Abstract:
:Our previous study showed that kainate (KA) receptor subunit GluR6 played an important role in ischemia-induced MLK3 and JNK activation and neuronal degeneration through the GluR6-PSD95-MLK3 signaling module. However, whether the KA receptors subunit GluR6 is involved in the activation of p38 MAP kinase during the transient brain ischemia/reperfusion (I/R) in the rat hippocampal CA1 subfield is still unknown. In this present study, we first evaluated the time-course of phospho-p38 MAP kinase at various time-points after 15 min of ischemia and then observed the effects of antagonist of KA receptor subunit GluR6, GluR6 antisence oligodeoxynucleotides on the phosphorylation of p38 MAP kinase induced by I/R. Results showed that inhibiting KA receptor GluR6 or suppressing the expression of KA receptor GluR6 could down-regulate the elevation of phospho-p38 MAP kinase induced by I/R. These drugs also reduced the phosphorylation of MLK3, MKK3/MKK6, MKK4, and MAPKAPK2. Additionally, our results indicated administration of three drugs, including p38 MAP kinase inhibitor before brain ischemia significantly decreased the number of TUNEL-positive cells detected at 3 days of reperfusion and increased the number of the surviving CA1 pyramidal cells at 5 days of reperfusion after 15 min of ischemia. Taken together, we suggest that GluR6-contained KA receptors can mediate p38 MAP kinase activation through a kinase cascade, including MLK3, MKK3/MKK6, and MKK4 and then induce increased phosphorylation of MAPKAPK-2 during ischemia injury and ultimately result in neuronal cell death in the rat hippocampal CA1 region.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Chen J,Li C,Pei DS,Han D,Liu XM,Jiang HX,Wang XT,Guan QH,Wen XR,Hou XY,Zhang GYdoi
10.1002/hipo.20479subject
Has Abstractpub_date
2009-01-01 00:00:00pages
79-89issue
1eissn
1050-9631issn
1098-1063journal_volume
19pub_type
杂志文章相关文献
HIPPOCAMPUS文献大全abstract::The hippocampus and related structures are thought to be capable of 1) representing cortical activity in a way that minimizes overlap of the representations assigned to different cortical patterns (pattern separation); and 2) modifying synaptic connections so that these representations can later be reinstated from par...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450040605
更新日期:1994-12-01 00:00:00
abstract::We aimed at identifying the cerebral structures whose synaptic function subserves the recollection of lifetime's episodic autobiographical memory (AM) via autonoetic consciousness. Twelve healthy middle-aged subjects (mean age: 59 years +/- 2.5) underwent a specially designed cognitive test to assess the ability to re...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20406
更新日期:2008-01-01 00:00:00
abstract::Lynn Nadel has been a trailblazer in memory research for decades. In just one example, Nadel and Zola-Morgan [Infantile amnesia, In Infant memory, Springer, Boston, MA, 1984, pp. 145-172] were the first to present the provocative notion that the extended development of the hippocampus may underlie the period of infant...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23149
更新日期:2020-08-01 00:00:00
abstract::The hippocampus is critical for memory tasks which require an active maintenance of memory for a short period of time; however, the underlying neural mechanisms remain unknown. Most theoretical and computational models, which date back to the classic proposals by Donald Hebb in , have been self-constrained by anatomy,...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22136
更新日期:2013-09-01 00:00:00
abstract::The ventral portion of the rodent hippocampus (HPC; anterior in primates) has been implicated in the detection and resolution of approach-avoidance conflict, which arises when an organism encounters a stimulus that predicts both positive and negative outcomes. Previous work has found differential regulation of approac...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23182
更新日期:2020-06-01 00:00:00
abstract::Spike-timing-dependent long-term potentiation (LTP) and long-term depression (LTD) were investigated in the CA1 area of hippocampal slices using optical imaging. A pair of electrical pulses were used to stimulate the Schaffer-commissural collateral and the stratum oriens with various sets of relative timing (tau) betw...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20035
更新日期:2005-01-01 00:00:00
abstract::To examine the effects of long-term potentiation (LTP) on individual neurons in the intact brain, anesthetized rats were implanted with a recording stereotrode in the right CA1 layer of the hippocampus and a stimulating electrode in the right and left CA3 layers. The evoked and spontaneous firing of single CA1 neurons...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/1098-1063(2000)10:3<207::AID-HIPO1>3.0.CO;
