Hippocampal modulation of cingulo-thalamic neuronal activity and discriminative avoidance learning in rabbits.

abstract：:Spatial navigation relies on multiple mnemonic mechanisms and previous work in younger adults has described two separate types of spatial memory. One type uses directional as well as boundary-related information for spatial memory and mainly implicates the hippocampal formation. The other type has been linked to direc...

journal_title：Hippocampus

authors： Schuck NW,Doeller CF,Schjeide BM,Schröder J,Frensch PA,Bertram L,Li SC

更新日期：2013-10-01 00:00:00

abstract：:Deficits in episodic memory are associated with deficits in the ability to imagine future experiences (i.e., mental time travel). We show that K.C., a person with episodic amnesia and an inability to imagine future experiences, nonetheless systematically discounts the value of future rewards, and his discounting is wi...

journal_title：Hippocampus

authors： Kwan D,Craver CF,Green L,Myerson J,Boyer P,Rosenbaum RS

更新日期：2012-06-01 00:00:00

abstract：:In the mammalian brain, newly acquired memories depend on the hippocampus (HPC) for maintenance and recall, but over time, the neocortex takes over these functions, rendering memories HPC-independent. The process responsible for this transformation is called systems memory consolidation. Reactivation of a well-consoli...

journal_title：Hippocampus

authors： Helfer P,Shultz TR

更新日期：2020-07-01 00:00:00

abstract：:In rodents, pyramidal cell firing patterns from waking may be replayed in nonrapid eye movement sleep (NREM) sleep during hippocampal sharp wave ripples (HC-SWR). In humans, HC-SWR have only been recorded with electrodes implanted to localize epileptogenicity. Here, we characterize human HC-SWR with rigorous rejection...

journal_title：Hippocampus

authors： Jiang X,Gonzalez-Martinez J,Cash SS,Chauvel P,Gale J,Halgren E

更新日期：2020-06-01 00:00:00

abstract：:Hippocampal place cells respond heterogeneously to elemental changes of a compound spatial context, suggesting that they form a distributed code of context, whereby context information is shared across a population of neurons. The question arises as to what this distributed code might be useful for. The present study ...

journal_title：Hippocampus

authors： Anderson MI,Killing S,Morris C,O'Donoghue A,Onyiagha D,Stevenson R,Verriotis M,Jeffery KJ

更新日期：2006-01-01 00:00:00

abstract：:Once thought to produce global, nonspecific brain injury, drugs of abuse are now known to produce selective neuro-adaptations in particular brain regions. These neuro-adaptations are being closely examined for clues to the development, maintenance, and treatment of addiction. The hippocampus is an area of particular i...

journal_title：Hippocampus

authors： Eisch AJ,Harburg GC

更新日期：2006-01-01 00:00:00

abstract：:Trans-synaptic cell-adhesion molecules have been implicated in regulating CNS synaptogenesis. Among these, the Neuroligin (NL) family (NLs 1-4) of postsynaptic adhesion proteins has been shown to promote the development and specification of excitatory versus inhibitory synapses. NLs form a heterophilic complex with th...

journal_title：Hippocampus

authors： Dahlhaus R,Hines RM,Eadie BD,Kannangara TS,Hines DJ,Brown CE,Christie BR,El-Husseini A

更新日期：2010-02-01 00:00:00

abstract：:Early life stress predisposes to the development of psychiatric disorders. In this context the hippocampal formation is of particular interest, because it is affected by stress on the structural and cognitive level. Since little is known how early life stress is translated on the molecular level, we mimicked early lif...

journal_title：Hippocampus

authors： Gross CM,Flubacher A,Tinnes S,Heyer A,Scheller M,Herpfer I,Berger M,Frotscher M,Lieb K,Haas CA

更新日期：2012-03-01 00:00:00

abstract：:Hippocampal mossy fibers have long been proposed to impose new patterns to learn onto CA3 neurons during new memory formation. However, inconsistent with this theory, we found in our previous study that mossy fiber stimulation induces only transient changes in CA3 spatial firing in a familiar environment. Here, we tes...

journal_title：Hippocampus

authors： Lee J,Bae C,Lee D,Jung MW

更新日期：2020-07-01 00:00:00

abstract：:Although the importance of cAMP-response element binding protein (CREB) phosphorylation in long-term memory formation is well documented for hippocampus-dependent tasks, little is known about the changes in phosphorylated CREB (pCREB) that occur during the process of extinction. The purpose of this study was to charac...

