Increased levels of acidic calponin during dendritic spine plasticity after pilocarpine-induced seizures.

abstract：:A forced-choice discrimination paradigm was used in two experiments, to evaluate retrograde and anterograde amnesia in rats after hippocampal ablation. In a within-subjects design (Experiment 1), rats were trained on a set of 10 olfactory discriminations 4 weeks before surgery and on a separate set of 10 discriminatio...

journal_title：Hippocampus

authors： Jonasson Z,Ballantyne JK,Baxter MG

更新日期：2004-01-01 00:00:00

abstract：:Accurate and reproducible in vivo measurement of hippocampal volumes using magnetic resonance (MR) imaging is complicated by the morphological complexity of the structure. Additionally, separation of certain parts of the hippocampus from the adjacent brain structures on MR images is sometimes very difficult. These dif...

journal_title：Hippocampus

authors： Pantel J,O'Leary DS,Cretsinger K,Bockholt HJ,Keefe H,Magnotta VA,Andreasen NC

更新日期：2000-01-01 00:00:00

abstract：:Neuronal mechanisms of episodic memory, the conscious recollection of autobiographical events, are largely unknown because electrophysiological studies in humans are conducted only in exceptional circumstances. Unit recording studies in animals are thus crucial for understanding the neurophysiological substrate that e...

journal_title：Hippocampus

authors： Ferbinteanu J,Kennedy PJ,Shapiro ML

更新日期：2006-01-01 00:00:00

abstract：:To ask if the properties of spatial learning supported by the hippocampus are distinct from the properties of conditioning, we conducted a blocking-like experiment in which the measured variable was not a conditioned response but rather the ability of a novel visual stimulus to control the location of place cell firin...

journal_title：Hippocampus

authors： Barry J,Muller R

更新日期：2011-05-01 00:00:00

abstract：:We recorded neuromagnetic fields evoked by a somatosensory oddball task requiring subjects to discriminate target stimuli from nontarget stimuli, which are different in stimulation intensity, with a mental count of the target stimuli. A whole head type 80-channel magnetoencephalography (MEG) system with a 50-mm baseli...

journal_title：Hippocampus

authors： Hamada Y,Sugino K,Kado H,Suzuki R

更新日期：2004-01-01 00:00:00

abstract：:Down syndrome (DS), the leading genetic cause of mental retardation, is characterized by reduced number of cortical neurons and brain size. The occurrence of these defects starting from early life stages points at altered developmental neurogenesis as their major determinant. The goal of our study was to obtain compar...

journal_title：Hippocampus

authors： Contestabile A,Fila T,Ceccarelli C,Bonasoni P,Bonapace L,Santini D,Bartesaghi R,Ciani E

更新日期：2007-01-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP), a neurotrophic and neuromodulatory peptide, was recently shown to enhance NMDA receptor-mediated currents in the hippocampus (Macdonald, et al. 2005. J Neurosci 25:11374-11384). To check if PACAP might also modulate AMPA receptor function, we tested its effec...

journal_title：Hippocampus

authors： Costa L,Santangelo F,Li Volsi G,Ciranna L

更新日期：2009-01-01 00:00:00

abstract：:Norepinephrine, is involved in the enhancement of learning and memory formation by regulating synaptic mechanisms through its ability to activate pre- and post-synaptic adrenergic receptors. Here we show that β-agonists of norepinephrine facilitate the induction of both associational LTP and sharp wave ripples (SPW-Rs...

journal_title：Hippocampus

authors： Ul Haq R,Anderson M,Liotta A,Shafiq M,Sherkheli MA,Heinemann U

更新日期：2016-12-01 00:00:00

abstract：:The survival of adult-born dentate gyrus granule cells critically depends on their synaptic integration into the existing neuronal network. Excitatory inputs are thought to increase the survival rate of adult born neurons. Therefore, whether enhancing the stability of newly formed excitatory synapses by overexpressing...

journal_title：Hippocampus

authors： Doengi M,Krupp AJ,Körber N,Stein V

更新日期：2016-03-01 00:00:00

abstract：:Adaptive memory requires the organism to form associations that bridge between events separated in time. Many studies show interactions between hippocampus (HPC) and prefrontal cortex (PFC) during formation of such associations. We analyze neural recording from monkey HPC and PFC during a memory task that requires the...