更新日期:2000-01-01 00:00:00
abstract::In all species examined, the dentate gyrus develops over an extended period that begins during gestation and continues up to adulthood. The aim of this study was to investigate the pattern of postnatal cell production in the dentate gyrus of the guinea pig, a rodent whose brain development has features more closely re...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20050
更新日期:2005-01-01 00:00:00
abstract::Nuclear factor-kappa B (NFκB) signal is essential for neuronal survival and its activation may protect neuron against various stimuli. Since purinergic signals activate NFκB through the P2X7 receptor, we investigated the distinct pattern of NF-κB phosphorylation in neurons by P2X7 receptor activation following status ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22109
更新日期:2013-06-01 00:00:00
abstract::C57 and DBA mice were trained in a crossed maze to assess possible strain differences in place or response learning as a function of training duration (8 or 17 days) and extramaze cueing conditions. The first condition consisted of a diffuse visually cued environment (rich cueing). The second was the same plus an expl...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10007
更新日期:2002-01-01 00:00:00
abstract::Hippocampal neurons are selectively active when a rat occupies restricted locations in an environment. These place cells derive their specificity from a multitude of sources, including idiothetic cues and sensory input derived from both distal and local landmarks. Most experiments have attempted to dissociate the rela...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10092
更新日期:2003-01-01 00:00:00
abstract::Nitric oxide (NO) is a gaseous neuromessenger. Although increasing evidence reveals significant physiological effects of NO in the hippocampal synaptic plasticity, the spatial distribution of NO production has remained largely uncharacterized due to the poor development of techniques for real-time NO imaging. In this ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20064
更新日期:2005-01-01 00:00:00
abstract::It has been well-established that cell proliferation and neurogenesis in the adult mouse dentate gyrus (DG) can be regulated by voluntary exercise. Recent evidence has suggested that the effects of voluntary exercise can in turn be influenced by environmental factors that regulate the amount of stress an animal is exp...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20514
更新日期:2009-10-01 00:00:00
abstract::The functional organization of the perforant path input to the dentate gyrus of the exposed hippocampus was studied in adult rabbits anesthetized with urethane and chloralose. Electrical stimulation of perforant path fibers caused excitation of granule cells along narrow, nearly transverse strips (lamellae) of tissue....
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20538
更新日期:2009-07-01 00:00:00
abstract::Presenting stimuli again after presentation of intervening stimuli improves their retention, an effect known as the spacing effect. However, using event-related potentials (ERPs), we had observed that immediate, in comparison to spaced, repetition of pictures induced a positive frontal potential at 200-300 ms. This po...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22534
更新日期:2016-04-01 00:00:00
abstract::GABAergic inhibitory interneurons control fundamental aspects of neuronal network function. Their functional roles are assumed to be defined by the identity of their input synapses, the architecture of their dendritic tree, the passive and active membrane properties and finally the nature of their postsynaptic targets...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22214
更新日期:2014-02-01 00:00:00
abstract::Granule cells born in the adult dentate gyrus undergo a 4-week developmental period characterized by high susceptibility to cell death. Two forms of hippocampus-dependent learning have been shown to rescue many of the new neurons during this critical period. Here, we show that a natural form of associative learning, s...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20097
更新日期:2005-01-01 00:00:00
abstract::Individual variation in the attribution of motivational salience to reward-related cues is believed to underlie addiction vulnerability. Pavlovian conditioned approach measures individual variation in motivational salience by identifying rats that are attracted to and motivated by reward cues (sign-trackers) or motiva...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22619
更新日期:2016-11-01 00:00:00
