Theta oscillation-coupled dendritic spiking integrates inputs on a long time scale.

abstract：:Alzheimer's disease (AD) and ageing are associated with impaired learning and memory, and recent findings point toward modulating chromatin remodeling through histone acetylation as a promising therapeutic strategy. Here we report that systemic administration of the HDAC inhibitor 4-phenylbutyrate (PBA) reinstated fea...

journal_title：Hippocampus

authors： Ricobaraza A,Cuadrado-Tejedor M,Marco S,Pérez-Otaño I,García-Osta A

更新日期：2012-05-01 00:00:00

abstract：:This study investigated the effects of progesterone (P4) on the production and survival of neurons in the hippocampal dentate gyrus of adult male mice. The administration of P4 (4 mg/kg) for 3 consecutive days beginning on the 0-2nd day after the first BrdU-injection (BrdU-D(0-2)) produced an approximately twofold inc...

journal_title：Hippocampus

authors： Zhang Z,Yang R,Zhou R,Li L,Sokabe M,Chen L

更新日期：2010-03-01 00:00:00

abstract：:The role of perforant pathway-dentate granule cell synapses in cognitive behavior was examined focusing on synaptic Zn(2+) signaling in the dentate gyrus. Object recognition memory was transiently impaired when extracellular Zn(2+) levels were decreased by injection of clioquinol and N,N,N',N'-tetrakis-(2-pyridylmethy...

journal_title：Hippocampus

authors： Takeda A,Tamano H,Ogawa T,Takada S,Nakamura M,Fujii H,Ando M

更新日期：2014-11-01 00:00:00

abstract：:Although the importance of cAMP-response element binding protein (CREB) phosphorylation in long-term memory formation is well documented for hippocampus-dependent tasks, little is known about the changes in phosphorylated CREB (pCREB) that occur during the process of extinction. The purpose of this study was to charac...

journal_title：Hippocampus

authors： Porte Y,Trifilieff P,Wolff M,Micheau J,Buhot MC,Mons N

更新日期：2011-11-01 00:00:00

abstract：:Our lives are a continuous stream of experience. Our episodic memories on the other hand have a definitive beginning, middle, and end. Theories of event segmentation suggest that salient changes in our environment produce event boundaries which partition the past from the present and, as a result, produce discretized ...

journal_title：Hippocampus

authors： Griffiths BJ,Fuentemilla L

更新日期：2020-02-01 00:00:00

abstract：:Nearby grid cells have been observed to express a remarkable degree of long-range order, which is often idealized as extending potentially to infinity. Yet their strict periodic firing and ensemble coherence are theoretically possible only in flat environments, much unlike the burrows which rodents usually live in. Ar...

journal_title：Hippocampus

authors： Stella F,Urdapilleta E,Luo Y,Treves A

更新日期：2020-04-01 00:00:00

abstract：:Metabolic integrity of glial cells in field CA1 of the guinea pig hippocampus is critical to maintenance of synaptic transmission (Keyser and Pellmar [1994] Glia 10:237-243). To determine if this tight glial-neuronal coupling is equally important in other brain regions, we compared the effect of fluoroacetate (FAC), a...

journal_title：Hippocampus

authors： Keyser DO,Pellmar TC

更新日期：1997-01-01 00:00:00

abstract：:Granule cells with recurrent basal dendrites (RBDs) were previously reported in both control and epileptic rats. RBDs are dendrites that arise from the basal half of granule cell bodies and curve toward and extend into the molecular layer. They are increased in frequency in the pilocarpine model of epilepsy. The prese...

journal_title：Hippocampus

authors： Dashtipour K,Yan XX,Dinh TT,Okazaki MM,Nadler JV,Ribak CE

更新日期：2002-01-01 00:00:00

abstract：:Adult neurogenesis continues throughout life in the mammalian hippocampus. The precise function of the adult generated neurons remains uncertain although there is growing evidence that they are involved in hippocampus-dependent learning and memory. Training rats on a hidden platform version of the Morris water task ha...

journal_title：Hippocampus

authors： Epp JR,Haack AK,Galea LA

更新日期：2010-07-01 00:00:00

abstract：:It is well documented that place cells and grid cells in echolocating bats show properties similar to those described in rodents, and yet, continuous theta-frequency oscillations, proposed to play a central role in grid/place cell formation, are not present in bat recordings. These comparative neurophysiological data ...

