Abstract:
:This study examines whether 4-8-Hz theta oscillations can be seen in the human hippocampus, and whether these oscillations increase during virtual movement and searching, as they do in rodents. Recordings from both hippocampal and neocortical depth electrodes were analyzed while six epileptic patients played a virtual taxi-driver game. During the game, the patients alternated between searching for passengers, whose locations were random, and delivering them to stores, whose locations remained constant. In both hippocampus and neocortex, theta increased during virtual movement in all phases of the game. Hippocampal and neocortical theta activity were also significantly correlated with each other, but this correlation did not differ between neocortex and hippocampus and within disparate neocortical electrodes. Our findings demonstrate the existence of movement-related theta oscillations in human hippocampus, and suggest that both cortical and hippocampal oscillations play a role in attention and sensorimotor integration.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Ekstrom AD,Caplan JB,Ho E,Shattuck K,Fried I,Kahana MJdoi
10.1002/hipo.20109keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
881-9issue
7eissn
1050-9631issn
1098-1063journal_volume
15pub_type
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