Abstract:
:Increased consumption of high-fat diet (HFD) leads to obesity and adverse neurocognitive outcomes. Childhood and adolescence are important periods of brain maturation shaping cognitive function. These periods could consequently be particularly sensitive to the detrimental effects of HFD intake. In mice, juvenile and adulthood consumption of HFD induce similar morphometric and metabolic changes. However, only juvenile exposure to HFD abolishes relational memory flexibility, assessed after initial radial-maze concurrent spatial discrimination learning, and decreases neurogenesis. Our results identify a critical period of development covering adolescence with higher sensitivity to HFD-induced hippocampal dysfunction at both behavioral and cellular levels.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Boitard C,Etchamendy N,Sauvant J,Aubert A,Tronel S,Marighetto A,Layé S,Ferreira Gdoi
10.1002/hipo.22032subject
Has Abstractpub_date
2012-11-01 00:00:00pages
2095-100issue
11eissn
1050-9631issn
1098-1063journal_volume
22pub_type
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