Unilateral inner ear damage results in lasting changes in hippocampal CA1 field potentials in vitro.

abstract：:A little over 20 years ago, (Teyler and DiScenna,1986; Behav Neurosci 100:147-152) proposed the hippocampal memory index theory. It offered an account of episodic memory based on the intrinsic organization of the hippocampus, its synaptic physiology and its anatomical relationship to other regions of the brain. The es...

journal_title：Hippocampus

authors： Teyler TJ,Rudy JW

更新日期：2007-01-01 00:00:00

abstract：:Neurons in the supramammillary nucleus (SUM) of urethane-anesthetized rats fire rhythmically in synchrony with hippocampal theta rhythm. As these neurons project to the septum and hippocampus, it is generally assumed that their role is to mediate ascending activation, leading to the hippocampal theta rhythm. However, ...

journal_title：Hippocampus

authors： Kocsis B,Kaminski M

更新日期：2006-01-01 00:00:00

abstract：:Granule cells born in the adult dentate gyrus undergo a 4-week developmental period characterized by high susceptibility to cell death. Two forms of hippocampus-dependent learning have been shown to rescue many of the new neurons during this critical period. Here, we show that a natural form of associative learning, s...

journal_title：Hippocampus

authors： Olariu A,Cleaver KM,Shore LE,Brewer MD,Cameron HA

更新日期：2005-01-01 00:00:00

abstract：:Rats use time-of-day cues to modulate learned taste aversion memories. If adult rats are accustomed to drinking saline in the evening and they receive a lithium chloride injection after drinking saline in the morning, they form a stronger aversion to saline than rats that were conditioned after drinking saline at the ...

journal_title：Hippocampus

authors： Manrique T,Morón I,Ballesteros MA,Guerrero RM,Fenton AA,Gallo M

更新日期：2009-01-01 00:00:00

abstract：:The mechanism supporting the role of the hippocampal formation in novelty detection remains controversial. A comparator function has been variously ascribed to CA1 or subiculum, whereas the theta rhythm has been suggested to separate neural firing into encoding and retrieval phases. We investigated theta phase of firi...

journal_title：Hippocampus

authors： Lever C,Burton S,Jeewajee A,Wills TJ,Cacucci F,Burgess N,O'Keefe J

更新日期：2010-02-01 00:00:00

abstract：:Two patients, with magnetic resonance imaging (MRI)-confirmed relatively selective hippocampal damage, showed distinct patterns of performance on tests of recall, item recognition, and associative recognition. Patient AC showed a mean bilateral volume reduction of the hippocampus of 28%, but displayed no memory defici...

journal_title：Hippocampus

authors： Holdstock JS,Parslow DM,Morris RG,Fleminger S,Abrahams S,Denby C,Montaldi D,Mayes AR

更新日期：2008-01-01 00:00:00

abstract：:The present study has investigated the role of ATP in the induction of synaptic plasticity, using local application of ATP by picopump administration into the stratum radiatum of guinea pig hippocampal region CA1. Excitatory postsynaptic currents (EPSCs) evoked by stimulation of Schaffer collateral/commissural afferen...

journal_title：Hippocampus

authors： Yamazaki Y,Kaneko K,Fujii S,Kato H,Ito K

更新日期：2003-01-01 00:00:00

abstract：:Short periods of forced exercise have been reported to selectively induce enhancements in hippocampal-dependent cognitive function, possibly via brain-derived neurotrophic factor (BDNF)-mediated mechanisms. In this study, we report that 1 week of treadmill running significantly enhanced both object displacement (spati...

journal_title：Hippocampus

authors： Griffin EW,Bechara RG,Birch AM,Kelly AM

更新日期：2009-10-01 00:00:00

abstract：:Nuclear factor-kappa B (NFκB) signal is essential for neuronal survival and its activation may protect neuron against various stimuli. Since purinergic signals activate NFκB through the P2X7 receptor, we investigated the distinct pattern of NF-κB phosphorylation in neurons by P2X7 receptor activation following status ...

journal_title：Hippocampus

authors： Kim JE,Kim DS,Jin Ryu H,Il Kim W,Kim MJ,Won Kim D,Young Choi S,Kang TC

更新日期：2013-06-01 00:00:00

abstract：:L-aspartate is the amino-acid residue most susceptible to spontaneous isomerization. This denaturation causes an alteration in the biological activity of the protein and is regarded as an aging process of the protein. Protein L-isoaspartyl methyltransferase (PIMT) repairs this post-translational modification and thus ...

