Abstract:
:Nuclear factor-kappa B (NFκB) signal is essential for neuronal survival and its activation may protect neuron against various stimuli. Since purinergic signals activate NFκB through the P2X7 receptor, we investigated the distinct pattern of NF-κB phosphorylation in neurons by P2X7 receptor activation following status epilepticus (SE) in an effort to understand the role of P2X7 receptor in epileptogenic insult. In non-SE animals, 2'(3')-O-(4-benzoyl)benzoyl adenosine 5'-triphosphate (BzATP, a P2X7R agonist) treatment increased only p52-Ser869 NF-κB phosphorylation in neuron. Following SE, p52-Ser865, p52-Ser869, p65-Ser276, p65-Ser311, p65-Ser468, and p65-Ser529 NF-κB phosphorylation was significantly decreased in CA1 and CA3 neurons. However, BzATP treatment prevented reductions in p65-Ser276, p65-Ser311, p65-Ser529, and p52-Ser869 NF-κB phosphorylations in CA1 and/or CA3 neurons induced by SE. Furthermore, BzATP treatment reduced SE-induced p65-Ser311, p65-Ser468, p65-Ser536, and p52-Ser869 NF-κB phosphorylations in astrocytes. These findings indicate that P2X7 functions may be involved in the regulation of SE-induced reactive astrocytes and neuronal degeneration via NF-κB phosphorylations in response to pilocarpine-induced SE in the rat hippocampus.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Kim JE,Kim DS,Jin Ryu H,Il Kim W,Kim MJ,Won Kim D,Young Choi S,Kang TCdoi
10.1002/hipo.22109subject
Has Abstractpub_date
2013-06-01 00:00:00pages
500-14issue
6eissn
1050-9631issn
1098-1063journal_volume
23pub_type
杂志文章相关文献
HIPPOCAMPUS文献大全abstract::Functional neuroimaging is uniquely placed to examine the dynamic nature of normal human memory, the distributed brain networks that support it, and how they are modulated. Memory has traditionally been classified into context-specific memories personally experienced ("episodic memory") and impersonal non-context-spec...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1999)9:1<54::AID-HIPO6>3.0
更新日期:1999-01-01 00:00:00
abstract::Both the hippocampus and ventromedial prefrontal cortex (vmPFC) appear to be critical for episodic future simulation. Damage to either structure affects one's ability to remember the past and imagine the future, and both structures are commonly activated as part of a wider core network during future simulation. Howeve...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22812
更新日期:2018-02-01 00:00:00
abstract::Wnt proteins have emerged as transmembrane signaling molecules that regulate learning and memory as well as synaptic plasticity at central synapses (Inestrosa and Arenas (2010) Nat Rev Neurosci 11:77-86; Maguschak and Ressler (2011) J Neurosci 31:13057-13067; Tabatadze et al. (2012) Hippocampus 22: 1228-1241; Fortress...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22239
更新日期:2014-04-01 00:00:00
abstract::Hippocampal adult neurogenesis contributes to key functions of the dentate gyrus (DG), including contextual discrimination. This is due, at least in part, to the unique form of plasticity that new neurons display at a specific stage of their development when compared with the surrounding principal neurons. In addition...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22313
更新日期:2014-11-01 00:00:00
abstract::In contextual fear conditioning (CFC), hippocampus is thought to process environmental stimuli into a configural representation of the context and send it to amygdala nuclei, which current evidences point to be the site of CS-US association and fear memory storage. If it is true, hippocampus should influence learning-...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22118
更新日期:2013-07-01 00:00:00
abstract::The hippocampus plays an important role in spatial learning and memory. However, the biochemical alterations that subserve this function remain to be fully elucidated. In this study, rats were subjected to a single-trial contextual fear conditioning (CFC) paradigm; the activation of different protein kinase C (PKC) su...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10015
更新日期:2002-01-01 00:00:00
abstract::This study investigated the effects of neonatal hippocampal ablation on the development of spatial learning and memory abilities in rats. Newborn rats sustained bilateral electrolytic lesions of the hippocampus or were sham-operated on postnatal day 1 (PN1). At PN20-25, PN50-55, or PN90-95, separate groups of rats wer...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1997)7:4<403::AID-HIPO6>3.
