Abstract:
:It has been demonstrated that the dorsal CA1 subregion of the hippocampus mediates temporal processing of information, that dorsal CA3 participates in the spatiotemporal processing of memory, and the dorsal dentate gyrus (DG) mediates spatial pattern separation. A temporal ordering of spatial locations task was developed to test the role of the dorsal DG, CA3, and CA1 for the temporal processing of spatial information with either high or low levels of spatial interference. The results indicate that animals with DG lesions showed difficulty performing the task at high levels of spatial interference, but were able to perform the task well when there was low spatial interference. Animals with lesions to CA3 did not show a preference for either spatial location presented during the study phase during the preference test, suggesting impaired spatiotemporal processing. Animals with lesions to CA1 showed a preference for a later presented spatial location over the earlier, the opposite preference to that shown by control animals.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Hunsaker MR,Kesner RPdoi
10.1002/hipo.20455subject
Has Abstractpub_date
2008-01-01 00:00:00pages
955-64issue
9eissn
1050-9631issn
1098-1063journal_volume
18pub_type
杂志文章相关文献
HIPPOCAMPUS文献大全abstract::To minimize the variability in the extent of lesions made by injections of the excitotoxin ibotenic acid in rhesus monkeys, we developed and validated an MRI-based method to determine the efficacy of the injections soon after surgery. T2-weighted MR images were obtained 6-11 days after surgery from 17 brain hemisphere...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.1050
更新日期:2001-01-01 00:00:00
abstract::The electrically induced increase in hippocampal synaptic strength known as long-term potentiation (LTP) is thought to involve some of the same mechanisms as those mediating information storage during spatial learning. Physiological saturation of synaptic weights might therefore be expected to occlude spatial learning...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450030205
更新日期:1993-04-01 00:00:00
abstract::In rodents, chronic stress induces long-lasting structural and functional alterations in the hippocampus, as well as learning and memory impairments. The neural cell adhesion molecule (NCAM) was previously hypothesized to be a key molecule in mediating the effects of stress due to its role in neuronal remodeling and s...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20723
更新日期:2011-01-01 00:00:00
abstract::It is well established that aging is associated with declines in episodic memory. In recent years, an emphasis has emerged on the development of behavioral tasks and the identification of biomarkers that are predictive of cognitive decline in healthy as well as pathological aging. Here, we describe a memory task desig...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22224
更新日期:2014-03-01 00:00:00
abstract::Processing of multimodal sensory information by the morphological subdivisions of the hippocampus and its input and output structures was investigated in unanesthetized rabbits by extracellular recording of neuronal activity. Analysis shows principal differences between CA3 neurons with uniform multimodal, mainly inhi...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.1073
更新日期:2001-01-01 00:00:00
abstract::It is argued that while the hippocampus is not vital for all classes of configural learning, it is vital for a specific subclass of configural tasks called "structural learning." The defining feature of structural learning is that in addition to binding stimulus elements to make unique arrays (as in all configural lea...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.20323
更新日期:2007-01-01 00:00:00
abstract::A couple of papers indicate that patients with depression show a decrease in serum neuropeptide Y (NPY). To study the role of NPY in depression, we examined the effects of infusion of NPY into the hippocampus of learned helplessness (LH) rats (an animal model of depression). Infusion of NPY into the cerebral ventricle...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20264
更新日期:2007-01-01 00:00:00
abstract::During certain movements (termed "type I," "instrumental," or "voluntary"), the rodent hippocampal EEG is dominated by regular 7-10 Hz waves. This "theta rhythm" is accompanied by increased firing of hippocampal interneurons and dentate gyrus granule cells. No obvious theta rhythm is present in comparable situations i...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450010204
更新日期:1991-04-01 00:00:00
abstract::Previous attempts to elucidate whether a loss of hippocampal synapses occurs during aging provided conflicting results, possibly due to the unavailability, at the time, of unbiased methods for synapse quantitation. This study was designed to reexamine the issue by means of modern technical procedures that provide unbi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450020411
更新日期:1992-10-01 00:00:00
abstract::Neurogenesis persists in the adult rat rostral forebrain subventricular zone (SVZ) and is stimulated by status epilepticus (SE). More caudal SVZ (cSVZ) neural progenitors migrate to the hippocampus after ischemic injury and contribute to CA1 pyramidal cell regeneration. Because SE also damages the hippocampus, we exam...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20166
更新日期:2006-01-01 00:00:00
abstract::Highly synchronized neural firing has been discussed in relation to learning and memory, for instance sharp-wave activity in hippocampus. We were interested to study how a postsynaptic CA1 pyramidal neuron would integrate input of different levels of synchronicity. In previous work using computational modeling we stud...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22061
更新日期:2013-01-01 00:00:00
abstract::Metabolic integrity of glial cells in field CA1 of the guinea pig hippocampus is critical to maintenance of synaptic transmission (Keyser and Pellmar [1994] Glia 10:237-243). To determine if this tight glial-neuronal coupling is equally important in other brain regions, we compared the effect of fluoroacetate (FAC), a...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1997)7:1<73::AID-HIPO7>3.0
更新日期:1997-01-01 00:00:00
abstract::Our previous study showed that kainate (KA) receptor subunit GluR6 played an important role in ischemia-induced MLK3 and JNK activation and neuronal degeneration through the GluR6-PSD95-MLK3 signaling module. However, whether the KA receptors subunit GluR6 is involved in the activation of p38 MAP kinase during the tra...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20479
更新日期:2009-01-01 00:00:00
