Abstract:
:The present study evaluated the effects of a single intrahippocampal administration of brain-derived neurotrophic factor (BDNF) on memory retention in a water maze. Adult rats were trained in a water maze (acquisition phase, day 1). Immediately after the last training trial subjects were injected in the right hippocampus with either BDNF (24 microg) or phosphate-buffered saline (1 microl). On day 2, all subjects were tested for memory retention in a probe trial and were subsequently tested for reversal learning. While no differences emerged in the probe trial, BDNF-treated subjects showed a shorter latency and a shorter path length to reach the platform during the reversal phase. A significant difference in their "turn angle" and in their swim paths suggests that they might have used a different search strategy compared with controls. Moreover, all subjects also underwent an elevated-plus maze test. BDNF-treated-animals showed a clear tendency to spend a greater amount of time in the open arms and a significantly higher frequency of grooming behavior and of the stretched-attend posture in this maze area, but no differences in locomotion. Overall, these results indicate that administration of BDNF improves performance in a spatial memory task and has enduring effects on emotional behavior.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Cirulli F,Berry A,Chiarotti F,Alleva Edoi
10.1002/hipo.10220keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
802-7issue
7eissn
1050-9631issn
1098-1063journal_volume
14pub_type
杂志文章相关文献
HIPPOCAMPUS文献大全abstract::Granule cells with recurrent basal dendrites (RBDs) were previously reported in both control and epileptic rats. RBDs are dendrites that arise from the basal half of granule cell bodies and curve toward and extend into the molecular layer. They are increased in frequency in the pilocarpine model of epilepsy. The prese...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.1114
更新日期:2002-01-01 00:00:00
abstract::In this article, we present a framework to perform statistical shape analysis for segmented hippocampi, including an efficient permutation test for detecting subtle class differences, and a regularized discriminative direction method for visualizing the shape discrepancy. Fisher permutation and bootstrap tests are pre...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20639
更新日期:2009-06-01 00:00:00
abstract::The hippocampus receives two streams of information, spatial and nonspatial, via major afferent inputs from the medial (MEC) and lateral entorhinal cortexes (LEC). The MEC and LEC projections in the temporoammonic pathway are topographically organized along the transverse-axis of area CA1. The potential for functional...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20909
更新日期:2012-02-01 00:00:00
abstract::The multifactorial causes impacting the risk of developing sporadic forms of Alzheimer's disease (AD) remain to date poorly understood. Epidemiologic studies in humans and research in rodents have suggested that hypothyroidism could participate in the etiology of AD. Recently, we reported that adult-onset hypothyroidi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22319
更新日期:2014-11-01 00:00:00
abstract::We have previously shown that, in HEK 293 cells, overexpression of acidic calponin, an actin-binding protein, induces remodeling of actin filaments, leading to a change in cell morphology. In addition, this protein is found in dendritic spines of adult hippocampal neurons. We hypothesized that this protein plays a rol...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10136
更新日期:2003-01-01 00:00:00
abstract::One functional aspect of theta oscillations that recent studies have begun to explore in humans is their role for the recollection of personal events. A specific role of theta for recollection but not for stimulus-familiarity would support links between cortical theta oscillations and hippocampal functioning, given th...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20125
更新日期:2005-01-01 00:00:00
abstract::Learning and memory can be controlled by distinct memory systems. How these systems are coordinated to optimize learning and behavior has long been unclear. Accumulating evidence indicates that stress may modulate the engagement of multiple memory systems. In particular, rodent and human studies demonstrate that stres...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.22175
更新日期:2013-11-01 00:00:00
abstract::Individuals with schizophrenia display a number of structural and cytoarchitectural alterations in the hippocampus, suggesting that other functions such as synaptic plasticity may also be modified. Altered hippocampal plasticity is likely to affect memory processing, and therefore any such pathology may contribute to ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22193
更新日期:2013-12-01 00:00:00
abstract::The selective lesion of basal forebrain cholinergic neurons (BFCNs) is an unestimable tool to study the implication of these neurons in cognition, an interest widely motivated by their degeneration in Alzheimer's disease. Here we evaluated the histochemical and behavioral effects of a selective lesion of BFCNs in C57B...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20422
更新日期:2008-01-01 00:00:00
abstract::It is well established that aging is associated with declines in episodic memory. In recent years, an emphasis has emerged on the development of behavioral tasks and the identification of biomarkers that are predictive of cognitive decline in healthy as well as pathological aging. Here, we describe a memory task desig...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22224
更新日期:2014-03-01 00:00:00
abstract::As part of an earlier experiment (Kwok and Buckley, 2009), six macaque monkeys (three with fornix transection and three unoperated controls) were trained postoperatively to discriminate a total of 104 new concurrent visuospatial conditional problems to criterion. Our experiment measured and compared long-term retentio...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20733
更新日期:2010-08-01 00:00:00
abstract::The entorhinal cortex has long been recognized as an important interface between the hippocampal formation and the neocortex. The notion of bidirectional connections between the entorhinal cortex and the hippocampal formation have led to the suggestion that hippocampal output originating in CA1 and subiculum may reent...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20022
更新日期:2004-01-01 00:00:00
abstract::Although there are many types of epilepsy, temporal lobe epilepsy (TLE) is probably in humans the most common and most often studied. TLE represents 40% of the total epilepsy form of the disease and is difficult to treat. Despite a wealth of descriptive data obtained from the disease history of patients, the EEG recor...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22246
更新日期:2014-06-01 00:00:00
