Abstract:
:The past decade has witnessed burgeoning evidence that antidepressant medications and physical exercise increase the expression of hippocampal brain-derived neurotrophic factor (BDNF). This phenomenon has gained widespread appeal, because BDNF is one of the first macromolecules observed to play a central role not only in the treatment of mood disorders, but also in neuronal survival-, growth-, and plasticity-related signaling cascades. Thus, it has become critical to understand how BDNF synthesis is regulated. Much evidence exists that changes in BDNF expression result from the activation/phosphorylation of the transcription factor, cAMP-response-element binding protein (CREB) following the administration of antidepressant medications. Utilizing a mouse model genetically engineered with an inducible CREB repressor, our current study provides evidence that increases in BDNF expression and cellular survival signaling resulting from physical exercise are also dependent upon activation of this central transcription factor. The transcription and expression of hippocampal BDNF, as well as the activation of Akt, a key survival signaling molecule, were measured following acute exercise, and also following short-term treatment with the norepinephrine reuptake inhibitor, reboxetine. We found that both interventions led to a marked increase in hippocampal BDNF mRNA, BDNF protein, and Akt phosphorylation (as well as CREB phosphorylation) in wild-type mice. As expected, activation of the CREB repressor in mutant mice sharply decreased CREB phosphorylation. In addition, all measures noted above remained at baseline levels when mutant mice exercised or received reboxetine. Increases in BDNF and phospho-Akt were also prevented when mutant mice received a combination of exercise and antidepressant treatment. The results are discussed in the context of what is currently known about BDNF signaling.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Chen MJ,Russo-Neustadt AAdoi
10.1002/hipo.20579subject
Has Abstractpub_date
2009-10-01 00:00:00pages
962-72issue
10eissn
1050-9631issn
1098-1063journal_volume
19pub_type
杂志文章相关文献
HIPPOCAMPUS文献大全abstract::One of the most striking features of the hippocampal network is its ability to self-generate neuronal sequences representing temporally compressed, spatially coherent paths. These brief events, often termed "replay" in the scientific literature, are largely confined to non-exploratory states such as sleep or quiet res...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22824
更新日期:2020-01-01 00:00:00
abstract::The mechanisms of Ca2+ responses evoked in hippocampal glial cells in situ, by local application of glutamate and by synaptic activation, were studied in slices from juvenile rats using the membrane permeant fluorescent Ca2+ indicator fluo-3AM and confocal microscopy. Ca2+ responses induced by local application of glu...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.1031
更新日期:2001-01-01 00:00:00
abstract::We have shown previously that chronic nicotine treatment reverses adult-onset hypothyroidism-induced impairment of late-phase long-term potentiation (L-LTP) in area CA1 of the hippocampus. In the present study, basal and stimulated levels of signaling molecules essential for the expression of L-LTP were determined in ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20306
更新日期:2007-01-01 00:00:00
abstract::An extensive cortical network consisting of structures in the medial temporal lobe (hippocampus and parahippocampal cortex), lateral parietal cortex, retrosplenial cortex, and medial prefrontal cortex has recently attracted attention in cognitive neuroscience research, linking the network to both episodic memory and s...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20490
更新日期:2009-02-01 00:00:00
abstract::One functional aspect of theta oscillations that recent studies have begun to explore in humans is their role for the recollection of personal events. A specific role of theta for recollection but not for stimulus-familiarity would support links between cortical theta oscillations and hippocampal functioning, given th...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20125
更新日期:2005-01-01 00:00:00
abstract::Individual variation in the attribution of motivational salience to reward-related cues is believed to underlie addiction vulnerability. Pavlovian conditioned approach measures individual variation in motivational salience by identifying rats that are attracted to and motivated by reward cues (sign-trackers) or motiva...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22619
更新日期:2016-11-01 00:00:00
abstract::We review evidence from experiments conducted in our laboratory on retrograde amnesia in rats with damage to the hippocampal formation. In a new experiment reported here, we show that N-methyl-D-aspartate (NMDA)-induced hippocampal damage produced retrograde amnesia for both hidden platform and two-choice visible plat...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/1098-1063(2001)11:1<27::AID-HIPO1017>3.0.C
更新日期:2001-01-01 00:00:00
abstract::Neurons in the supramammillary nucleus (SUM) of urethane-anesthetized rats fire rhythmically in synchrony with hippocampal theta rhythm. As these neurons project to the septum and hippocampus, it is generally assumed that their role is to mediate ascending activation, leading to the hippocampal theta rhythm. However, ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20180
更新日期:2006-01-01 00:00:00
abstract::Accurate and reproducible in vivo measurement of hippocampal volumes using magnetic resonance (MR) imaging is complicated by the morphological complexity of the structure. Additionally, separation of certain parts of the hippocampus from the adjacent brain structures on MR images is sometimes very difficult. These dif...