journal_title：Hippocampus

authors： Cruzado NA,Tiganj Z,Brincat SL,Miller EK,Howard MW

更新日期：2020-12-01 00:00:00

abstract：:The hippocampus is essential for the consolidation of some explicit long-term memories, including trace conditioning. Lesions and pharmacological manipulations of the dorsal hippocampus (DH) have provided strong evidence for its involvement in the acquisition and expression of trace fear memories. However, no studies ...

journal_title：Hippocampus

authors： Pierson JL,Pullins SE,Quinn JJ

更新日期：2015-07-01 00:00:00

abstract：:In the mammalian brain, newly acquired memories depend on the hippocampus (HPC) for maintenance and recall, but over time, the neocortex takes over these functions, rendering memories HPC-independent. The process responsible for this transformation is called systems memory consolidation. Reactivation of a well-consoli...

journal_title：Hippocampus

authors： Helfer P,Shultz TR

更新日期：2020-07-01 00:00:00

abstract：:CA3 lesions impair encoding, whereas CA1 lesions impair retrieval during learning of a Hebb-Williams maze. CA3 efferents in the fimbria were transected, taking care to spare cholinergic and GABAergic afferents. CA1 efferents in the dorsal fornix were similarly transected. Fimbria transections, but not dorsal fornix tr...

journal_title：Hippocampus

authors： Hunsaker MR,Tran GT,Kesner RP

更新日期：2008-01-01 00:00:00

abstract：:Sleep is important for memory consolidation, and an abundant literature suggests that reactivation in the hippocampus during sleep is instrumental to this process. Yet, the current interpretation of activity during sharp-waves ripples (SWRs), as replay of wake experiences, relies on hypotheses that, while widely accep...

journal_title：Hippocampus

authors： Laventure S,Benchenane K

更新日期：2020-01-01 00:00:00

abstract：:For well over a century, ethanol was believed to exert its effects on cognition and behavior by producing a ubiquitous depression of central nervous system activity. A general disruption in brain function was consistent with the belief that ethanol's effects on cognition and behavior were also quite general. Substanti...

journal_title：Hippocampus

authors： White AM,Matthews DB,Best PJ

更新日期：2000-01-01 00:00:00

abstract：:Functional differences in the anterior and posterior hippocampus during episodic memory processing have not been examined in human electrophysiological data. This is in spite of strong evidence for such differences in rodent data, including greater place cell specificity in the dorsal hippocampus, greater sensitivity ...

journal_title：Hippocampus

authors： Lin JJ,Rugg MD,Das S,Stein J,Rizzuto DS,Kahana MJ,Lega BC

更新日期：2017-10-01 00:00:00

abstract：:The role of perforant pathway-dentate granule cell synapses in cognitive behavior was examined focusing on synaptic Zn(2+) signaling in the dentate gyrus. Object recognition memory was transiently impaired when extracellular Zn(2+) levels were decreased by injection of clioquinol and N,N,N',N'-tetrakis-(2-pyridylmethy...

journal_title：Hippocampus

authors： Takeda A,Tamano H,Ogawa T,Takada S,Nakamura M,Fujii H,Ando M

更新日期：2014-11-01 00:00:00

abstract：:C57 and DBA mice were trained in a crossed maze to assess possible strain differences in place or response learning as a function of training duration (8 or 17 days) and extramaze cueing conditions. The first condition consisted of a diffuse visually cued environment (rich cueing). The second was the same plus an expl...

journal_title：Hippocampus

authors： Passino E,Middei S,Restivo L,Bertaina-Anglade V,Ammassari-Teule M

更新日期：2002-01-01 00:00:00

abstract：:Aniracetam reversibly increased synaptic responses mediated by the AMPA but not the NMDA subclass of glutamate receptors in hippocampus and was considerably more potent than structurally similar nootropics. The drug had greater effects on field excitatory postsynaptic potentials (EPSPs) in the dentate gyrus and CA1 re...

journal_title：Hippocampus

authors： Xiao P,Staubli U,Kessler M,Lynch G

更新日期：1991-10-01 00:00:00

abstract：:Stratum lacunosum-moleculare interneurons (L-Mi) in hippocampal area CA3 target the apical dendrite of pyramidal cells providing feedforward inhibition. Here we report that selective activation of group III metabotropic glutamate receptors (mGluRs) 4/8 with L(+)-2-amino-4-phosphnobytyric acid (L-AP4; 10 μM) decreased ...

