Sleep to find your way: the role of sleep in the consolidation of memory for navigation in humans.

abstract：:Norepinephrine, is involved in the enhancement of learning and memory formation by regulating synaptic mechanisms through its ability to activate pre- and post-synaptic adrenergic receptors. Here we show that β-agonists of norepinephrine facilitate the induction of both associational LTP and sharp wave ripples (SPW-Rs...

journal_title：Hippocampus

authors： Ul Haq R,Anderson M,Liotta A,Shafiq M,Sherkheli MA,Heinemann U

更新日期：2016-12-01 00:00:00

abstract：:Schizophrenia is a devastating psychiatric illness with a complex pathophysiology. We have recently documented schizophrenia-like endophenotypes in phospholipase C-β1 knockout (PLC-β1(-/-)) mice, including deficits in prepulse inhibition, hyperlocomotion, and cognitive impairments. PLC-β1 signals via multiple G-protei...

journal_title：Hippocampus

authors： Manning EE,Ransome MI,Burrows EL,Hannan AJ

更新日期：2012-02-01 00:00:00

abstract：:Sleep is important for memory consolidation, and an abundant literature suggests that reactivation in the hippocampus during sleep is instrumental to this process. Yet, the current interpretation of activity during sharp-waves ripples (SWRs), as replay of wake experiences, relies on hypotheses that, while widely accep...

journal_title：Hippocampus

authors： Laventure S,Benchenane K

更新日期：2020-01-01 00:00:00

abstract：:The hippocampus and the medial temporal lobe cortex [medial temporal lobe cortices (MTLC)] both contribute to long-term memory. Although their contributions are thought to be dissociable, the nature of the representations that each region supports remains unclear. The Complementary Learning Systems (CLS) modeling appr...

journal_title：Hippocampus

authors： Duff MC,Warren DE,Gupta R,Vidal JP,Tranel D,Cohen NJ

更新日期：2012-05-01 00:00:00

abstract：:Neurons in the supramammillary nucleus (SUM) of urethane-anesthetized rats fire rhythmically in synchrony with hippocampal theta rhythm. As these neurons project to the septum and hippocampus, it is generally assumed that their role is to mediate ascending activation, leading to the hippocampal theta rhythm. However, ...

journal_title：Hippocampus

authors： Kocsis B,Kaminski M

更新日期：2006-01-01 00:00:00

abstract：:The hippocampus plays an important role in spatial learning and memory. However, the biochemical alterations that subserve this function remain to be fully elucidated. In this study, rats were subjected to a single-trial contextual fear conditioning (CFC) paradigm; the activation of different protein kinase C (PKC) su...

journal_title：Hippocampus

authors： Young E,Cesena T,Meiri KF,Perrone-Bizzozero NI

更新日期：2002-01-01 00:00:00

abstract：:One functional aspect of theta oscillations that recent studies have begun to explore in humans is their role for the recollection of personal events. A specific role of theta for recollection but not for stimulus-familiarity would support links between cortical theta oscillations and hippocampal functioning, given th...

journal_title：Hippocampus

authors： Guderian S,Düzel E

更新日期：2005-01-01 00:00:00

abstract：:Two patients, with magnetic resonance imaging (MRI)-confirmed relatively selective hippocampal damage, showed distinct patterns of performance on tests of recall, item recognition, and associative recognition. Patient AC showed a mean bilateral volume reduction of the hippocampus of 28%, but displayed no memory defici...

journal_title：Hippocampus

authors： Holdstock JS,Parslow DM,Morris RG,Fleminger S,Abrahams S,Denby C,Montaldi D,Mayes AR

更新日期：2008-01-01 00:00:00

abstract：:For well over a century, ethanol was believed to exert its effects on cognition and behavior by producing a ubiquitous depression of central nervous system activity. A general disruption in brain function was consistent with the belief that ethanol's effects on cognition and behavior were also quite general. Substanti...

journal_title：Hippocampus

authors： White AM,Matthews DB,Best PJ

更新日期：2000-01-01 00:00:00

abstract：:The effects of selective ibotenate lesions of the complete hippocampus (CHip), the hippocampal ventral pole (VP), or the medial prefrontal cortex (mPFC) in male rats were assessed on several measures related to energy regulation (i.e., body weight gain, food intake, body adiposity, metabolic activity, general behavior...

