解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Rationale: P21-activated kinase 6 (PAK6) is a member of the class II PAKs family, which is a conserved family of serine/threonine kinases. Although the effects of PAK6 on many malignancies, especially in prostate cancer, have been studied for a long time, the role of PAK6 in mitochondria remains unknown. Methods: The ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.42874
更新日期:2020-02-03 00:00:00
abstract::Acute liver failure is characterized by the rapid development of liver dysfunction and remarkably high mortality. Accumulating evidence suggests that soyasaponin possesses potential anti-inflammatory activities. Here, we aimed to investigate the potential role of soyasaponin II in acute liver failure and establish the...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.40128
更新日期:2020-02-03 00:00:00
abstract::Rationale: Mesenchymal cell-derived osteosarcoma is a rare malignant bone tumor affecting children and adolescents. PTEN down-regulation or function-loss mutation is associated with the aggressive of osteosarcoma. Explicating the regulatory mechanism of PTEN might highlight new targets for improving the survival rate ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.41279
更新日期:2020-02-03 00:00:00
abstract::[This corrects the article DOI: 10.7150/thno.21516.]. ...
journal_title:Theranostics
pub_type: 已发布勘误
doi:10.7150/thno.42847
更新日期:2020-01-18 00:00:00
abstract::CUB-domain containing protein 1 (CDCP1) is a cancer associated cell surface protein that amplifies pro-tumorigenic signalling by other receptors including EGFR and HER2. Its potential as a cancer target is supported by studies showing that anti-CDCP1 antibodies inhibit cell migration and survival in vitro, and tumor g...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.30736
更新日期:2020-01-12 00:00:00
abstract::Zinc-finger proteins (ZFPs) are the largest transcription factor family in mammals, involved in the regulation of multiple physiologic processes including cell differentiation, proliferation, apoptosis and neoplastic transformation. Approximately one-third of ZFPs are Krüppel-associated box domain (KRAB)-ZFPs. Methods...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.35861
更新日期:2020-01-12 00:00:00
abstract::Granzyme B (GrB) is an essential cytotoxic effector in cancer immunotherapy as it can be a potential biomarker to predict the efficacy of immunotherapies including checkpoint inhibitors. Monitoring the Granzyme B activity in cells would help determine a patient's clinical response to treatment and lead to better treat...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.37728
更新日期:2020-01-01 00:00:00
abstract::RNA molecules (e.g., siRNA, microRNA, and mRNA) have shown tremendous potential for immunomodulation and cancer immunotherapy. They can activate both innate and adaptive immune system responses by silencing or upregulating immune-relevant genes. In addition, mRNA-based vaccines have recently been actively pursued and ...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.35568
更新日期:2020-01-01 00:00:00
abstract::In the mammalian skeletal system, osteogenesis and angiogenesis are intimately linked during bone growth and regeneration in bone modeling and during bone homeostasis in bone remodeling. Recent studies have expanded our knowledge about the molecular and cellular mechanisms responsible for coupling angiogenesis and bon...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.34126
更新日期:2020-01-01 00:00:00
abstract::The mineral dust-induced gene (mdig) is overexpressed in a number of human cancers, suggesting critical roles of this gene played on the pathogenesis of cancers. Unlike several other JmjC-domain containing proteins that exhibit histone demethylase activity, it remains enigmatic whether mdig is involved in the demethyl...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.36220
更新日期:2020-01-01 00:00:00
abstract::Nanobubble (NB), which simultaneously enhances ultrasound (US) images and access therapeutic platforms, is required for future cancer treatment. Methods: We designed a theranostic agent for novel cancer treatment by using an NB-encapsulated hybrid nanosystem that can be monitored by US and fluorescent imaging and acti...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.38684
更新日期:2020-01-01 00:00:00
abstract::Purpose: Cancer immunotherapy depends on a systemic immune response, but the basic underlying mechanisms are still largely unknown. Despite the very successful and widespread use of checkpoint inhibitors in the clinic, the majority of cancer patients do not benefit from this type of treatment. In this translational st...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.35989
更新日期:2020-01-01 00:00:00
abstract::Resistance to the chemotherapeutic drug 5'-azacytidine (5'-AZA) is a major obstacle in the treatment of patients with acute myeloid leukemia (AML). The uridine-cytidine kinase 1 (UCK1) has an established role in activating 5'-AZA and its protein level is significantly downregulated in patients resistant to the drug. H...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.36503
更新日期:2020-01-01 00:00:00
abstract::Objective: Vascular smooth muscle cells (VSMCs) undergo the phenotypic changes from contractile to synthetic state during vascular remodeling after ischemia. SIRT1 protects against stress-induced vascular remodeling via maintaining VSMC differentiated phenotype. However, the effect of smooth muscle SIRT1 on the functi...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.39320