journal_title：Hippocampus

authors： Porte Y,Trifilieff P,Wolff M,Micheau J,Buhot MC,Mons N

更新日期：2011-11-01 00:00:00

abstract：:Although there are many types of epilepsy, temporal lobe epilepsy (TLE) is probably in humans the most common and most often studied. TLE represents 40% of the total epilepsy form of the disease and is difficult to treat. Despite a wealth of descriptive data obtained from the disease history of patients, the EEG recor...

journal_title：Hippocampus

authors： Mériaux C,Franck J,Park DB,Quanico J,Kim YH,Chung CK,Park YM,Steinbusch H,Salzet M,Fournier I

更新日期：2014-06-01 00:00:00

abstract：:Adult neurogenesis continues throughout life in the mammalian hippocampus. The precise function of the adult generated neurons remains uncertain although there is growing evidence that they are involved in hippocampus-dependent learning and memory. Training rats on a hidden platform version of the Morris water task ha...

journal_title：Hippocampus

authors： Epp JR,Haack AK,Galea LA

更新日期：2010-07-01 00:00:00

abstract：:Structural integrity of the human hippocampus is widely acknowledged to be necessary for the successful encoding and retrieval of autobiographical memories. However, evidence for an association between hippocampal volume and the ability to recall such memories in healthy individuals is mixed. Here we examined this iss...

journal_title：Hippocampus

authors： Barry DN,Clark IA,Maguire EA

更新日期：2020-12-15 00:00:00

abstract：:Our previous study showed that kainate (KA) receptor subunit GluR6 played an important role in ischemia-induced MLK3 and JNK activation and neuronal degeneration through the GluR6-PSD95-MLK3 signaling module. However, whether the KA receptors subunit GluR6 is involved in the activation of p38 MAP kinase during the tra...

journal_title：Hippocampus

authors： Chen J,Li C,Pei DS,Han D,Liu XM,Jiang HX,Wang XT,Guan QH,Wen XR,Hou XY,Zhang GY

更新日期：2009-01-01 00:00:00

abstract：:Rats use time-of-day cues to modulate learned taste aversion memories. If adult rats are accustomed to drinking saline in the evening and they receive a lithium chloride injection after drinking saline in the morning, they form a stronger aversion to saline than rats that were conditioned after drinking saline at the ...

journal_title：Hippocampus

authors： Manrique T,Morón I,Ballesteros MA,Guerrero RM,Fenton AA,Gallo M

更新日期：2009-01-01 00:00:00

abstract：:Previous attempts to elucidate whether a loss of hippocampal synapses occurs during aging provided conflicting results, possibly due to the unavailability, at the time, of unbiased methods for synapse quantitation. This study was designed to reexamine the issue by means of modern technical procedures that provide unbi...

journal_title：Hippocampus

authors： Geinisman Y,deToledo-Morrell L,Morrell F,Persina IS,Rossi M

更新日期：1992-10-01 00:00:00

abstract：:The hippocampus and the medial temporal lobe cortex [medial temporal lobe cortices (MTLC)] both contribute to long-term memory. Although their contributions are thought to be dissociable, the nature of the representations that each region supports remains unclear. The Complementary Learning Systems (CLS) modeling appr...

journal_title：Hippocampus

authors： Duff MC,Warren DE,Gupta R,Vidal JP,Tranel D,Cohen NJ

更新日期：2012-05-01 00:00:00

abstract：:Intracellular recording and computational modelling suggest that interactions of subthreshold membrane potential oscillation frequency in different dendritic branches of entorhinal cortex stellate cells could underlie the functional coding of continuous dimensions of space and time. Among other things, these interacti...

journal_title：Hippocampus

authors： Hasselmo ME,Giocomo LM,Zilli EA

更新日期：2007-01-01 00:00:00

abstract：:The locomotor effects of intra-NAcc injection of dopamine receptor agonists following discrete lesion or inhibition of the DH or the VH have been poorly investigated using only the indirect dopamine receptor agonist amphetamine. In the present study, we investigated how lidocaine in the DH or the VH modulated hyperloc...

journal_title：Hippocampus

authors： Rouillon C,Abraini JH,David HN

更新日期：2007-01-01 00:00:00

abstract：:The present study investigated the delayed and persistent effects of 4 beta-phorbol 12,13-dibutyrate (PDBu) on the K(+)-evoked release of endogenous glutamate and dynorphin B-like immunoreactivity from a subcellular fraction (P3) that is enriched in hippocampal mossy fiber synaptosomes. It is demonstrated that the alp...

