Alterations in the balance of protein kinase and phosphatase activities and age-related impairments of synaptic transmission and long-term potentiation.

abstract：:Cocaine induces an increase in hippocampal and nucleus accumbens (Nac) serotonin (5-HT) concentration parallel to locomotor activation. Both effects can be modulated by systemic 5-HT(1A)-receptor agonism/antagonism. Given the contribution of the hippocampus to spontaneous behavioral activity, these observations sugges...

journal_title：Hippocampus

authors： Müller CP,Thönnessen H,Barros M,Tomaz C,Carey RJ,Huston JP

更新日期：2004-01-01 00:00:00

abstract：:An extensive cortical network consisting of structures in the medial temporal lobe (hippocampus and parahippocampal cortex), lateral parietal cortex, retrosplenial cortex, and medial prefrontal cortex has recently attracted attention in cognitive neuroscience research, linking the network to both episodic memory and s...

journal_title：Hippocampus

authors： Peters J,Daum I,Gizewski E,Forsting M,Suchan B

更新日期：2009-02-01 00:00:00

abstract：:We recorded neuromagnetic fields evoked by a somatosensory oddball task requiring subjects to discriminate target stimuli from nontarget stimuli, which are different in stimulation intensity, with a mental count of the target stimuli. A whole head type 80-channel magnetoencephalography (MEG) system with a 50-mm baseli...

journal_title：Hippocampus

authors： Hamada Y,Sugino K,Kado H,Suzuki R

更新日期：2004-01-01 00:00:00

abstract：:Various paradigms have been used to assess the capacity of the adult brain to undergo activity-dependent morphological plasticity. In this report we have employed recurrent limbic seizures as a means of studying the effects of this form of enhanced neuronal activity on cellular morphology and, in particular, on the in...

journal_title：Hippocampus

authors： Bundman MC,Pico RM,Gall CM

更新日期：1994-10-01 00:00:00

abstract：:In this study the subcortical afferents for the rat PER areas 35 and 36, POR, and the lateral and medial entorhinal areas (LEA and MEA) were characterized. We analyzed 33 retrograde tract-tracing experiments distributed across the five regions. For each experiment, we estimated the total numbers, percentages, and dens...

journal_title：Hippocampus

authors： Tomás Pereira I,Agster KL,Burwell RD

更新日期：2016-09-01 00:00:00

abstract：:Trans-synaptic cell-adhesion molecules have been implicated in regulating CNS synaptogenesis. Among these, the Neuroligin (NL) family (NLs 1-4) of postsynaptic adhesion proteins has been shown to promote the development and specification of excitatory versus inhibitory synapses. NLs form a heterophilic complex with th...

journal_title：Hippocampus

authors： Dahlhaus R,Hines RM,Eadie BD,Kannangara TS,Hines DJ,Brown CE,Christie BR,El-Husseini A

更新日期：2010-02-01 00:00:00

abstract：:We have previously shown that exposing rats to a relatively high dose of ethanol during early postnatal life can result in an alteration in spatial learning ability. The hippocampal formation is known to be involved in the control of this ability. The purpose of the present study was to determine whether exposure of r...

journal_title：Hippocampus

authors： Miki T,Harris SJ,Wilce PA,Takeuchi Y,Bedi KS

更新日期：2004-01-01 00:00:00

abstract：:Structures in the caudal diencephalon including the posterior hypothalamic nucleus, the supramammillary nucleus (SUM) and the nuclei of the mammillary body (MB) occupy a strategic position in the crossroads of ascending and descending traffic between the brainstem and the limbic forebrain (septum/hippocampus). In this...

journal_title：Hippocampus

authors： Kocsis B,Vertes RP

更新日期：1997-01-01 00:00:00

abstract：:Trace eyeblink classical conditioning is a non-spatial learning paradigm that requires an intact hippocampus. This task is hippocampus-dependent because the auditory tone conditioned stimulus (CS) is temporally separated from the corneal airpuff unconditioned stimulus (US) by a 500-ms trace interval. Our laboratory ha...

journal_title：Hippocampus

authors： McEchron MD,Disterhoft JF

更新日期：1999-01-01 00:00:00

abstract：:Neurons in the supramammillary nucleus (SUM) of urethane-anesthetized rats fire rhythmically in synchrony with hippocampal theta rhythm. As these neurons project to the septum and hippocampus, it is generally assumed that their role is to mediate ascending activation, leading to the hippocampal theta rhythm. However, ...

