Naturalistic stimulus trains evoke reproducible subicular responses both within and between animals in vivo.

abstract：:Neuregulins (NRGs) are ligands of ErbB receptor tyrosine kinases. The NRG1-ErbB4 pathway has been shown to modulate hippocampal synaptic plasticity and network oscillations in the adult rodent brain. To identify cells that mediate these effects, here we determine the expression pattern of ErbB4 in four functionally di...

journal_title：Hippocampus

authors： Neddens J,Buonanno A

更新日期：2010-06-01 00:00:00

abstract：:The importance of the hippocampal theta oscillation (4-8 Hz) to memory formation has been well-established through studies in animals, prompting researchers to propose comprehensive theories of memory and learning that rely on theta oscillations for integrating information in the hippocampus and neocortex. Yet, empiri...

journal_title：Hippocampus

authors： Lega BC,Jacobs J,Kahana M

更新日期：2012-04-01 00:00:00

abstract：:The effects of selective ibotenate lesions of the complete hippocampus (CHip), the hippocampal ventral pole (VP), or the medial prefrontal cortex (mPFC) in male rats were assessed on several measures related to energy regulation (i.e., body weight gain, food intake, body adiposity, metabolic activity, general behavior...

journal_title：Hippocampus

authors： Davidson TL,Chan K,Jarrard LE,Kanoski SE,Clegg DJ,Benoit SC

更新日期：2009-03-01 00:00:00

abstract：:In this review, we aim to reappraise the organization of intrinsic and extrinsic networks of the entorhinal cortex with a focus on the concept of parallel cortical connectivity streams. The concept of two entorhinal areas, the lateral and medial entorhinal cortex, belonging to two parallel input-output streams mediati...

journal_title：Hippocampus

authors： Nilssen ES,Doan TP,Nigro MJ,Ohara S,Witter MP

更新日期：2019-12-01 00:00:00

abstract：:Neuronal mechanisms of episodic memory, the conscious recollection of autobiographical events, are largely unknown because electrophysiological studies in humans are conducted only in exceptional circumstances. Unit recording studies in animals are thus crucial for understanding the neurophysiological substrate that e...

journal_title：Hippocampus

authors： Ferbinteanu J,Kennedy PJ,Shapiro ML

更新日期：2006-01-01 00:00:00

abstract：:Recent studies have demonstrated that remembering past experiences and imagining future scenarios recruits a core network including the hippocampus. Even so, constructing future events engages the hippocampus more than remembering past events. This fMRI study examined whether increased hippocampal activity for future ...

journal_title：Hippocampus

authors： Addis DR,Cheng T,Roberts RP,Schacter DL

更新日期：2011-10-01 00:00:00

abstract：:In urethane-anesthetized rats, cortical regions which provide distal dendritic excitation of the dentate gyrus and CA1 of the dorsal hippocampus were studied using current source density analysis. Electrical stimulation of the lateral perforant path (LPP) in the lateral angular bundle, lateral entorhinal cortex (LEC),...

journal_title：Hippocampus

authors： Canning KJ,Leung LS

更新日期：1997-01-01 00:00:00

abstract：:Hippocampal mossy fibers have long been proposed to impose new patterns to learn onto CA3 neurons during new memory formation. However, inconsistent with this theory, we found in our previous study that mossy fiber stimulation induces only transient changes in CA3 spatial firing in a familiar environment. Here, we tes...

journal_title：Hippocampus

authors： Lee J,Bae C,Lee D,Jung MW

更新日期：2020-07-01 00:00:00

abstract：:The induction of long-lasting memory storage depends on the behavioral state of humans and animals. This behavioral state is mediated by neuromodulatory systems, like the cholinergic-septum-hippocampal circuit. Cholinergic neurotransmission is known to affect short-term activity-dependent plasticity in various brain a...

journal_title：Hippocampus

authors： Navakkode S,Korte M

更新日期：2012-02-01 00:00:00

abstract：:Episodic memory deficits are evident in late-life depression (LLD) and are associated with subtle synaptic and neurochemical changes in the medial temporal lobes (MTL). However, the particular mechanisms by which memory impairment occurs in LLD are currently unknown. We tested older adults with (DS+) and without (DS-)...

