Effects of age and alcohol exposure during early life on pyramidal cell numbers in the CA1-CA3 region of the rat hippocampus.

Abstract:

:We have previously shown that exposing rats to a relatively high dose of ethanol during early postnatal life can result in an alteration in spatial learning ability. The hippocampal formation is known to be involved in the control of this ability. The purpose of the present study was to determine whether exposure of rats to ethanol during early postnatal life had either immediate or delayed effects on the numbers of pyramidal cells in the CA1-CA3 subregion of the hippocampus. Wistar rats were exposed to a relatively high daily dose of ethanol at postnatal day 10-15 by placing them for 3 h/day in a chamber containing ethanol vapor. Groups of ethanol-treated (ET), separation control (SC), and mother-reared control (MRC) rats were anesthetized and killed at 16 and 30 days of age by perfusion with phosphate-buffered 2.5% glutaraldehyde. The Cavalieri principle was used to determine the volumes of the CA1 and CA2+CA3 regions. The physical disector method was used to estimate the numerical density of neurons in each of the subdivisions. The total number of pyramidal cells was calculated by multiplying the appropriate estimates of the numerical density by the volume. There were significant age-related reductions in the total numbers of pyramidal cells at 16-30 days of age irrespective of the groups examined. Ethanol treated rats were found to have slightly but significantly fewer pyramidal cell neurons than either the MRC or SC groups. These observations indicate that pyramidal cells in the hippocampus may be vulnerable to a relatively high dose of ethanol exposure during this short period of early postnatal life.

journal_name

Hippocampus

journal_title

Hippocampus

authors

Miki T,Harris SJ,Wilce PA,Takeuchi Y,Bedi KS

doi

10.1002/hipo.10155

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

124-34

issue

1

eissn

1050-9631

issn

1098-1063

journal_volume

14

pub_type

杂志文章
  • Human hippocampal theta activity during virtual navigation.

    abstract::This study examines whether 4-8-Hz theta oscillations can be seen in the human hippocampus, and whether these oscillations increase during virtual movement and searching, as they do in rodents. Recordings from both hippocampal and neocortical depth electrodes were analyzed while six epileptic patients played a virtual...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20109

    authors: Ekstrom AD,Caplan JB,Ho E,Shattuck K,Fried I,Kahana MJ

    更新日期:2005-01-01 00:00:00

  • MRI-Based evaluation of locus and extent of neurotoxic lesions in monkeys.

    abstract::To minimize the variability in the extent of lesions made by injections of the excitotoxin ibotenic acid in rhesus monkeys, we developed and validated an MRI-based method to determine the efficacy of the injections soon after surgery. T2-weighted MR images were obtained 6-11 days after surgery from 17 brain hemisphere...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.1050

    authors: Málková L,Lex CK,Mishkin M,Saunders RC

    更新日期:2001-01-01 00:00:00

  • Hippocampal shape analysis for Alzheimer's disease using an efficient hypothesis test and regularized discriminative deformation.

    abstract::In this article, we present a framework to perform statistical shape analysis for segmented hippocampi, including an efficient permutation test for detecting subtle class differences, and a regularized discriminative direction method for visualizing the shape discrepancy. Fisher permutation and bootstrap tests are pre...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20639

    authors: Zhou L,Lieby P,Barnes N,Réglade-Meslin C,Walker J,Cherbuin N,Hartley R

    更新日期:2009-06-01 00:00:00

  • Semantic retrieval over time in the aging brain: Structural evidence of hippocampal contribution.

    abstract::This study investigates relationship between regional cerebral volumes and performances over time of a categorical fluency task, in a sample of older adults (n = 316). Using voxel-wise technique, the relationship between local grey matter volume and Isaacs Set Test (IST) scores at its early (first 15 sec) and late (la...

    journal_title:Hippocampus

    pub_type: 杂志文章,多中心研究

    doi:10.1002/hipo.22423

    authors: Catheline G,Amieva H,Dilharreguy B,Bernard C,Duperron MG,Helmer C,Dartigues JF,Allard M

    更新日期:2015-09-01 00:00:00

  • Postnatal neurogenesis in the dentate gyrus of the guinea pig.

    abstract::In all species examined, the dentate gyrus develops over an extended period that begins during gestation and continues up to adulthood. The aim of this study was to investigate the pattern of postnatal cell production in the dentate gyrus of the guinea pig, a rodent whose brain development has features more closely re...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20050

    authors: Guidi S,Ciani E,Severi S,Contestabile A,Bartesaghi R

    更新日期:2005-01-01 00:00:00

  • Lesions of the ventral hippocampus attenuate the acquisition but not expression of sign-tracking behavior in rats.

