Motivation-related neuronal activity in the object discrimination task in monkey septal nuclei.

Abstract:

:Septal nuclei are suggested to work as an interface between the hippocampal formation, involved in higher cognitive functions, and the hypothalamus, involved in motivational behaviors such as feeding, drinking, and intracranial self-stimulation. In the present study, to elucidate a role of the septal nuclei in motivational behaviors, single neuron activity was recorded from water- and food-deprived monkeys during discrimination of objects associated with juice, and during ingestion of juice. Of 349 neurons recorded from two monkeys, 67 responded in the ingestion phase of the object discrimination task. Of these 67 neurons, 31 were further tested with the noncontingent liquid (juice or water) test in which liquid was provided until the animals became satiated. These 31 septal neurons were classified into two groups: type I neurons (n = 10) responded to juice ingestion with inhibition, and type II neurons (n = 21) responded with excitation. The spontaneous firing rates of the type I neurons were higher in the deprived condition and decreased as the animal became satiated by intake of liquid. Nine type II neurons responded to the sight of a white object associated with juice as well as ingestion of juice. The response magnitudes of the type II neurons to both the sight of the white object and ingestion of juice also decreased by satiation. However, spontaneous firing rates of the type II neurons did not change. These activity changes of both type I and II neurons were well correlated with changes in motivational state of the monkey estimated by the behavioral test. The results suggest that the activity of type I neurons reflects thirst or hunger drive levels, and that responses of type II neurons are related to reward perception. These type I and II neurons were located mainly in the anterior part of the septal nuclei. Results of the present study suggest, along with previous lesion and anatomical studies, that the septal nuclei exert a powerful influence on the motivational/drive systems through the projection to the hypothalamus.

journal_name

Hippocampus

journal_title

Hippocampus

authors

Nishijo H,Kita T,Tamura R,Eifuku S,Terasawa K,Ono T

doi

10.1002/(SICI)1098-1063(1997)7:5<536::AID-HIPO9>3.

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

536-48

issue

5

eissn

1050-9631

issn

1098-1063

journal_volume

7

pub_type

杂志文章
  • Functional connectivity of hippocampal and prefrontal networks during episodic and spatial memory based on real-world environments.

    abstract::Several recent studies have compared episodic and spatial memory in neuroimaging paradigms in order to understand better the contribution of the hippocampus to each of these tasks. In the present study, we build on previous findings showing common neural activation in default network areas during episodic and spatial ...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22352

    authors: Robin J,Hirshhorn M,Rosenbaum RS,Winocur G,Moscovitch M,Grady CL

    更新日期:2015-01-01 00:00:00

  • Episodic memory--from brain to mind.

    abstract::Neuronal mechanisms of episodic memory, the conscious recollection of autobiographical events, are largely unknown because electrophysiological studies in humans are conducted only in exceptional circumstances. Unit recording studies in animals are thus crucial for understanding the neurophysiological substrate that e...

    journal_title:Hippocampus

    pub_type: 杂志文章,评审

    doi:10.1002/hipo.20204

    authors: Ferbinteanu J,Kennedy PJ,Shapiro ML

    更新日期:2006-01-01 00:00:00

  • Social isolation prevents exercise-induced proliferation of hippocampal progenitor cells in female rats.

    abstract::Social isolation negatively affects the behavior and health of laboratory rats. Recently, it has been found that social isolation retards exercise-induced neurogenesis in the hippocampal dentate gyrus (DG) of male rats (Stranahan et al. (2006) Nat Neurosci 9:526-533). Since male and female rats react differently to ho...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20563

    authors: Leasure JL,Decker L

    更新日期:2009-10-01 00:00:00

  • Cooperation between cholinergic and glutamatergic receptors are essential to induce BDNF-dependent long-lasting memory storage.

    abstract::The induction of long-lasting memory storage depends on the behavioral state of humans and animals. This behavioral state is mediated by neuromodulatory systems, like the cholinergic-septum-hippocampal circuit. Cholinergic neurotransmission is known to affect short-term activity-dependent plasticity in various brain a...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20902

    authors: Navakkode S,Korte M

    更新日期:2012-02-01 00:00:00

  • Temporally-specific retrograde amnesia in two cases of discrete bilateral hippocampal pathology.

    abstract::The role of the hippocampus in retrograde amnesia remains controversial and poorly understood. Two cases are reported of discrete bilateral hippocampal damage, one of which was a rare case of limbic encephalitis secondary to the human herpes virus 6. Detailed memory testing showed marked anterograde memory impairment,...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/(SICI)1098-1063(1999)9:3<247::AID-HIPO5>3.