journal_title：Hippocampus

authors： Leal SL,Noche JA,Murray EA,Yassa MA

更新日期：2017-04-01 00:00:00

abstract：:We have previously shown that, in HEK 293 cells, overexpression of acidic calponin, an actin-binding protein, induces remodeling of actin filaments, leading to a change in cell morphology. In addition, this protein is found in dendritic spines of adult hippocampal neurons. We hypothesized that this protein plays a rol...

journal_title：Hippocampus

authors： Ferhat L,Esclapez M,Represa A,Fattoum A,Shirao T,Ben-Ari Y

更新日期：2003-01-01 00:00:00

abstract：:As part of an earlier experiment (Kwok and Buckley, 2009), six macaque monkeys (three with fornix transection and three unoperated controls) were trained postoperatively to discriminate a total of 104 new concurrent visuospatial conditional problems to criterion. Our experiment measured and compared long-term retentio...

journal_title：Hippocampus

authors： Kwok SC,Buckley MJ

更新日期：2010-08-01 00:00:00

abstract：:Trans-synaptic cell-adhesion molecules have been implicated in regulating CNS synaptogenesis. Among these, the Neuroligin (NL) family (NLs 1-4) of postsynaptic adhesion proteins has been shown to promote the development and specification of excitatory versus inhibitory synapses. NLs form a heterophilic complex with th...

journal_title：Hippocampus

authors： Dahlhaus R,Hines RM,Eadie BD,Kannangara TS,Hines DJ,Brown CE,Christie BR,El-Husseini A

更新日期：2010-02-01 00:00:00

abstract：:This study investigates relationship between regional cerebral volumes and performances over time of a categorical fluency task, in a sample of older adults (n = 316). Using voxel-wise technique, the relationship between local grey matter volume and Isaacs Set Test (IST) scores at its early (first 15 sec) and late (la...

journal_title：Hippocampus

authors： Catheline G,Amieva H,Dilharreguy B,Bernard C,Duperron MG,Helmer C,Dartigues JF,Allard M

更新日期：2015-09-01 00:00:00

abstract：:Changes in synaptic efficacy and morphology have been proposed as mechanisms underlying learning and memory processes. In our previous studies, high frequency stimulation (HFS) sufficient to induce LTP at the hippocampal mossy fiber (MF) pathway, leads to MF synaptogenesis, in a prominent contralateral form, at the st...

journal_title：Hippocampus

authors： Schjetnan AG,Escobar ML

更新日期：2012-01-01 00:00:00

abstract：:Individual variation in the attribution of motivational salience to reward-related cues is believed to underlie addiction vulnerability. Pavlovian conditioned approach measures individual variation in motivational salience by identifying rats that are attracted to and motivated by reward cues (sign-trackers) or motiva...

journal_title：Hippocampus

authors： Fitzpatrick CJ,Creeden JF,Perrine SA,Morrow JD

更新日期：2016-11-01 00:00:00

abstract：:The survival of adult-born dentate gyrus granule cells critically depends on their synaptic integration into the existing neuronal network. Excitatory inputs are thought to increase the survival rate of adult born neurons. Therefore, whether enhancing the stability of newly formed excitatory synapses by overexpressing...

journal_title：Hippocampus

authors： Doengi M,Krupp AJ,Körber N,Stein V

更新日期：2016-03-01 00:00:00

abstract：:This study examined the ability of cognitively normal young adults (n = 30) and older adults (n = 30) to perform a delayed match-to-sample task involving varying degrees of spatial interference to assess spatial pattern separation. Each trial consisted of a sample phase followed by a choice phase. During the sample ph...

journal_title：Hippocampus

authors： Holden HM,Hoebel C,Loftis K,Gilbert PE

更新日期：2012-09-01 00:00:00

abstract：:A striking similarity has been suggested between past and future thinking in Alzheimer's Disease (AD), a similarity attributable to abnormalities in common modular cognitive functions and neuroanatomical substrates. This study extends this literature by identifying specific executive function deficits underlying past ...

journal_title：Hippocampus

authors： El Haj M,Antoine P,Kapogiannis D

更新日期：2015-11-01 00:00:00

abstract：:A large body of neuroscientific work indicates that exposure to experienced stress causes damage to both cortical and hippocampal cells and results in impairments to cognitive abilities associated with these structures. Similarly, work within the domain of cognitive aging demonstrates that elderly participants who rep...

