Galantamine enhancement of long-term potentiation is mediated by calcium/calmodulin-dependent protein kinase II and protein kinase C activation.

abstract：:Dual-process theories of episodic memory state that retrieval is contingent on two independent processes: familiarity (providing a sense of oldness) and recollection (recovering events and their context). A variety of studies have reported distinct neural signatures for familiarity and recollection, supporting dual-pr...

journal_title：Hippocampus

authors： Greve A,Donaldson DI,van Rossum MC

更新日期：2010-02-01 00:00:00

abstract：:Although it is well established that the integrity of the medial temporal lobe (MTL) is critical for declarative memory, the functional organization of the MTL remains a matter of intense debate. One issue that has received little consideration so far is whether the hippocampus can function normally in the presence of...

journal_title：Hippocampus

authors： Bowles B,O'Neil EB,Mirsattari SM,Poppenk J,Köhler S

更新日期：2011-08-01 00:00:00

abstract：:We often engage in counterfactual (CF) thinking, which involves reflecting on "what might have been." Creating alternative versions of reality seems to have parallels with recollecting the past and imagining the future in requiring the simulation of internally generated models of complex events. Given that episodic me...

journal_title：Hippocampus

authors： Mullally SL,Maguire EA

更新日期：2014-11-01 00:00:00

abstract：:Nearby grid cells have been observed to express a remarkable degree of long-range order, which is often idealized as extending potentially to infinity. Yet their strict periodic firing and ensemble coherence are theoretically possible only in flat environments, much unlike the burrows which rodents usually live in. Ar...

journal_title：Hippocampus

authors： Stella F,Urdapilleta E,Luo Y,Treves A

更新日期：2020-04-01 00:00:00

abstract：:Ontogenesis of GABAergic signaling may play an important role in developmental changes in seizure susceptibility in the high-potassium model of ictogenesis in vitro. The age-dependent effects of [K(+)](o) on the reversal potential of the GABA(A)-mediated responses and membrane potential in hippocampal slices in vitro ...

journal_title：Hippocampus

authors： Isaev D,Isaeva E,Khazipov R,Holmes GL

更新日期：2007-01-01 00:00:00

abstract：:The advent of high-resolution magnetic resonance imaging (MRI) has enabled in vivo research in a variety of populations and diseases on the structure and function of hippocampal subfields and subdivisions of the parahippocampal gyrus. Because of the many extant and highly discrepant segmentation protocols, comparing r...

journal_title：Hippocampus

authors： Wisse LEM,Daugherty AM,Olsen RK,Berron D,Carr VA,Stark CEL,Amaral RSC,Amunts K,Augustinack JC,Bender AR,Bernstein JD,Boccardi M,Bocchetta M,Burggren A,Chakravarty MM,Chupin M,Ekstrom A,de Flores R,Insausti R,Kanel P

更新日期：2017-01-01 00:00:00

abstract：:A large body of neuroscientific work indicates that exposure to experienced stress causes damage to both cortical and hippocampal cells and results in impairments to cognitive abilities associated with these structures. Similarly, work within the domain of cognitive aging demonstrates that elderly participants who rep...

journal_title：Hippocampus

authors： Marshall AC,Cooper NR,Geeraert N

更新日期：2016-03-01 00:00:00

abstract：:Two recent meta-analyses, drawing on data from many of the same studies with monkeys, reached different conclusions about the relationship between hippocampal damage and recognition memory performance. Both studies found evidence of recognition memory impairment following hippocampal damage. However, Zola et al. (J Ne...

journal_title：Hippocampus

authors： Zola SM,Squire LR

更新日期：2001-01-01 00:00:00

abstract：:The induction of long-lasting memory storage depends on the behavioral state of humans and animals. This behavioral state is mediated by neuromodulatory systems, like the cholinergic-septum-hippocampal circuit. Cholinergic neurotransmission is known to affect short-term activity-dependent plasticity in various brain a...

journal_title：Hippocampus

authors： Navakkode S,Korte M

更新日期：2012-02-01 00:00:00

abstract：:There is limited knowledge regarding how the brain controls the timing of meals. Similarly, there is a large gap in our understanding of how top-down cognitive processes, such as memory influence energy intake. We hypothesize that dorsal hippocampal (dHC) neurons, which are critical for episodic memory, form a memory ...

