Abstract:
:The electrically induced increase in hippocampal synaptic strength known as long-term potentiation (LTP) is thought to involve some of the same mechanisms as those mediating information storage during spatial learning. Physiological saturation of synaptic weights might therefore be expected to occlude spatial learning. In support of this, Castro et al. (Castro CA, Silbert LH, McNaughton BL, Barnes CA, 1989, Nature 342:545-548) reported that repeated induction of LTP to asymptotic levels, over a 14-day period, blocked the ability of rats to learn the position of a hidden platform in a water maze shortly afterwards. The authors have attempted to replicate this finding in two experiments. In Experiment 1, rats were given either 400 Hz stimulation as 50 trains/day over a 5-day period, to induce LTP, or were given the same number of stimulus pulses at 1 Hz. Two hours after the last stimulation session they underwent eight spatial learning trials, occurring at 2-hour intervals. In Experiment 2, the procedure of Castro et al. was followed exactly, with LTP induced by 10 trains of 400 Hz stimulation daily for 14 days. Spatial learning trials began 10 minutes after the last stimulation session and consisted of 12 trials with alternating 30-second and 2-minute intervals. In neither experiment was a significant impairment of spatial learning observed. However, there was a strong positive correlation, in both experiments, between the final level of LTP and subsequent performance in the water maze.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Jeffery KJ,Morris RGdoi
10.1002/hipo.450030205subject
Has Abstractpub_date
1993-04-01 00:00:00pages
133-40issue
2eissn
1050-9631issn
1098-1063journal_volume
3pub_type
杂志文章相关文献
HIPPOCAMPUS文献大全abstract::The ERK/MAPK signaling pathway has been extensively studied in the context of learning and memory. Defects in this pathway underlie genetic diseases associated with intellectual disability, including impaired learning and memory. Numerous studies have investigated the impact of acute ERK/MAPK inhibition on long-term p...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22769
更新日期:2017-12-01 00:00:00
abstract::Gelsolin is an actin-binding protein that regulates actin filament-severing and capping activity in the various processes of cell motilities. Here, we report the expression of gelsolin mRNA and protein in the hippocampus following transections of the entorhinal afferents. Northern blot analysis showed that transcript ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20134
更新日期:2006-01-01 00:00:00
abstract::It is well documented that place cells and grid cells in echolocating bats show properties similar to those described in rodents, and yet, continuous theta-frequency oscillations, proposed to play a central role in grid/place cell formation, are not present in bat recordings. These comparative neurophysiological data ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22469
更新日期:2015-12-01 00:00:00
abstract::Changes in synaptic efficacy and morphology have been proposed as mechanisms underlying learning and memory processes. In our previous studies, high frequency stimulation (HFS) sufficient to induce LTP at the hippocampal mossy fiber (MF) pathway, leads to MF synaptogenesis, in a prominent contralateral form, at the st...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20866
更新日期:2012-01-01 00:00:00
abstract::We recorded neuromagnetic fields evoked by a somatosensory oddball task requiring subjects to discriminate target stimuli from nontarget stimuli, which are different in stimulation intensity, with a mental count of the target stimuli. A whole head type 80-channel magnetoencephalography (MEG) system with a 50-mm baseli...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10196
更新日期:2004-01-01 00:00:00
abstract::This study examines the extent to which simultaneous olfactory discrimination learning increases spine density on hippocampal CA1 pyramidal neurons in C57BL/6J (C57) and DBA/2J (DBA) inbred mice, characterized by spontaneous differences in hippocampal plasticity and hippocampus-related learning. The behavioral data fi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20174
更新日期:2006-01-01 00:00:00
abstract::Short-term memory was assessed in two groups of amnesic patients. Six patients had confirmed or suspected damage to the hippocampal formation, and six patients had diencephalic damage as a result of alcoholic Korsakoff's syndrome. Verbal short-term memory was evaluated with seven separate administrations of the standa...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450020207
更新日期:1992-04-01 00:00:00
abstract::The entorhinal cortex has long been recognized as an important interface between the hippocampal formation and the neocortex. The notion of bidirectional connections between the entorhinal cortex and the hippocampal formation have led to the suggestion that hippocampal output originating in CA1 and subiculum may reent...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20022
更新日期:2004-01-01 00:00:00
abstract::We have studied 5-hydroxytryptamine (5-HT) release in the hippocampal formation following electrical stimulation of the dorsal and median raphé nuclei in the behaving rat. The primary finding in this study is a decrease in neuronal release of serotonin in the dorsal hippocampal formation following electrical stimulati...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1998)8:3<262::AID-HIPO8>3.