abstract::It has been well-established that cell proliferation and neurogenesis in the adult mouse dentate gyrus (DG) can be regulated by voluntary exercise. Recent evidence has suggested that the effects of voluntary exercise can in turn be influenced by environmental factors that regulate the amount of stress an animal is exp...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20514
更新日期:2009-10-01 00:00:00
abstract::Adaptive memory requires the organism to form associations that bridge between events separated in time. Many studies show interactions between hippocampus (HPC) and prefrontal cortex (PFC) during formation of such associations. We analyze neural recording from monkey HPC and PFC during a memory task that requires the...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23282
更新日期:2020-12-01 00:00:00
abstract::The goal of the present research was to assess the degree to which a pattern completion process operates in cue-induced relapse to cocaine-seeking behavior. Using a novel cue-preference version of the place preference task, rats were administered cocaine or saline, which resulted in a preference for the cocaine-paired...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22570
更新日期:2016-07-01 00:00:00
abstract::We aimed at identifying the cerebral structures whose synaptic function subserves the recollection of lifetime's episodic autobiographical memory (AM) via autonoetic consciousness. Twelve healthy middle-aged subjects (mean age: 59 years +/- 2.5) underwent a specially designed cognitive test to assess the ability to re...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20406
更新日期:2008-01-01 00:00:00
abstract::Adult neurogenesis in the dentate gyrus (DG) plays a crucial role for pattern separation, and there are sex differences in the regulation of neurogenesis. Although sex differences, favoring males, in spatial navigation have been reported, it is not known whether there are sex differences in pattern separation. The cur...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22493
更新日期:2016-01-01 00:00:00
abstract::The mechanisms underlying memory are under intense investigation. One of the most promising candidates at the cellular level is long-term potentiation (LTP). Numerous pharmacological and molecular genetic manipulations have led to alteration in both LTP and memory. However, the causal relationship between these phenot...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.10101
更新日期:2002-01-01 00:00:00
abstract::Down syndrome (DS), the leading genetic cause of mental retardation, is characterized by reduced number of cortical neurons and brain size. The occurrence of these defects starting from early life stages points at altered developmental neurogenesis as their major determinant. The goal of our study was to obtain compar...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20308
更新日期:2007-01-01 00:00:00
abstract::Information storage in the brain is a temporally graded process involving different memory types or phases. It has been assumed for over a century that one or more short-term memory (STM) processes are involved in processing new information while long-term memory (LTM) is being formed. Because brain-derived neutrophic...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10035
更新日期:2002-01-01 00:00:00
abstract::Previous investigation of CA1-evoked subicular responses has used either single low-frequency pulses (LF), paired-pulses (PP), or high-frequency bursts. Here we test for the first time how subiculum responds to naturalistic stimulation trains (NSTs). We recorded CA1-evoked field potentials from dorsal rat subiculum in...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20629
更新日期:2010-02-01 00:00:00
abstract::Animal studies on the effects of chronic variable stress during the peripubertal-juvenile period on hippocampal structure and function are lacking. Twenty-eight-day-old Sprague-Dawley rats were subjected to random, variable physical or social stress regimens for 4 weeks. Hippocampal volume was found to continue to gro...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10207
更新日期:2004-01-01 00:00:00
abstract::The past decade has witnessed burgeoning evidence that antidepressant medications and physical exercise increase the expression of hippocampal brain-derived neurotrophic factor (BDNF). This phenomenon has gained widespread appeal, because BDNF is one of the first macromolecules observed to play a central role not only...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20579
更新日期:2009-10-01 00:00:00
abstract::The hippocampus plays an important role in spatial learning and memory. However, the biochemical alterations that subserve this function remain to be fully elucidated. In this study, rats were subjected to a single-trial contextual fear conditioning (CFC) paradigm; the activation of different protein kinase C (PKC) su...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10015
更新日期:2002-01-01 00:00:00
abstract::Effective navigation depends upon reliable estimates of head direction (HD). Visual, vestibular, and outflow motor signals combine for this purpose in a brain system that includes dorsal tegmental nucleus, lateral mammillary nuclei, anterior dorsal thalamic nucleus, and the postsubiculum. Learning is needed to combine...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22040
更新日期:2012-12-01 00:00:00
abstract::This study examines whether 4-8-Hz theta oscillations can be seen in the human hippocampus, and whether these oscillations increase during virtual movement and searching, as they do in rodents. Recordings from both hippocampal and neocortical depth electrodes were analyzed while six epileptic patients played a virtual...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20109
更新日期:2005-01-01 00:00:00
abstract::We have shown previously that chronic nicotine treatment reverses adult-onset hypothyroidism-induced impairment of late-phase long-term potentiation (L-LTP) in area CA1 of the hippocampus. In the present study, basal and stimulated levels of signaling molecules essential for the expression of L-LTP were determined in ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20306
更新日期:2007-01-01 00:00:00
abstract::In contextual fear conditioning (CFC), hippocampus is thought to process environmental stimuli into a configural representation of the context and send it to amygdala nuclei, which current evidences point to be the site of CS-US association and fear memory storage. If it is true, hippocampus should influence learning-...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22118
更新日期:2013-07-01 00:00:00
abstract::White matter hyperintensities (WMH) constitute the visible spectrum of cerebral small vessel disease (SVD) markers and are associated with cognitive decline, although they do not fully account for memory decline observed in individuals with SVD. We hypothesize that WMH might exert their effect on memory decline indire...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23039
更新日期:2019-06-01 00:00:00