journal_title：Hippocampus

authors： Ikegaya Y,Yamada M,Fukuda T,Kuroyanagi H,Shirasawa T,Nishiyama N

更新日期：2001-01-01 00:00:00

abstract：:In this review, we aim to reappraise the organization of intrinsic and extrinsic networks of the entorhinal cortex with a focus on the concept of parallel cortical connectivity streams. The concept of two entorhinal areas, the lateral and medial entorhinal cortex, belonging to two parallel input-output streams mediati...

journal_title：Hippocampus

authors： Nilssen ES,Doan TP,Nigro MJ,Ohara S,Witter MP

更新日期：2019-12-01 00:00:00

abstract：:Although the importance of cAMP-response element binding protein (CREB) phosphorylation in long-term memory formation is well documented for hippocampus-dependent tasks, little is known about the changes in phosphorylated CREB (pCREB) that occur during the process of extinction. The purpose of this study was to charac...

journal_title：Hippocampus

authors： Porte Y,Trifilieff P,Wolff M,Micheau J,Buhot MC,Mons N

更新日期：2011-11-01 00:00:00

abstract：:The present study evaluated the effects of a single intrahippocampal administration of brain-derived neurotrophic factor (BDNF) on memory retention in a water maze. Adult rats were trained in a water maze (acquisition phase, day 1). Immediately after the last training trial subjects were injected in the right hippocam...

journal_title：Hippocampus

authors： Cirulli F,Berry A,Chiarotti F,Alleva E

更新日期：2004-01-01 00:00:00

abstract：:Sleep is important for memory consolidation, and an abundant literature suggests that reactivation in the hippocampus during sleep is instrumental to this process. Yet, the current interpretation of activity during sharp-waves ripples (SWRs), as replay of wake experiences, relies on hypotheses that, while widely accep...

journal_title：Hippocampus

authors： Laventure S,Benchenane K

更新日期：2020-01-01 00:00:00

abstract：:The hippocampus receives robust serotonergic innervation that is thought to control the excitability of both pyramidal cells and GABAergic interneurons. Previous work has addressed serotonergic regulation of pyramidal cells but considerable gaps remain in our understanding of how serotonin regulates different interneu...

journal_title：Hippocampus

authors： Wyskiel DR,Andrade R

更新日期：2016-09-01 00:00:00

abstract：:The importance of the perirhinal cortex for visual recognition memory performance is undisputed. However, it has not been clear whether its contribution to performance is mainly perceptual, or mainly mnemonic, or whether the perirhinal cortex contributes to both perception and memory. We determined the effects of medi...

journal_title：Hippocampus

authors： Buffalo EA,Reber PJ,Squire LR

更新日期：1998-01-01 00:00:00

abstract：:The mechanisms of Ca2+ responses evoked in hippocampal glial cells in situ, by local application of glutamate and by synaptic activation, were studied in slices from juvenile rats using the membrane permeant fluorescent Ca2+ indicator fluo-3AM and confocal microscopy. Ca2+ responses induced by local application of glu...

journal_title：Hippocampus

authors： Latour I,Gee CE,Robitaille R,Lacaille JC

更新日期：2001-01-01 00:00:00

abstract：:Episodic memory improves during childhood and this improvement has been associated with age differences in hippocampal function, but previous research has not manipulated the possible underlying mechanisms. We tested the hypothesis that age-related differences in hippocampal activation may reflect changes in retrieval...

journal_title：Hippocampus

authors： DeMaster D,Coughlin C,Ghetti S

更新日期：2016-04-01 00:00:00

abstract：:One functional aspect of theta oscillations that recent studies have begun to explore in humans is their role for the recollection of personal events. A specific role of theta for recollection but not for stimulus-familiarity would support links between cortical theta oscillations and hippocampal functioning, given th...

journal_title：Hippocampus

authors： Guderian S,Düzel E

更新日期：2005-01-01 00:00:00

abstract：:Our lives are a continuous stream of experience. Our episodic memories on the other hand have a definitive beginning, middle, and end. Theories of event segmentation suggest that salient changes in our environment produce event boundaries which partition the past from the present and, as a result, produce discretized ...