journal_title：Hippocampus

authors： Henderson YO,Nalloor R,Vazdarjanova A,Parent MB

更新日期：2016-03-01 00:00:00

abstract：:Hippocampal synaptic plasticity comprises a key cellular mechanism for information storage. In the hippocampus, both long-term potentiation (LTP) and long-term depression (LTD) are triggered by synaptic Ca2+ -elevations that are typically mediated by the opening of voltage-gated cation channels, such as N-methyl-d-asp...

journal_title：Hippocampus

authors： Jansen S,Gottschling C,Faissner A,Manahan-Vaughan D

更新日期：2017-08-01 00:00:00

abstract：:Studies of differential eyeblink conditioning (CS+ and CS-) have demonstrated that successful conditioning requires awareness of the stimulus contingencies and that delay conditioning does not. Two experiments were carried out to determine whether awareness is also important for single-cue trace eyeblink conditioning....

journal_title：Hippocampus

authors： Manns JR,Clark RE,Squire LR

更新日期：2000-01-01 00:00:00

abstract：:Trace eyeblink classical conditioning is a non-spatial learning paradigm that requires an intact hippocampus. This task is hippocampus-dependent because the auditory tone conditioned stimulus (CS) is temporally separated from the corneal airpuff unconditioned stimulus (US) by a 500-ms trace interval. Our laboratory ha...

journal_title：Hippocampus

authors： McEchron MD,Disterhoft JF

更新日期：1999-01-01 00:00:00

abstract：:The hippocampus creates distinct episodes from highly similar events through a process called pattern separation and can retrieve memories from partial or degraded cues through a process called pattern completion. These processes have been studied in humans using tasks where participants must distinguish studied items...

journal_title：Hippocampus

authors： Molitor RJ,Ko PC,Hussey EP,Ally BA

更新日期：2014-06-01 00:00:00

abstract：:Although the importance of cAMP-response element binding protein (CREB) phosphorylation in long-term memory formation is well documented for hippocampus-dependent tasks, little is known about the changes in phosphorylated CREB (pCREB) that occur during the process of extinction. The purpose of this study was to charac...

journal_title：Hippocampus

authors： Porte Y,Trifilieff P,Wolff M,Micheau J,Buhot MC,Mons N

更新日期：2011-11-01 00:00:00

abstract：:This study investigated the effects of progesterone (P4) on the production and survival of neurons in the hippocampal dentate gyrus of adult male mice. The administration of P4 (4 mg/kg) for 3 consecutive days beginning on the 0-2nd day after the first BrdU-injection (BrdU-D(0-2)) produced an approximately twofold inc...

journal_title：Hippocampus

authors： Zhang Z,Yang R,Zhou R,Li L,Sokabe M,Chen L

更新日期：2010-03-01 00:00:00

abstract：:Granule cells with recurrent basal dendrites (RBDs) were previously reported in both control and epileptic rats. RBDs are dendrites that arise from the basal half of granule cell bodies and curve toward and extend into the molecular layer. They are increased in frequency in the pilocarpine model of epilepsy. The prese...

journal_title：Hippocampus

authors： Dashtipour K,Yan XX,Dinh TT,Okazaki MM,Nadler JV,Ribak CE

更新日期：2002-01-01 00:00:00

abstract：:In this article, we present a framework to perform statistical shape analysis for segmented hippocampi, including an efficient permutation test for detecting subtle class differences, and a regularized discriminative direction method for visualizing the shape discrepancy. Fisher permutation and bootstrap tests are pre...

journal_title：Hippocampus

authors： Zhou L,Lieby P,Barnes N,Réglade-Meslin C,Walker J,Cherbuin N,Hartley R

更新日期：2009-06-01 00:00:00

abstract：:Space and time are both essential features of episodic memory, for which the hippocampus is critical (Howard & Eichenbaum, 2015). Spatial tasks have been used effectively to study the behavioral relevance of place cells. However, the behavioral paradigms utilized for the study of time cells have not used time duration...

journal_title：Hippocampus

authors： Sabariego M,Tabrizi NS,Marshall GJ,McLagan AN,Jawad S,Hales JB

更新日期：2021-01-01 00:00:00

abstract：:The present study evaluated the effects of a single intrahippocampal administration of brain-derived neurotrophic factor (BDNF) on memory retention in a water maze. Adult rats were trained in a water maze (acquisition phase, day 1). Immediately after the last training trial subjects were injected in the right hippocam...