更新日期:2020-01-01 00:00:00
abstract::The structural modification of existing AMPs is an effective strategy to develop antimicrobial agents with high-efficiency, low-cost and low-toxicity antimicrobial agents. Methods: Here, we truncated 14-amino-acids at the N-terminus of MSI-78 to obtain MSI and further modified MSI to obtain four peptide analogs: MSI-1...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.39157
更新日期:2020-01-01 00:00:00
abstract::Luminal androgen receptor (LAR) breast cancer accounts for 10% of all triple-negative breast cancers (TNBC). Anti-androgen therapy for this subtype is in development, but yields only partial clinical benefits. In this study, we aimed to characterize the genomic alterations of LAR TNBC, to analyze activation of the PI3...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.36182
更新日期:2020-01-01 00:00:00
abstract::Monocyte derived macrophages (MDMs) infiltrate sites of infection or injury and upregulate cyclooxygenase-2 (COX-2), an enzyme that stimulates prostaglandin-E2 (PgE2). Nanotheranostics combine therapeutic and diagnostic agents into a single nanosystem. In previous studies, we demonstrated that a nanotheranostic strate...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.41309
更新日期:2020-01-01 00:00:00
abstract::Cancer metastasis is a Gordian knot for tumor diagnosis and therapy. Many studies have demonstrated that metastatic processes are inevitably affected by the tumor microenvironment. Histopathology is used universally as the gold standard for cancer diagnosis despite the lengthy preparation process and invasiveness. Met...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.40869
更新日期:2020-01-01 00:00:00
abstract::Rationale: Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a co-inhibitory checkpoint receptor that is expressed by naïve T-cells in lymph nodes (LNs) to inhibit activation against "self" antigens (Ags). In cancer, anti-CTLA-4 blocks inhibitory action, enabling robust activation of T-cells against tumor Ags pr...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.35280
更新日期:2019-10-22 00:00:00
abstract::Rationale: Spatial-temporal control of cell fate in vivo is of great importance for regenerative medicine. Currently, there remain no practical strategies to tune cell-fate spatial-temporally. Optogenetics is a biological technique that widely used to control cell activity in genetically defined neurons in a spatiotem...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.36455
更新日期:2019-10-18 00:00:00
abstract::Constructing nanosystems that synergistically combine therapeutic and diagnostic features is of great interest to the nanomedicine community but also remains a tremendous challenge. Methods: In this work, we report novel catalytic nanoparticles composed of the enzyme catalase, encapsulated in a polymer shell and surfa...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.37054
更新日期:2019-10-17 00:00:00
abstract::Targeted therapy and immunotherapy have become mainstream in cancer treatment. However, only patient subsets benefit from these expensive therapies, and often responses are short-lived or coincide with side effects. A growing modality in precision oncology is the development of theranostics, as this enables patient se...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.34941
更新日期:2019-10-15 00:00:00
abstract::Cell-based immunotherapy for the treatment of hematologic malignancies, such as leukemia and lymphoma, has seen much success and played an increasingly important role in clinical studies. Nevertheless, the efficacy of immunotherapy in solid tumors still needs improvements due to the immunosuppressive properties of tum...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.35900
更新日期:2019-10-14 00:00:00
abstract::Purpose: Colitis-associated colorectal cancer (CAC) poses substantial challenges for effective treatment. Currently, there is a considerable need for the development of orally bioavailable dosage forms that enable the safe and effective delivery of therapeutic drugs to local diseased lesions in the gastrointestinal tr...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.38081
更新日期:2019-10-12 00:00:00
abstract::Hypoxia is a key hallmark of solid tumors and tumor hypoxia usually contributes to cancer progression, therapeutic resistance and poor outcome. Accurately detecting and imaging tumor hypoxia with high spatial resolution would be conducive to formulating optimized treatment plan and thus achieving better patient outcom...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.36755
更新日期:2019-09-25 00:00:00
abstract::Background: The dense fibrotic stroma enveloping pancreatic tumors is a major cause of drug resistance. Pancreatic stellate cells (PSCs) in the stroma can be activated to induce intra-tumor fibrosis and worsen patient survival; however, the molecular basics for the regulation of PSC activation remains unclear. Methods...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.36830
更新日期:2019-09-23 00:00:00
abstract::Purpose: Positron emission tomography (PET) imaging of apoptosis is very important for early evaluation of tumor therapeutic efficacy. A stimuli-responsive probe based on the peptide sequence Asp-Glu-Val-Asp (DEVD), [18F]DEVD-Cys(StBu)-PPG(CBT)-AmBF3 ([18F]1), for PET imaging of tumor apoptosis was designed and prepar...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.35084