更新日期:1997-01-01 00:00:00
abstract::Anatomical and electrophysiological studies collectively suggest that the entorhinal cortex consists of several subregions, each of which is involved in the processing of different types of information. Consistent with this idea, we previously reported that the dorsolateral portion of the entorhinal cortex (DLE), but ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22466
更新日期:2015-11-01 00:00:00
abstract::Granule cells born in the adult dentate gyrus undergo a 4-week developmental period characterized by high susceptibility to cell death. Two forms of hippocampus-dependent learning have been shown to rescue many of the new neurons during this critical period. Here, we show that a natural form of associative learning, s...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20097
更新日期:2005-01-01 00:00:00
abstract::Place and grid cells in the hippocampal formation are commonly thought to support a unified and coherent cognitive map of space. This mapping mechanism faces a challenge when a navigator is placed in a familiar environment that has been deformed from its original shape. Under such circumstances, many transformations c...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23265
更新日期:2021-01-01 00:00:00
abstract::An extensive cortical network consisting of structures in the medial temporal lobe (hippocampus and parahippocampal cortex), lateral parietal cortex, retrosplenial cortex, and medial prefrontal cortex has recently attracted attention in cognitive neuroscience research, linking the network to both episodic memory and s...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20490
更新日期:2009-02-01 00:00:00
abstract::Granule cells of the mouse fascia dentata are widely used in studies on neuronal development and plasticity. In contrast to the rat, however, high-resolution morphometric data on these cells are scarce. Thus, we have analyzed granule cells in the fascia dentata of the adult Thy1-GFP mouse (C57BL/6 background). In this...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20398
更新日期:2008-01-01 00:00:00
abstract::Sleep is important for memory consolidation, and an abundant literature suggests that reactivation in the hippocampus during sleep is instrumental to this process. Yet, the current interpretation of activity during sharp-waves ripples (SWRs), as replay of wake experiences, relies on hypotheses that, while widely accep...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23143
更新日期:2020-01-01 00:00:00
abstract::Both natural and synthetic cannabinoid receptor (e.g., CB1) agonists such as Δ(9)-THC, WIN 55,212-2 (WIN-2), and HU-210 disrupt spatial cognition presumably through the inhibition of synchrony of hippocampal ensemble firing to task-related events. Although the CB1 receptor agonist CP 55,940 also disrupts the synchrono...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20769
更新日期:2011-05-01 00:00:00
abstract::Changes in synaptic efficacy and morphology have been proposed as mechanisms underlying learning and memory processes. In our previous studies, high frequency stimulation (HFS) sufficient to induce LTP at the hippocampal mossy fiber (MF) pathway, leads to MF synaptogenesis, in a prominent contralateral form, at the st...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20866
更新日期:2012-01-01 00:00:00
abstract::To clarify the specific contribution of the medial temporal lobe structures in spatial memory, we tested monkeys (Macaca mulatta) with sham operations and with lesions of either the hippocampal formation, areas TH/TF or perirhinal cortex on two versions of the visual-paired comparison task, measuring Spatial Location,...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20369
更新日期:2008-01-01 00:00:00
abstract::In this study the subcortical afferents for the rat PER areas 35 and 36, POR, and the lateral and medial entorhinal areas (LEA and MEA) were characterized. We analyzed 33 retrograde tract-tracing experiments distributed across the five regions. For each experiment, we estimated the total numbers, percentages, and dens...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22603
更新日期:2016-09-01 00:00:00
abstract::The mechanisms underlying memory are under intense investigation. One of the most promising candidates at the cellular level is long-term potentiation (LTP). Numerous pharmacological and molecular genetic manipulations have led to alteration in both LTP and memory. However, the causal relationship between these phenot...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.10101
更新日期:2002-01-01 00:00:00
abstract::We have previously shown that in urethane-anesthetized rats the frequency of rhythmical slow activity in the hippocampus ("theta") is controlled by the medial supramammillary nucleus (SuM). In particular, injections of procaine into SuM in urethane-anesthetized animals reduce the frequency of theta. However, it has be...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450050605