journal_title：Hippocampus

authors： Marshall AC,Cooper NR,Geeraert N

更新日期：2016-03-01 00:00:00

abstract：:Converging behavioral, electrophysiological, and neurochemical data suggest that lesions to the peripheral vestibular system result in impairment of the hippocampus. Nonetheless, relatively few studies have examined the hippocampus or behavior related to it, over a long period of time following the lesion, to determin...

journal_title：Hippocampus

authors： Zheng Y,Goddard M,Darlington CL,Smith PF

更新日期：2007-01-01 00:00:00

abstract：:The hippocampal theta rhythm is frequently viewed as a clocking mechanism that coordinates the spiking activity of neurons across the hippocampus to form coherent neural assemblies. Phase precession is a form of temporal coding evidencing this mechanism and is degraded following systemic pharmacological disruption of ...

journal_title：Hippocampus

authors： Venditto SJC,Le B,Newman EL

更新日期：2019-11-01 00:00:00

abstract：:Rats use time-of-day cues to modulate learned taste aversion memories. If adult rats are accustomed to drinking saline in the evening and they receive a lithium chloride injection after drinking saline in the morning, they form a stronger aversion to saline than rats that were conditioned after drinking saline at the ...

journal_title：Hippocampus

authors： Manrique T,Morón I,Ballesteros MA,Guerrero RM,Fenton AA,Gallo M

更新日期：2009-01-01 00:00:00

abstract：:Synaptic responses mediated by the N-methyl-D-aspartate receptor (NMDAr) and non-NMDAr activation were compared in CA1 hippocampal region of young (3-4 months old) and aged (25-33 months old) Sprague-Dawley rats with the use of ex vivo extracellular recordings techniques. In aged rats, the amplitude of the NMDAr-media...

journal_title：Hippocampus

authors： Jouvenceau A,Dutar P,Billard JM

更新日期：1998-01-01 00:00:00

abstract：:To investigate involvement of the hippocampal formation in spatial information processing, activity of neurons in the hippocampal formation of the conscious monkey was recorded during presentation of various visual and auditory stimuli from several directions around the monkey. Of 1,047 neurons recorded, 106 (10.1%) r...

journal_title：Hippocampus

authors： Tamura R,Ono T,Fukuda M,Nakamura K

更新日期：1992-07-01 00:00:00

abstract：:Animal studies on the effects of chronic variable stress during the peripubertal-juvenile period on hippocampal structure and function are lacking. Twenty-eight-day-old Sprague-Dawley rats were subjected to random, variable physical or social stress regimens for 4 weeks. Hippocampal volume was found to continue to gro...

journal_title：Hippocampus

authors： Isgor C,Kabbaj M,Akil H,Watson SJ

更新日期：2004-01-01 00:00:00

abstract：:Functional differences in the anterior and posterior hippocampus during episodic memory processing have not been examined in human electrophysiological data. This is in spite of strong evidence for such differences in rodent data, including greater place cell specificity in the dorsal hippocampus, greater sensitivity ...

journal_title：Hippocampus

authors： Lin JJ,Rugg MD,Das S,Stein J,Rizzuto DS,Kahana MJ,Lega BC

更新日期：2017-10-01 00:00:00

abstract：:One of the most striking features of the hippocampal network is its ability to self-generate neuronal sequences representing temporally compressed, spatially coherent paths. These brief events, often termed "replay" in the scientific literature, are largely confined to non-exploratory states such as sleep or quiet res...

journal_title：Hippocampus

authors： Pfeiffer BE

更新日期：2020-01-01 00:00:00

abstract：:It is well established that aging is associated with declines in episodic memory. In recent years, an emphasis has emerged on the development of behavioral tasks and the identification of biomarkers that are predictive of cognitive decline in healthy as well as pathological aging. Here, we describe a memory task desig...

journal_title：Hippocampus

authors： Reagh ZM,Roberts JM,Ly M,DiProspero N,Murray E,Yassa MA

更新日期：2014-03-01 00:00:00

abstract：:The conditioned cue preference (CCP) task was used to study the ability of rats to discriminate between spatial locations. Food-deprived rats explored an eight-arm radial maze with no food present (pre-exposure). On subsequent days, they were alternately confined in one arm of the maze with food and in another arm wit...

journal_title：Hippocampus

authors： Gaskin S,Chai SC,White NM

更新日期：2005-01-01 00:00:00