abstract::In contextual fear conditioning (CFC), the use of pharmacological and lesion approaches has helped to understand that there are differential roles for the dorsal hippocampus (DH) and the ventral hippocampus (VH) in the acquisition, consolidation and retrieval phases. Concomitant analysis of the DH and the VH in indivi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22470
更新日期:2015-12-01 00:00:00
abstract::The hippocampal formation plays a role in mnemonic tasks and epileptic discharges in vivo. In vitro, these functions and malfunctions may relate to persistent firing (PF) and depolarization block (DB), respectively. Pyramidal neurons of the CA1 field have previously been reported to engage in either PF or DB during ch...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23078
更新日期:2019-09-01 00:00:00
abstract::Neuropsychological analyses of amnesic patients, as well as lesion experiments, indicate that the temporal lobe is essential for the encoding, storage, and expression of object recognition memory (ORM). However, temporal lobe structures directly involved in the consolidation and reconsolidation of these memories are n...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20669
更新日期:2010-05-01 00:00:00
abstract::Short-term memory was assessed in two groups of amnesic patients. Six patients had confirmed or suspected damage to the hippocampal formation, and six patients had diencephalic damage as a result of alcoholic Korsakoff's syndrome. Verbal short-term memory was evaluated with seven separate administrations of the standa...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450020207
更新日期:1992-04-01 00:00:00
abstract::Neuropsychologists have clearly implicated the hippocampus in the consolidation of memory, particularly episodic memory, the mental replay of past experiences. When recorded from behaving animals, by far the most obvious firing pattern of the primary neurons of the hippocampus is the place field: a cell tends to fire ...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.20199
更新日期:2006-01-01 00:00:00
abstract::To study the possible involvement of the hippocampus in learned conditional responding, rats with aspiration lesions of the hippocampus and others that had the hippocampus removed with ibotenic acid were trained on concurrent Pavlovian conditional and nonconditional discriminations. In agreement with the results repor...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450010110
更新日期:1991-01-01 00:00:00
abstract::Stratum lacunosum-moleculare interneurons (L-Mi) in hippocampal area CA3 target the apical dendrite of pyramidal cells providing feedforward inhibition. Here we report that selective activation of group III metabotropic glutamate receptors (mGluRs) 4/8 with L(+)-2-amino-4-phosphnobytyric acid (L-AP4; 10 μM) decreased ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20842
更新日期:2011-12-01 00:00:00
abstract::Cocaine induces an increase in hippocampal and nucleus accumbens (Nac) serotonin (5-HT) concentration parallel to locomotor activation. Both effects can be modulated by systemic 5-HT(1A)-receptor agonism/antagonism. Given the contribution of the hippocampus to spontaneous behavioral activity, these observations sugges...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10209
更新日期:2004-01-01 00:00:00
abstract::Our model of the spatial and temporal aspects of place cell firing and their role in rat navigation is reviewed. The model provides a candidate mechanism, at the level of individual cells, by which place cell information concerning self-localization could be used to guide navigation to previously visited reward sites....
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1996)6:6<749::AID-HIPO16>3
更新日期:1996-01-01 00:00:00
abstract::Episodic memory deficits are evident in late-life depression (LLD) and are associated with subtle synaptic and neurochemical changes in the medial temporal lobes (MTL). However, the particular mechanisms by which memory impairment occurs in LLD are currently unknown. We tested older adults with (DS+) and without (DS-)...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22705
更新日期:2017-04-01 00:00:00
abstract::The importance of the perirhinal cortex for visual recognition memory performance is undisputed. However, it has not been clear whether its contribution to performance is mainly perceptual, or mainly mnemonic, or whether the perirhinal cortex contributes to both perception and memory. We determined the effects of medi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1998)8:4<330::AID-HIPO3>3.
更新日期:1998-01-01 00:00:00
abstract::Temporal difference learning (TD) is a popular algorithm in machine learning. Two learning signals that are derived from this algorithm, the predictive value and the prediction error, have been shown to explain changes in neural activity and behavior during learning across species. Here, the predictive value signal is...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20535
更新日期:2009-05-01 00:00:00
abstract::Two patients, with magnetic resonance imaging (MRI)-confirmed relatively selective hippocampal damage, showed distinct patterns of performance on tests of recall, item recognition, and associative recognition. Patient AC showed a mean bilateral volume reduction of the hippocampus of 28%, but displayed no memory defici...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20427
更新日期:2008-01-01 00:00:00
abstract::Hippocampal neurogenesis declines substantially in chronic temporal lobe epilepsy (TLE). However, it is unclear whether this decline is linked to altered production of new cells and/or diminished survival and neuronal fate-choice decision of newly born cells. We quantified different components of hippocampal neurogene...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20594
更新日期:2010-01-01 00:00:00
abstract::We investigated the effects of a surgical lesion of one vestibular inner ear (unilateral vestibular damage [UVD]) on the field potential responses of CA1 neurons in vitro. Hippocampal slices were removed from rats at 4-6 weeks or 5-6 months post-UVD, and the field responses of CA1 neurons to electrical stimulation of ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10174
更新日期:2003-01-01 00:00:00
abstract::Rats were trained on an operant conditional discrimination in which an ambiguous stimulus (X) indicated both the occasions on which responding in the presence of a second cue (A) would be reinforced and the occasions on which responding in the presence of a third cue (B) would not be reinforced (X --> A+, A-, X --> B-...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1998)8:2<138::AID-HIPO6>3.
更新日期:1998-01-01 00:00:00
abstract::Watermaze tests of place learning and memory in rodents and corresponding reverse-translated human paradigms in real or virtual environments are key tools to study hippocampal function. In common variants, the animal or human participant has to find a hidden goal that remains in the same place over many trials, allowi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22992
更新日期:2018-11-01 00:00:00