Abstract:
:Place and grid cells in the hippocampal formation are commonly thought to support a unified and coherent cognitive map of space. This mapping mechanism faces a challenge when a navigator is placed in a familiar environment that has been deformed from its original shape. Under such circumstances, many transformations could plausibly serve to map a navigator's familiar cognitive map to the deformed space. Previous empirical results indicate that the firing fields of rodent place and grid cells stretch or compress in a manner that approximately matches the environmental deformation, and human spatial memory exhibits similar distortions. These effects have been interpreted as evidence that reshaping a familiar environment elicits an analogously reshaped cognitive map. However, recent work has suggested an alternative explanation, whereby deformation-induced distortions of the grid code are attributable to a mechanism that dynamically anchors grid fields to the most recently experienced boundary, thus causing history-dependent shifts in grid phase. This interpretation raises the possibility that human spatial memory will exhibit similar history-dependent dynamics. To test this prediction, we taught participants the locations of objects in a virtual environment and then probed their memory for these locations in deformed versions of this environment. Across three experiments with variable access to visual and vestibular cues, we observed the predicted pattern, whereby the remembered locations of objects were shifted from trial to trial depending on the boundary of origin of the participant's movement trajectory. These results provide evidence for a dynamic anchoring mechanism that governs both neuronal firing and spatial memory.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Keinath AT,Rechnitz O,Balasubramanian V,Epstein RAdoi
10.1002/hipo.23265subject
Has Abstractpub_date
2021-01-01 00:00:00pages
89-101issue
1eissn
1050-9631issn
1098-1063journal_volume
31pub_type
杂志文章相关文献
HIPPOCAMPUS文献大全abstract::Nitric oxide (NO) is a gaseous neuromessenger. Although increasing evidence reveals significant physiological effects of NO in the hippocampal synaptic plasticity, the spatial distribution of NO production has remained largely uncharacterized due to the poor development of techniques for real-time NO imaging. In this ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20064
更新日期:2005-01-01 00:00:00
abstract::The importance of the hippocampal theta oscillation (4-8 Hz) to memory formation has been well-established through studies in animals, prompting researchers to propose comprehensive theories of memory and learning that rely on theta oscillations for integrating information in the hippocampus and neocortex. Yet, empiri...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20937
更新日期:2012-04-01 00:00:00
abstract::Key pathological features of Parkinson's Disease (PD) include the progressive degeneration of midbrain dopaminergic (DA) neurons and hindbrain noradrenergic (NA) neurons. The loss of DA neurons has been extensively studied and is the main cause of motor dysfunction. Importantly, however, there are a range of 'non-move...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22835
更新日期:2018-05-01 00:00:00
abstract::Human navigation studies show that landmarks are used for orientation, whereas objects contribute to the contextual representation of an environment. What constitutes a landmark? Classic rodent studies show that hippocampal place fields are controlled by distal, polarizing cues. Place fields, however, are also influen...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22331
更新日期:2014-11-01 00:00:00
abstract::Two patients, with magnetic resonance imaging (MRI)-confirmed relatively selective hippocampal damage, showed distinct patterns of performance on tests of recall, item recognition, and associative recognition. Patient AC showed a mean bilateral volume reduction of the hippocampus of 28%, but displayed no memory defici...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20427
更新日期:2008-01-01 00:00:00
abstract::The mammalian hippocampus plays a key role in spatial learning and memory, but the exact nature of the hippocampal representation of space is still being explored. Recently, there has been a fair amount of success in modeling hippocampal spatial maps in rats, assuming a topological perspective on spatial information p...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22610
更新日期:2016-10-01 00:00:00
abstract::Aniracetam reversibly increased synaptic responses mediated by the AMPA but not the NMDA subclass of glutamate receptors in hippocampus and was considerably more potent than structurally similar nootropics. The drug had greater effects on field excitatory postsynaptic potentials (EPSPs) in the dentate gyrus and CA1 re...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450010405
