Abstract:
:Effective navigation depends upon reliable estimates of head direction (HD). Visual, vestibular, and outflow motor signals combine for this purpose in a brain system that includes dorsal tegmental nucleus, lateral mammillary nuclei, anterior dorsal thalamic nucleus, and the postsubiculum. Learning is needed to combine such different cues to provide reliable estimates of HD. A neural model is developed to explain how these three types of signals combine adaptively within the above brain regions to generate a consistent and reliable HD estimate, in both light and darkness, which explains the following experimental facts. Each HD cell is tuned to a preferred head direction. The cell's firing rate is maximal at the preferred direction and decreases as the head turns from the preferred direction. The HD estimate is controlled by the vestibular system when visual cues are not available. A well-established visual cue anchors the cell's preferred direction when the cue is in the animal's field of view. Distal visual cues are more effective than proximal cues for anchoring the preferred direction. The introduction of novel cues in either a novel or familiar environment can gain control over a cell's preferred direction within minutes. Turning out the lights or removing all familiar cues does not change the cell's firing activity, but it may accumulate a drift in the cell's preferred direction. The anticipated time interval (ATI) of the HD estimate is greater in early processing stages of the HD system than at later stages. The model contributes to an emerging unified neural model of how multiple processing stages in spatial navigation, including postsubiculum head direction cells, entorhinal grid cells, and hippocampal place cells, are calibrated through learning in response to multiple types of signals as an animal navigates in the world.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Fortenberry B,Gorchetchnikov A,Grossberg Sdoi
10.1002/hipo.22040subject
Has Abstractpub_date
2012-12-01 00:00:00pages
2219-37issue
12eissn
1050-9631issn
1098-1063journal_volume
22pub_type
杂志文章相关文献
HIPPOCAMPUS文献大全abstract::There is an ongoing debate regarding the respective role of anterior subhippocampal structures and the hippocampus in recognition memory. Here, we report a double anatomo-functional dissociation observed in two brain-damaged patients, FRG and JMG. They both suffered from complete destruction of left MTL structures. In...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20848
更新日期:2011-09-01 00:00:00
abstract::This study examines whether 4-8-Hz theta oscillations can be seen in the human hippocampus, and whether these oscillations increase during virtual movement and searching, as they do in rodents. Recordings from both hippocampal and neocortical depth electrodes were analyzed while six epileptic patients played a virtual...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20109
更新日期:2005-01-01 00:00:00
abstract::Granule cells with recurrent basal dendrites (RBDs) were previously reported in both control and epileptic rats. RBDs are dendrites that arise from the basal half of granule cell bodies and curve toward and extend into the molecular layer. They are increased in frequency in the pilocarpine model of epilepsy. The prese...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.1114
更新日期:2002-01-01 00:00:00
abstract::Neuronal oscillations and cross-frequency interactions in the rat hippocampus relate in important ways to memory processes and serve as a model for studying oscillatory activity in cognition more broadly. We report here that hippocampal synchrony (CA3-CA1 coherence) increased markedly in the low gamma range as rats we...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22228
更新日期:2014-03-01 00:00:00
abstract::To ask if the properties of spatial learning supported by the hippocampus are distinct from the properties of conditioning, we conducted a blocking-like experiment in which the measured variable was not a conditioned response but rather the ability of a novel visual stimulus to control the location of place cell firin...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20764
