解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::We investigate the existence of oscillatory dynamics and multiple steady-state flow rates in a network with a simple topology and in vivo microvascular blood flow constitutive laws. Unlike many previous analytic studies, we employ the most biologically relevant models of the physical properties of whole blood. Through...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-015-0089-1
更新日期:2015-07-01 00:00:00
abstract::It has been recently observed that the dynamical properties of mass action systems arising from many models of biochemical reaction networks can be characterized by considering the corresponding properties of a related generalized mass action system. The correspondence process known as network translation in particula...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-015-0077-5
更新日期:2015-06-01 00:00:00
abstract::This study investigates fluid flow and elastic deformation in tissues that are drained by the primary lymphatic system. A model is formulated based on the Rossi hypothesis that states that the primary lymphatic valves, which are formed by overlapping endothelial cells around the circumferential lining of lymphatic cap...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-015-0078-4
更新日期:2015-06-01 00:00:00
abstract::At least four distinct lineages of CD4+ T cells play diverse roles in the immune system. Both in vivo and in vitro, naïve CD4+ T cells often differentiate into a variety of cellular phenotypes. Previously, we developed a mathematical framework to study heterogeneous differentiation of two lineages governed by a mutual...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-015-0076-6
更新日期:2015-06-01 00:00:00
abstract::Mathematical modeling is a powerful tool for unraveling the complexities of the molecular regulatory networks underlying all aspects of cell physiology. To support this claim, we review our experiences modeling the cyclin-dependent kinase (CDK) network that controls events of the eukaryotic cell cycle. The model was d...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-014-0009-9
更新日期:2015-05-01 00:00:00
abstract::Cardiac and neural systems share common features of intrinsic oscillation in some cells as well as the ability to propagate excitation. One theoretical approach to study such systems is to develop realistic models for the tissue. This involves first developing detailed ionic "Hodgkin-Huxley"-type models of individual ...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-014-0015-y
更新日期:2015-05-01 00:00:00
abstract::Collective dynamics of migrating cell populations drive key processes in tissue formation and maintenance under normal and diseased conditions. Collective cell behavior at the tissue level is typically characterized by considering cell density patterns such as clusters and moving cell fronts. However, there are also i...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-015-0079-3
更新日期:2015-04-01 00:00:00
abstract::Developing a quantitative science of sustainability requires bridging mathematical concepts from fields contributing to sustainability science. The concept of substitutability is central to sustainability but is defined differently by different fields. Specifically, economics tends to define substitutability as a marg...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-014-9963-5
更新日期:2015-02-01 00:00:00
abstract::Preserving a system's viability in the presence of diversity erosion is critical if the goal is to sustainably support biodiversity. Reduction in population heterogeneity, whether inter- or intraspecies, may increase population fragility, either decreasing its ability to adapt effectively to environmental changes or f...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章,评审
doi:10.1007/s11538-014-9983-1
更新日期:2015-02-01 00:00:00
abstract::In phylogenetics, a common strategy used to construct an evolutionary tree for a set of species [Formula: see text] is to search in the space of all such trees for one that optimizes some given score function (such as the minimum evolution, parsimony or likelihood score). As this can be computationally intensive, it w...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-014-0049-1
更新日期:2015-01-01 00:00:00
abstract::Turing patterns can be observed in reaction-diffusion systems where chemical species have different diffusion constants. In recent years, several studies investigated the effects of noise on Turing patterns and showed that the parameter regimes, for which stochastic Turing patterns are observed, can be larger than the...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-014-0044-6
更新日期:2014-12-01 00:00:00
abstract::Dispersal heterogeneity is increasingly being observed in ecological populations and has long been suspected as an explanation for observations of non-Gaussian dispersal. Recent empirical and theoretical studies have begun to confirm this. Using an integro-difference model, we allow an individual's diffusivity to be d...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-014-0014-z
更新日期:2014-11-01 00:00:00
abstract::Chemical reactions are discrete, stochastic events. As such, the species' molecular numbers can be described by an associated master equation. However, handling such an equation may become difficult due to the large size of reaction networks. A commonly used approach to forecast the behaviour of reaction networks is t...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-014-9985-z
更新日期:2014-09-01 00:00:00