更新日期:1991-10-01 00:00:00
abstract::The hippocampus and the medial temporal lobe cortex [medial temporal lobe cortices (MTLC)] both contribute to long-term memory. Although their contributions are thought to be dissociable, the nature of the representations that each region supports remains unclear. The Complementary Learning Systems (CLS) modeling appr...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20967
更新日期:2012-05-01 00:00:00
abstract::Down syndrome (DS), the leading genetic cause of mental retardation, is characterized by reduced number of cortical neurons and brain size. The occurrence of these defects starting from early life stages points at altered developmental neurogenesis as their major determinant. The goal of our study was to obtain compar...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20308
更新日期:2007-01-01 00:00:00
abstract::It is argued that while the hippocampus is not vital for all classes of configural learning, it is vital for a specific subclass of configural tasks called "structural learning." The defining feature of structural learning is that in addition to binding stimulus elements to make unique arrays (as in all configural lea...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.20323
更新日期:2007-01-01 00:00:00
abstract::Reorganization of excitatory and inhibitory circuits in the hippocampal formation following seizure-induced neuronal loss has been proposed to underlie the development of chronic seizures in temporal lobe epilepsy (TLE). Here, we investigated whether specific morphological alterations of the GABAergic system can be re...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.1060
更新日期:2001-01-01 00:00:00
abstract::At the neuromuscular junction, spontaneous miniature excitatory synaptic currents mediated by acetylcholine are considered elementary, "quantal" transmissions. These miniature conductances can be quantitatively dichotomized into a large-mode class whose mode is the mean of a normal, bell-shaped distribution and a smal...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450030110
更新日期:1993-01-01 00:00:00
abstract::Rett syndrome (RTT) is a neurodevelopment disorder associated with intellectual disabilities and caused by loss-of-function mutations in the gene encoding the transcriptional regulator Methyl-CpG-binding Protein-2 (MeCP2). Neuronal dysfunction and changes in cortical excitability occur in RTT individuals and Mecp2-def...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22360
更新日期:2015-02-01 00:00:00
abstract::The locomotor effects of intra-NAcc injection of dopamine receptor agonists following discrete lesion or inhibition of the DH or the VH have been poorly investigated using only the indirect dopamine receptor agonist amphetamine. In the present study, we investigated how lidocaine in the DH or the VH modulated hyperloc...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20337
更新日期:2007-01-01 00:00:00
abstract::Hippocampal synaptic plasticity comprises a key cellular mechanism for information storage. In the hippocampus, both long-term potentiation (LTP) and long-term depression (LTD) are triggered by synaptic Ca2+ -elevations that are typically mediated by the opening of voltage-gated cation channels, such as N-methyl-d-asp...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22742
更新日期:2017-08-01 00:00:00
abstract::The electrophysiological properties of neurons in the rat perirhinal cortex were analyzed with intracellular recordings in an in vitro slice preparation. Cells included in this study (n = 59) had resting membrane potential (RMP) = -73.9 +/- 8.5 mV (mean +/- SD), action potential amplitude = 95.5 +/- 10.4 mV, input res...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.1081
更新日期:2001-01-01 00:00:00
abstract::The vestibular system contributes to the performance of various spatial memory tasks, but few studies have attempted to disambiguate the roles of the semicircular canals and otolith organs in this performance. This study tested the otolithic contribution to spatial working and reference memory by evaluating the perfor...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22300
更新日期:2014-10-01 00:00:00
abstract::Watermaze tests of place learning and memory in rodents and corresponding reverse-translated human paradigms in real or virtual environments are key tools to study hippocampal function. In common variants, the animal or human participant has to find a hidden goal that remains in the same place over many trials, allowi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22992
更新日期:2018-11-01 00:00:00