    abstract::Individual variation in the attribution of motivational salience to reward-related cues is believed to underlie addiction vulnerability. Pavlovian conditioned approach measures individual variation in motivational salience by identifying rats that are attracted to and motivated by reward cues (sign-trackers) or motiva...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22619

    authors: Fitzpatrick CJ,Creeden JF,Perrine SA,Morrow JD

    更新日期:2016-11-01 00:00:00

  • Genetic ablation of tenascin-C expression leads to abnormal hippocampal CA1 structure and electrical activity in vivo.

    abstract::Despite evidence that the extracellular matrix glycoprotein tenascin-C (TNC) is implicated in brain development and plasticity, its roles in the intact adult brain are unknown. Here we report that spontaneous local field potential (LFP) activity in freely moving adult TNC-deficient mice is abnormal. The power of corti...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20585

    authors: Gurevicius K,Kuang F,Stoenica L,Irintchev A,Gureviciene I,Dityatev A,Schachner M,Tanila H

    更新日期:2009-12-01 00:00:00

  • Naloxone injections into CA3 disrupt pattern completion associated with relapse from cocaine seeking.

    abstract::The goal of the present research was to assess the degree to which a pattern completion process operates in cue-induced relapse to cocaine-seeking behavior. Using a novel cue-preference version of the place preference task, rats were administered cocaine or saline, which resulted in a preference for the cocaine-paired...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22570

    authors: Kesner RP,Kirk RA,Clark JK,Moore A,Keefe K

    更新日期:2016-07-01 00:00:00

  • Expression of the snoRNA host gene gas5 in the hippocampus is upregulated by age and psychogenic stress and correlates with reduced novelty-induced behavior in C57BL/6 mice.

    abstract::The growth arrest specific 5 (gas5) is a noncoding protein gene that hosts small nucleolar RNAs. Based on the observation that gas5 RNA level in the brain is highest in the hippocampus and remarkably enhanced in aged mice, we tested the hypothesis that gas5 is involved in functions controlled by the hippocampus and kn...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20701

    authors: Meier I,Fellini L,Jakovcevski M,Schachner M,Morellini F

    更新日期:2010-09-01 00:00:00

  • Subcortical connections of the perirhinal, postrhinal, and entorhinal cortices of the rat. I. afferents.

    abstract::In this study the subcortical afferents for the rat PER areas 35 and 36, POR, and the lateral and medial entorhinal areas (LEA and MEA) were characterized. We analyzed 33 retrograde tract-tracing experiments distributed across the five regions. For each experiment, we estimated the total numbers, percentages, and dens...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22603

    authors: Tomás Pereira I,Agster KL,Burwell RD

    更新日期:2016-09-01 00:00:00

  • Place cell assemblies remain intact, despite reduced phase precession, after cholinergic disruption.

    abstract::The hippocampal theta rhythm is frequently viewed as a clocking mechanism that coordinates the spiking activity of neurons across the hippocampus to form coherent neural assemblies. Phase precession is a form of temporal coding evidencing this mechanism and is degraded following systemic pharmacological disruption of ...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.23100

    authors: Venditto SJC,Le B,Newman EL

    更新日期:2019-11-01 00:00:00

  • The relationship between behavior acquisition and persistence abilities: Involvement of adult hippocampal neurogenesis.

    abstract::The influence of the learning process on the persistence of the newly acquired behavior is relevant both for our knowledge of the learning/memory mechanisms and for the educational policy. However, it is unclear whether during an operant conditioning process with a continuous reinforcement paradigm, individual differe...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22568

    authors: Gradari S,Pérez-Domper P,Butler RG,Martínez-Cué C,de Polavieja GG,Trejo JL

    更新日期:2016-07-01 00:00:00

  • Alterations in the balance of protein kinase and phosphatase activities and age-related impairments of synaptic transmission and long-term potentiation.

    abstract::Aging is associated with an impaired ability to maintain long-term potentiation (LTP), but the underlying cause of the impairment remains unclear. To gain a better understanding of the cellular and molecular mechanisms responsible for this impairment, the synaptic transmission and plasticity were studied in the CA1 re...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.10032

    authors: Hsu KS,Huang CC,Liang YC,Wu HM,Chen YL,Lo SW,Ho WC

    更新日期:2002-01-01 00:00:00

  • Spine changes associated with long-term potentiation.