journal_title：Hippocampus

authors： Horiuchi TK,Moss CF

更新日期：2015-12-01 00:00:00

abstract：:The importance of the perirhinal cortex for visual recognition memory performance is undisputed. However, it has not been clear whether its contribution to performance is mainly perceptual, or mainly mnemonic, or whether the perirhinal cortex contributes to both perception and memory. We determined the effects of medi...

journal_title：Hippocampus

authors： Buffalo EA,Reber PJ,Squire LR

更新日期：1998-01-01 00:00:00

abstract：:In the human neocortex, progressive synaptogenesis in early postnatal life is followed by a decline in synaptic density, then stability from adolescence until middle age. No comparable data are available in the hippocampus. In this study, the integral synaptic vesicle protein synaptophysin, measured immunoautoradiogra...

journal_title：Hippocampus

authors： Eastwood SL,Weickert CS,Webster MJ,Herman MM,Kleinman JE,Harrison PJ

更新日期：2006-01-01 00:00:00

abstract：:Neuronal mechanisms of episodic memory, the conscious recollection of autobiographical events, are largely unknown because electrophysiological studies in humans are conducted only in exceptional circumstances. Unit recording studies in animals are thus crucial for understanding the neurophysiological substrate that e...

journal_title：Hippocampus

authors： Ferbinteanu J,Kennedy PJ,Shapiro ML

更新日期：2006-01-01 00:00:00

abstract：:Previous studies with excitotoxically lesioned organotypic hippocampal slice cultures (OHSC) have revealed that the immunosuppressant mycophenolate mofetil (MMF) inhibits microglial activation and suppresses neuronal injury in the dentate gyrus. We here investigate whether MMF also has beneficial effects on axon survi...

journal_title：Hippocampus

authors： Oest TM,Dehghani F,Korf HW,Hailer NP

更新日期：2006-01-01 00:00:00

abstract：:Highly synchronized neural firing has been discussed in relation to learning and memory, for instance sharp-wave activity in hippocampus. We were interested to study how a postsynaptic CA1 pyramidal neuron would integrate input of different levels of synchronicity. In previous work using computational modeling we stud...

journal_title：Hippocampus

authors： Tigerholm J,Migliore M,Fransén E

更新日期：2013-01-01 00:00:00

abstract：:The aim of this study was to investigate the role of the human hippocampus in episodic retrieval of odors, in comparison with episodic retrieval of visual objects. Subjects encoded a set of unique odors and objects, and retrieval was tested the next day during functional magnetic resonance imaging (fMRI). Subjects wer...

journal_title：Hippocampus

authors： Lehn H,Kjønigsen LJ,Kjelvik G,Håberg AK

更新日期：2013-02-01 00:00:00

abstract：:The perirhinal cortex (PRC) is known to play an important role in object recognition. Little is known, however, regarding the activity of PRC neurons during the presentation of stimuli that are commonly used for recognition memory tasks in rodents, that is, three-dimensional objects. Rats in the present study were exp...

journal_title：Hippocampus

authors： Burke SN,Maurer AP,Hartzell AL,Nematollahi S,Uprety A,Wallace JL,Barnes CA

更新日期：2012-10-01 00:00:00

abstract：:Our previous study showed that kainate (KA) receptor subunit GluR6 played an important role in ischemia-induced MLK3 and JNK activation and neuronal degeneration through the GluR6-PSD95-MLK3 signaling module. However, whether the KA receptors subunit GluR6 is involved in the activation of p38 MAP kinase during the tra...

journal_title：Hippocampus

authors： Chen J,Li C,Pei DS,Han D,Liu XM,Jiang HX,Wang XT,Guan QH,Wen XR,Hou XY,Zhang GY

更新日期：2009-01-01 00:00:00

abstract：:The mammalian hippocampus plays a key role in spatial learning and memory, but the exact nature of the hippocampal representation of space is still being explored. Recently, there has been a fair amount of success in modeling hippocampal spatial maps in rats, assuming a topological perspective on spatial information p...

journal_title：Hippocampus

authors： Hoffman K,Babichev A,Dabaghian Y

更新日期：2016-10-01 00:00:00

abstract：:Throughout the adult life of most mammals, new neurons are continuously generated in the dentate gyrus of the hippocampal formation. Recent work has documented specific cognitive deficits after elimination of adult hippocampal neurogenesis in rodents, suggesting that these neurons may contribute to information process...