abstract::Although a large body of evidence indicates that sleep plays an important role in learning and memory processes, the actual existence of a sleep-dependent spatial memory consolidation has been not firmly established. Here, by using a computerized 3D virtual navigation tool, we were able to show that topographical orie...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20444
更新日期:2008-01-01 00:00:00
abstract::The ERK/MAPK signaling pathway has been extensively studied in the context of learning and memory. Defects in this pathway underlie genetic diseases associated with intellectual disability, including impaired learning and memory. Numerous studies have investigated the impact of acute ERK/MAPK inhibition on long-term p...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22769
更新日期:2017-12-01 00:00:00
abstract::Cocaine induces an increase in hippocampal and nucleus accumbens (Nac) serotonin (5-HT) concentration parallel to locomotor activation. Both effects can be modulated by systemic 5-HT(1A)-receptor agonism/antagonism. Given the contribution of the hippocampus to spontaneous behavioral activity, these observations sugges...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10209
更新日期:2004-01-01 00:00:00
abstract::Previous attempts to elucidate whether a loss of hippocampal synapses occurs during aging provided conflicting results, possibly due to the unavailability, at the time, of unbiased methods for synapse quantitation. This study was designed to reexamine the issue by means of modern technical procedures that provide unbi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450020411
更新日期:1992-10-01 00:00:00
abstract::Despite evidence that the extracellular matrix glycoprotein tenascin-C (TNC) is implicated in brain development and plasticity, its roles in the intact adult brain are unknown. Here we report that spontaneous local field potential (LFP) activity in freely moving adult TNC-deficient mice is abnormal. The power of corti...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20585
更新日期:2009-12-01 00:00:00
abstract::People retain more new verbal episodic information for at least 7 days if they rest for a few minutes after learning than if they attend to new information. It is hypothesized that rest allows for superior consolidation of new memories. In rodents, rest periods promote hippocampal replay of a recently travelled route,...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22424
更新日期:2015-09-01 00:00:00
abstract::Two patients, with magnetic resonance imaging (MRI)-confirmed relatively selective hippocampal damage, showed distinct patterns of performance on tests of recall, item recognition, and associative recognition. Patient AC showed a mean bilateral volume reduction of the hippocampus of 28%, but displayed no memory defici...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20427
更新日期:2008-01-01 00:00:00
abstract::Key pathological features of Parkinson's Disease (PD) include the progressive degeneration of midbrain dopaminergic (DA) neurons and hindbrain noradrenergic (NA) neurons. The loss of DA neurons has been extensively studied and is the main cause of motor dysfunction. Importantly, however, there are a range of 'non-move...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22835
更新日期:2018-05-01 00:00:00
abstract::Temporal difference learning (TD) is a popular algorithm in machine learning. Two learning signals that are derived from this algorithm, the predictive value and the prediction error, have been shown to explain changes in neural activity and behavior during learning across species. Here, the predictive value signal is...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20535
更新日期:2009-05-01 00:00:00
abstract::Two experiments assessed the effects of 1) combined subicular complex and posterior cingulate cortical lesions on training-induced neuronal activity (TIA) in the anterior ventral (AV) and medial dorsal (MD) thalamic nuclei; 2) hippocampal (Ammon's horn and dentate gyrus) lesions on TIA in cingulate cortex and in the A...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1998)8:5<491::AID-HIPO8>3.
更新日期:1998-01-01 00:00:00
abstract::We have previously shown that in urethane-anesthetized rats the frequency of rhythmical slow activity in the hippocampus ("theta") is controlled by the medial supramammillary nucleus (SuM). In particular, injections of procaine into SuM in urethane-anesthetized animals reduce the frequency of theta. However, it has be...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450050605
更新日期:1995-01-01 00:00:00
abstract::Exposing rats to an enriched environment over an extended period of time has been shown to enhance hippocampal long-term potentiation (LTP). Whether such prolonged exposure to environmental manipulation is necessary for LTP enhancement and whether the environmentally induced enhancement can persist long after the cess...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10017
更新日期:2002-01-01 00:00:00