更新日期:2011-05-01 00:00:00
abstract::The electrically induced increase in hippocampal synaptic strength known as long-term potentiation (LTP) is thought to involve some of the same mechanisms as those mediating information storage during spatial learning. Physiological saturation of synaptic weights might therefore be expected to occlude spatial learning...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450030205
更新日期:1993-04-01 00:00:00
abstract::Schizophrenia is a devastating psychiatric illness with a complex pathophysiology. We have recently documented schizophrenia-like endophenotypes in phospholipase C-β1 knockout (PLC-β1(-/-)) mice, including deficits in prepulse inhibition, hyperlocomotion, and cognitive impairments. PLC-β1 signals via multiple G-protei...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20900
更新日期:2012-02-01 00:00:00
abstract::Although the entorhinal cortex is a key structure connecting the hippocampal formation with the rest of the cerebral cortex, little is known about its early chemoanatomical development in primates. In the present study, a cytoarchitectonic analysis and immunocytochemical detection of somatostatin, neurotensin, parvalb...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450030305
更新日期:1993-07-01 00:00:00
abstract::Ontogenesis of GABAergic signaling may play an important role in developmental changes in seizure susceptibility in the high-potassium model of ictogenesis in vitro. The age-dependent effects of [K(+)](o) on the reversal potential of the GABA(A)-mediated responses and membrane potential in hippocampal slices in vitro ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20259
更新日期:2007-01-01 00:00:00
abstract::Spatial navigation relies on multiple mnemonic mechanisms and previous work in younger adults has described two separate types of spatial memory. One type uses directional as well as boundary-related information for spatial memory and mainly implicates the hippocampal formation. The other type has been linked to direc...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22148
更新日期:2013-10-01 00:00:00
abstract::Recent evidence suggests that activity-regulated cytoskeleton associated protein (Arc) and brain-derived neurotrophic factor (BDNF) are key players in the cellular mechanisms that trigger synaptic changes and memory consolidation. Cholinergic deafferentiation of hippocampus has been largely shown to induce memory impa...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20812
更新日期:2011-09-01 00:00:00
abstract::Our previous study showed that kainate (KA) receptor subunit GluR6 played an important role in ischemia-induced MLK3 and JNK activation and neuronal degeneration through the GluR6-PSD95-MLK3 signaling module. However, whether the KA receptors subunit GluR6 is involved in the activation of p38 MAP kinase during the tra...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20479
更新日期:2009-01-01 00:00:00
abstract::Replicas of an aspect of an experienced event can serve as effective reminders, yet little is known about the neural basis of such reminding effects. Here we examined the neural activity underlying the memory-enhancing effect of reminders 1 week after encoding of naturalistic film clip events. We used fMRI to determin...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23260
更新日期:2021-01-01 00:00:00
abstract::Short-term memory was assessed in two groups of amnesic patients. Six patients had confirmed or suspected damage to the hippocampal formation, and six patients had diencephalic damage as a result of alcoholic Korsakoff's syndrome. Verbal short-term memory was evaluated with seven separate administrations of the standa...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450020207
更新日期:1992-04-01 00:00:00
abstract::The effects of intradentate colchicine injections on the performance of tasks requiring spatial working and reference memory are controversial. Multiple-site colchicine injections (7 microg/microl; via a drawn micropipette) throughout the dentate gyrus (DG) of rats (nine sites in each hemisphere, 0.06 microl at each s...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1999)9:6<668::AID-HIPO8>3.
