosplenial cortex projects to a discrete terminal ...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.450020102
更新日期:1992-01-01 00:00:00
abstract::In the present study, 93 cells in the superior colliculus (SC) were recorded extracellularly during the simultaneous occurrence of spontaneous theta field activity, sensory-induced (tail pinch) theta field activity, and large amplitude irregular (LIA) field activity, recorded from an electrode located in the stratum m...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1999)9:5<500::AID-HIPO3>3.
更新日期:1999-01-01 00:00:00
abstract::The goal of the present research was to assess the degree to which a pattern completion process operates in cue-induced relapse to cocaine-seeking behavior. Using a novel cue-preference version of the place preference task, rats were administered cocaine or saline, which resulted in a preference for the cocaine-paired...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22570
更新日期:2016-07-01 00:00:00
abstract::The hippocampus and related structures are thought to be capable of 1) representing cortical activity in a way that minimizes overlap of the representations assigned to different cortical patterns (pattern separation); and 2) modifying synaptic connections so that these representations can later be reinstated from par...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450040605
更新日期:1994-12-01 00:00:00
abstract::Throughout the adult life of most mammals, new neurons are continuously generated in the dentate gyrus of the hippocampal formation. Recent work has documented specific cognitive deficits after elimination of adult hippocampal neurogenesis in rodents, suggesting that these neurons may contribute to information process...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20860
更新日期:2012-01-01 00:00:00
abstract::Lynn Nadel has been a trailblazer in memory research for decades. In just one example, Nadel and Zola-Morgan [Infantile amnesia, In Infant memory, Springer, Boston, MA, 1984, pp. 145-172] were the first to present the provocative notion that the extended development of the hippocampus may underlie the period of infant...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23149
更新日期:2020-08-01 00:00:00
abstract::The hippocampus receives robust serotonergic innervation that is thought to control the excitability of both pyramidal cells and GABAergic interneurons. Previous work has addressed serotonergic regulation of pyramidal cells but considerable gaps remain in our understanding of how serotonin regulates different interneu...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22611
更新日期:2016-09-01 00:00:00
abstract::Previous attempts to elucidate whether a loss of hippocampal synapses occurs during aging provided conflicting results, possibly due to the unavailability, at the time, of unbiased methods for synapse quantitation. This study was designed to reexamine the issue by means of modern technical procedures that provide unbi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450020411
更新日期:1992-10-01 00:00:00
abstract::The effects of selective ibotenate lesions of the complete hippocampus (CHip), the hippocampal ventral pole (VP), or the medial prefrontal cortex (mPFC) in male rats were assessed on several measures related to energy regulation (i.e., body weight gain, food intake, body adiposity, metabolic activity, general behavior...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20499
更新日期:2009-03-01 00:00:00
abstract::In urethane-anesthetized rats, cortical regions which provide distal dendritic excitation of the dentate gyrus and CA1 of the dorsal hippocampus were studied using current source density analysis. Electrical stimulation of the lateral perforant path (LPP) in the lateral angular bundle, lateral entorhinal cortex (LEC),...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1997)7:6<643::AID-HIPO6>3.
更新日期:1997-01-01 00:00:00