abstract::The selective lesion of basal forebrain cholinergic neurons (BFCNs) is an unestimable tool to study the implication of these neurons in cognition, an interest widely motivated by their degeneration in Alzheimer's disease. Here we evaluated the histochemical and behavioral effects of a selective lesion of BFCNs in C57B...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20422
更新日期:2008-01-01 00:00:00
abstract::We have previously shown that in urethane-anesthetized rats the frequency of rhythmical slow activity in the hippocampus ("theta") is controlled by the medial supramammillary nucleus (SuM). In particular, injections of procaine into SuM in urethane-anesthetized animals reduce the frequency of theta. However, it has be...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450050605
更新日期:1995-01-01 00:00:00
abstract::The entorhinal cortex has long been recognized as an important interface between the hippocampal formation and the neocortex. The notion of bidirectional connections between the entorhinal cortex and the hippocampal formation have led to the suggestion that hippocampal output originating in CA1 and subiculum may reent...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20022
更新日期:2004-01-01 00:00:00
abstract::A large body of evidence exists to demonstrate that excitatory amino acids (EAA) and their receptors are involved in the pathophysiological mechanisms linking several acute brain insults, such as cerebral ischemia, to neuronal degeneration and death. Accordingly, the use of EAA receptor antagonists can be beneficial i...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450050111
更新日期:1995-01-01 00:00:00
abstract::CA3 lesions impair encoding, whereas CA1 lesions impair retrieval during learning of a Hebb-Williams maze. CA3 efferents in the fimbria were transected, taking care to spare cholinergic and GABAergic afferents. CA1 efferents in the dorsal fornix were similarly transected. Fimbria transections, but not dorsal fornix tr...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20429
更新日期:2008-01-01 00:00:00
abstract::Social isolation negatively affects the behavior and health of laboratory rats. Recently, it has been found that social isolation retards exercise-induced neurogenesis in the hippocampal dentate gyrus (DG) of male rats (Stranahan et al. (2006) Nat Neurosci 9:526-533). Since male and female rats react differently to ho...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20563
更新日期:2009-10-01 00:00:00
abstract::Neuropsychologists have clearly implicated the hippocampus in the consolidation of memory, particularly episodic memory, the mental replay of past experiences. When recorded from behaving animals, by far the most obvious firing pattern of the primary neurons of the hippocampus is the place field: a cell tends to fire ...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.20199
更新日期:2006-01-01 00:00:00
abstract::Unilateral injection of kainic acid (KA) into the dorsal hippocampus of adult mice induces spontaneous recurrent partial seizures and replicates histopathological changes observed in human mesial temporal lobe epilepsy (MTLE) (Bouilleret V et al., Neuroscience 1999; 89:717-729). Alterations in pre- and postsynaptic co...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/1098-1063(2000)10:3<305::AID-HIPO11>3.0.CO
更新日期:2000-01-01 00:00:00
abstract::Information storage in the brain is a temporally graded process involving different memory types or phases. It has been assumed for over a century that one or more short-term memory (STM) processes are involved in processing new information while long-term memory (LTM) is being formed. Because brain-derived neutrophic...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10035
更新日期:2002-01-01 00:00:00
abstract::Our lives are a continuous stream of experience. Our episodic memories on the other hand have a definitive beginning, middle, and end. Theories of event segmentation suggest that salient changes in our environment produce event boundaries which partition the past from the present and, as a result, produce discretized ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23161
更新日期:2020-02-01 00:00:00
abstract::Highly synchronized neural firing has been discussed in relation to learning and memory, for instance sharp-wave activity in hippocampus. We were interested to study how a postsynaptic CA1 pyramidal neuron would integrate input of different levels of synchronicity. In previous work using computational modeling we stud...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22061
更新日期:2013-01-01 00:00:00
abstract::The mechanisms underlying memory are under intense investigation. One of the most promising candidates at the cellular level is long-term potentiation (LTP). Numerous pharmacological and molecular genetic manipulations have led to alteration in both LTP and memory. However, the causal relationship between these phenot...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.10101
更新日期:2002-01-01 00:00:00