abstract::A mathematical control model for the transmission dynamics of tuberculosis (TB) in South Korea is developed on the basis of the reported active-TB and relapse-TB incidence data. In this work, optimal control theory is used to propose optimal TB prevention and control strategy and rearrange the government TB budget for...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-014-9962-6
更新日期:2014-07-01 00:00:00
abstract::The scaling and shift of the gene expression boundary in a developing embryo are two key problems with regard to morphogen gradient formation in developmental biology. In this study, a bigradient model was applied to a nonlinear reaction diffusion system (NRDS) to investigate the location of morphogen gene expression ...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-014-9967-1
更新日期:2014-06-01 00:00:00
abstract::Farmers frequently decide where to locate the colonies of their domesticated eusocial bees, especially given the following mutually exclusive scenarios: (i) there are limited nectar and pollen sources within the vicinity of the apiary that cause competition among foragers; and (ii) there are fewer pollinators compared...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-014-9943-9
更新日期:2014-05-01 00:00:00
abstract::We address the problem of using nonlinear models to design experiments to characterize the dynamics of cellular processes by using the approach of the Maximally Informative Next Experiment (MINE), which was introduced in W. Dong et al. (PLoS ONE 3(8):e3105, 2008) and independently in M.M. Donahue et al. (IET Syst. Bio...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-014-9935-9
更新日期:2014-03-01 00:00:00
abstract::Bovine Babesiosis (BB) is a tick borne parasitic disease with worldwide over 1.3 billion bovines at potential risk of being infected. The disease, also called tick fever, causes significant mortality from infection by the protozoa upon exposure to infected ticks. An important factor in the spread of the disease is the...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-013-9912-8
更新日期:2014-01-01 00:00:00
abstract::Degradable scaffolds represent a promising solution for tissue engineering of damaged or degenerated articular cartilage which due to its avascular nature, is characterized by a low self-repair capacity. To estimate the articular cartilage regeneration process employing degradable scaffolds, we propose a mathematical ...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-013-9897-3
更新日期:2013-12-01 00:00:00
abstract::It is widely believed that the slowest dispersal strategy is selected in the evolutional if the environment is temporally invariant but spatially heterogeneous. Authors claim in this paper that this belief is true only if random dispersals with constant motility are considered. However, if a dispersal strategy with fi...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-013-9904-8
更新日期:2013-12-01 00:00:00
abstract::The apoptotic caspase-3/8 feedback loop describes the core of the extrinsic pro-apoptotic signaling pathway, an essential part of apoptosis. Latter is a prototype of the programmed cell death, which enables organisms to remove damaged or infected cells. The reaction network of the caspase-3/8 feedback loop in a single...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-013-9892-8
更新日期:2013-11-01 00:00:00
abstract::W.O. Kermack and A.G. McKendrick introduced in their fundamental paper, A Contribution to the Mathematical Theory of Epidemics, published in 1927, a deterministic model that captured the qualitative dynamic behavior of single infectious disease outbreaks. A Kermack–McKendrick discrete-time general framework, motivated...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-013-9866-x
更新日期:2013-10-01 00:00:00
abstract::The multifractal analysis of binary images of DNA is studied in order to define a methodological approach to the classification of DNA sequences. This method is based on the computation of some multifractality parameters on a suitable binary image of DNA, which takes into account the nucleotide distribution. The binar...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-013-9859-9
更新日期:2013-09-01 00:00:00
abstract::The mechanical behavior of the actin cytoskeleton has previously been investigated using both experimental and computational techniques. However, these investigations have not elucidated the role the cytoskeleton plays in the compression resistance of cells. The present study combines experimental compression techniqu...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-013-9812-y
更新日期:2013-08-01 00:00:00
abstract::This paper considers plant-pollinator systems in which plants are divided into two categories: The plants that secret a substantial volume of nectar in their flowers are called secretors, while those without secreting nectar are called nonsecretors (cheaters). The interaction between pollinators and secretors is mutua...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-013-9846-1
更新日期:2013-07-01 00:00:00
abstract::Logical modeling of biological regulatory networks gives rise to a representation of the system's dynamics as a so-called state transition graph. Analysis of such a graph in its entirety allows for a comprehensive understanding of the functionalities and behavior of the modeled system. However, the size of the vertex ...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-012-9782-5
更新日期:2013-06-01 00:00:00
abstract::Understanding how ecosystems evolve and how they respond to external perturbations is critical if we are to predict the effects of human intervention. A particular class of ecosystems whose dynamics are poorly understood are those in which the species are related via cross-feeding. In these ecosystems the metabolic ou...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-013-9828-3
