Exercise enhances hippocampal-dependent learning in the rat: evidence for a BDNF-related mechanism.

abstract：:We analyzed intracranial electroencephalographic (EEG) recordings from the medial temporal lobes of 12 epilepsy patients during a continuous word recognition paradigm, contrasting trials of correctly recognized repeated words (hits) and correctly identified new words (correct rejections). Using a wavelet-based analysi...

journal_title：Hippocampus

authors： Mormann F,Fell J,Axmacher N,Weber B,Lehnertz K,Elger CE,Fernández G

更新日期：2005-01-01 00:00:00

abstract：:With the aim of establishing a quantitative structural basis for comparative and experimental studies, the volumes of the hippocampal subdivisions and the total number of neurons in each subdivision were estimated in domestic pig brains using modern stereological techniques. In addition to a detailed description of th...

journal_title：Hippocampus

authors： Holm IE,West MJ

更新日期：1994-02-01 00:00:00

abstract：:Unilateral injection of kainic acid (KA) into the dorsal hippocampus of adult mice induces spontaneous recurrent partial seizures and replicates histopathological changes observed in human mesial temporal lobe epilepsy (MTLE) (Bouilleret V et al., Neuroscience 1999; 89:717-729). Alterations in pre- and postsynaptic co...

journal_title：Hippocampus

authors： Bouilleret V,Loup F,Kiener T,Marescaux C,Fritschy JM

更新日期：2000-01-01 00:00:00

abstract：:Temporal difference learning (TD) is a popular algorithm in machine learning. Two learning signals that are derived from this algorithm, the predictive value and the prediction error, have been shown to explain changes in neural activity and behavior during learning across species. Here, the predictive value signal is...

journal_title：Hippocampus

authors： Okatan M

更新日期：2009-05-01 00:00:00

abstract：:Converging behavioral, electrophysiological, and neurochemical data suggest that lesions to the peripheral vestibular system result in impairment of the hippocampus. Nonetheless, relatively few studies have examined the hippocampus or behavior related to it, over a long period of time following the lesion, to determin...

journal_title：Hippocampus

authors： Zheng Y,Goddard M,Darlington CL,Smith PF

更新日期：2007-01-01 00:00:00

abstract：:Stratum lacunosum-moleculare interneurons (L-Mi) in hippocampal area CA3 target the apical dendrite of pyramidal cells providing feedforward inhibition. Here we report that selective activation of group III metabotropic glutamate receptors (mGluRs) 4/8 with L(+)-2-amino-4-phosphnobytyric acid (L-AP4; 10 μM) decreased ...

journal_title：Hippocampus

authors： Cosgrove KE,Meriney SD,Barrionuevo G

更新日期：2011-12-01 00:00:00

abstract：:Highly synchronized neural firing has been discussed in relation to learning and memory, for instance sharp-wave activity in hippocampus. We were interested to study how a postsynaptic CA1 pyramidal neuron would integrate input of different levels of synchronicity. In previous work using computational modeling we stud...

journal_title：Hippocampus

authors： Tigerholm J,Migliore M,Fransén E

更新日期：2013-01-01 00:00:00

abstract：:To investigate involvement of the hippocampal formation in spatial information processing, activity of neurons in the hippocampal formation of the conscious monkey was recorded during presentation of various visual and auditory stimuli from several directions around the monkey. Of 1,047 neurons recorded, 106 (10.1%) r...

journal_title：Hippocampus

authors： Tamura R,Ono T,Fukuda M,Nakamura K

更新日期：1992-07-01 00:00:00

abstract：:The importance of the perirhinal cortex for visual recognition memory performance is undisputed. However, it has not been clear whether its contribution to performance is mainly perceptual, or mainly mnemonic, or whether the perirhinal cortex contributes to both perception and memory. We determined the effects of medi...

journal_title：Hippocampus

authors： Buffalo EA,Reber PJ,Squire LR

更新日期：1998-01-01 00:00:00

abstract：:Previous research has revealed that the functional components of spatial cognition are lateralized in the forebrain of birds, including the hippocampal formation (HF). To investigate how HF cells in the left and right avian brain may differentially participate in representations of space, we recorded single-units from...

journal_title：Hippocampus

authors： Siegel JJ,Nitz D,Bingman VP

更新日期：2006-01-01 00:00:00

abstract：:Hippocampal neurons are selectively active when a rat occupies restricted locations in an environment. These place cells derive their specificity from a multitude of sources, including idiothetic cues and sensory input derived from both distal and local landmarks. Most experiments have attempted to dissociate the rela...