journal_title：Hippocampus

authors： Cirulli F,Berry A,Chiarotti F,Alleva E

更新日期：2004-01-01 00:00:00

abstract：:The present study has investigated the role of ATP in the induction of synaptic plasticity, using local application of ATP by picopump administration into the stratum radiatum of guinea pig hippocampal region CA1. Excitatory postsynaptic currents (EPSCs) evoked by stimulation of Schaffer collateral/commissural afferen...

journal_title：Hippocampus

authors： Yamazaki Y,Kaneko K,Fujii S,Kato H,Ito K

更新日期：2003-01-01 00:00:00

abstract：:We recorded neuromagnetic fields evoked by a somatosensory oddball task requiring subjects to discriminate target stimuli from nontarget stimuli, which are different in stimulation intensity, with a mental count of the target stimuli. A whole head type 80-channel magnetoencephalography (MEG) system with a 50-mm baseli...

journal_title：Hippocampus

authors： Hamada Y,Sugino K,Kado H,Suzuki R

更新日期：2004-01-01 00:00:00

abstract：:In contextual fear conditioning (CFC), hippocampus is thought to process environmental stimuli into a configural representation of the context and send it to amygdala nuclei, which current evidences point to be the site of CS-US association and fear memory storage. If it is true, hippocampus should influence learning-...

journal_title：Hippocampus

authors： de Oliveira Coelho CA,Ferreira TL,Soares JC,Oliveira MG

更新日期：2013-07-01 00:00:00

abstract：:High-frequency stimulation of excitatory synapses in many regions of the brain triggers a lasting increase in the efficacy of synaptic transmission referred to as long-term potentiation (LTP) and believed to contribute to learning and memory. One hypothesis proposed to account for the stability and properties of this ...

journal_title：Hippocampus

authors： Muller D,Toni N,Buchs PA

更新日期：2000-01-01 00:00:00

abstract：:Neurogenesis persists in the adult rat rostral forebrain subventricular zone (SVZ) and is stimulated by status epilepticus (SE). More caudal SVZ (cSVZ) neural progenitors migrate to the hippocampus after ischemic injury and contribute to CA1 pyramidal cell regeneration. Because SE also damages the hippocampus, we exam...

journal_title：Hippocampus

authors： Parent JM,von dem Bussche N,Lowenstein DH

更新日期：2006-01-01 00:00:00

abstract：:To examine the effects of long-term potentiation (LTP) on individual neurons in the intact brain, anesthetized rats were implanted with a recording stereotrode in the right CA1 layer of the hippocampus and a stimulating electrode in the right and left CA3 layers. The evoked and spontaneous firing of single CA1 neurons...

journal_title：Hippocampus

authors： Martin PD,Shapiro ML

更新日期：2000-01-01 00:00:00

abstract：:The selective lesion of basal forebrain cholinergic neurons (BFCNs) is an unestimable tool to study the implication of these neurons in cognition, an interest widely motivated by their degeneration in Alzheimer's disease. Here we evaluated the histochemical and behavioral effects of a selective lesion of BFCNs in C57B...

journal_title：Hippocampus

authors： Moreau PH,Cosquer B,Jeltsch H,Cassel JC,Mathis C

更新日期：2008-01-01 00:00:00

abstract：:Key pathological features of Parkinson's Disease (PD) include the progressive degeneration of midbrain dopaminergic (DA) neurons and hindbrain noradrenergic (NA) neurons. The loss of DA neurons has been extensively studied and is the main cause of motor dysfunction. Importantly, however, there are a range of 'non-move...

journal_title：Hippocampus

authors： Ermine CM,Wright JL,Frausin S,Kauhausen JA,Parish CL,Stanic D,Thompson LH

更新日期：2018-05-01 00:00:00

abstract：:Persistent neural activity lasting for seconds after transient stimulation has been observed in several brain areas. This activity has been taken to be indicative of the integration of inputs on long time scales. Passive membrane properties render neural time constants to be on the order of milliseconds. Intense synap...

journal_title：Hippocampus

authors： Huhn Z,Orbán G,Erdi P,Lengyel M

更新日期：2005-01-01 00:00:00

abstract：:Alzheimer's disease (AD) and ageing are associated with impaired learning and memory, and recent findings point toward modulating chromatin remodeling through histone acetylation as a promising therapeutic strategy. Here we report that systemic administration of the HDAC inhibitor 4-phenylbutyrate (PBA) reinstated fea...

journal_title：Hippocampus

authors： Ricobaraza A,Cuadrado-Tejedor M,Marco S,Pérez-Otaño I,García-Osta A

更新日期：2012-05-01 00:00:00