journal_title:Hippocampus
pub_type: 临床试验,杂志文章
doi:10.1002/1098-1063(2000)10:6<752::AID-HIPO1012>3.0.
更新日期:2000-01-01 00:00:00
abstract::The importance of the perirhinal cortex for visual recognition memory performance is undisputed. However, it has not been clear whether its contribution to performance is mainly perceptual, or mainly mnemonic, or whether the perirhinal cortex contributes to both perception and memory. We determined the effects of medi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1998)8:4<330::AID-HIPO3>3.
更新日期:1998-01-01 00:00:00
abstract::With the aim of establishing a quantitative structural basis for comparative and experimental studies, the volumes of the hippocampal subdivisions and the total number of neurons in each subdivision were estimated in domestic pig brains using modern stereological techniques. In addition to a detailed description of th...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450040112
更新日期:1994-02-01 00:00:00
abstract::The hippocampus receives robust serotonergic innervation that is thought to control the excitability of both pyramidal cells and GABAergic interneurons. Previous work has addressed serotonergic regulation of pyramidal cells but considerable gaps remain in our understanding of how serotonin regulates different interneu...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22611
更新日期:2016-09-01 00:00:00
abstract::The locomotor effects of intra-NAcc injection of dopamine receptor agonists following discrete lesion or inhibition of the DH or the VH have been poorly investigated using only the indirect dopamine receptor agonist amphetamine. In the present study, we investigated how lidocaine in the DH or the VH modulated hyperloc...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20337
更新日期:2007-01-01 00:00:00
abstract::The ERK/MAPK signaling pathway has been extensively studied in the context of learning and memory. Defects in this pathway underlie genetic diseases associated with intellectual disability, including impaired learning and memory. Numerous studies have investigated the impact of acute ERK/MAPK inhibition on long-term p...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22769
更新日期:2017-12-01 00:00:00
abstract::This study investigated the effects of neonatal hippocampal ablation on the development of spatial learning and memory abilities in rats. Newborn rats sustained bilateral electrolytic lesions of the hippocampus or were sham-operated on postnatal day 1 (PN1). At PN20-25, PN50-55, or PN90-95, separate groups of rats wer...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1997)7:4<403::AID-HIPO6>3.