journal_title：Hippocampus

authors： Kocsis B,Kaminski M

更新日期：2006-01-01 00:00:00

abstract：:Functional differences in the anterior and posterior hippocampus during episodic memory processing have not been examined in human electrophysiological data. This is in spite of strong evidence for such differences in rodent data, including greater place cell specificity in the dorsal hippocampus, greater sensitivity ...

journal_title：Hippocampus

authors： Lin JJ,Rugg MD,Das S,Stein J,Rizzuto DS,Kahana MJ,Lega BC

更新日期：2017-10-01 00:00:00

abstract：:We often engage in counterfactual (CF) thinking, which involves reflecting on "what might have been." Creating alternative versions of reality seems to have parallels with recollecting the past and imagining the future in requiring the simulation of internally generated models of complex events. Given that episodic me...

journal_title：Hippocampus

authors： Mullally SL,Maguire EA

更新日期：2014-11-01 00:00:00

abstract：:Converging behavioral, electrophysiological, and neurochemical data suggest that lesions to the peripheral vestibular system result in impairment of the hippocampus. Nonetheless, relatively few studies have examined the hippocampus or behavior related to it, over a long period of time following the lesion, to determin...

journal_title：Hippocampus

authors： Zheng Y,Goddard M,Darlington CL,Smith PF

更新日期：2007-01-01 00:00:00

abstract：:Episodic memory improves during childhood and this improvement has been associated with age differences in hippocampal function, but previous research has not manipulated the possible underlying mechanisms. We tested the hypothesis that age-related differences in hippocampal activation may reflect changes in retrieval...

journal_title：Hippocampus

authors： DeMaster D,Coughlin C,Ghetti S

更新日期：2016-04-01 00:00:00

abstract：:Social isolation negatively affects the behavior and health of laboratory rats. Recently, it has been found that social isolation retards exercise-induced neurogenesis in the hippocampal dentate gyrus (DG) of male rats (Stranahan et al. (2006) Nat Neurosci 9:526-533). Since male and female rats react differently to ho...

journal_title：Hippocampus

authors： Leasure JL,Decker L

更新日期：2009-10-01 00:00:00

abstract：:Various forms of synaptic plasticity in the brain have been proposed to result from modifications in the properties of glutamate receptors by calcium-dependent mechanisms. In the present study, changes in glutamate receptors elicited by calcium treatment of previously frozen mouse brain sections were evaluated by qual...

journal_title：Hippocampus

authors： Lapierre L,Valastro B,Miceli D,Massicotte G

更新日期：2000-01-01 00:00:00

abstract：:Although the entorhinal cortex is a key structure connecting the hippocampal formation with the rest of the cerebral cortex, little is known about its early chemoanatomical development in primates. In the present study, a cytoarchitectonic analysis and immunocytochemical detection of somatostatin, neurotensin, parvalb...

journal_title：Hippocampus

authors： Berger B,Alvarez C,Goldman-Rakic PS

更新日期：1993-07-01 00:00:00

abstract：:Deficits in episodic memory are associated with deficits in the ability to imagine future experiences (i.e., mental time travel). We show that K.C., a person with episodic amnesia and an inability to imagine future experiences, nonetheless systematically discounts the value of future rewards, and his discounting is wi...

journal_title：Hippocampus

authors： Kwan D,Craver CF,Green L,Myerson J,Boyer P,Rosenbaum RS

更新日期：2012-06-01 00:00:00

abstract：:Schizophrenia is a devastating psychiatric illness with a complex pathophysiology. We have recently documented schizophrenia-like endophenotypes in phospholipase C-β1 knockout (PLC-β1(-/-)) mice, including deficits in prepulse inhibition, hyperlocomotion, and cognitive impairments. PLC-β1 signals via multiple G-protei...

journal_title：Hippocampus

authors： Manning EE,Ransome MI,Burrows EL,Hannan AJ

更新日期：2012-02-01 00:00:00

abstract：:Aging has been associated with a decline in relational memory, which is critically supported by the hippocampus. By adapting the transitivity paradigm (Bunsey and Eichenbaum (1996) Nature 379:255-257), which traditionally has been used in nonhuman animal research, this work examined the extent to which aging is accomp...

journal_title：Hippocampus

authors： Ryan JD,D'Angelo MC,Kamino D,Ostreicher M,Moses SN,Rosenbaum RS

更新日期：2016-02-01 00:00:00

abstract：:We aimed at identifying the cerebral structures whose synaptic function subserves the recollection of lifetime's episodic autobiographical memory (AM) via autonoetic consciousness. Twelve healthy middle-aged subjects (mean age: 59 years +/- 2.5) underwent a specially designed cognitive test to assess the ability to re...