更新日期:1999-01-01 00:00:00
abstract::Hippocampal theta oscillations have been implicated in spatial memory function in both rodents and humans. What is less clear is how hippocampal theta interacts with higher frequency oscillations to support long-term memory. Here we asked 10 presurgical epilepsy patients undergoing intracranial EEG recording to perfor...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23284
更新日期:2021-02-01 00:00:00
abstract::Previous work has shown that the dorsal hippocampus has greater activity than ventral regions during place navigation. Exposure to a novel context has also been found to increase hippocampal activation, possibly due to increased spatial demands. However, activation patterns in dorsal and ventral regions have not been ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23157
更新日期:2019-11-01 00:00:00
abstract::Previous studies with excitotoxically lesioned organotypic hippocampal slice cultures (OHSC) have revealed that the immunosuppressant mycophenolate mofetil (MMF) inhibits microglial activation and suppresses neuronal injury in the dentate gyrus. We here investigate whether MMF also has beneficial effects on axon survi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20182
更新日期:2006-01-01 00:00:00
abstract::The hippocampus, the prefrontal cortex, and interconnected neural circuits are implicated in several aspects of cognitive and memory processes. The present review is dedicated to the description of the anatomo-functional characteristics of the hippocampo-prefrontal pathway and related neuronal circuits in the rat. Thi...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/1098-1063(2000)10:4<411::AID-HIPO7>3.0.CO;
更新日期:2000-01-01 00:00:00
abstract::The entorhinal cortex has long been recognized as an important interface between the hippocampal formation and the neocortex. The notion of bidirectional connections between the entorhinal cortex and the hippocampal formation have led to the suggestion that hippocampal output originating in CA1 and subiculum may reent...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20022
更新日期:2004-01-01 00:00:00
abstract::We have previously shown that exposing rats to a relatively high dose of ethanol during early postnatal life can result in an alteration in spatial learning ability. The hippocampal formation is known to be involved in the control of this ability. The purpose of the present study was to determine whether exposure of r...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10155
更新日期:2004-01-01 00:00:00
abstract::The present study has investigated the role of ATP in the induction of synaptic plasticity, using local application of ATP by picopump administration into the stratum radiatum of guinea pig hippocampal region CA1. Excitatory postsynaptic currents (EPSCs) evoked by stimulation of Schaffer collateral/commissural afferen...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.7999
更新日期:2003-01-01 00:00:00
abstract::CA3 lesions impair encoding, whereas CA1 lesions impair retrieval during learning of a Hebb-Williams maze. CA3 efferents in the fimbria were transected, taking care to spare cholinergic and GABAergic afferents. CA1 efferents in the dorsal fornix were similarly transected. Fimbria transections, but not dorsal fornix tr...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20429
更新日期:2008-01-01 00:00:00
abstract::The locomotor effects of intra-NAcc injection of dopamine receptor agonists following discrete lesion or inhibition of the DH or the VH have been poorly investigated using only the indirect dopamine receptor agonist amphetamine. In the present study, we investigated how lidocaine in the DH or the VH modulated hyperloc...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20337
更新日期:2007-01-01 00:00:00
abstract::The electrophysiological properties of neurons in the rat perirhinal cortex were analyzed with intracellular recordings in an in vitro slice preparation. Cells included in this study (n = 59) had resting membrane potential (RMP) = -73.9 +/- 8.5 mV (mean +/- SD), action potential amplitude = 95.5 +/- 10.4 mV, input res...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.1081
更新日期:2001-01-01 00:00:00
abstract::Rats use time-of-day cues to modulate learned taste aversion memories. If adult rats are accustomed to drinking saline in the evening and they receive a lithium chloride injection after drinking saline in the morning, they form a stronger aversion to saline than rats that were conditioned after drinking saline at the ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20481
更新日期:2009-01-01 00:00:00
abstract::Vasopressin receptors are present in both the developing and mature dentate gyrus of the rat brain and are of the V1 vasopressor type. Because vasopressin has been shown to influence memory function when injected into the dentate gyrus, the influence of this peptide on an electrophysiological model of learning and mem...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450030211
更新日期:1993-04-01 00:00:00
abstract::Previous investigation of CA1-evoked subicular responses has used either single low-frequency pulses (LF), paired-pulses (PP), or high-frequency bursts. Here we test for the first time how subiculum responds to naturalistic stimulation trains (NSTs). We recorded CA1-evoked field potentials from dorsal rat subiculum in...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20629
更新日期:2010-02-01 00:00:00
abstract::We have studied 5-hydroxytryptamine (5-HT) release in the hippocampal formation following electrical stimulation of the dorsal and median raphé nuclei in the behaving rat. The primary finding in this study is a decrease in neuronal release of serotonin in the dorsal hippocampal formation following electrical stimulati...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1998)8:3<262::AID-HIPO8>3.
更新日期:1998-01-01 00:00:00
abstract::Although it is well established that the integrity of the medial temporal lobe (MTL) is critical for declarative memory, the functional organization of the MTL remains a matter of intense debate. One issue that has received little consideration so far is whether the hippocampus can function normally in the presence of...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20800
更新日期:2011-08-01 00:00:00