journal_title：Hippocampus

authors： Knierim JJ,Rao G

更新日期：2003-01-01 00:00:00

abstract：:The advent of high-resolution magnetic resonance imaging (MRI) has enabled in vivo research in a variety of populations and diseases on the structure and function of hippocampal subfields and subdivisions of the parahippocampal gyrus. Because of the many extant and highly discrepant segmentation protocols, comparing r...

journal_title：Hippocampus

authors： Wisse LEM,Daugherty AM,Olsen RK,Berron D,Carr VA,Stark CEL,Amaral RSC,Amunts K,Augustinack JC,Bender AR,Bernstein JD,Boccardi M,Bocchetta M,Burggren A,Chakravarty MM,Chupin M,Ekstrom A,de Flores R,Insausti R,Kanel P

更新日期：2017-01-01 00:00:00

abstract：:Hippocampal synaptic plasticity comprises a key cellular mechanism for information storage. In the hippocampus, both long-term potentiation (LTP) and long-term depression (LTD) are triggered by synaptic Ca2+ -elevations that are typically mediated by the opening of voltage-gated cation channels, such as N-methyl-d-asp...

journal_title：Hippocampus

authors： Jansen S,Gottschling C,Faissner A,Manahan-Vaughan D

更新日期：2017-08-01 00:00:00

abstract：:Hippocampal adult neurogenesis contributes to key functions of the dentate gyrus (DG), including contextual discrimination. This is due, at least in part, to the unique form of plasticity that new neurons display at a specific stage of their development when compared with the surrounding principal neurons. In addition...

journal_title：Hippocampus

authors： Darcy MJ,Trouche S,Jin SX,Feig LA

更新日期：2014-11-01 00:00:00

abstract：:The mechanisms of Ca2+ responses evoked in hippocampal glial cells in situ, by local application of glutamate and by synaptic activation, were studied in slices from juvenile rats using the membrane permeant fluorescent Ca2+ indicator fluo-3AM and confocal microscopy. Ca2+ responses induced by local application of glu...

journal_title：Hippocampus

authors： Latour I,Gee CE,Robitaille R,Lacaille JC

更新日期：2001-01-01 00:00:00

abstract：:Previous work has shown that the dorsal hippocampus has greater activity than ventral regions during place navigation. Exposure to a novel context has also been found to increase hippocampal activation, possibly due to increased spatial demands. However, activation patterns in dorsal and ventral regions have not been ...

journal_title：Hippocampus

authors： Lee JQ,Demchuk AM,Morgan E,McHugh R,McNaughton BL,Sutherland RJ,McDonald RJ

更新日期：2019-11-01 00:00:00

abstract：:Although a large body of evidence indicates that sleep plays an important role in learning and memory processes, the actual existence of a sleep-dependent spatial memory consolidation has been not firmly established. Here, by using a computerized 3D virtual navigation tool, we were able to show that topographical orie...

journal_title：Hippocampus

authors： Ferrara M,Iaria G,Tempesta D,Curcio G,Moroni F,Marzano C,De Gennaro L,Pacitti C

更新日期：2008-01-01 00:00:00

abstract：:The hippocampal theta rhythm is frequently viewed as a clocking mechanism that coordinates the spiking activity of neurons across the hippocampus to form coherent neural assemblies. Phase precession is a form of temporal coding evidencing this mechanism and is degraded following systemic pharmacological disruption of ...

journal_title：Hippocampus

authors： Venditto SJC,Le B,Newman EL

更新日期：2019-11-01 00:00:00

abstract：:Hippocampal place cells respond heterogeneously to elemental changes of a compound spatial context, suggesting that they form a distributed code of context, whereby context information is shared across a population of neurons. The question arises as to what this distributed code might be useful for. The present study ...

journal_title：Hippocampus

authors： Anderson MI,Killing S,Morris C,O'Donoghue A,Onyiagha D,Stevenson R,Verriotis M,Jeffery KJ

更新日期：2006-01-01 00:00:00

abstract：:Aniracetam reversibly increased synaptic responses mediated by the AMPA but not the NMDA subclass of glutamate receptors in hippocampus and was considerably more potent than structurally similar nootropics. The drug had greater effects on field excitatory postsynaptic potentials (EPSPs) in the dentate gyrus and CA1 re...

