Lateral entorhinal, perirhinal, and amygdala-entorhinal transition projections to hippocampal CA1 and dentate gyrus in the rat: a current source density study.

Abstract:

:In urethane-anesthetized rats, cortical regions which provide distal dendritic excitation of the dentate gyrus and CA1 of the dorsal hippocampus were studied using current source density analysis. Electrical stimulation of the lateral perforant path (LPP) in the lateral angular bundle, lateral entorhinal cortex (LEC), and amygdala-entorhinal transition (TR) resulted in a current sink in the outer molecular layer of the dentate gyrus accompanied by proximal sources; this sink-source pattern is distinctly different from the source-sink-source pattern evoked by medial perforant path stimulation. The progressive decrease of the sink latency following stimulation of the TR, LEC, and LPP (11.6, 7.8, and 3.6 ms, respectively, at the dorsal blade of the dentate gyrus) suggests a possible sequence of orthodromic activation of these structures. Stimulation of the LEC or TR (collectively termed cortical stimulation) differed from LPP (fiber) stimulation. A low threshold and small chronaxie were characteristic of fiber rather than cortical stimulation. In addition, cortical stimulation, possibly through excitation of intracortical circuits, evoked larger paired-pulse facilitation of the excitatory postsynaptic currents in dentate gyrus and more symmetric excitation of the dorsal and ventral blades of the dentate gyrus as compared to fiber stimulation. Stimulation of the perirhinal cortex (PRh) evoked a short-latency sink in the outer molecular layer of the dentate gyrus with no paired-pulse facilitation, similar to fiber stimulation. A distal dendritic CA1 sink was observed after LPP but not after PRh stimulation. An ibotenic acid injection that lesioned almost all the cells in the perirhinal cortex confirmed the hypothesis that PRh stimulation activated fibers of passage, perhaps in the rostral ventrolateral angular bundle. We conclude that the PRh does not provide a significant excitatory input to the DG or CA1. We have found distinct dendritic excitation of the dentate gyrus by the lateral versus medial perforant paths, and by fiber (LPP and MPP) versus cortical (LEC and TR) stimulation. We also emphasize that processing in the entorhinal cortex is important in the temporal shaping of the signals afferent to the hippocampus.

journal_name

Hippocampus

journal_title

Hippocampus

authors

Canning KJ,Leung LS

doi

10.1002/(SICI)1098-1063(1997)7:6<643::AID-HIPO6>3.

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

643-55

issue

6

eissn

1050-9631

issn

1098-1063

journal_volume

7

pub_type

杂志文章
  • Spatial responsiveness of monkey hippocampal neurons to various visual and auditory stimuli.

    abstract::To investigate involvement of the hippocampal formation in spatial information processing, activity of neurons in the hippocampal formation of the conscious monkey was recorded during presentation of various visual and auditory stimuli from several directions around the monkey. Of 1,047 neurons recorded, 106 (10.1%) r...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.450020309

    authors: Tamura R,Ono T,Fukuda M,Nakamura K

    更新日期:1992-07-01 00:00:00

  • The relationship between hippocampal subfield volumes and autobiographical memory persistence.

    abstract::Structural integrity of the human hippocampus is widely acknowledged to be necessary for the successful encoding and retrieval of autobiographical memories. However, evidence for an association between hippocampal volume and the ability to recall such memories in healthy individuals is mixed. Here we examined this iss...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.23293

    authors: Barry DN,Clark IA,Maguire EA

    更新日期:2020-12-15 00:00:00

  • Phase/amplitude reset and theta-gamma interaction in the human medial temporal lobe during a continuous word recognition memory task.

    abstract::We analyzed intracranial electroencephalographic (EEG) recordings from the medial temporal lobes of 12 epilepsy patients during a continuous word recognition paradigm, contrasting trials of correctly recognized repeated words (hits) and correctly identified new words (correct rejections). Using a wavelet-based analysi...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20117

    authors: Mormann F,Fell J,Axmacher N,Weber B,Lehnertz K,Elger CE,Fernández G

    更新日期:2005-01-01 00:00:00

  • 3D-reconstruction and functional properties of GFP-positive and GFP-negative granule cells in the fascia dentata of the Thy1-GFP mouse.

    abstract::Granule cells of the mouse fascia dentata are widely used in studies on neuronal development and plasticity. In contrast to the rat, however, high-resolution morphometric data on these cells are scarce. Thus, we have analyzed granule cells in the fascia dentata of the adult Thy1-GFP mouse (C57BL/6 background). In this...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20398

    authors: Vuksic M,Del Turco D,Bas Orth C,Burbach GJ,Feng G,Müller CM,Schwarzacher SW,Deller T

    更新日期:2008-01-01 00:00:00

  • Neuronal computations underlying the firing of place cells and their role in navigation.

    abstract::Our model of the spatial and temporal aspects of place cell firing and their role in rat navigation is reviewed. The model provides a candidate mechanism, at the level of individual cells, by which place cell information concerning self-localization could be used to guide navigation to previously visited reward sites....