更新日期:2019-09-21 00:00:00
abstract::Tumor hypoxia is an important reason for the limited therapeutic efficacy of photodynamic therapy (PDT) because of the oxygen requirement of the therapeutic process. PDT consumes tissue oxygen and destroys tumor vasculature, further hampering its own efficacy in promoting tumor deterioration. Therefore, overcoming the...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.36988
更新日期:2019-09-20 00:00:00
abstract::Rationale: Tumor angiogenesis promotes tumor development, progression, growth, and metastasis. Metronomic chemotherapy involves the frequent administration of low-dose chemotherapeutic agents to block angiogenic activity and reduce side effects. Methods: MDA-MB-231 cells were treated with various concentrations of art...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.33353
更新日期:2019-09-17 00:00:00
abstract::Identification of novel targets for triple-negative breast cancer (TNBC) is an urgent task as targeted therapies have increased the lifespans of Oestrogen Receptor +/ Progesterone Receptor + and HER2+ cancer patients. Methods: genes involved in protein processing in the endoplasmic reticulum, which have been reported ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.35383
更新日期:2019-08-21 00:00:00
abstract::Prolonged occlusion of multiple microvessels causes microvascular injury. G protein-coupled receptor 124 (GPR124) has been reported to be required for maintaining central nervous system (CNS) angiogenesis and blood-brain barrier integrity. However, the molecular mechanisms by which GPR124 regulates pericytes during is...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.34168
更新日期:2019-08-14 00:00:00
abstract::Mesenchymal stem cells (MSC) derived from adult tissues effectively promote wound healing. However, MSC quality varies, and the quantity of MSC is limited, as MSC are acquired through donations. Moreover, the survival and functioning of dissociated MSC delivered to an inflammatory lesion are subject to challenges. Met...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.32982
更新日期:2019-08-14 00:00:00
abstract::Sepsis is a major cause of patient mortality and morbidity from bacterial infections. Although neutrophils are known to be important in the development of sepsis, how distinctive neutrophil subtypes regulate inflammatory processes involved in septicemia remains unclear. Preconditioning protects organisms against subse...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.37139
更新日期:2019-08-14 00:00:00
abstract::The human skin is an attractive anti-tumor vaccination site due to the vast network of dendritic cell (DC) subsets that carry antigens to the draining lymph nodes and stimulate tumor specific CD4+ and CD8+ T cells in. Specific vaccine delivery to skin DC can be accomplished by targeting glycan coated antigens to C-typ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.35059
更新日期:2019-08-12 00:00:00
abstract::Autophagy is a dynamic and complicated catabolic process. Imaging autophagic flux can clearly advance knowledge of its pathophysiology significance. While the most common way autophagy is imaged relies on fluorescent protein-based probes, this method requires substantial genetic manipulation that severely restricts th...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.33867
更新日期:2019-08-01 00:00:00
abstract::Pulsed focused ultrasound (pFUS) technology is being developed for clinical neuro/immune modulation and regenerative medicine. Biological signal transduction of pFUS forces can require mechanosensitive or voltage-gated plasma membrane ion channels. Previous studies suggested pFUS is capable of activating either channe...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.33876
更新日期:2019-07-28 00:00:00
abstract::Deciphering the molecular and cellular processes involved in foam cell formation is critical to understanding the pathogenesis of atherosclerosis. Interferon regulatory factor 1 (IRF1) was first identified as a transcriptional regulator of type-I interferons (IFNs) and IFN inducible genes. Our study aims to explore th...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.36862
更新日期:2019-07-09 00:00:00
abstract::Background: Tobacco smoke (TS) critically contributes to the development of lung cancer; however, the underlying molecular mechanisms remain unclear. The induction of cancer stem cells (CSCs) by TS represents an early event in tumor initiation. The lung cancer-related gene ΔNp63α is highly expressed in epithelial tiss...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.33812
更新日期:2019-07-09 00:00:00
abstract::Inhibitor of apoptosis proteins (IAP) are cell death regulators that bind caspases and interfere with apoptotic signalling via death receptors or intrinsic cell death pathways. BIRC4/XIAP is the most potent anti-apoptotic IAP-member and it physically interacts with caspases via its BIR2 and its BIR3 domain. These doma...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.33758
更新日期:2019-07-09 00:00:00
abstract::With advances in nanoparticle (NP) synthesis and engineering, nanoscale agents with both therapeutic and diagnostic functions have been increasingly exploited for cancer management. Herein, we synthesized a new type of zwitterionic polymer-gated Au@TiO2 core-shell nanoparticles, which showed that they could selectivel...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.35418
更新日期:2019-07-09 00:00:00