journal_title：Hippocampus

authors： Xiao P,Staubli U,Kessler M,Lynch G

更新日期：1991-10-01 00:00:00

abstract：:Effective navigation depends upon reliable estimates of head direction (HD). Visual, vestibular, and outflow motor signals combine for this purpose in a brain system that includes dorsal tegmental nucleus, lateral mammillary nuclei, anterior dorsal thalamic nucleus, and the postsubiculum. Learning is needed to combine...

journal_title：Hippocampus

authors： Fortenberry B,Gorchetchnikov A,Grossberg S

更新日期：2012-12-01 00:00:00

abstract：:Although the parahippocampal cortex (PHc) is known to be critical for memory formation, little is known about what is encoded by this area. Using multi-voxel pattern analysis of high-resolution functional magnetic resonance imaging (MRI) data, we examined responses to blocks of categorically coherent stimuli and found...

journal_title：Hippocampus

authors： Diana RA,Yonelinas AP,Ranganath C

更新日期：2008-01-01 00:00:00

abstract：:Although it is well established that the integrity of the medial temporal lobe (MTL) is critical for declarative memory, the functional organization of the MTL remains a matter of intense debate. One issue that has received little consideration so far is whether the hippocampus can function normally in the presence of...

journal_title：Hippocampus

authors： Bowles B,O'Neil EB,Mirsattari SM,Poppenk J,Köhler S

更新日期：2011-08-01 00:00:00

abstract：:We aimed at identifying the cerebral structures whose synaptic function subserves the recollection of lifetime's episodic autobiographical memory (AM) via autonoetic consciousness. Twelve healthy middle-aged subjects (mean age: 59 years +/- 2.5) underwent a specially designed cognitive test to assess the ability to re...

journal_title：Hippocampus

authors： Piolino P,Desgranges B,Hubert V,Bernard FA,Matuszewski V,Chételat G,Baron JC,Eustache F

更新日期：2008-01-01 00:00:00

abstract：:LTD of synaptic transmission is a form of long-term synaptic plasticity with the potential to be as significant as LTP to both the activity-dependent development of neural circuitry and adult memory storage. In addition, interactions between LTP and LTD and the dynamic regulation of the gain of synaptic plasticity mec...

journal_title：Hippocampus

authors： Stanton PK

更新日期：1996-01-01 00:00:00

abstract：:The electrophysiological properties of neurons in the rat perirhinal cortex were analyzed with intracellular recordings in an in vitro slice preparation. Cells included in this study (n = 59) had resting membrane potential (RMP) = -73.9 +/- 8.5 mV (mean +/- SD), action potential amplitude = 95.5 +/- 10.4 mV, input res...

journal_title：Hippocampus

authors： D'Antuono M,Biagini G,Tancredi V,Avoli M

更新日期：2001-01-01 00:00:00

abstract：:Changes in the spatial arrangement or identity of objects inside a familiar environment induce reexploration. The present study looks at modifications of place cell activity during such renewed exploration. Hungry rats foraged for food in a cylinder with a salient cue card attached to the wall and with two distinct ob...

journal_title：Hippocampus

authors： Lenck-Santini PP,Rivard B,Muller RU,Poucet B

更新日期：2005-01-01 00:00:00

abstract：:Spike-timing-dependent long-term potentiation (LTP) and long-term depression (LTD) were investigated in the CA1 area of hippocampal slices using optical imaging. A pair of electrical pulses were used to stimulate the Schaffer-commissural collateral and the stratum oriens with various sets of relative timing (tau) betw...

journal_title：Hippocampus

authors： Tsukada M,Aihara T,Kobayashi Y,Shimazaki H

更新日期：2005-01-01 00:00:00

abstract：:A large body of evidence exists to demonstrate that excitatory amino acids (EAA) and their receptors are involved in the pathophysiological mechanisms linking several acute brain insults, such as cerebral ischemia, to neuronal degeneration and death. Accordingly, the use of EAA receptor antagonists can be beneficial i...

journal_title：Hippocampus

authors： Virgili M,Contestabile A,Barnabei O

更新日期：1995-01-01 00:00:00

abstract：:In all species examined, the dentate gyrus develops over an extended period that begins during gestation and continues up to adulthood. The aim of this study was to investigate the pattern of postnatal cell production in the dentate gyrus of the guinea pig, a rodent whose brain development has features more closely re...

journal_title：Hippocampus

authors： Guidi S,Ciani E,Severi S,Contestabile A,Bartesaghi R

更新日期：2005-01-01 00:00:00