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/(SICI)1098-1063(1996)6:6<749::AID-HIPO16>3

    authors: Burgess N,O'Keefe J

    更新日期:1996-01-01 00:00:00

  • Motivation-related neuronal activity in the object discrimination task in monkey septal nuclei.

    abstract::Septal nuclei are suggested to work as an interface between the hippocampal formation, involved in higher cognitive functions, and the hypothalamus, involved in motivational behaviors such as feeding, drinking, and intracranial self-stimulation. In the present study, to elucidate a role of the septal nuclei in motivat...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/(SICI)1098-1063(1997)7:5<536::AID-HIPO9>3.

    authors: Nishijo H,Kita T,Tamura R,Eifuku S,Terasawa K,Ono T

    更新日期:1997-01-01 00:00:00

  • Relationship between magnitude of damage to the hippocampus and impaired recognition memory in monkeys.

    abstract::Two recent meta-analyses, drawing on data from many of the same studies with monkeys, reached different conclusions about the relationship between hippocampal damage and recognition memory performance. Both studies found evidence of recognition memory impairment following hippocampal damage. However, Zola et al. (J Ne...

    journal_title:Hippocampus

    pub_type: 杂志文章,评审

    doi:10.1002/hipo.1027

    authors: Zola SM,Squire LR

    更新日期:2001-01-01 00:00:00

  • Delayed effects of chronic variable stress during peripubertal-juvenile period on hippocampal morphology and on cognitive and stress axis functions in rats.

    abstract::Animal studies on the effects of chronic variable stress during the peripubertal-juvenile period on hippocampal structure and function are lacking. Twenty-eight-day-old Sprague-Dawley rats were subjected to random, variable physical or social stress regimens for 4 weeks. Hippocampal volume was found to continue to gro...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.10207

    authors: Isgor C,Kabbaj M,Akil H,Watson SJ

    更新日期:2004-01-01 00:00:00

  • Intrinsic cellular and molecular properties of in vivo hippocampal synaptic plasticity are altered in the absence of key synaptic matrix molecules.

    abstract::Hippocampal synaptic plasticity comprises a key cellular mechanism for information storage. In the hippocampus, both long-term potentiation (LTP) and long-term depression (LTD) are triggered by synaptic Ca2+ -elevations that are typically mediated by the opening of voltage-gated cation channels, such as N-methyl-d-asp...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22742

    authors: Jansen S,Gottschling C,Faissner A,Manahan-Vaughan D

    更新日期:2017-08-01 00:00:00

  • A new human delayed-matching-to-place test in a virtual environment reverse-translated from the rodent watermaze paradigm: Characterization of performance measures and sex differences.

    abstract::Watermaze tests of place learning and memory in rodents and corresponding reverse-translated human paradigms in real or virtual environments are key tools to study hippocampal function. In common variants, the animal or human participant has to find a hidden goal that remains in the same place over many trials, allowi...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22992

    authors: Buckley MG,Bast T

    更新日期:2018-11-01 00:00:00

  • Human temporal lobe epilepsy analyses by tissue proteomics.

    abstract::Although there are many types of epilepsy, temporal lobe epilepsy (TLE) is probably in humans the most common and most often studied. TLE represents 40% of the total epilepsy form of the disease and is difficult to treat. Despite a wealth of descriptive data obtained from the disease history of patients, the EEG recor...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22246

    authors: Mériaux C,Franck J,Park DB,Quanico J,Kim YH,Chung CK,Park YM,Steinbusch H,Salzet M,Fournier I

    更新日期:2014-06-01 00:00:00

  • Synchronicity of excitatory inputs drives hippocampal networks to distinct oscillatory patterns.

    abstract::The rodent hippocampus expresses a variety of neuronal network oscillations depending on the behavioral state of the animal. Locomotion and active exploration are accompanied by theta-nested gamma oscillations while resting states and slow-wave sleep are dominated by intermittent sharp wave-ripple complexes. It is bel...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.23214

    authors: Geschwill P,Kaiser ME,Grube P,Lehmann N,Thome C,Draguhn A,Hollnagel JO,Both M

    更新日期:2020-10-01 00:00:00

  • Chronic impairment of ERK signaling in glutamatergic neurons of the forebrain does not affect spatial memory retention and LTP in the same manner as acute blockade of the ERK pathway.