journal_title：Hippocampus

authors： Lacefield CO,Itskov V,Reardon T,Hen R,Gordon JA

更新日期：2012-01-01 00:00:00

abstract：:The hippocampus is essential for learning and memory but also regulates emotional behavior. We previously identified the hippocampus as a major brain region that differs in rats bred for emotionality differences. Rats bred for low novelty response (LRs) exhibit high levels of anxiety- and depression-like behavior comp...

journal_title：Hippocampus

authors： Widman AJ,Cohen JL,McCoy CR,Unroe KA,Glover ME,Khan AU,Bredemann T,McMahon LL,Clinton SM

更新日期：2019-10-01 00:00:00

abstract：:Neuropsychological analyses of amnesic patients, as well as lesion experiments, indicate that the temporal lobe is essential for the encoding, storage, and expression of object recognition memory (ORM). However, temporal lobe structures directly involved in the consolidation and reconsolidation of these memories are n...

journal_title：Hippocampus

authors： Romero-Granados R,Fontán-Lozano A,Delgado-García JM,Carrión AM

更新日期：2010-05-01 00:00:00

abstract：:Hippocampal mossy fibers have long been proposed to impose new patterns to learn onto CA3 neurons during new memory formation. However, inconsistent with this theory, we found in our previous study that mossy fiber stimulation induces only transient changes in CA3 spatial firing in a familiar environment. Here, we tes...

journal_title：Hippocampus

authors： Lee J,Bae C,Lee D,Jung MW

更新日期：2020-07-01 00:00:00

abstract：:Replicas of an aspect of an experienced event can serve as effective reminders, yet little is known about the neural basis of such reminding effects. Here we examined the neural activity underlying the memory-enhancing effect of reminders 1 week after encoding of naturalistic film clip events. We used fMRI to determin...

journal_title：Hippocampus

authors： Sekeres MJ,Moscovitch M,Winocur G,Pishdadian S,Nichol D,Grady CL

更新日期：2021-01-01 00:00:00

abstract：:For memory retrieval, pattern completion is a crucial process that restores memories from partial or degraded cues. Neurocognitive aging models suggest that the aged memory system is biased toward pattern completion, resulting in a behavioral preference for retrieval over encoding of memories. Here, we built on our pr...

journal_title：Hippocampus

authors： Vieweg P,Riemer M,Berron D,Wolbers T

更新日期：2019-04-01 00:00:00

abstract：:There is extensive research regarding the neural mechanisms involved in satiety and meal termination; in contrast, there is very limited understanding of how meal onset is regulated. On the basis of several converging lines of evidence, we hypothesized that hippocampal neurons form a memory of a meal and inhibit meal ...

journal_title：Hippocampus

authors： Henderson YO,Smith GP,Parent MB

更新日期：2013-01-01 00:00:00

abstract：:The entorhinal cortex has long been recognized as an important interface between the hippocampal formation and the neocortex. The notion of bidirectional connections between the entorhinal cortex and the hippocampal formation have led to the suggestion that hippocampal output originating in CA1 and subiculum may reent...

journal_title：Hippocampus

authors： Kloosterman F,van Haeften T,Lopes da Silva FH

更新日期：2004-01-01 00:00:00

abstract：:To minimize the variability in the extent of lesions made by injections of the excitotoxin ibotenic acid in rhesus monkeys, we developed and validated an MRI-based method to determine the efficacy of the injections soon after surgery. T2-weighted MR images were obtained 6-11 days after surgery from 17 brain hemisphere...

journal_title：Hippocampus

authors： Málková L,Lex CK,Mishkin M,Saunders RC

更新日期：2001-01-01 00:00:00

abstract：:People retain more new verbal episodic information for at least 7 days if they rest for a few minutes after learning than if they attend to new information. It is hypothesized that rest allows for superior consolidation of new memories. In rodents, rest periods promote hippocampal replay of a recently travelled route,...

journal_title：Hippocampus

authors： Craig M,Dewar M,Della Sala S,Wolbers T

更新日期：2015-09-01 00:00:00

abstract：:Individual variation in the attribution of motivational salience to reward-related cues is believed to underlie addiction vulnerability. Pavlovian conditioned approach measures individual variation in motivational salience by identifying rats that are attracted to and motivated by reward cues (sign-trackers) or motiva...

journal_title：Hippocampus

authors： Fitzpatrick CJ,Creeden JF,Perrine SA,Morrow JD

更新日期：2016-11-01 00:00:00