更新日期:2013-05-01 00:00:00
abstract::Mathematical models have been used to simulate HIV transmission and to study the use of preexposure prophylaxis (PrEP) for HIV prevention. Often a single intervention outcome over 10 years has been used to evaluate the effectiveness of PrEP interventions. However, different metrics express a wide variation over time a...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-013-9824-7
更新日期:2013-04-01 00:00:00
abstract::This paper is devoted to the investigation of the effects of periodic drug treatment on a standard within-host virus model. We first introduce the basic reproduction ratio for the model, and then show that the infection free equilibrium is globally asymptotically stable, and the disease eventually disappears if R0<1, ...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-013-9820-y
更新日期:2013-03-01 00:00:00
abstract::With increasing fishing pressures having brought several stocks to the brink of collapse, there is a need for developing efficient harvesting methods that account for factors beyond merely yield or profit. We consider the dynamics and management of a stage-structured fish stock. Our work is based on a consumer-resourc...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-012-9789-y
更新日期:2013-01-01 00:00:00
abstract::We address the observation that, in some cases, patients infected with the hepatitis C virus (HCV) are cleared of HCV when super-infected with the hepatitis A virus (HAV). We hypothesise that this phenomenon can be explained by the competitive exclusion principle, including the action of the immune system, and show th...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-012-9795-0
更新日期:2013-01-01 00:00:00
abstract::Cell polarization is an important part of the response of eukaryotic cells to stimuli, and forms a primary step in cell motility, differentiation, and many cellular functions. Among the important biochemical players implicated in the onset of intracellular asymmetries that constitute the early phases of polarization a...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-012-9766-5
更新日期:2012-11-01 00:00:00
abstract::Cell cycle times are vital parameters in cancer research, and short cell cycle times are often related to poor survival of cancer patients. A method for experimental estimation of cell cycle times, or doubling times of cultured cancer cell populations, based on addition of paclitaxel (an inhibitor of cell division) ha...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-012-9764-7
更新日期:2012-10-01 00:00:00
abstract::Spatial oscillations of proteins in bacteria have recently attracted much attention. The cellular mechanism underlying these oscillations can be studied at molecular as well as at more macroscopic levels. We construct a minimal mathematical model with two proteins that is able to produce self-sustained regular pole-to...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-012-9752-y
更新日期:2012-09-01 00:00:00
abstract::A mathematical model for the plant-pollinator-robber interaction is studied to understand the factors leading to the widespread occurrence and stability of such interactions. In the interaction, a flowering plant provides resource for its pollinator and the pollinator has both positive and negative effects on the plan...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-012-9750-0
更新日期:2012-09-01 00:00:00
abstract::Alcohol consumption and abuse is widespread in sub-Saharan Africa where most HIV infections occur and has been associated with risky sexual behaviors. It may therefore be one of the most common, potentially modifiable HIV risk factors in this region. A deterministic system of ordinary differential equations incorporat...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-012-9747-8
更新日期:2012-09-01 00:00:00
abstract::The paper presents results on the asymptotic properties of the least-squares estimates (LSEs) of the reaction constants in mass-action, stochastic, biochemical network models. LSEs are assumed to be based on the longitudinal data from partially observed trajectories of a stochastic dynamical system, modeled as a conti...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-012-9744-y
更新日期:2012-08-01 00:00:00
abstract::We introduce here a gene evolution model which is an extension of the time-continuous stochastic IDIS model (Lèbre and Michel in J. Comput. Biol. Chem. 34:259-267, 2010) to sequence length. This new IDISL (Insertion Deletion Independent of Substitution based on sequence Length) model gives an analytical expression of ...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-012-9735-z
更新日期:2012-08-01 00:00:00
abstract::We describe and analyze a periodically-forced difference equation model for malaria in mosquitoes that captures the effects of seasonality and allows the mosquitoes to feed on a heterogeneous population of hosts. We numerically show the existence of a unique globally asymptotically stable periodic orbit and calculate ...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-011-9710-0
更新日期:2012-05-01 00:00:00
abstract::We study crossflow filtration mechanisms in suspension-feeding fishes using computational fluid dynamics to model fluid flow and food particle movement in the vicinity of the gill rakers. During industrial and biological crossflow filtration, particles are retained when they remain suspended in the mainstream flow tra...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-011-9709-6
更新日期:2012-04-01 00:00:00