    abstract::The ERK/MAPK signaling pathway has been extensively studied in the context of learning and memory. Defects in this pathway underlie genetic diseases associated with intellectual disability, including impaired learning and memory. Numerous studies have investigated the impact of acute ERK/MAPK inhibition on long-term p...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22769

    authors: Vithayathil J,Pucilowska J,Friel D,Landreth GE

    更新日期:2017-12-01 00:00:00

  • Place navigation in the Morris water task results in greater nuclear Arc mRNA expression in dorsal compared to ventral CA1.

    abstract::Previous work has shown that the dorsal hippocampus has greater activity than ventral regions during place navigation. Exposure to a novel context has also been found to increase hippocampal activation, possibly due to increased spatial demands. However, activation patterns in dorsal and ventral regions have not been ...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.23157

    authors: Lee JQ,Demchuk AM,Morgan E,McHugh R,McNaughton BL,Sutherland RJ,McDonald RJ

    更新日期:2019-11-01 00:00:00

  • BDNF-triggered events in the rat hippocampus are required for both short- and long-term memory formation.

    abstract::Information storage in the brain is a temporally graded process involving different memory types or phases. It has been assumed for over a century that one or more short-term memory (STM) processes are involved in processing new information while long-term memory (LTM) is being formed. Because brain-derived neutrophic...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.10035

    authors: Alonso M,Vianna MR,Depino AM,Mello e Souza T,Pereira P,Szapiro G,Viola H,Pitossi F,Izquierdo I,Medina JH

    更新日期:2002-01-01 00:00:00

  • Hippocampal theta-related cellular activity in the superior colliculus of the urethane-anesthetized rat.

    abstract::In the present study, 93 cells in the superior colliculus (SC) were recorded extracellularly during the simultaneous occurrence of spontaneous theta field activity, sensory-induced (tail pinch) theta field activity, and large amplitude irregular (LIA) field activity, recorded from an electrode located in the stratum m...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/(SICI)1098-1063(1999)9:5<500::AID-HIPO3>3.

    authors: Natsume K,Hallworth NE,Szgatti TL,Bland BH

    更新日期:1999-01-01 00:00:00

  • Microarray analysis of rat hippocampus exposed to excitotoxicity: reversal Na(+)/Ca(2+) exchanger NCX3 is overexpressed in glial cells.

    abstract::Multiple factors are involved in the glutamate-induced excitotoxicity phenomenon, such as overload of ionotropic and metabotropic receptors, excess Ca(2+) influx, nitric oxide synthase activation, oxidative damage due to increase in free radicals, and release of endogenous polyamine, among others. In order to attempt ...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20869

    authors: Ortuño-Sahagún D,Rivera-Cervantes MC,Gudiño-Cabrera G,Junyent F,Verdaguer E,Auladell C,Pallàs M,Camins A,Beas-Zárate C

    更新日期:2012-02-01 00:00:00

  • Connections between the retrosplenial cortex and the hippocampal formation in the rat: a review.

    abstract::The retrosplenial cortex is situated at the crossroads between the hippocampal formation and many areas of the neocortex, but few studies have examined the connections between the hippocampal formation and the retrosplenial cortex in detail. Each subdivision of the retrosplenial cortex projects to a discrete terminal ...

    journal_title:Hippocampus

    pub_type: 杂志文章,评审

    doi:10.1002/hipo.450020102

    authors: Wyss JM,Van Groen T

    更新日期:1992-01-01 00:00:00

  • Cholinergic, but not NMDA, receptors in the lateral entorhinal cortex mediate acquisition in trace eyeblink conditioning.

    abstract::Anatomical and electrophysiological studies collectively suggest that the entorhinal cortex consists of several subregions, each of which is involved in the processing of different types of information. Consistent with this idea, we previously reported that the dorsolateral portion of the entorhinal cortex (DLE), but ...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22466

    authors: Tanninen SE,Yu X,Giritharan T,Tran L,Bakir R,Volle J,Morrissey MD,Takehara-Nishiuchi K

    更新日期:2015-11-01 00:00:00

  • Hippocampal shape analysis for Alzheimer's disease using an efficient hypothesis test and regularized discriminative deformation.

    abstract::In this article, we present a framework to perform statistical shape analysis for segmented hippocampi, including an efficient permutation test for detecting subtle class differences, and a regularized discriminative direction method for visualizing the shape discrepancy. Fisher permutation and bootstrap tests are pre...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20639

    authors: Zhou L,Lieby P,Barnes N,Réglade-Meslin C,Walker J,Cherbuin N,Hartley R

    更新日期:2009-06-01 00:00:00

  • Lesions of the ventral hippocampus attenuate the acquisition but not expression of sign-tracking behavior in rats.

    abstract::Individual variation in the attribution of motivational salience to reward-related cues is believed to underlie addiction vulnerability. Pavlovian conditioned approach measures individual variation in motivational salience by identifying rats that are attracted to and motivated by reward cues (sign-trackers) or motiva...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22619

    authors: Fitzpatrick CJ,Creeden JF,Perrine SA,Morrow JD

    更新日期:2016-11-01 00:00:00

  • The impact of experienced stress on aged spatial discrimination: Cortical overreliance as a result of hippocampal impairment.

