Reminders activate the prefrontal-medial temporal cortex and attenuate forgetting of event memory.

abstract：:Individuals with schizophrenia display a number of structural and cytoarchitectural alterations in the hippocampus, suggesting that other functions such as synaptic plasticity may also be modified. Altered hippocampal plasticity is likely to affect memory processing, and therefore any such pathology may contribute to ...

journal_title：Hippocampus

authors： Savanthrapadian S,Wolff AR,Logan BJ,Eckert MJ,Bilkey DK,Abraham WC

更新日期：2013-12-01 00:00:00

abstract：:The ventral portion of the rodent hippocampus (HPC; anterior in primates) has been implicated in the detection and resolution of approach-avoidance conflict, which arises when an organism encounters a stimulus that predicts both positive and negative outcomes. Previous work has found differential regulation of approac...

journal_title：Hippocampus

authors： Yeates DCM,Ussling A,Lee ACH,Ito R

更新日期：2020-06-01 00:00:00

abstract：:In this study the subcortical afferents for the rat PER areas 35 and 36, POR, and the lateral and medial entorhinal areas (LEA and MEA) were characterized. We analyzed 33 retrograde tract-tracing experiments distributed across the five regions. For each experiment, we estimated the total numbers, percentages, and dens...

journal_title：Hippocampus

authors： Tomás Pereira I,Agster KL,Burwell RD

更新日期：2016-09-01 00:00:00

abstract：:It is argued that while the hippocampus is not vital for all classes of configural learning, it is vital for a specific subclass of configural tasks called "structural learning." The defining feature of structural learning is that in addition to binding stimulus elements to make unique arrays (as in all configural lea...

journal_title：Hippocampus

authors： Aggleton JP,Sanderson DJ,Pearce JM

更新日期：2007-01-01 00:00:00

abstract：:Despite evidence that the extracellular matrix glycoprotein tenascin-C (TNC) is implicated in brain development and plasticity, its roles in the intact adult brain are unknown. Here we report that spontaneous local field potential (LFP) activity in freely moving adult TNC-deficient mice is abnormal. The power of corti...

journal_title：Hippocampus

authors： Gurevicius K,Kuang F,Stoenica L,Irintchev A,Gureviciene I,Dityatev A,Schachner M,Tanila H

更新日期：2009-12-01 00:00:00

abstract：:Hippocampal neurons are selectively active when a rat occupies restricted locations in an environment. These place cells derive their specificity from a multitude of sources, including idiothetic cues and sensory input derived from both distal and local landmarks. Most experiments have attempted to dissociate the rela...

journal_title：Hippocampus

authors： Knierim JJ,Rao G

更新日期：2003-01-01 00:00:00

abstract：:Stratum lacunosum-moleculare interneurons (L-Mi) in hippocampal area CA3 target the apical dendrite of pyramidal cells providing feedforward inhibition. Here we report that selective activation of group III metabotropic glutamate receptors (mGluRs) 4/8 with L(+)-2-amino-4-phosphnobytyric acid (L-AP4; 10 μM) decreased ...

journal_title：Hippocampus

authors： Cosgrove KE,Meriney SD,Barrionuevo G

更新日期：2011-12-01 00:00:00

abstract：:White matter hyperintensities (WMH) constitute the visible spectrum of cerebral small vessel disease (SVD) markers and are associated with cognitive decline, although they do not fully account for memory decline observed in individuals with SVD. We hypothesize that WMH might exert their effect on memory decline indire...

journal_title：Hippocampus

authors： van Leijsen EMC,Tay J,van Uden IWM,Kooijmans ECM,Bergkamp MI,van der Holst HM,Ghafoorian M,Platel B,Norris DG,Kessels RPC,Markus HS,Tuladhar AM,de Leeuw FE

更新日期：2019-06-01 00:00:00

abstract：:The hippocampus is critical for memory tasks which require an active maintenance of memory for a short period of time; however, the underlying neural mechanisms remain unknown. Most theoretical and computational models, which date back to the classic proposals by Donald Hebb in , have been self-constrained by anatomy,...

journal_title：Hippocampus

authors： Knauer B,Jochems A,Valero-Aracama MJ,Yoshida M

更新日期：2013-09-01 00:00:00

abstract：:Subjective and objective memory deficits represent a frequent and ill-understood aspect of multiple sclerosis (MS), and a significant cause of disability and quality of life reduction. The aim of the study is to verify the role of hippocampal and temporal associative fibers' damage in MS-related memory complaints. To ...