更新日期:1997-01-01 00:00:00
abstract::A couple of papers indicate that patients with depression show a decrease in serum neuropeptide Y (NPY). To study the role of NPY in depression, we examined the effects of infusion of NPY into the hippocampus of learned helplessness (LH) rats (an animal model of depression). Infusion of NPY into the cerebral ventricle...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20264
更新日期:2007-01-01 00:00:00
abstract::The authors propose a computational theory of the hippocampal region's function in mediating stimulus representations. The theory assumes that the hippocampal region develops new stimulus representations that enhance the discriminability of differentially predictive cues while compressing the representation of redunda...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450030410
更新日期:1993-10-01 00:00:00
abstract::The influence of the learning process on the persistence of the newly acquired behavior is relevant both for our knowledge of the learning/memory mechanisms and for the educational policy. However, it is unclear whether during an operant conditioning process with a continuous reinforcement paradigm, individual differe...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22568
更新日期:2016-07-01 00:00:00
abstract::The vestibular system contributes to the performance of various spatial memory tasks, but few studies have attempted to disambiguate the roles of the semicircular canals and otolith organs in this performance. This study tested the otolithic contribution to spatial working and reference memory by evaluating the perfor...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22300
更新日期:2014-10-01 00:00:00
abstract::Exposing rats to an enriched environment over an extended period of time has been shown to enhance hippocampal long-term potentiation (LTP). Whether such prolonged exposure to environmental manipulation is necessary for LTP enhancement and whether the environmentally induced enhancement can persist long after the cess...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10017
更新日期:2002-01-01 00:00:00
abstract::To clarify the specific contribution of the medial temporal lobe structures in spatial memory, we tested monkeys (Macaca mulatta) with sham operations and with lesions of either the hippocampal formation, areas TH/TF or perirhinal cortex on two versions of the visual-paired comparison task, measuring Spatial Location,...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20369
更新日期:2008-01-01 00:00:00
abstract::Previous investigation of CA1-evoked subicular responses has used either single low-frequency pulses (LF), paired-pulses (PP), or high-frequency bursts. Here we test for the first time how subiculum responds to naturalistic stimulation trains (NSTs). We recorded CA1-evoked field potentials from dorsal rat subiculum in...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20629
更新日期:2010-02-01 00:00:00
abstract::In all species examined, the dentate gyrus develops over an extended period that begins during gestation and continues up to adulthood. The aim of this study was to investigate the pattern of postnatal cell production in the dentate gyrus of the guinea pig, a rodent whose brain development has features more closely re...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20050
更新日期:2005-01-01 00:00:00
abstract::For well over a century, ethanol was believed to exert its effects on cognition and behavior by producing a ubiquitous depression of central nervous system activity. A general disruption in brain function was consistent with the belief that ethanol's effects on cognition and behavior were also quite general. Substanti...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1098-1063(2000)10:1<88::AID-HIPO10>3
更新日期:2000-01-01 00:00:00
abstract::In this review, we aim to reappraise the organization of intrinsic and extrinsic networks of the entorhinal cortex with a focus on the concept of parallel cortical connectivity streams. The concept of two entorhinal areas, the lateral and medial entorhinal cortex, belonging to two parallel input-output streams mediati...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.23145
更新日期:2019-12-01 00:00:00
abstract::A large body of neuroscientific work indicates that exposure to experienced stress causes damage to both cortical and hippocampal cells and results in impairments to cognitive abilities associated with these structures. Similarly, work within the domain of cognitive aging demonstrates that elderly participants who rep...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22525
更新日期:2016-03-01 00:00:00
abstract::Dual-process theories of episodic memory state that retrieval is contingent on two independent processes: familiarity (providing a sense of oldness) and recollection (recovering events and their context). A variety of studies have reported distinct neural signatures for familiarity and recollection, supporting dual-pr...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20606
更新日期:2010-02-01 00:00:00
abstract::There is limited knowledge regarding how the brain controls the timing of meals. Similarly, there is a large gap in our understanding of how top-down cognitive processes, such as memory influence energy intake. We hypothesize that dorsal hippocampal (dHC) neurons, which are critical for episodic memory, form a memory ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22532
更新日期:2016-03-01 00:00:00
abstract::The precise timing of pre-postsynaptic activity is vital for the induction of long-term potentiation (LTP) or depression (LTD) at many central synapses. We show in synapses of rat CA1 pyramidal neurons in vitro that spike timing dependent plasticity (STDP) protocols that induce LTP at glutamatergic synapses can evoke ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22196
更新日期:2013-12-01 00:00:00
abstract::In rodents, pyramidal cell firing patterns from waking may be replayed in nonrapid eye movement sleep (NREM) sleep during hippocampal sharp wave ripples (HC-SWR). In humans, HC-SWR have only been recorded with electrodes implanted to localize epileptogenicity. Here, we characterize human HC-SWR with rigorous rejection...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23183
更新日期:2020-06-01 00:00:00