journal_title：Hippocampus

authors： Griffiths BJ,Fuentemilla L

更新日期：2020-02-01 00:00:00

abstract：:Ontogenesis of GABAergic signaling may play an important role in developmental changes in seizure susceptibility in the high-potassium model of ictogenesis in vitro. The age-dependent effects of [K(+)](o) on the reversal potential of the GABA(A)-mediated responses and membrane potential in hippocampal slices in vitro ...

journal_title：Hippocampus

authors： Isaev D,Isaeva E,Khazipov R,Holmes GL

更新日期：2007-01-01 00:00:00

abstract：:Neuropsychologists have clearly implicated the hippocampus in the consolidation of memory, particularly episodic memory, the mental replay of past experiences. When recorded from behaving animals, by far the most obvious firing pattern of the primary neurons of the hippocampus is the place field: a cell tends to fire ...

journal_title：Hippocampus

authors： Kentros C

更新日期：2006-01-01 00:00:00

abstract：:In a comparative approach, the anatomical organization of the hippocampus was investigated in two species of megachiropteran bats, the grey-headed flying fox, Pteropus poliocephalus, and the little red flying fox, Pteropus scapulatus. In general, the cytoarchitectonic appearance of the flying fox hippocampus correspon...

journal_title：Hippocampus

authors： Buhl EH,Dann JF

更新日期：1991-04-01 00:00:00

abstract：:Short-term memory was assessed in two groups of amnesic patients. Six patients had confirmed or suspected damage to the hippocampal formation, and six patients had diencephalic damage as a result of alcoholic Korsakoff's syndrome. Verbal short-term memory was evaluated with seven separate administrations of the standa...

journal_title：Hippocampus

authors： Cave CB,Squire LR

更新日期：1992-04-01 00:00:00

abstract：:We have previously shown that exposing rats to a relatively high dose of ethanol during early postnatal life can result in an alteration in spatial learning ability. The hippocampal formation is known to be involved in the control of this ability. The purpose of the present study was to determine whether exposure of r...

journal_title：Hippocampus

authors： Miki T,Harris SJ,Wilce PA,Takeuchi Y,Bedi KS

更新日期：2004-01-01 00:00:00

abstract：:Our previous study showed that kainate (KA) receptor subunit GluR6 played an important role in ischemia-induced MLK3 and JNK activation and neuronal degeneration through the GluR6-PSD95-MLK3 signaling module. However, whether the KA receptors subunit GluR6 is involved in the activation of p38 MAP kinase during the tra...

journal_title：Hippocampus

authors： Chen J,Li C,Pei DS,Han D,Liu XM,Jiang HX,Wang XT,Guan QH,Wen XR,Hou XY,Zhang GY

更新日期：2009-01-01 00:00:00

abstract：:Structures in the caudal diencephalon including the posterior hypothalamic nucleus, the supramammillary nucleus (SUM) and the nuclei of the mammillary body (MB) occupy a strategic position in the crossroads of ascending and descending traffic between the brainstem and the limbic forebrain (septum/hippocampus). In this...

journal_title：Hippocampus

authors： Kocsis B,Vertes RP

更新日期：1997-01-01 00:00:00

abstract：:Wnt proteins have emerged as transmembrane signaling molecules that regulate learning and memory as well as synaptic plasticity at central synapses (Inestrosa and Arenas (2010) Nat Rev Neurosci 11:77-86; Maguschak and Ressler (2011) J Neurosci 31:13057-13067; Tabatadze et al. (2012) Hippocampus 22: 1228-1241; Fortress...

journal_title：Hippocampus

authors： Tabatadze N,McGonigal R,Neve RL,Routtenberg A

更新日期：2014-04-01 00:00:00

abstract：:Individual variation in the attribution of motivational salience to reward-related cues is believed to underlie addiction vulnerability. Pavlovian conditioned approach measures individual variation in motivational salience by identifying rats that are attracted to and motivated by reward cues (sign-trackers) or motiva...

journal_title：Hippocampus

authors： Fitzpatrick CJ,Creeden JF,Perrine SA,Morrow JD

更新日期：2016-11-01 00:00:00

abstract：:Previous work has shown that immunohistochemical imaging of Fos protein is a reliable marker for changes in activity related to recognition memory in the perirhinal (PRH) cortex of the medial temporal lobe; however, whether PRH Fos expression is necessary for recognition memory had not been established. To investigate...

journal_title：Hippocampus

authors： Seoane A,Tinsley CJ,Brown MW

更新日期：2012-11-01 00:00:00