    abstract::High-frequency stimulation of excitatory synapses in many regions of the brain triggers a lasting increase in the efficacy of synaptic transmission referred to as long-term potentiation (LTP) and believed to contribute to learning and memory. One hypothesis proposed to account for the stability and properties of this ...

    journal_title:Hippocampus

    pub_type: 杂志文章,评审

    doi:10.1002/1098-1063(2000)10:5<596::AID-HIPO10>3.0.CO

    authors: Muller D,Toni N,Buchs PA

    更新日期:2000-01-01 00:00:00

  • Vasopressin induction of long-lasting potentiation of synaptic transmission in the dentate gyrus.

    abstract::Vasopressin receptors are present in both the developing and mature dentate gyrus of the rat brain and are of the V1 vasopressor type. Because vasopressin has been shown to influence memory function when injected into the dentate gyrus, the influence of this peptide on an electrophysiological model of learning and mem...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.450030211

    authors: Chen C,Díaz Brinton RD,Shors TJ,Thompson RF

    更新日期:1993-04-01 00:00:00

  • Retrieval flexibility and reinstatement in the developing hippocampus.

    abstract::Episodic memory improves during childhood and this improvement has been associated with age differences in hippocampal function, but previous research has not manipulated the possible underlying mechanisms. We tested the hypothesis that age-related differences in hippocampal activation may reflect changes in retrieval...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22538

    authors: DeMaster D,Coughlin C,Ghetti S

    更新日期:2016-04-01 00:00:00

  • Simultaneous blockade of non-NMDA ionotropic receptors and NMDA receptor-associated ionophore partially protects hippocampal slices from protein synthesis impairment due to simulated ischemia.

    abstract::A large body of evidence exists to demonstrate that excitatory amino acids (EAA) and their receptors are involved in the pathophysiological mechanisms linking several acute brain insults, such as cerebral ischemia, to neuronal degeneration and death. Accordingly, the use of EAA receptor antagonists can be beneficial i...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.450050111

    authors: Virgili M,Contestabile A,Barnabei O

    更新日期:1995-01-01 00:00:00

  • Neonatal hippocampal damage in rats: long-term spatial memory deficits and associations with magnitude of hippocampal damage.

    abstract::This study investigated the effects of neonatal hippocampal ablation on the development of spatial learning and memory abilities in rats. Newborn rats sustained bilateral electrolytic lesions of the hippocampus or were sham-operated on postnatal day 1 (PN1). At PN20-25, PN50-55, or PN90-95, separate groups of rats wer...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/(SICI)1098-1063(1997)7:4<403::AID-HIPO6>3.

    authors: Altemus KL,Almli CR

    更新日期:1997-01-01 00:00:00

  • Hippocampal place cells: the "where" of episodic memory?

    abstract::Neuropsychologists have clearly implicated the hippocampus in the consolidation of memory, particularly episodic memory, the mental replay of past experiences. When recorded from behaving animals, by far the most obvious firing pattern of the primary neurons of the hippocampus is the place field: a cell tends to fire ...

    journal_title:Hippocampus

    pub_type: 杂志文章,评审

    doi:10.1002/hipo.20199

    authors: Kentros C

    更新日期:2006-01-01 00:00:00

  • Spatial responsiveness of monkey hippocampal neurons to various visual and auditory stimuli.

    abstract::To investigate involvement of the hippocampal formation in spatial information processing, activity of neurons in the hippocampal formation of the conscious monkey was recorded during presentation of various visual and auditory stimuli from several directions around the monkey. Of 1,047 neurons recorded, 106 (10.1%) r...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.450020309

    authors: Tamura R,Ono T,Fukuda M,Nakamura K

    更新日期:1992-07-01 00:00:00

  • Modelling the dopamine and noradrenergic cell loss that occurs in Parkinson's disease and the impact on hippocampal neurogenesis.

    abstract::Key pathological features of Parkinson's Disease (PD) include the progressive degeneration of midbrain dopaminergic (DA) neurons and hindbrain noradrenergic (NA) neurons. The loss of DA neurons has been extensively studied and is the main cause of motor dysfunction. Importantly, however, there are a range of 'non-move...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22835

    authors: Ermine CM,Wright JL,Frausin S,Kauhausen JA,Parish CL,Stanic D,Thompson LH

    更新日期:2018-05-01 00:00:00

  • Human hippocampal theta oscillations and the formation of episodic memories.