    authors: Kapur N,Brooks DJ

    更新日期:1999-01-01 00:00:00

  • A computational model of systems memory consolidation and reconsolidation.

    abstract::In the mammalian brain, newly acquired memories depend on the hippocampus (HPC) for maintenance and recall, but over time, the neocortex takes over these functions, rendering memories HPC-independent. The process responsible for this transformation is called systems memory consolidation. Reactivation of a well-consoli...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.23187

    authors: Helfer P,Shultz TR

    更新日期:2020-07-01 00:00:00

  • Alteration of NMDA receptor-mediated synaptic responses in CA1 area of the aged rat hippocampus: contribution of GABAergic and cholinergic deficits.

    abstract::Synaptic responses mediated by the N-methyl-D-aspartate receptor (NMDAr) and non-NMDAr activation were compared in CA1 hippocampal region of young (3-4 months old) and aged (25-33 months old) Sprague-Dawley rats with the use of ex vivo extracellular recordings techniques. In aged rats, the amplitude of the NMDAr-media...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/(SICI)1098-1063(1998)8:6<627::AID-HIPO5>3.

    authors: Jouvenceau A,Dutar P,Billard JM

    更新日期:1998-01-01 00:00:00

  • Hippocampal neurons inhibit meal onset.

    abstract::There is extensive research regarding the neural mechanisms involved in satiety and meal termination; in contrast, there is very limited understanding of how meal onset is regulated. On the basis of several converging lines of evidence, we hypothesized that hippocampal neurons form a memory of a meal and inhibit meal ...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22062

    authors: Henderson YO,Smith GP,Parent MB

    更新日期:2013-01-01 00:00:00

  • Cytoarchitecture, neuronal composition, and entorhinal afferents of the flying fox hippocampus.

    abstract::In a comparative approach, the anatomical organization of the hippocampus was investigated in two species of megachiropteran bats, the grey-headed flying fox, Pteropus poliocephalus, and the little red flying fox, Pteropus scapulatus. In general, the cytoarchitectonic appearance of the flying fox hippocampus correspon...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.450010203

    authors: Buhl EH,Dann JF

    更新日期:1991-04-01 00:00:00

  • Task difficulty in the Morris water task influences the survival of new neurons in the dentate gyrus.

    abstract::Adult neurogenesis continues throughout life in the mammalian hippocampus. The precise function of the adult generated neurons remains uncertain although there is growing evidence that they are involved in hippocampus-dependent learning and memory. Training rats on a hidden platform version of the Morris water task ha...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20692

    authors: Epp JR,Haack AK,Galea LA

    更新日期:2010-07-01 00:00:00

  • Two case studies illustrating how relatively selective hippocampal lesions in humans can have quite different effects on memory.

    abstract::Two patients, with magnetic resonance imaging (MRI)-confirmed relatively selective hippocampal damage, showed distinct patterns of performance on tests of recall, item recognition, and associative recognition. Patient AC showed a mean bilateral volume reduction of the hippocampus of 28%, but displayed no memory defici...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20427

    authors: Holdstock JS,Parslow DM,Morris RG,Fleminger S,Abrahams S,Denby C,Montaldi D,Mayes AR

    更新日期:2008-01-01 00:00:00

  • Theta oscillation-coupled dendritic spiking integrates inputs on a long time scale.

    abstract::Persistent neural activity lasting for seconds after transient stimulation has been observed in several brain areas. This activity has been taken to be indicative of the integration of inputs on long time scales. Passive membrane properties render neural time constants to be on the order of milliseconds. Intense synap...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20112

    authors: Huhn Z,Orbán G,Erdi P,Lengyel M

    更新日期:2005-01-01 00:00:00

  • Mossy fiber plasticity and enhanced hippocampal excitability, without hippocampal cell loss or altered neurogenesis, in an animal model of prolonged febrile seizures.

    abstract::Seizures induced by fever (febrile seizures) are the most frequent seizures affecting infants and children; however, their impact on the developing hippocampal formation is not completely understood. Such understanding is highly important because of the potential relationship of prolonged febrile seizures to temporal ...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.10089

    authors: Bender RA,Dubé C,Gonzalez-Vega R,Mina EW,Baram TZ

    更新日期:2003-01-01 00:00:00

  • Retrograde amnesia after hippocampal damage: recent vs. remote memories in two tasks.

    abstract::We review evidence from experiments conducted in our laboratory on retrograde amnesia in rats with damage to the hippocampal formation. In a new experiment reported here, we show that N-methyl-D-aspartate (NMDA)-induced hippocampal damage produced retrograde amnesia for both hidden platform and two-choice visible plat...