journal_title：Hippocampus

authors： Davidson TL,Chan K,Jarrard LE,Kanoski SE,Clegg DJ,Benoit SC

更新日期：2009-03-01 00:00:00

abstract：:Alzheimer's disease (AD) and ageing are associated with impaired learning and memory, and recent findings point toward modulating chromatin remodeling through histone acetylation as a promising therapeutic strategy. Here we report that systemic administration of the HDAC inhibitor 4-phenylbutyrate (PBA) reinstated fea...

journal_title：Hippocampus

authors： Ricobaraza A,Cuadrado-Tejedor M,Marco S,Pérez-Otaño I,García-Osta A

更新日期：2012-05-01 00:00:00

abstract：:Wnt proteins have emerged as transmembrane signaling molecules that regulate learning and memory as well as synaptic plasticity at central synapses (Inestrosa and Arenas (2010) Nat Rev Neurosci 11:77-86; Maguschak and Ressler (2011) J Neurosci 31:13057-13067; Tabatadze et al. (2012) Hippocampus 22: 1228-1241; Fortress...

journal_title：Hippocampus

authors： Tabatadze N,McGonigal R,Neve RL,Routtenberg A

更新日期：2014-04-01 00:00:00

abstract：:Rats use time-of-day cues to modulate learned taste aversion memories. If adult rats are accustomed to drinking saline in the evening and they receive a lithium chloride injection after drinking saline in the morning, they form a stronger aversion to saline than rats that were conditioned after drinking saline at the ...

journal_title：Hippocampus

authors： Manrique T,Morón I,Ballesteros MA,Guerrero RM,Fenton AA,Gallo M

更新日期：2009-01-01 00:00:00

abstract：:Increased consumption of high-fat diet (HFD) leads to obesity and adverse neurocognitive outcomes. Childhood and adolescence are important periods of brain maturation shaping cognitive function. These periods could consequently be particularly sensitive to the detrimental effects of HFD intake. In mice, juvenile and a...

journal_title：Hippocampus

authors： Boitard C,Etchamendy N,Sauvant J,Aubert A,Tronel S,Marighetto A,Layé S,Ferreira G

更新日期：2012-11-01 00:00:00

abstract：:There is an ongoing debate regarding the respective role of anterior subhippocampal structures and the hippocampus in recognition memory. Here, we report a double anatomo-functional dissociation observed in two brain-damaged patients, FRG and JMG. They both suffered from complete destruction of left MTL structures. In...

journal_title：Hippocampus

authors： Barbeau EJ,Pariente J,Felician O,Puel M

更新日期：2011-09-01 00:00:00

abstract：:During certain movements (termed "type I," "instrumental," or "voluntary"), the rodent hippocampal EEG is dominated by regular 7-10 Hz waves. This "theta rhythm" is accompanied by increased firing of hippocampal interneurons and dentate gyrus granule cells. No obvious theta rhythm is present in comparable situations i...

journal_title：Hippocampus

authors： Halgren E

更新日期：1991-04-01 00:00:00

abstract：:The ERK/MAPK signaling pathway has been extensively studied in the context of learning and memory. Defects in this pathway underlie genetic diseases associated with intellectual disability, including impaired learning and memory. Numerous studies have investigated the impact of acute ERK/MAPK inhibition on long-term p...

journal_title：Hippocampus

authors： Vithayathil J,Pucilowska J,Friel D,Landreth GE

更新日期：2017-12-01 00:00:00

abstract：:A forced-choice discrimination paradigm was used in two experiments, to evaluate retrograde and anterograde amnesia in rats after hippocampal ablation. In a within-subjects design (Experiment 1), rats were trained on a set of 10 olfactory discriminations 4 weeks before surgery and on a separate set of 10 discriminatio...

journal_title：Hippocampus

authors： Jonasson Z,Ballantyne JK,Baxter MG

更新日期：2004-01-01 00:00:00

abstract：:An extensive cortical network consisting of structures in the medial temporal lobe (hippocampus and parahippocampal cortex), lateral parietal cortex, retrosplenial cortex, and medial prefrontal cortex has recently attracted attention in cognitive neuroscience research, linking the network to both episodic memory and s...

journal_title：Hippocampus

authors： Peters J,Daum I,Gizewski E,Forsting M,Suchan B

更新日期：2009-02-01 00:00:00

abstract：:The aim of this study was to investigate the role of the human hippocampus in episodic retrieval of odors, in comparison with episodic retrieval of visual objects. Subjects encoded a set of unique odors and objects, and retrieval was tested the next day during functional magnetic resonance imaging (fMRI). Subjects wer...

