Bilateral vestibular deafferentation impairs performance in a spatial forced alternation task in rats.

abstract：:Thrombin and other clotting factors regulate long-term potentiation (LTP) in the hippocampus through the activation of the protease activated receptor 1 (PAR1) and consequent potentiation of N-methyl-d-aspartate receptor (NMDAR) functions. We have recently shown that the activation of PAR1 either by thrombin or the an...

journal_title：Hippocampus

authors： Maggio N,Itsekson Z,Ikenberg B,Strehl A,Vlachos A,Blatt I,Tanne D,Chapman J

更新日期：2014-08-01 00:00:00

abstract：:Temporal difference learning (TD) is a popular algorithm in machine learning. Two learning signals that are derived from this algorithm, the predictive value and the prediction error, have been shown to explain changes in neural activity and behavior during learning across species. Here, the predictive value signal is...

journal_title：Hippocampus

authors： Okatan M

更新日期：2009-05-01 00:00:00

abstract：:As part of an earlier experiment (Kwok and Buckley, 2009), six macaque monkeys (three with fornix transection and three unoperated controls) were trained postoperatively to discriminate a total of 104 new concurrent visuospatial conditional problems to criterion. Our experiment measured and compared long-term retentio...

journal_title：Hippocampus

authors： Kwok SC,Buckley MJ

更新日期：2010-08-01 00:00:00

abstract：:Neural correlates of spatial representation can be found in the activity of the hippocampal place cells. These neurons are characterized by firing whenever the animal is located in a particular area of the space, the place field. Place fields are modulated by sensory cues, such as visual, auditory, or olfactory cues, ...

journal_title：Hippocampus

authors： Gener T,Perez-Mendez L,Sanchez-Vives MV

更新日期：2013-12-01 00:00:00

abstract：:Adult neurogenesis in the dentate gyrus (DG) plays a crucial role for pattern separation, and there are sex differences in the regulation of neurogenesis. Although sex differences, favoring males, in spatial navigation have been reported, it is not known whether there are sex differences in pattern separation. The cur...

journal_title：Hippocampus

authors： Yagi S,Chow C,Lieblich SE,Galea LA

更新日期：2016-01-01 00:00:00

abstract：:Multiple factors are involved in the glutamate-induced excitotoxicity phenomenon, such as overload of ionotropic and metabotropic receptors, excess Ca(2+) influx, nitric oxide synthase activation, oxidative damage due to increase in free radicals, and release of endogenous polyamine, among others. In order to attempt ...

journal_title：Hippocampus

authors： Ortuño-Sahagún D,Rivera-Cervantes MC,Gudiño-Cabrera G,Junyent F,Verdaguer E,Auladell C,Pallàs M,Camins A,Beas-Zárate C

更新日期：2012-02-01 00:00:00

abstract：:Rats use time-of-day cues to modulate learned taste aversion memories. If adult rats are accustomed to drinking saline in the evening and they receive a lithium chloride injection after drinking saline in the morning, they form a stronger aversion to saline than rats that were conditioned after drinking saline at the ...

journal_title：Hippocampus

authors： Manrique T,Morón I,Ballesteros MA,Guerrero RM,Fenton AA,Gallo M

更新日期：2009-01-01 00:00:00

abstract：:A little over 20 years ago, (Teyler and DiScenna,1986; Behav Neurosci 100:147-152) proposed the hippocampal memory index theory. It offered an account of episodic memory based on the intrinsic organization of the hippocampus, its synaptic physiology and its anatomical relationship to other regions of the brain. The es...

journal_title：Hippocampus

authors： Teyler TJ,Rudy JW

更新日期：2007-01-01 00:00:00

abstract：:The vestibular system contributes to the performance of various spatial memory tasks, but few studies have attempted to disambiguate the roles of the semicircular canals and otolith organs in this performance. This study tested the otolithic contribution to spatial working and reference memory by evaluating the perfor...

journal_title：Hippocampus

authors： Yoder RM,Kirby SL

更新日期：2014-10-01 00:00:00

abstract：:Both natural and synthetic cannabinoid receptor (e.g., CB1) agonists such as Δ(9)-THC, WIN 55,212-2 (WIN-2), and HU-210 disrupt spatial cognition presumably through the inhibition of synchrony of hippocampal ensemble firing to task-related events. Although the CB1 receptor agonist CP 55,940 also disrupts the synchrono...