    journal_title:Hippocampus

    pub_type: 杂志文章,评审

    doi:10.1002/1098-1063(2001)11:1<27::AID-HIPO1017>3.0.C

    authors: Sutherland RJ,Weisend MP,Mumby D,Astur RS,Hanlon FM,Koerner A,Thomas MJ,Wu Y,Moses SN,Cole C,Hamilton DA,Hoesing JM

    更新日期:2001-01-01 00:00:00

  • Para/autocrine regulation of estrogen receptors in hippocampal neurons.

    abstract::Previous studies have shown that estrogens, originating from ovaries, have a wide variety of estrogen receptor (ER)-mediated effects in the hippocampus. In the present study, we have investigated whether estrogens, which are synthesized in the hippocampus, could induce these effects as well. As a parameter, we used ER...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.10075

    authors: Prange-Kiel J,Wehrenberg U,Jarry H,Rune GM

    更新日期:2003-01-01 00:00:00

  • Does hippocampus associate discontiguous events? Evidence from event-related fMRI.

    abstract::To examine the hypothesis that the hippocampus is necessary to overcome temporal or spatial "discontiguity" (Wallenstein et al., Trends Neurosci 1998; 21:317-323), subjects were imaged by functional magnetic resonance imaging (fMRI) when they were making judgments as to whether two words were semantically related. Two...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20054

    authors: Luo J,Niki K

    更新日期:2005-01-01 00:00:00

  • Ras-GRF2 mediates long-term potentiation, survival, and response to an enriched environment of newborn neurons in the hippocampus.

    abstract::Hippocampal adult neurogenesis contributes to key functions of the dentate gyrus (DG), including contextual discrimination. This is due, at least in part, to the unique form of plasticity that new neurons display at a specific stage of their development when compared with the surrounding principal neurons. In addition...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22313

    authors: Darcy MJ,Trouche S,Jin SX,Feig LA

    更新日期:2014-11-01 00:00:00

  • Simultaneous blockade of non-NMDA ionotropic receptors and NMDA receptor-associated ionophore partially protects hippocampal slices from protein synthesis impairment due to simulated ischemia.

    abstract::A large body of evidence exists to demonstrate that excitatory amino acids (EAA) and their receptors are involved in the pathophysiological mechanisms linking several acute brain insults, such as cerebral ischemia, to neuronal degeneration and death. Accordingly, the use of EAA receptor antagonists can be beneficial i...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.450050111

    authors: Virgili M,Contestabile A,Barnabei O

    更新日期:1995-01-01 00:00:00

  • A double dissociation of subcortical hippocampal efferents for encoding and consolidation/retrieval of spatial information.

    abstract::CA3 lesions impair encoding, whereas CA1 lesions impair retrieval during learning of a Hebb-Williams maze. CA3 efferents in the fimbria were transected, taking care to spare cholinergic and GABAergic afferents. CA1 efferents in the dorsal fornix were similarly transected. Fimbria transections, but not dorsal fornix tr...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20429

    authors: Hunsaker MR,Tran GT,Kesner RP

    更新日期:2008-01-01 00:00:00

  • Attention, configuration, and hippocampal function.

    abstract::We present a neural network that characterizes a remarkably large number of classical conditioning paradigms and describes the effects of many neurophysiological manipulations. First, the network 1) describes behavior in real time 2) comprises simple and configural stimulus representations, and 3) includes attentional...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/(SICI)1098-1063(1996)6:6<621::AID-HIPO6>3.

    authors: Buhusi CV,Schmajuk NA

    更新日期:1996-01-01 00:00:00

  • Temporal firing characteristics and the strategic role of subicular neurons in short-term memory.

    abstract::The role of subicular neurons is explored with respect to their participation in short-term memory during performance of a spatial Delayed-Nonmatch-to-Sample (DNMS) task by well-trained rats. Subicular and CA1 neuron firing was examined in the same animals in relation to the encoding of task-relevant events during the...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.10119

    authors: Hampson RE,Deadwyler SA

    更新日期:2003-01-01 00:00:00

  • Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation.

    abstract::The effects of selective ibotenate lesions of the complete hippocampus (CHip), the hippocampal ventral pole (VP), or the medial prefrontal cortex (mPFC) in male rats were assessed on several measures related to energy regulation (i.e., body weight gain, food intake, body adiposity, metabolic activity, general behavior...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20499

    authors: Davidson TL,Chan K,Jarrard LE,Kanoski SE,Clegg DJ,Benoit SC

    更新日期:2009-03-01 00:00:00

  • Hippocampal shape analysis for Alzheimer's disease using an efficient hypothesis test and regularized discriminative deformation.

