Abstract:
:Neuropsychologists have clearly implicated the hippocampus in the consolidation of memory, particularly episodic memory, the mental replay of past experiences. When recorded from behaving animals, by far the most obvious firing pattern of the primary neurons of the hippocampus is the place field: a cell tends to fire only when the animal's head is in a particular part of its environment. It seems reasonable to suspect that the primary firing correlate of the primary neurons of a structure should underlie the primary function of that structure as revealed by behavioral lesion experiments. However, we are currently still at a loss to explain how the firing of hippocampal neurons contributes to hippocampal function. This review seeks to examine the commonalities between place cells and episodic memory, and posits that an analogy can be made between the stabilization of place fields and the consolidation of memory.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Kentros Cdoi
10.1002/hipo.20199subject
Has Abstractpub_date
2006-01-01 00:00:00pages
743-54issue
9eissn
1050-9631issn
1098-1063journal_volume
16pub_type
杂志文章,评审相关文献
HIPPOCAMPUS文献大全abstract::Trace eyeblink classical conditioning is a non-spatial learning paradigm that requires an intact hippocampus. This task is hippocampus-dependent because the auditory tone conditioned stimulus (CS) is temporally separated from the corneal airpuff unconditioned stimulus (US) by a 500-ms trace interval. Our laboratory ha...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1098-1063(1999)9:4<385::AID-HIPO5>3.
更新日期:1999-01-01 00:00:00
abstract::Subjective and objective memory deficits represent a frequent and ill-understood aspect of multiple sclerosis (MS), and a significant cause of disability and quality of life reduction. The aim of the study is to verify the role of hippocampal and temporal associative fibers' damage in MS-related memory complaints. To ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22237
更新日期:2014-04-01 00:00:00
abstract::Dorsoventral lesion studies of the hippocampus have indicated that the dorsal axis of the hippocampus is important for spatial processing and the ventral axis of the hippocampus is important for olfactory learning and memory and anxiety. There is some evidence to suggest that the ventral CA3 and ventral CA1 conduct pa...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22248
更新日期:2014-05-01 00:00:00
abstract::During certain movements (termed "type I," "instrumental," or "voluntary"), the rodent hippocampal EEG is dominated by regular 7-10 Hz waves. This "theta rhythm" is accompanied by increased firing of hippocampal interneurons and dentate gyrus granule cells. No obvious theta rhythm is present in comparable situations i...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450010204
更新日期:1991-04-01 00:00:00
abstract::There is limited knowledge regarding how the brain controls the timing of meals. Similarly, there is a large gap in our understanding of how top-down cognitive processes, such as memory influence energy intake. We hypothesize that dorsal hippocampal (dHC) neurons, which are critical for episodic memory, form a memory ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22532
更新日期:2016-03-01 00:00:00
abstract::LTD of synaptic transmission is a form of long-term synaptic plasticity with the potential to be as significant as LTP to both the activity-dependent development of neural circuitry and adult memory storage. In addition, interactions between LTP and LTD and the dynamic regulation of the gain of synaptic plasticity mec...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1098-1063(1996)6:1<35::AID-HIPO7>3.0
更新日期:1996-01-01 00:00:00
abstract::Previous work has shown that the dorsal hippocampus has greater activity than ventral regions during place navigation. Exposure to a novel context has also been found to increase hippocampal activation, possibly due to increased spatial demands. However, activation patterns in dorsal and ventral regions have not been ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23157
更新日期:2019-11-01 00:00:00
abstract::Neuregulins (NRGs) are ligands of ErbB receptor tyrosine kinases. The NRG1-ErbB4 pathway has been shown to modulate hippocampal synaptic plasticity and network oscillations in the adult rodent brain. To identify cells that mediate these effects, here we determine the expression pattern of ErbB4 in four functionally di...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20675
更新日期:2010-06-01 00:00:00
abstract::The importance of the perirhinal cortex for visual recognition memory performance is undisputed. However, it has not been clear whether its contribution to performance is mainly perceptual, or mainly mnemonic, or whether the perirhinal cortex contributes to both perception and memory. We determined the effects of medi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1998)8:4<330::AID-HIPO3>3.
