Neuroanatomical and behavioral effects of a novel version of the cholinergic immunotoxin mu p75-saporin in mice.

abstract：:We have previously shown that in urethane-anesthetized rats the frequency of rhythmical slow activity in the hippocampus ("theta") is controlled by the medial supramammillary nucleus (SuM). In particular, injections of procaine into SuM in urethane-anesthetized animals reduce the frequency of theta. However, it has be...

journal_title：Hippocampus

authors： McNaughton N,Logan B,Panickar KS,Kirk IJ,Pan WX,Brown NT,Heenan A

更新日期：1995-01-01 00:00:00

abstract：:Williams syndrome (WS), a genetic deletion syndrome, is characterized by severe visuospatial deficits affecting performance on both tabletop spatial tasks and on tasks which assess orientation and navigation. Nevertheless, previous studies of WS spatial capacities have ignored the fact that two different spatial memor...

journal_title：Hippocampus

authors： Bostelmann M,Fragnière E,Costanzo F,Di Vara S,Menghini D,Vicari S,Lavenex P,Lavenex PB

更新日期：2017-11-01 00:00:00

abstract：:The role of perforant pathway-dentate granule cell synapses in cognitive behavior was examined focusing on synaptic Zn(2+) signaling in the dentate gyrus. Object recognition memory was transiently impaired when extracellular Zn(2+) levels were decreased by injection of clioquinol and N,N,N',N'-tetrakis-(2-pyridylmethy...

journal_title：Hippocampus

authors： Takeda A,Tamano H,Ogawa T,Takada S,Nakamura M,Fujii H,Ando M

更新日期：2014-11-01 00:00:00

abstract：:An extensive cortical network consisting of structures in the medial temporal lobe (hippocampus and parahippocampal cortex), lateral parietal cortex, retrosplenial cortex, and medial prefrontal cortex has recently attracted attention in cognitive neuroscience research, linking the network to both episodic memory and s...

journal_title：Hippocampus

authors： Peters J,Daum I,Gizewski E,Forsting M,Suchan B

更新日期：2009-02-01 00:00:00

abstract：:To ask if the properties of spatial learning supported by the hippocampus are distinct from the properties of conditioning, we conducted a blocking-like experiment in which the measured variable was not a conditioned response but rather the ability of a novel visual stimulus to control the location of place cell firin...

journal_title：Hippocampus

authors： Barry J,Muller R

更新日期：2011-05-01 00:00:00

abstract：:Rett syndrome (RTT) is a neurodevelopment disorder associated with intellectual disabilities and caused by loss-of-function mutations in the gene encoding the transcriptional regulator Methyl-CpG-binding Protein-2 (MeCP2). Neuronal dysfunction and changes in cortical excitability occur in RTT individuals and Mecp2-def...

journal_title：Hippocampus

authors： Calfa G,Li W,Rutherford JM,Pozzo-Miller L

更新日期：2015-02-01 00:00:00

abstract：:It has been well-established that cell proliferation and neurogenesis in the adult mouse dentate gyrus (DG) can be regulated by voluntary exercise. Recent evidence has suggested that the effects of voluntary exercise can in turn be influenced by environmental factors that regulate the amount of stress an animal is exp...

journal_title：Hippocampus

authors： Kannangara TS,Webber A,Gil-Mohapel J,Christie BR

更新日期：2009-10-01 00:00:00

abstract：:The role of subicular neurons is explored with respect to their participation in short-term memory during performance of a spatial Delayed-Nonmatch-to-Sample (DNMS) task by well-trained rats. Subicular and CA1 neuron firing was examined in the same animals in relation to the encoding of task-relevant events during the...

journal_title：Hippocampus

authors： Hampson RE,Deadwyler SA

更新日期：2003-01-01 00:00:00

abstract：:The ERK/MAPK signaling pathway has been extensively studied in the context of learning and memory. Defects in this pathway underlie genetic diseases associated with intellectual disability, including impaired learning and memory. Numerous studies have investigated the impact of acute ERK/MAPK inhibition on long-term p...

journal_title：Hippocampus

authors： Vithayathil J,Pucilowska J,Friel D,Landreth GE

更新日期：2017-12-01 00:00:00

abstract：:For well over a century, ethanol was believed to exert its effects on cognition and behavior by producing a ubiquitous depression of central nervous system activity. A general disruption in brain function was consistent with the belief that ethanol's effects on cognition and behavior were also quite general. Substanti...