journal_title：Hippocampus

authors： Cosgrove KE,Meriney SD,Barrionuevo G

更新日期：2011-12-01 00:00:00

abstract：:White matter hyperintensities (WMH) constitute the visible spectrum of cerebral small vessel disease (SVD) markers and are associated with cognitive decline, although they do not fully account for memory decline observed in individuals with SVD. We hypothesize that WMH might exert their effect on memory decline indire...

journal_title：Hippocampus

authors： van Leijsen EMC,Tay J,van Uden IWM,Kooijmans ECM,Bergkamp MI,van der Holst HM,Ghafoorian M,Platel B,Norris DG,Kessels RPC,Markus HS,Tuladhar AM,de Leeuw FE

更新日期：2019-06-01 00:00:00

abstract：:Changes in the spatial arrangement or identity of objects inside a familiar environment induce reexploration. The present study looks at modifications of place cell activity during such renewed exploration. Hungry rats foraged for food in a cylinder with a salient cue card attached to the wall and with two distinct ob...

journal_title：Hippocampus

authors： Lenck-Santini PP,Rivard B,Muller RU,Poucet B

更新日期：2005-01-01 00:00:00

abstract：:Hippocampal neurogenesis declines substantially in chronic temporal lobe epilepsy (TLE). However, it is unclear whether this decline is linked to altered production of new cells and/or diminished survival and neuronal fate-choice decision of newly born cells. We quantified different components of hippocampal neurogene...

journal_title：Hippocampus

authors： Hattiangady B,Shetty AK

更新日期：2010-01-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is a class of neurodevelopmental disorders characterized by persistent deficits in social communication/interaction, together with restricted/repetitive patterns of behavior. ASD is among the most heritable neuropsychiatric conditions, and while available evidence points to a complex set...

journal_title：Hippocampus

authors： Sungur AÖ,Jochner MCE,Harb H,Kılıç A,Garn H,Schwarting RKW,Wöhr M

更新日期：2017-08-01 00:00:00

abstract：:Human navigation studies show that landmarks are used for orientation, whereas objects contribute to the contextual representation of an environment. What constitutes a landmark? Classic rodent studies show that hippocampal place fields are controlled by distal, polarizing cues. Place fields, however, are also influen...

journal_title：Hippocampus

authors： Scaplen KM,Gulati AA,Heimer-McGinn VL,Burwell RD

更新日期：2014-11-01 00:00:00

abstract：:Our model of the spatial and temporal aspects of place cell firing and their role in rat navigation is reviewed. The model provides a candidate mechanism, at the level of individual cells, by which place cell information concerning self-localization could be used to guide navigation to previously visited reward sites....

journal_title：Hippocampus

authors： Burgess N,O'Keefe J

更新日期：1996-01-01 00:00:00

abstract：:In rodents, pyramidal cell firing patterns from waking may be replayed in nonrapid eye movement sleep (NREM) sleep during hippocampal sharp wave ripples (HC-SWR). In humans, HC-SWR have only been recorded with electrodes implanted to localize epileptogenicity. Here, we characterize human HC-SWR with rigorous rejection...

journal_title：Hippocampus

authors： Jiang X,Gonzalez-Martinez J,Cash SS,Chauvel P,Gale J,Halgren E

更新日期：2020-06-01 00:00:00

abstract：:In this study the subcortical afferents for the rat PER areas 35 and 36, POR, and the lateral and medial entorhinal areas (LEA and MEA) were characterized. We analyzed 33 retrograde tract-tracing experiments distributed across the five regions. For each experiment, we estimated the total numbers, percentages, and dens...

journal_title：Hippocampus

authors： Tomás Pereira I,Agster KL,Burwell RD

更新日期：2016-09-01 00:00:00

abstract：:Anatomical and electrophysiological studies collectively suggest that the entorhinal cortex consists of several subregions, each of which is involved in the processing of different types of information. Consistent with this idea, we previously reported that the dorsolateral portion of the entorhinal cortex (DLE), but ...

journal_title：Hippocampus

authors： Tanninen SE,Yu X,Giritharan T,Tran L,Bakir R,Volle J,Morrissey MD,Takehara-Nishiuchi K

更新日期：2015-11-01 00:00:00

abstract：:To investigate involvement of the hippocampal formation in spatial information processing, activity of neurons in the hippocampal formation of the conscious monkey was recorded during presentation of various visual and auditory stimuli from several directions around the monkey. Of 1,047 neurons recorded, 106 (10.1%) r...

journal_title：Hippocampus

authors： Tamura R,Ono T,Fukuda M,Nakamura K

更新日期：1992-07-01 00:00:00