更新日期:1995-01-01 00:00:00
abstract::Space and time are both essential features of episodic memory, for which the hippocampus is critical (Howard & Eichenbaum, 2015). Spatial tasks have been used effectively to study the behavioral relevance of place cells. However, the behavioral paradigms utilized for the study of time cells have not used time duration...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23261
更新日期:2021-01-01 00:00:00
abstract::Individual variation in the attribution of motivational salience to reward-related cues is believed to underlie addiction vulnerability. Pavlovian conditioned approach measures individual variation in motivational salience by identifying rats that are attracted to and motivated by reward cues (sign-trackers) or motiva...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22619
更新日期:2016-11-01 00:00:00
abstract::Nearby grid cells have been observed to express a remarkable degree of long-range order, which is often idealized as extending potentially to infinity. Yet their strict periodic firing and ensemble coherence are theoretically possible only in flat environments, much unlike the burrows which rodents usually live in. Ar...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23144
更新日期:2020-04-01 00:00:00
abstract::To investigate involvement of the hippocampal formation in spatial information processing, activity of neurons in the hippocampal formation of the conscious monkey was recorded during presentation of various visual and auditory stimuli from several directions around the monkey. Of 1,047 neurons recorded, 106 (10.1%) r...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450020309
更新日期:1992-07-01 00:00:00
abstract::Increased consumption of high-fat diet (HFD) leads to obesity and adverse neurocognitive outcomes. Childhood and adolescence are important periods of brain maturation shaping cognitive function. These periods could consequently be particularly sensitive to the detrimental effects of HFD intake. In mice, juvenile and a...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22032
更新日期:2012-11-01 00:00:00
abstract::The aim of this study was to investigate the role of the human hippocampus in episodic retrieval of odors, in comparison with episodic retrieval of visual objects. Subjects encoded a set of unique odors and objects, and retrieval was tested the next day during functional magnetic resonance imaging (fMRI). Subjects wer...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22073
更新日期:2013-02-01 00:00:00
abstract::The present study investigated the delayed and persistent effects of 4 beta-phorbol 12,13-dibutyrate (PDBu) on the K(+)-evoked release of endogenous glutamate and dynorphin B-like immunoreactivity from a subcellular fraction (P3) that is enriched in hippocampal mossy fiber synaptosomes. It is demonstrated that the alp...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450030212
更新日期:1993-04-01 00:00:00
abstract::Ontogenesis of GABAergic signaling may play an important role in developmental changes in seizure susceptibility in the high-potassium model of ictogenesis in vitro. The age-dependent effects of [K(+)](o) on the reversal potential of the GABA(A)-mediated responses and membrane potential in hippocampal slices in vitro ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20259
更新日期:2007-01-01 00:00:00
abstract::Despite evidence that the extracellular matrix glycoprotein tenascin-C (TNC) is implicated in brain development and plasticity, its roles in the intact adult brain are unknown. Here we report that spontaneous local field potential (LFP) activity in freely moving adult TNC-deficient mice is abnormal. The power of corti...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20585
更新日期:2009-12-01 00:00:00
abstract::Spike-timing-dependent long-term potentiation (LTP) and long-term depression (LTD) were investigated in the CA1 area of hippocampal slices using optical imaging. A pair of electrical pulses were used to stimulate the Schaffer-commissural collateral and the stratum oriens with various sets of relative timing (tau) betw...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20035
更新日期:2005-01-01 00:00:00
abstract::The survival of adult-born dentate gyrus granule cells critically depends on their synaptic integration into the existing neuronal network. Excitatory inputs are thought to increase the survival rate of adult born neurons. Therefore, whether enhancing the stability of newly formed excitatory synapses by overexpressing...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22524
更新日期:2016-03-01 00:00:00