    abstract::A large body of neuroscientific work indicates that exposure to experienced stress causes damage to both cortical and hippocampal cells and results in impairments to cognitive abilities associated with these structures. Similarly, work within the domain of cognitive aging demonstrates that elderly participants who rep...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22525

    authors: Marshall AC,Cooper NR,Geeraert N

    更新日期:2016-03-01 00:00:00

  • SynCAM 1 improves survival of adult-born neurons by accelerating synapse maturation.

    abstract::The survival of adult-born dentate gyrus granule cells critically depends on their synaptic integration into the existing neuronal network. Excitatory inputs are thought to increase the survival rate of adult born neurons. Therefore, whether enhancing the stability of newly formed excitatory synapses by overexpressing...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.22524

    authors: Doengi M,Krupp AJ,Körber N,Stein V

    更新日期:2016-03-01 00:00:00

  • Hippocampus, aging, and segregating memories.

    abstract::Rats use time-of-day cues to modulate learned taste aversion memories. If adult rats are accustomed to drinking saline in the evening and they receive a lithium chloride injection after drinking saline in the morning, they form a stronger aversion to saline than rats that were conditioned after drinking saline at the ...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20481

    authors: Manrique T,Morón I,Ballesteros MA,Guerrero RM,Fenton AA,Gallo M

    更新日期:2009-01-01 00:00:00

  • Partial coherence and frustration in self-organizing spherical grids.

    abstract::Nearby grid cells have been observed to express a remarkable degree of long-range order, which is often idealized as extending potentially to infinity. Yet their strict periodic firing and ensemble coherence are theoretically possible only in flat environments, much unlike the burrows which rodents usually live in. Ar...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.23144

    authors: Stella F,Urdapilleta E,Luo Y,Treves A

    更新日期:2020-04-01 00:00:00

  • Nicotine prevents disruption of the late phase LTP-related molecular cascade in adult-onset hypothyroidism.

    abstract::We have shown previously that chronic nicotine treatment reverses adult-onset hypothyroidism-induced impairment of late-phase long-term potentiation (L-LTP) in area CA1 of the hippocampus. In the present study, basal and stimulated levels of signaling molecules essential for the expression of L-LTP were determined in ...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20306

    authors: Alzoubi KH,Aleisa AM,Alkadhi KA

    更新日期:2007-01-01 00:00:00

  • Cholinergic hypofunction impairs memory acquisition possibly through hippocampal Arc and BDNF downregulation.

    abstract::Recent evidence suggests that activity-regulated cytoskeleton associated protein (Arc) and brain-derived neurotrophic factor (BDNF) are key players in the cellular mechanisms that trigger synaptic changes and memory consolidation. Cholinergic deafferentiation of hippocampus has been largely shown to induce memory impa...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20812

    authors: Gil-Bea FJ,Solas M,Mateos L,Winblad B,Ramírez MJ,Cedazo-Mínguez A

    更新日期:2011-09-01 00:00:00

  • Vasopressin induction of long-lasting potentiation of synaptic transmission in the dentate gyrus.

    abstract::Vasopressin receptors are present in both the developing and mature dentate gyrus of the rat brain and are of the V1 vasopressor type. Because vasopressin has been shown to influence memory function when injected into the dentate gyrus, the influence of this peptide on an electrophysiological model of learning and mem...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.450030211

    authors: Chen C,Díaz Brinton RD,Shors TJ,Thompson RF

    更新日期:1993-04-01 00:00:00

  • Neonatal exposure to novelty enhances long-term potentiation in CA1 of the rat hippocampus.

    abstract::Exposing rats to an enriched environment over an extended period of time has been shown to enhance hippocampal long-term potentiation (LTP). Whether such prolonged exposure to environmental manipulation is necessary for LTP enhancement and whether the environmentally induced enhancement can persist long after the cess...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.10017

    authors: Tang AC,Zou B

    更新日期:2002-01-01 00:00:00

  • Infusion of neuropeptide Y into CA3 region of hippocampus produces antidepressant-like effect via Y1 receptor.

    abstract::A couple of papers indicate that patients with depression show a decrease in serum neuropeptide Y (NPY). To study the role of NPY in depression, we examined the effects of infusion of NPY into the hippocampus of learned helplessness (LH) rats (an animal model of depression). Infusion of NPY into the cerebral ventricle...

    journal_title:Hippocampus

    pub_type: 杂志文章

    doi:10.1002/hipo.20264

    authors: Ishida H,Shirayama Y,Iwata M,Katayama S,Yamamoto A,Kawahara R,Nakagome K

    更新日期:2007-01-01 00:00:00