    abstract::The importance of the hippocampal theta oscillation (4-8 Hz) to memory formation has been well-established through studies in animals, prompting researchers to propose comprehensive theories of memory and learning that rely on theta oscillations for integrating information in the hippocampus and neocortex. Yet, empiri...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20937

    authors: Lega BC,Jacobs J,Kahana M

    更新日期:2012-04-01 00:00:00

  • GluR6-containing KA receptor mediates the activation of p38 MAP kinase in rat hippocampal CA1 region during brain ischemia injury.

    abstract::Our previous study showed that kainate (KA) receptor subunit GluR6 played an important role in ischemia-induced MLK3 and JNK activation and neuronal degeneration through the GluR6-PSD95-MLK3 signaling module. However, whether the KA receptors subunit GluR6 is involved in the activation of p38 MAP kinase during the tra...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20479

    authors: Chen J,Li C,Pei DS,Han D,Liu XM,Jiang HX,Wang XT,Guan QH,Wen XR,Hou XY,Zhang GY

    更新日期:2009-01-01 00:00:00

  • A model of topological mapping of space in bat hippocampus.

    abstract::The mammalian hippocampus plays a key role in spatial learning and memory, but the exact nature of the hippocampal representation of space is still being explored. Recently, there has been a fair amount of success in modeling hippocampal spatial maps in rats, assuming a topological perspective on spatial information p...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22610

    authors: Hoffman K,Babichev A,Dabaghian Y

    更新日期:2016-10-01 00:00:00

  • LTD, LTP, and the sliding threshold for long-term synaptic plasticity.

    abstract::LTD of synaptic transmission is a form of long-term synaptic plasticity with the potential to be as significant as LTP to both the activity-dependent development of neural circuitry and adult memory storage. In addition, interactions between LTP and LTD and the dynamic regulation of the gain of synaptic plasticity mec...

    journal_title:Hippocampus

    pub_type: 杂志文章,评审

    doi:10.1002/(SICI)1098-1063(1996)6:1<35::AID-HIPO7>3.0

    authors: Stanton PK

    更新日期:1996-01-01 00:00:00

  • Correlates of reward-predictive value in learning-related hippocampal neural activity.

    abstract::Temporal difference learning (TD) is a popular algorithm in machine learning. Two learning signals that are derived from this algorithm, the predictive value and the prediction error, have been shown to explain changes in neural activity and behavior during learning across species. Here, the predictive value signal is...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20535

    authors: Okatan M

    更新日期:2009-05-01 00:00:00

  • Para/autocrine regulation of estrogen receptors in hippocampal neurons.

    abstract::Previous studies have shown that estrogens, originating from ovaries, have a wide variety of estrogen receptor (ER)-mediated effects in the hippocampus. In the present study, we have investigated whether estrogens, which are synthesized in the hippocampus, could induce these effects as well. As a parameter, we used ER...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.10075

    authors: Prange-Kiel J,Wehrenberg U,Jarry H,Rune GM

    更新日期:2003-01-01 00:00:00

  • Integration of synchronous synaptic input in CA1 pyramidal neuron depends on spatial and temporal distributions of the input.

    abstract::Highly synchronized neural firing has been discussed in relation to learning and memory, for instance sharp-wave activity in hippocampus. We were interested to study how a postsynaptic CA1 pyramidal neuron would integrate input of different levels of synchronicity. In previous work using computational modeling we stud...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22061

    authors: Tigerholm J,Migliore M,Fransén E

    更新日期:2013-01-01 00:00:00

  • Preserved anterograde and retrograde memory of rapidly acquired olfactory discrminations after neurotoxic hippocampal lesions.

    abstract::A forced-choice discrimination paradigm was used in two experiments, to evaluate retrograde and anterograde amnesia in rats after hippocampal ablation. In a within-subjects design (Experiment 1), rats were trained on a set of 10 olfactory discriminations 4 weeks before surgery and on a separate set of 10 discriminatio...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.10146

    authors: Jonasson Z,Ballantyne JK,Baxter MG

    更新日期:2004-01-01 00:00:00

  • Individual phases of contextual fear conditioning differentially modulate dorsal and ventral hippocampal GluA1-3, GluN1-containing receptor complexes and subunits.

    abstract::In contextual fear conditioning (CFC), the use of pharmacological and lesion approaches has helped to understand that there are differential roles for the dorsal hippocampus (DH) and the ventral hippocampus (VH) in the acquisition, consolidation and retrieval phases. Concomitant analysis of the DH and the VH in indivi...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22470

    authors: Sase S,Sase A,Sialana FJ Jr,Gröger M,Bennett KL,Stork O,Lubec G,Li L

    更新日期:2015-12-01 00:00:00