journal_title：Hippocampus

authors： Goonawardena AV,Riedel G,Hampson RE

更新日期：2011-05-01 00:00:00

abstract：:The rodent hippocampus expresses a variety of neuronal network oscillations depending on the behavioral state of the animal. Locomotion and active exploration are accompanied by theta-nested gamma oscillations while resting states and slow-wave sleep are dominated by intermittent sharp wave-ripple complexes. It is bel...

journal_title：Hippocampus

authors： Geschwill P,Kaiser ME,Grube P,Lehmann N,Thome C,Draguhn A,Hollnagel JO,Both M

更新日期：2020-10-01 00:00:00

abstract：:Once thought to produce global, nonspecific brain injury, drugs of abuse are now known to produce selective neuro-adaptations in particular brain regions. These neuro-adaptations are being closely examined for clues to the development, maintenance, and treatment of addiction. The hippocampus is an area of particular i...

journal_title：Hippocampus

authors： Eisch AJ,Harburg GC

更新日期：2006-01-01 00:00:00

abstract：:Unilateral injection of kainic acid (KA) into the dorsal hippocampus of adult mice induces spontaneous recurrent partial seizures and replicates histopathological changes observed in human mesial temporal lobe epilepsy (MTLE) (Bouilleret V et al., Neuroscience 1999; 89:717-729). Alterations in pre- and postsynaptic co...

journal_title：Hippocampus

authors： Bouilleret V,Loup F,Kiener T,Marescaux C,Fritschy JM

更新日期：2000-01-01 00:00:00

abstract：:Previous attempts to elucidate whether a loss of hippocampal synapses occurs during aging provided conflicting results, possibly due to the unavailability, at the time, of unbiased methods for synapse quantitation. This study was designed to reexamine the issue by means of modern technical procedures that provide unbi...

journal_title：Hippocampus

authors： Geinisman Y,deToledo-Morrell L,Morrell F,Persina IS,Rossi M

更新日期：1992-10-01 00:00:00

abstract：:Paired-pulse depression (PPD), a short-term neural plasticity, was studied in hippocampal CA1 of urethane-anesthetized rats in vivo, using field potential recordings and current source density analysis. PPD was robust when an ipsilateral CA3 (iCA3) conditioning pulse of moderate stimulus intensity was followed 30-200 ...

journal_title：Hippocampus

authors： Leung LS,Peloquin P,Canning KJ

更新日期：2008-01-01 00:00:00

abstract：:The modulatory actions of GABA(A) receptor subunits are crucial for morphological and transcriptional neuronal activities. In this study, growth of hamster hippocampal neurons on biohybrid membrane substrates allowed us to show for the first time that the two major GABA(A) alpha receptor subunits (alpha(2,5)) are capa...

journal_title：Hippocampus

authors： Giusi G,Facciolo RM,Rende M,Alò R,Di Vito A,Salerno S,Morelli S,De Bartolo L,Drioli E,Canonaco M

更新日期：2009-11-01 00:00:00

abstract：:To ask if the properties of spatial learning supported by the hippocampus are distinct from the properties of conditioning, we conducted a blocking-like experiment in which the measured variable was not a conditioned response but rather the ability of a novel visual stimulus to control the location of place cell firin...

journal_title：Hippocampus

authors： Barry J,Muller R

更新日期：2011-05-01 00:00:00

abstract：:Metabolic integrity of glial cells in field CA1 of the guinea pig hippocampus is critical to maintenance of synaptic transmission (Keyser and Pellmar [1994] Glia 10:237-243). To determine if this tight glial-neuronal coupling is equally important in other brain regions, we compared the effect of fluoroacetate (FAC), a...

journal_title：Hippocampus

authors： Keyser DO,Pellmar TC

更新日期：1997-01-01 00:00:00

abstract：:Aging has been associated with a decline in relational memory, which is critically supported by the hippocampus. By adapting the transitivity paradigm (Bunsey and Eichenbaum (1996) Nature 379:255-257), which traditionally has been used in nonhuman animal research, this work examined the extent to which aging is accomp...

journal_title：Hippocampus

authors： Ryan JD,D'Angelo MC,Kamino D,Ostreicher M,Moses SN,Rosenbaum RS

更新日期：2016-02-01 00:00:00

abstract：:We investigated the effects of a surgical lesion of one vestibular inner ear (unilateral vestibular damage [UVD]) on the field potential responses of CA1 neurons in vitro. Hippocampal slices were removed from rats at 4-6 weeks or 5-6 months post-UVD, and the field responses of CA1 neurons to electrical stimulation of ...