journal_title：Hippocampus

authors： Lehn H,Kjønigsen LJ,Kjelvik G,Håberg AK

更新日期：2013-02-01 00:00:00

abstract：:Aging has been associated with a decline in relational memory, which is critically supported by the hippocampus. By adapting the transitivity paradigm (Bunsey and Eichenbaum (1996) Nature 379:255-257), which traditionally has been used in nonhuman animal research, this work examined the extent to which aging is accomp...

journal_title：Hippocampus

authors： Ryan JD,D'Angelo MC,Kamino D,Ostreicher M,Moses SN,Rosenbaum RS

更新日期：2016-02-01 00:00:00

abstract：:Animal studies on the effects of chronic variable stress during the peripubertal-juvenile period on hippocampal structure and function are lacking. Twenty-eight-day-old Sprague-Dawley rats were subjected to random, variable physical or social stress regimens for 4 weeks. Hippocampal volume was found to continue to gro...

journal_title：Hippocampus

authors： Isgor C,Kabbaj M,Akil H,Watson SJ

更新日期：2004-01-01 00:00:00

abstract：:High-frequency stimulation of excitatory synapses in many regions of the brain triggers a lasting increase in the efficacy of synaptic transmission referred to as long-term potentiation (LTP) and believed to contribute to learning and memory. One hypothesis proposed to account for the stability and properties of this ...

journal_title：Hippocampus

authors： Muller D,Toni N,Buchs PA

更新日期：2000-01-01 00:00:00

abstract：:Place and grid cells in the hippocampal formation are commonly thought to support a unified and coherent cognitive map of space. This mapping mechanism faces a challenge when a navigator is placed in a familiar environment that has been deformed from its original shape. Under such circumstances, many transformations c...

journal_title：Hippocampus

authors： Keinath AT,Rechnitz O,Balasubramanian V,Epstein RA

更新日期：2021-01-01 00:00:00

abstract：:LTD of synaptic transmission is a form of long-term synaptic plasticity with the potential to be as significant as LTP to both the activity-dependent development of neural circuitry and adult memory storage. In addition, interactions between LTP and LTD and the dynamic regulation of the gain of synaptic plasticity mec...

journal_title：Hippocampus

authors： Stanton PK

更新日期：1996-01-01 00:00:00

abstract：:Spike-timing-dependent long-term potentiation (LTP) and long-term depression (LTD) were investigated in the CA1 area of hippocampal slices using optical imaging. A pair of electrical pulses were used to stimulate the Schaffer-commissural collateral and the stratum oriens with various sets of relative timing (tau) betw...

journal_title：Hippocampus

authors： Tsukada M,Aihara T,Kobayashi Y,Shimazaki H

更新日期：2005-01-01 00:00:00

abstract：:A striking similarity has been suggested between past and future thinking in Alzheimer's Disease (AD), a similarity attributable to abnormalities in common modular cognitive functions and neuroanatomical substrates. This study extends this literature by identifying specific executive function deficits underlying past ...

journal_title：Hippocampus

authors： El Haj M,Antoine P,Kapogiannis D

更新日期：2015-11-01 00:00:00

abstract：:To investigate involvement of the hippocampal formation in spatial information processing, activity of neurons in the hippocampal formation of the conscious monkey was recorded during presentation of various visual and auditory stimuli from several directions around the monkey. Of 1,047 neurons recorded, 106 (10.1%) r...

journal_title：Hippocampus

authors： Tamura R,Ono T,Fukuda M,Nakamura K

更新日期：1992-07-01 00:00:00

abstract：:Converging behavioral, electrophysiological, and neurochemical data suggest that lesions to the peripheral vestibular system result in impairment of the hippocampus. Nonetheless, relatively few studies have examined the hippocampus or behavior related to it, over a long period of time following the lesion, to determin...

journal_title：Hippocampus

authors： Zheng Y,Goddard M,Darlington CL,Smith PF

更新日期：2007-01-01 00:00:00

abstract：:Watermaze tests of place learning and memory in rodents and corresponding reverse-translated human paradigms in real or virtual environments are key tools to study hippocampal function. In common variants, the animal or human participant has to find a hidden goal that remains in the same place over many trials, allowi...

journal_title：Hippocampus

authors： Buckley MG,Bast T

更新日期：2018-11-01 00:00:00