journal_title：Hippocampus

authors： Piolino P,Desgranges B,Hubert V,Bernard FA,Matuszewski V,Chételat G,Baron JC,Eustache F

更新日期：2008-01-01 00:00:00

abstract：:Structural integrity of the human hippocampus is widely acknowledged to be necessary for the successful encoding and retrieval of autobiographical memories. However, evidence for an association between hippocampal volume and the ability to recall such memories in healthy individuals is mixed. Here we examined this iss...

journal_title：Hippocampus

authors： Barry DN,Clark IA,Maguire EA

更新日期：2020-12-15 00:00:00

abstract：:GABAergic inhibitory interneurons control fundamental aspects of neuronal network function. Their functional roles are assumed to be defined by the identity of their input synapses, the architecture of their dendritic tree, the passive and active membrane properties and finally the nature of their postsynaptic targets...

journal_title：Hippocampus

authors： Hosp JA,Strüber M,Yanagawa Y,Obata K,Vida I,Jonas P,Bartos M

更新日期：2014-02-01 00:00:00

abstract：:A couple of papers indicate that patients with depression show a decrease in serum neuropeptide Y (NPY). To study the role of NPY in depression, we examined the effects of infusion of NPY into the hippocampus of learned helplessness (LH) rats (an animal model of depression). Infusion of NPY into the cerebral ventricle...

journal_title：Hippocampus

authors： Ishida H,Shirayama Y,Iwata M,Katayama S,Yamamoto A,Kawahara R,Nakagome K

更新日期：2007-01-01 00:00:00

abstract：:Nuclear factor-kappa B (NFκB) signal is essential for neuronal survival and its activation may protect neuron against various stimuli. Since purinergic signals activate NFκB through the P2X7 receptor, we investigated the distinct pattern of NF-κB phosphorylation in neurons by P2X7 receptor activation following status ...

journal_title：Hippocampus

authors： Kim JE,Kim DS,Jin Ryu H,Il Kim W,Kim MJ,Won Kim D,Young Choi S,Kang TC

更新日期：2013-06-01 00:00:00

abstract：:The importance of the perirhinal cortex for visual recognition memory performance is undisputed. However, it has not been clear whether its contribution to performance is mainly perceptual, or mainly mnemonic, or whether the perirhinal cortex contributes to both perception and memory. We determined the effects of medi...

journal_title：Hippocampus

authors： Buffalo EA,Reber PJ,Squire LR

更新日期：1998-01-01 00:00:00

abstract：:We analyzed intracranial electroencephalographic (EEG) recordings from the medial temporal lobes of 12 epilepsy patients during a continuous word recognition paradigm, contrasting trials of correctly recognized repeated words (hits) and correctly identified new words (correct rejections). Using a wavelet-based analysi...

journal_title：Hippocampus

authors： Mormann F,Fell J,Axmacher N,Weber B,Lehnertz K,Elger CE,Fernández G

更新日期：2005-01-01 00:00:00

abstract：:L-aspartate is the amino-acid residue most susceptible to spontaneous isomerization. This denaturation causes an alteration in the biological activity of the protein and is regarded as an aging process of the protein. Protein L-isoaspartyl methyltransferase (PIMT) repairs this post-translational modification and thus ...

journal_title：Hippocampus

authors： Ikegaya Y,Yamada M,Fukuda T,Kuroyanagi H,Shirasawa T,Nishiyama N

更新日期：2001-01-01 00:00:00

abstract：:High-frequency stimulation of excitatory synapses in many regions of the brain triggers a lasting increase in the efficacy of synaptic transmission referred to as long-term potentiation (LTP) and believed to contribute to learning and memory. One hypothesis proposed to account for the stability and properties of this ...

journal_title：Hippocampus

authors： Muller D,Toni N,Buchs PA

更新日期：2000-01-01 00:00:00

abstract：:We have previously shown that, in HEK 293 cells, overexpression of acidic calponin, an actin-binding protein, induces remodeling of actin filaments, leading to a change in cell morphology. In addition, this protein is found in dendritic spines of adult hippocampal neurons. We hypothesized that this protein plays a rol...

journal_title：Hippocampus

authors： Ferhat L,Esclapez M,Represa A,Fattoum A,Shirao T,Ben-Ari Y

更新日期：2003-01-01 00:00:00