    abstract::In this article, we present a framework to perform statistical shape analysis for segmented hippocampi, including an efficient permutation test for detecting subtle class differences, and a regularized discriminative direction method for visualizing the shape discrepancy. Fisher permutation and bootstrap tests are pre...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20639

    authors: Zhou L,Lieby P,Barnes N,Réglade-Meslin C,Walker J,Cherbuin N,Hartley R

    更新日期:2009-06-01 00:00:00

  • Disruption of amygdala-entorhinal-hippocampal network in late-life depression.

    abstract::Episodic memory deficits are evident in late-life depression (LLD) and are associated with subtle synaptic and neurochemical changes in the medial temporal lobes (MTL). However, the particular mechanisms by which memory impairment occurs in LLD are currently unknown. We tested older adults with (DS+) and without (DS-)...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22705

    authors: Leal SL,Noche JA,Murray EA,Yassa MA

    更新日期:2017-04-01 00:00:00

  • In the temporal organization of episodic memory, the hippocampus supports the experience of elapsed time.

    abstract::Space and time are both essential features of episodic memory, for which the hippocampus is critical (Howard & Eichenbaum, 2015). Spatial tasks have been used effectively to study the behavioral relevance of place cells. However, the behavioral paradigms utilized for the study of time cells have not used time duration...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.23261

    authors: Sabariego M,Tabrizi NS,Marshall GJ,McLagan AN,Jawad S,Hales JB

    更新日期:2021-01-01 00:00:00

  • Spatial analysis of spike-timing-dependent LTP and LTD in the CA1 area of hippocampal slices using optical imaging.

    abstract::Spike-timing-dependent long-term potentiation (LTP) and long-term depression (LTD) were investigated in the CA1 area of hippocampal slices using optical imaging. A pair of electrical pulses were used to stimulate the Schaffer-commissural collateral and the stratum oriens with various sets of relative timing (tau) betw...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20035

    authors: Tsukada M,Aihara T,Kobayashi Y,Shimazaki H

    更新日期:2005-01-01 00:00:00

  • Double dissociation of learned approach-avoidance conflict processing and spatial pattern separation along the dorsoventral axis of the dentate gyrus.

    abstract::The ventral portion of the rodent hippocampus (HPC; anterior in primates) has been implicated in the detection and resolution of approach-avoidance conflict, which arises when an organism encounters a stimulus that predicts both positive and negative outcomes. Previous work has found differential regulation of approac...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.23182

    authors: Yeates DCM,Ussling A,Lee ACH,Ito R

    更新日期:2020-06-01 00:00:00

  • Ethanol, memory, and hippocampal function: a review of recent findings.

    abstract::For well over a century, ethanol was believed to exert its effects on cognition and behavior by producing a ubiquitous depression of central nervous system activity. A general disruption in brain function was consistent with the belief that ethanol's effects on cognition and behavior were also quite general. Substanti...

    journal_title:Hippocampus

    pub_type: 杂志文章,评审

    doi:10.1002/(SICI)1098-1063(2000)10:1<88::AID-HIPO10>3

    authors: White AM,Matthews DB,Best PJ

    更新日期:2000-01-01 00:00:00

  • Hippocampal involvement in retrieval of odor vs. object memories.

    abstract::The aim of this study was to investigate the role of the human hippocampus in episodic retrieval of odors, in comparison with episodic retrieval of visual objects. Subjects encoded a set of unique odors and objects, and retrieval was tested the next day during functional magnetic resonance imaging (fMRI). Subjects wer...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22073

    authors: Lehn H,Kjønigsen LJ,Kjelvik G,Håberg AK

    更新日期:2013-02-01 00:00:00

  • Hippocampus 5-HT(1A)-receptors attenuate cocaine-induced hyperlocomotion and the increase in hippocampal but not nucleus accumbens 5-HT.

    abstract::Cocaine induces an increase in hippocampal and nucleus accumbens (Nac) serotonin (5-HT) concentration parallel to locomotor activation. Both effects can be modulated by systemic 5-HT(1A)-receptor agonism/antagonism. Given the contribution of the hippocampus to spontaneous behavioral activity, these observations sugges...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.10209

    authors: Müller CP,Thönnessen H,Barros M,Tomaz C,Carey RJ,Huston JP

    更新日期:2004-01-01 00:00:00