更新日期:1998-01-01 00:00:00
abstract::We investigated the effects of a surgical lesion of one vestibular inner ear (unilateral vestibular damage [UVD]) on the field potential responses of CA1 neurons in vitro. Hippocampal slices were removed from rats at 4-6 weeks or 5-6 months post-UVD, and the field responses of CA1 neurons to electrical stimulation of ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10174
更新日期:2003-01-01 00:00:00
abstract::The aim of this study was to investigate the role of the human hippocampus in episodic retrieval of odors, in comparison with episodic retrieval of visual objects. Subjects encoded a set of unique odors and objects, and retrieval was tested the next day during functional magnetic resonance imaging (fMRI). Subjects wer...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22073
更新日期:2013-02-01 00:00:00
abstract::Unilateral injection of kainic acid (KA) into the dorsal hippocampus of adult mice induces spontaneous recurrent partial seizures and replicates histopathological changes observed in human mesial temporal lobe epilepsy (MTLE) (Bouilleret V et al., Neuroscience 1999; 89:717-729). Alterations in pre- and postsynaptic co...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/1098-1063(2000)10:3<305::AID-HIPO11>3.0.CO
更新日期:2000-01-01 00:00:00
abstract::With the aim of establishing a quantitative structural basis for comparative and experimental studies, the volumes of the hippocampal subdivisions and the total number of neurons in each subdivision were estimated in domestic pig brains using modern stereological techniques. In addition to a detailed description of th...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450040112
更新日期:1994-02-01 00:00:00
abstract::The importance of the hippocampal theta oscillation (4-8 Hz) to memory formation has been well-established through studies in animals, prompting researchers to propose comprehensive theories of memory and learning that rely on theta oscillations for integrating information in the hippocampus and neocortex. Yet, empiri...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20937
更新日期:2012-04-01 00:00:00
abstract::The vestibular system contributes to the performance of various spatial memory tasks, but few studies have attempted to disambiguate the roles of the semicircular canals and otolith organs in this performance. This study tested the otolithic contribution to spatial working and reference memory by evaluating the perfor...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22300
更新日期:2014-10-01 00:00:00
abstract::The hippocampus creates distinct episodes from highly similar events through a process called pattern separation and can retrieve memories from partial or degraded cues through a process called pattern completion. These processes have been studied in humans using tasks where participants must distinguish studied items...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22256
更新日期:2014-06-01 00:00:00
abstract::Functional neuroimaging is uniquely placed to examine the dynamic nature of normal human memory, the distributed brain networks that support it, and how they are modulated. Memory has traditionally been classified into context-specific memories personally experienced ("episodic memory") and impersonal non-context-spec...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1999)9:1<54::AID-HIPO6>3.0
更新日期:1999-01-01 00:00:00
abstract::It has been well-established that cell proliferation and neurogenesis in the adult mouse dentate gyrus (DG) can be regulated by voluntary exercise. Recent evidence has suggested that the effects of voluntary exercise can in turn be influenced by environmental factors that regulate the amount of stress an animal is exp...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20514
更新日期:2009-10-01 00:00:00
abstract::Accurate and reproducible in vivo measurement of hippocampal volumes using magnetic resonance (MR) imaging is complicated by the morphological complexity of the structure. Additionally, separation of certain parts of the hippocampus from the adjacent brain structures on MR images is sometimes very difficult. These dif...
journal_title:Hippocampus
pub_type: 临床试验,杂志文章
doi:10.1002/1098-1063(2000)10:6<752::AID-HIPO1012>3.0.