更新日期:1998-01-01 00:00:00
abstract::Rats use time-of-day cues to modulate learned taste aversion memories. If adult rats are accustomed to drinking saline in the evening and they receive a lithium chloride injection after drinking saline in the morning, they form a stronger aversion to saline than rats that were conditioned after drinking saline at the ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20481
更新日期:2009-01-01 00:00:00
abstract::Wnt proteins have emerged as transmembrane signaling molecules that regulate learning and memory as well as synaptic plasticity at central synapses (Inestrosa and Arenas (2010) Nat Rev Neurosci 11:77-86; Maguschak and Ressler (2011) J Neurosci 31:13057-13067; Tabatadze et al. (2012) Hippocampus 22: 1228-1241; Fortress...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22239
更新日期:2014-04-01 00:00:00
abstract::Kindling is characterized by a progressive intensification of seizure activity culminating in generalized seizures following repeated administration of an initially subconvulsive electrical or chemical stimulus. Since it is known that epilepsy induces morphological alterations in the limbic system, we examined the neu...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10179
更新日期:2004-01-01 00:00:00
abstract::Although it is well established that the integrity of the medial temporal lobe (MTL) is critical for declarative memory, the functional organization of the MTL remains a matter of intense debate. One issue that has received little consideration so far is whether the hippocampus can function normally in the presence of...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20800
更新日期:2011-08-01 00:00:00
abstract::Although the entorhinal cortex is a key structure connecting the hippocampal formation with the rest of the cerebral cortex, little is known about its early chemoanatomical development in primates. In the present study, a cytoarchitectonic analysis and immunocytochemical detection of somatostatin, neurotensin, parvalb...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450030305
更新日期:1993-07-01 00:00:00
abstract::In the human neocortex, progressive synaptogenesis in early postnatal life is followed by a decline in synaptic density, then stability from adolescence until middle age. No comparable data are available in the hippocampus. In this study, the integral synaptic vesicle protein synaptophysin, measured immunoautoradiogra...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20194
更新日期:2006-01-01 00:00:00
abstract::The aim of this study was to investigate the role of the human hippocampus in episodic retrieval of odors, in comparison with episodic retrieval of visual objects. Subjects encoded a set of unique odors and objects, and retrieval was tested the next day during functional magnetic resonance imaging (fMRI). Subjects wer...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22073
更新日期:2013-02-01 00:00:00
abstract::Alzheimer's disease (AD) and ageing are associated with impaired learning and memory, and recent findings point toward modulating chromatin remodeling through histone acetylation as a promising therapeutic strategy. Here we report that systemic administration of the HDAC inhibitor 4-phenylbutyrate (PBA) reinstated fea...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20883
更新日期:2012-05-01 00:00:00
abstract::A striking similarity has been suggested between past and future thinking in Alzheimer's Disease (AD), a similarity attributable to abnormalities in common modular cognitive functions and neuroanatomical substrates. This study extends this literature by identifying specific executive function deficits underlying past ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22465
更新日期:2015-11-01 00:00:00
abstract::In rodents, pyramidal cell firing patterns from waking may be replayed in nonrapid eye movement sleep (NREM) sleep during hippocampal sharp wave ripples (HC-SWR). In humans, HC-SWR have only been recorded with electrodes implanted to localize epileptogenicity. Here, we characterize human HC-SWR with rigorous rejection...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23183
更新日期:2020-06-01 00:00:00
abstract::Key pathological features of Parkinson's Disease (PD) include the progressive degeneration of midbrain dopaminergic (DA) neurons and hindbrain noradrenergic (NA) neurons. The loss of DA neurons has been extensively studied and is the main cause of motor dysfunction. Importantly, however, there are a range of 'non-move...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22835
更新日期:2018-05-01 00:00:00
abstract::Longitudinal studies on patients for schizophrenia suggest that functional brain perturbations precede the onset of symptoms. Rats with a neonatal ventral hippocampal lesion (NVHL) are considered as a heuristic neurodevelopmental model of schizophrenia. We characterized basal metabolic changes observed in NVHL rats be...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20686
更新日期:2010-07-01 00:00:00
abstract::Aniracetam reversibly increased synaptic responses mediated by the AMPA but not the NMDA subclass of glutamate receptors in hippocampus and was considerably more potent than structurally similar nootropics. The drug had greater effects on field excitatory postsynaptic potentials (EPSPs) in the dentate gyrus and CA1 re...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450010405
更新日期:1991-10-01 00:00:00
abstract::Seizures induced by fever (febrile seizures) are the most frequent seizures affecting infants and children; however, their impact on the developing hippocampal formation is not completely understood. Such understanding is highly important because of the potential relationship of prolonged febrile seizures to temporal ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10089
更新日期:2003-01-01 00:00:00
abstract::Fear can be extinguished by repeated exposure to a cue that signals threat. However, extinction does not erase fear, as an extinguished cue presented in a context distinct from that of extinction results in renewed fear of that cue. The hippocampus, which is involved in the formation of contextual representations, is ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20954
更新日期:2012-05-01 00:00:00
abstract::With the aim of establishing a quantitative structural basis for comparative and experimental studies, the volumes of the hippocampal subdivisions and the total number of neurons in each subdivision were estimated in domestic pig brains using modern stereological techniques. In addition to a detailed description of th...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450040112
更新日期:1994-02-01 00:00:00
abstract::Replicas of an aspect of an experienced event can serve as effective reminders, yet little is known about the neural basis of such reminding effects. Here we examined the neural activity underlying the memory-enhancing effect of reminders 1 week after encoding of naturalistic film clip events. We used fMRI to determin...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23260
更新日期:2021-01-01 00:00:00
abstract::Vasopressin receptors are present in both the developing and mature dentate gyrus of the rat brain and are of the V1 vasopressor type. Because vasopressin has been shown to influence memory function when injected into the dentate gyrus, the influence of this peptide on an electrophysiological model of learning and mem...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450030211
更新日期:1993-04-01 00:00:00
abstract::It is well established that aging is associated with declines in episodic memory. In recent years, an emphasis has emerged on the development of behavioral tasks and the identification of biomarkers that are predictive of cognitive decline in healthy as well as pathological aging. Here, we describe a memory task desig...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22224
更新日期:2014-03-01 00:00:00
abstract::Throughout the adult life of most mammals, new neurons are continuously generated in the dentate gyrus of the hippocampal formation. Recent work has documented specific cognitive deficits after elimination of adult hippocampal neurogenesis in rodents, suggesting that these neurons may contribute to information process...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20860
更新日期:2012-01-01 00:00:00
abstract::The mechanisms underlying memory are under intense investigation. One of the most promising candidates at the cellular level is long-term potentiation (LTP). Numerous pharmacological and molecular genetic manipulations have led to alteration in both LTP and memory. However, the causal relationship between these phenot...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.10101
更新日期:2002-01-01 00:00:00