journal_title：Hippocampus

authors： Pardini M,Bergamino M,Bommarito G,Bonzano L,Luigi Mancardi G,Roccatagliata L

更新日期：2014-04-01 00:00:00

abstract：:Evidence for morphological substrates of long-term changes in synaptic efficacy is controversial, partly because it is difficult to employ an unambiguous control. We have used a high-frequency stimulation protocol in vivo to induce long-term potentiation (LTP) in the hippocampal dentate gyrus of aged (22-month-old) ra...

journal_title：Hippocampus

authors： Dhanrajan TM,Lynch MA,Kelly A,Popov VI,Rusakov DA,Stewart MG

更新日期：2004-01-01 00:00:00

abstract：:The hippocampus receives robust serotonergic innervation that is thought to control the excitability of both pyramidal cells and GABAergic interneurons. Previous work has addressed serotonergic regulation of pyramidal cells but considerable gaps remain in our understanding of how serotonin regulates different interneu...

journal_title：Hippocampus

authors： Wyskiel DR,Andrade R

更新日期：2016-09-01 00:00:00

abstract：:Neural correlates of spatial representation can be found in the activity of the hippocampal place cells. These neurons are characterized by firing whenever the animal is located in a particular area of the space, the place field. Place fields are modulated by sensory cues, such as visual, auditory, or olfactory cues, ...

journal_title：Hippocampus

authors： Gener T,Perez-Mendez L,Sanchez-Vives MV

更新日期：2013-12-01 00:00:00

abstract：:With the aim of establishing a quantitative structural basis for comparative and experimental studies, the volumes of the hippocampal subdivisions and the total number of neurons in each subdivision were estimated in domestic pig brains using modern stereological techniques. In addition to a detailed description of th...

journal_title：Hippocampus

authors： Holm IE,West MJ

更新日期：1994-02-01 00:00:00

abstract：:At the neuromuscular junction, spontaneous miniature excitatory synaptic currents mediated by acetylcholine are considered elementary, "quantal" transmissions. These miniature conductances can be quantitatively dichotomized into a large-mode class whose mode is the mean of a normal, bell-shaped distribution and a smal...

journal_title：Hippocampus

authors： Vautrin J,Schaffner AE,Barker JL

更新日期：1993-01-01 00:00:00

abstract：:To examine the hypothesis that the hippocampus is necessary to overcome temporal or spatial "discontiguity" (Wallenstein et al., Trends Neurosci 1998; 21:317-323), subjects were imaged by functional magnetic resonance imaging (fMRI) when they were making judgments as to whether two words were semantically related. Two...

journal_title：Hippocampus

authors： Luo J,Niki K

更新日期：2005-01-01 00:00:00

abstract：:Increased consumption of high-fat diet (HFD) leads to obesity and adverse neurocognitive outcomes. Childhood and adolescence are important periods of brain maturation shaping cognitive function. These periods could consequently be particularly sensitive to the detrimental effects of HFD intake. In mice, juvenile and a...

journal_title：Hippocampus

authors： Boitard C,Etchamendy N,Sauvant J,Aubert A,Tronel S,Marighetto A,Layé S,Ferreira G

更新日期：2012-11-01 00:00:00

abstract：:The mechanisms underlying memory are under intense investigation. One of the most promising candidates at the cellular level is long-term potentiation (LTP). Numerous pharmacological and molecular genetic manipulations have led to alteration in both LTP and memory. However, the causal relationship between these phenot...

journal_title：Hippocampus

authors： Gerlai R

更新日期：2002-01-01 00:00:00

abstract：:This study examined the ability of cognitively normal young adults (n = 30) and older adults (n = 30) to perform a delayed match-to-sample task involving varying degrees of spatial interference to assess spatial pattern separation. Each trial consisted of a sample phase followed by a choice phase. During the sample ph...

journal_title：Hippocampus

authors： Holden HM,Hoebel C,Loftis K,Gilbert PE

更新日期：2012-09-01 00:00:00

abstract：:Early life stress predisposes to the development of psychiatric disorders. In this context the hippocampal formation is of particular interest, because it is affected by stress on the structural and cognitive level. Since little is known how early life stress is translated on the molecular level, we mimicked early lif...

journal_title：Hippocampus

authors： Gross CM,Flubacher A,Tinnes S,Heyer A,Scheller M,Herpfer I,Berger M,Frotscher M,Lieb K,Haas CA