journal_title：Hippocampus

authors： White AM,Matthews DB,Best PJ

更新日期：2000-01-01 00:00:00

abstract：:Two recent meta-analyses, drawing on data from many of the same studies with monkeys, reached different conclusions about the relationship between hippocampal damage and recognition memory performance. Both studies found evidence of recognition memory impairment following hippocampal damage. However, Zola et al. (J Ne...

journal_title：Hippocampus

authors： Zola SM,Squire LR

更新日期：2001-01-01 00:00:00

abstract：:Intracellular recording and computational modelling suggest that interactions of subthreshold membrane potential oscillation frequency in different dendritic branches of entorhinal cortex stellate cells could underlie the functional coding of continuous dimensions of space and time. Among other things, these interacti...

journal_title：Hippocampus

authors： Hasselmo ME,Giocomo LM,Zilli EA

更新日期：2007-01-01 00:00:00

abstract：:Cocaine induces an increase in hippocampal and nucleus accumbens (Nac) serotonin (5-HT) concentration parallel to locomotor activation. Both effects can be modulated by systemic 5-HT(1A)-receptor agonism/antagonism. Given the contribution of the hippocampus to spontaneous behavioral activity, these observations sugges...

journal_title：Hippocampus

authors： Müller CP,Thönnessen H,Barros M,Tomaz C,Carey RJ,Huston JP

更新日期：2004-01-01 00:00:00

abstract：:Two experiments assessed the effects of 1) combined subicular complex and posterior cingulate cortical lesions on training-induced neuronal activity (TIA) in the anterior ventral (AV) and medial dorsal (MD) thalamic nuclei; 2) hippocampal (Ammon's horn and dentate gyrus) lesions on TIA in cingulate cortex and in the A...

journal_title：Hippocampus

authors： Kang E,Gabriel M

更新日期：1998-01-01 00:00:00

abstract：:To examine the effects of long-term potentiation (LTP) on individual neurons in the intact brain, anesthetized rats were implanted with a recording stereotrode in the right CA1 layer of the hippocampus and a stimulating electrode in the right and left CA3 layers. The evoked and spontaneous firing of single CA1 neurons...

journal_title：Hippocampus

authors： Martin PD,Shapiro ML

更新日期：2000-01-01 00:00:00

abstract：:The hippocampal theta rhythm is frequently viewed as a clocking mechanism that coordinates the spiking activity of neurons across the hippocampus to form coherent neural assemblies. Phase precession is a form of temporal coding evidencing this mechanism and is degraded following systemic pharmacological disruption of ...

journal_title：Hippocampus

authors： Venditto SJC,Le B,Newman EL

更新日期：2019-11-01 00:00:00

abstract：:One functional aspect of theta oscillations that recent studies have begun to explore in humans is their role for the recollection of personal events. A specific role of theta for recollection but not for stimulus-familiarity would support links between cortical theta oscillations and hippocampal functioning, given th...

journal_title：Hippocampus

authors： Guderian S,Düzel E

更新日期：2005-01-01 00:00:00

abstract：:Structures in the caudal diencephalon including the posterior hypothalamic nucleus, the supramammillary nucleus (SUM) and the nuclei of the mammillary body (MB) occupy a strategic position in the crossroads of ascending and descending traffic between the brainstem and the limbic forebrain (septum/hippocampus). In this...

journal_title：Hippocampus

authors： Kocsis B,Vertes RP

更新日期：1997-01-01 00:00:00

abstract：:Despite evidence that the extracellular matrix glycoprotein tenascin-C (TNC) is implicated in brain development and plasticity, its roles in the intact adult brain are unknown. Here we report that spontaneous local field potential (LFP) activity in freely moving adult TNC-deficient mice is abnormal. The power of corti...

journal_title：Hippocampus

authors： Gurevicius K,Kuang F,Stoenica L,Irintchev A,Gureviciene I,Dityatev A,Schachner M,Tanila H

更新日期：2009-12-01 00:00:00

abstract：:Hippocampal synaptic plasticity comprises a key cellular mechanism for information storage. In the hippocampus, both long-term potentiation (LTP) and long-term depression (LTD) are triggered by synaptic Ca2+ -elevations that are typically mediated by the opening of voltage-gated cation channels, such as N-methyl-d-asp...