journal_title：Hippocampus

authors： Terrian DM,Ways DK,Gannon RL,Zetts DA

更新日期：1993-04-01 00:00:00

abstract：:A large body of evidence exists to demonstrate that excitatory amino acids (EAA) and their receptors are involved in the pathophysiological mechanisms linking several acute brain insults, such as cerebral ischemia, to neuronal degeneration and death. Accordingly, the use of EAA receptor antagonists can be beneficial i...

journal_title：Hippocampus

authors： Virgili M,Contestabile A,Barnabei O

更新日期：1995-01-01 00:00:00

abstract：:Episodic memory deficits are evident in late-life depression (LLD) and are associated with subtle synaptic and neurochemical changes in the medial temporal lobes (MTL). However, the particular mechanisms by which memory impairment occurs in LLD are currently unknown. We tested older adults with (DS+) and without (DS-)...

journal_title：Hippocampus

authors： Leal SL,Noche JA,Murray EA,Yassa MA

更新日期：2017-04-01 00:00:00

abstract：:A forced-choice discrimination paradigm was used in two experiments, to evaluate retrograde and anterograde amnesia in rats after hippocampal ablation. In a within-subjects design (Experiment 1), rats were trained on a set of 10 olfactory discriminations 4 weeks before surgery and on a separate set of 10 discriminatio...

journal_title：Hippocampus

authors： Jonasson Z,Ballantyne JK,Baxter MG

更新日期：2004-01-01 00:00:00

abstract：:Neuregulins (NRGs) are ligands of ErbB receptor tyrosine kinases. The NRG1-ErbB4 pathway has been shown to modulate hippocampal synaptic plasticity and network oscillations in the adult rodent brain. To identify cells that mediate these effects, here we determine the expression pattern of ErbB4 in four functionally di...

journal_title：Hippocampus

authors： Neddens J,Buonanno A

更新日期：2010-06-01 00:00:00

abstract：:The aim of this study was to investigate the role of the human hippocampus in episodic retrieval of odors, in comparison with episodic retrieval of visual objects. Subjects encoded a set of unique odors and objects, and retrieval was tested the next day during functional magnetic resonance imaging (fMRI). Subjects wer...

journal_title：Hippocampus

authors： Lehn H,Kjønigsen LJ,Kjelvik G,Håberg AK

更新日期：2013-02-01 00:00:00

abstract：:Adaptive memory requires the organism to form associations that bridge between events separated in time. Many studies show interactions between hippocampus (HPC) and prefrontal cortex (PFC) during formation of such associations. We analyze neural recording from monkey HPC and PFC during a memory task that requires the...

journal_title：Hippocampus

authors： Cruzado NA,Tiganj Z,Brincat SL,Miller EK,Howard MW

更新日期：2020-12-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP), a neurotrophic and neuromodulatory peptide, was recently shown to enhance NMDA receptor-mediated currents in the hippocampus (Macdonald, et al. 2005. J Neurosci 25:11374-11384). To check if PACAP might also modulate AMPA receptor function, we tested its effec...

journal_title：Hippocampus

authors： Costa L,Santangelo F,Li Volsi G,Ciranna L

更新日期：2009-01-01 00:00:00

abstract：:Although the entorhinal cortex is a key structure connecting the hippocampal formation with the rest of the cerebral cortex, little is known about its early chemoanatomical development in primates. In the present study, a cytoarchitectonic analysis and immunocytochemical detection of somatostatin, neurotensin, parvalb...

journal_title：Hippocampus

authors： Berger B,Alvarez C,Goldman-Rakic PS

更新日期：1993-07-01 00:00:00

abstract：:Both the hippocampus and ventromedial prefrontal cortex (vmPFC) appear to be critical for episodic future simulation. Damage to either structure affects one's ability to remember the past and imagine the future, and both structures are commonly activated as part of a wider core network during future simulation. Howeve...

journal_title：Hippocampus

authors： Campbell KL,Madore KP,Benoit RG,Thakral PP,Schacter DL

更新日期：2018-02-01 00:00:00

abstract：:The rodent hippocampus expresses a variety of neuronal network oscillations depending on the behavioral state of the animal. Locomotion and active exploration are accompanied by theta-nested gamma oscillations while resting states and slow-wave sleep are dominated by intermittent sharp wave-ripple complexes. It is bel...

journal_title：Hippocampus

authors： Geschwill P,Kaiser ME,Grube P,Lehmann N,Thome C,Draguhn A,Hollnagel JO,Both M

更新日期：2020-10-01 00:00:00