更新日期：2012-03-01 00:00:00

abstract：:Our previous study showed that kainate (KA) receptor subunit GluR6 played an important role in ischemia-induced MLK3 and JNK activation and neuronal degeneration through the GluR6-PSD95-MLK3 signaling module. However, whether the KA receptors subunit GluR6 is involved in the activation of p38 MAP kinase during the tra...

journal_title：Hippocampus

authors： Chen J,Li C,Pei DS,Han D,Liu XM,Jiang HX,Wang XT,Guan QH,Wen XR,Hou XY,Zhang GY

更新日期：2009-01-01 00:00:00

abstract：:Vasopressin receptors are present in both the developing and mature dentate gyrus of the rat brain and are of the V1 vasopressor type. Because vasopressin has been shown to influence memory function when injected into the dentate gyrus, the influence of this peptide on an electrophysiological model of learning and mem...

journal_title：Hippocampus

authors： Chen C,Díaz Brinton RD,Shors TJ,Thompson RF

更新日期：1993-04-01 00:00:00

abstract：:We have previously shown that in urethane-anesthetized rats the frequency of rhythmical slow activity in the hippocampus ("theta") is controlled by the medial supramammillary nucleus (SuM). In particular, injections of procaine into SuM in urethane-anesthetized animals reduce the frequency of theta. However, it has be...

journal_title：Hippocampus

authors： McNaughton N,Logan B,Panickar KS,Kirk IJ,Pan WX,Brown NT,Heenan A

更新日期：1995-01-01 00:00:00

abstract：:Both natural and synthetic cannabinoid receptor (e.g., CB1) agonists such as Δ(9)-THC, WIN 55,212-2 (WIN-2), and HU-210 disrupt spatial cognition presumably through the inhibition of synchrony of hippocampal ensemble firing to task-related events. Although the CB1 receptor agonist CP 55,940 also disrupts the synchrono...

journal_title：Hippocampus

authors： Goonawardena AV,Riedel G,Hampson RE

更新日期：2011-05-01 00:00:00

abstract：:Neuropsychological analyses of amnesic patients, as well as lesion experiments, indicate that the temporal lobe is essential for the encoding, storage, and expression of object recognition memory (ORM). However, temporal lobe structures directly involved in the consolidation and reconsolidation of these memories are n...

journal_title：Hippocampus

authors： Romero-Granados R,Fontán-Lozano A,Delgado-García JM,Carrión AM

更新日期：2010-05-01 00:00:00

abstract：:Persistent neural activity lasting for seconds after transient stimulation has been observed in several brain areas. This activity has been taken to be indicative of the integration of inputs on long time scales. Passive membrane properties render neural time constants to be on the order of milliseconds. Intense synap...

journal_title：Hippocampus

authors： Huhn Z,Orbán G,Erdi P,Lengyel M

更新日期：2005-01-01 00:00:00

abstract：:The survival of adult-born dentate gyrus granule cells critically depends on their synaptic integration into the existing neuronal network. Excitatory inputs are thought to increase the survival rate of adult born neurons. Therefore, whether enhancing the stability of newly formed excitatory synapses by overexpressing...

journal_title：Hippocampus

authors： Doengi M,Krupp AJ,Körber N,Stein V

更新日期：2016-03-01 00:00:00

abstract：:This study examines whether 4-8-Hz theta oscillations can be seen in the human hippocampus, and whether these oscillations increase during virtual movement and searching, as they do in rodents. Recordings from both hippocampal and neocortical depth electrodes were analyzed while six epileptic patients played a virtual...

journal_title：Hippocampus

authors： Ekstrom AD,Caplan JB,Ho E,Shattuck K,Fried I,Kahana MJ

更新日期：2005-01-01 00:00:00

abstract：:Short periods of forced exercise have been reported to selectively induce enhancements in hippocampal-dependent cognitive function, possibly via brain-derived neurotrophic factor (BDNF)-mediated mechanisms. In this study, we report that 1 week of treadmill running significantly enhanced both object displacement (spati...

journal_title：Hippocampus

authors： Griffin EW,Bechara RG,Birch AM,Kelly AM

更新日期：2009-10-01 00:00:00

abstract：:Although the entorhinal cortex is a key structure connecting the hippocampal formation with the rest of the cerebral cortex, little is known about its early chemoanatomical development in primates. In the present study, a cytoarchitectonic analysis and immunocytochemical detection of somatostatin, neurotensin, parvalb...

journal_title：Hippocampus

authors： Berger B,Alvarez C,Goldman-Rakic PS

更新日期：1993-07-01 00:00:00