更新日期:2000-01-01 00:00:00
abstract::We have previously shown that exposing rats to a relatively high dose of ethanol during early postnatal life can result in an alteration in spatial learning ability. The hippocampal formation is known to be involved in the control of this ability. The purpose of the present study was to determine whether exposure of r...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10155
更新日期:2004-01-01 00:00:00
abstract::The role of perforant pathway-dentate granule cell synapses in cognitive behavior was examined focusing on synaptic Zn(2+) signaling in the dentate gyrus. Object recognition memory was transiently impaired when extracellular Zn(2+) levels were decreased by injection of clioquinol and N,N,N',N'-tetrakis-(2-pyridylmethy...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22322
更新日期:2014-11-01 00:00:00
abstract::Adaptive memory requires the organism to form associations that bridge between events separated in time. Many studies show interactions between hippocampus (HPC) and prefrontal cortex (PFC) during formation of such associations. We analyze neural recording from monkey HPC and PFC during a memory task that requires the...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23282
更新日期:2020-12-01 00:00:00
abstract::Reorganization of excitatory and inhibitory circuits in the hippocampal formation following seizure-induced neuronal loss has been proposed to underlie the development of chronic seizures in temporal lobe epilepsy (TLE). Here, we investigated whether specific morphological alterations of the GABAergic system can be re...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.1060
更新日期:2001-01-01 00:00:00
abstract::Functional differences in the anterior and posterior hippocampus during episodic memory processing have not been examined in human electrophysiological data. This is in spite of strong evidence for such differences in rodent data, including greater place cell specificity in the dorsal hippocampus, greater sensitivity ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22751
更新日期:2017-10-01 00:00:00
abstract::This study investigated the effects of neonatal hippocampal ablation on the development of spatial learning and memory abilities in rats. Newborn rats sustained bilateral electrolytic lesions of the hippocampus or were sham-operated on postnatal day 1 (PN1). At PN20-25, PN50-55, or PN90-95, separate groups of rats wer...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1997)7:4<403::AID-HIPO6>3.
更新日期:1997-01-01 00:00:00
abstract::Septal nuclei are suggested to work as an interface between the hippocampal formation, involved in higher cognitive functions, and the hypothalamus, involved in motivational behaviors such as feeding, drinking, and intracranial self-stimulation. In the present study, to elucidate a role of the septal nuclei in motivat...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1997)7:5<536::AID-HIPO9>3.
更新日期:1997-01-01 00:00:00
abstract::A large body of evidence exists to demonstrate that excitatory amino acids (EAA) and their receptors are involved in the pathophysiological mechanisms linking several acute brain insults, such as cerebral ischemia, to neuronal degeneration and death. Accordingly, the use of EAA receptor antagonists can be beneficial i...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450050111
更新日期:1995-01-01 00:00:00
abstract::CA3 lesions impair encoding, whereas CA1 lesions impair retrieval during learning of a Hebb-Williams maze. CA3 efferents in the fimbria were transected, taking care to spare cholinergic and GABAergic afferents. CA1 efferents in the dorsal fornix were similarly transected. Fimbria transections, but not dorsal fornix tr...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20429
更新日期:2008-01-01 00:00:00
abstract::Studies of differential eyeblink conditioning (CS+ and CS-) have demonstrated that successful conditioning requires awareness of the stimulus contingencies and that delay conditioning does not. Two experiments were carried out to determine whether awareness is also important for single-cue trace eyeblink conditioning....
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(2000)10:2<181::AID-HIPO7>3
更新日期:2000-01-01 00:00:00
abstract::Neuropsychological analyses of amnesic patients, as well as lesion experiments, indicate that the temporal lobe is essential for the encoding, storage, and expression of object recognition memory (ORM). However, temporal lobe structures directly involved in the consolidation and reconsolidation of these memories are n...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20669
更新日期:2010-05-01 00:00:00