journal_title：Hippocampus

authors： Jansen S,Gottschling C,Faissner A,Manahan-Vaughan D

更新日期：2017-08-01 00:00:00

abstract：:In rodents, chronic stress induces long-lasting structural and functional alterations in the hippocampus, as well as learning and memory impairments. The neural cell adhesion molecule (NCAM) was previously hypothesized to be a key molecule in mediating the effects of stress due to its role in neuronal remodeling and s...

journal_title：Hippocampus

authors： Bisaz R,Schachner M,Sandi C

更新日期：2011-01-01 00:00:00

abstract：:The electrically induced increase in hippocampal synaptic strength known as long-term potentiation (LTP) is thought to involve some of the same mechanisms as those mediating information storage during spatial learning. Physiological saturation of synaptic weights might therefore be expected to occlude spatial learning...

journal_title：Hippocampus

authors： Jeffery KJ,Morris RG

更新日期：1993-04-01 00:00:00

abstract：:Nearby grid cells have been observed to express a remarkable degree of long-range order, which is often idealized as extending potentially to infinity. Yet their strict periodic firing and ensemble coherence are theoretically possible only in flat environments, much unlike the burrows which rodents usually live in. Ar...

journal_title：Hippocampus

authors： Stella F,Urdapilleta E,Luo Y,Treves A

更新日期：2020-04-01 00:00:00

abstract：:Reorganization of excitatory and inhibitory circuits in the hippocampal formation following seizure-induced neuronal loss has been proposed to underlie the development of chronic seizures in temporal lobe epilepsy (TLE). Here, we investigated whether specific morphological alterations of the GABAergic system can be re...

journal_title：Hippocampus

authors： André V,Marescaux C,Nehlig A,Fritschy JM

更新日期：2001-01-01 00:00:00

abstract：:It is argued that while the hippocampus is not vital for all classes of configural learning, it is vital for a specific subclass of configural tasks called "structural learning." The defining feature of structural learning is that in addition to binding stimulus elements to make unique arrays (as in all configural lea...

journal_title：Hippocampus

authors： Aggleton JP,Sanderson DJ,Pearce JM

更新日期：2007-01-01 00:00:00

abstract：:C57 and DBA mice were trained in a crossed maze to assess possible strain differences in place or response learning as a function of training duration (8 or 17 days) and extramaze cueing conditions. The first condition consisted of a diffuse visually cued environment (rich cueing). The second was the same plus an expl...

journal_title：Hippocampus

authors： Passino E,Middei S,Restivo L,Bertaina-Anglade V,Ammassari-Teule M

更新日期：2002-01-01 00:00:00

abstract：:In contextual fear conditioning (CFC), the use of pharmacological and lesion approaches has helped to understand that there are differential roles for the dorsal hippocampus (DH) and the ventral hippocampus (VH) in the acquisition, consolidation and retrieval phases. Concomitant analysis of the DH and the VH in indivi...

journal_title：Hippocampus

authors： Sase S,Sase A,Sialana FJ Jr,Gröger M,Bennett KL,Stork O,Lubec G,Li L

更新日期：2015-12-01 00:00:00

abstract：:Aging has been associated with a decline in relational memory, which is critically supported by the hippocampus. By adapting the transitivity paradigm (Bunsey and Eichenbaum (1996) Nature 379:255-257), which traditionally has been used in nonhuman animal research, this work examined the extent to which aging is accomp...

journal_title：Hippocampus

authors： Ryan JD,D'Angelo MC,Kamino D,Ostreicher M,Moses SN,Rosenbaum RS

更新日期：2016-02-01 00:00:00

abstract：:The hippocampus, the prefrontal cortex, and interconnected neural circuits are implicated in several aspects of cognitive and memory processes. The present review is dedicated to the description of the anatomo-functional characteristics of the hippocampo-prefrontal pathway and related neuronal circuits in the rat. Thi...

journal_title：Hippocampus

authors： Thierry AM,Gioanni Y,Dégénétais E,Glowinski J

更新日期：2000-01-01 00:00:00

abstract：:The electrophysiological properties of neurons in the rat perirhinal cortex were analyzed with intracellular recordings in an in vitro slice preparation. Cells included in this study (n = 59) had resting membrane potential (RMP) = -73.9 +/- 8.5 mV (mean +/- SD), action potential amplitude = 95.5 +/- 10.4 mV, input res...

journal_title：Hippocampus

authors： D'Antuono M,Biagini G,Tancredi V,Avoli M

更新日期：2001-01-01 00:00:00