journal_title：Hippocampus

authors： Zheng Y,Kerr DS,Darlington CL,Smith PF

更新日期：2003-01-01 00:00:00

abstract：:Although a large body of evidence indicates that sleep plays an important role in learning and memory processes, the actual existence of a sleep-dependent spatial memory consolidation has been not firmly established. Here, by using a computerized 3D virtual navigation tool, we were able to show that topographical orie...

journal_title：Hippocampus

authors： Ferrara M,Iaria G,Tempesta D,Curcio G,Moroni F,Marzano C,De Gennaro L,Pacitti C

更新日期：2008-01-01 00:00:00

abstract：:Although there are many types of epilepsy, temporal lobe epilepsy (TLE) is probably in humans the most common and most often studied. TLE represents 40% of the total epilepsy form of the disease and is difficult to treat. Despite a wealth of descriptive data obtained from the disease history of patients, the EEG recor...

journal_title：Hippocampus

authors： Mériaux C,Franck J,Park DB,Quanico J,Kim YH,Chung CK,Park YM,Steinbusch H,Salzet M,Fournier I

更新日期：2014-06-01 00:00:00

abstract：:Neuregulins (NRGs) are ligands of ErbB receptor tyrosine kinases. The NRG1-ErbB4 pathway has been shown to modulate hippocampal synaptic plasticity and network oscillations in the adult rodent brain. To identify cells that mediate these effects, here we determine the expression pattern of ErbB4 in four functionally di...

journal_title：Hippocampus

authors： Neddens J,Buonanno A

更新日期：2010-06-01 00:00:00

abstract：:Schizophrenia is a devastating psychiatric illness with a complex pathophysiology. We have recently documented schizophrenia-like endophenotypes in phospholipase C-β1 knockout (PLC-β1(-/-)) mice, including deficits in prepulse inhibition, hyperlocomotion, and cognitive impairments. PLC-β1 signals via multiple G-protei...

journal_title：Hippocampus

authors： Manning EE,Ransome MI,Burrows EL,Hannan AJ

更新日期：2012-02-01 00:00:00

abstract：:The electrophysiological properties of neurons in the rat perirhinal cortex were analyzed with intracellular recordings in an in vitro slice preparation. Cells included in this study (n = 59) had resting membrane potential (RMP) = -73.9 +/- 8.5 mV (mean +/- SD), action potential amplitude = 95.5 +/- 10.4 mV, input res...

journal_title：Hippocampus

authors： D'Antuono M,Biagini G,Tancredi V,Avoli M

更新日期：2001-01-01 00:00:00

abstract：:The locomotor effects of intra-NAcc injection of dopamine receptor agonists following discrete lesion or inhibition of the DH or the VH have been poorly investigated using only the indirect dopamine receptor agonist amphetamine. In the present study, we investigated how lidocaine in the DH or the VH modulated hyperloc...

journal_title：Hippocampus

authors： Rouillon C,Abraini JH,David HN

更新日期：2007-01-01 00:00:00

abstract：:Our lives are a continuous stream of experience. Our episodic memories on the other hand have a definitive beginning, middle, and end. Theories of event segmentation suggest that salient changes in our environment produce event boundaries which partition the past from the present and, as a result, produce discretized ...

journal_title：Hippocampus

authors： Griffiths BJ,Fuentemilla L

更新日期：2020-02-01 00:00:00

abstract：:It is well documented that place cells and grid cells in echolocating bats show properties similar to those described in rodents, and yet, continuous theta-frequency oscillations, proposed to play a central role in grid/place cell formation, are not present in bat recordings. These comparative neurophysiological data ...

journal_title：Hippocampus

authors： Horiuchi TK,Moss CF

更新日期：2015-12-01 00:00:00

abstract：:Place and grid cells in the hippocampal formation are commonly thought to support a unified and coherent cognitive map of space. This mapping mechanism faces a challenge when a navigator is placed in a familiar environment that has been deformed from its original shape. Under such circumstances, many transformations c...

journal_title：Hippocampus

authors： Keinath AT,Rechnitz O,Balasubramanian V,Epstein RA

更新日期：2021-01-01 00:00:00

abstract：:Functional differences in the anterior and posterior hippocampus during episodic memory processing have not been examined in human electrophysiological data. This is in spite of strong evidence for such differences in rodent data, including greater place cell specificity in the dorsal hippocampus, greater sensitivity ...

journal_title：Hippocampus

authors： Lin JJ,Rugg MD,Das S,Stein J,Rizzuto DS,Kahana MJ,Lega BC

更新日期：2017-10-01 00:00:00